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QUETIAPINE FUMARATE (quetiapine fumarate)
- Schizophrenia
- Bipolar disorder in remission
- Depression associated with bipolar disorder
- Mania associated with bipolar disorder
100 mg tablet
- 1 tablet (100 mg) by oral route 2 times per day
200 mg tablet
- 1 tablet (200 mg) by oral route 2 times per day
25 mg tablet
- 1 tablet (25 mg) by oral route 2 times per day
300 mg tablet
- 1 tablet (300 mg) by oral route once daily
400 mg tablet
- 1 tablet (400 mg) by oral route 2 times per day
50 mg tablet
- 1 tablet (50 mg) by oral route 2 times per day
quetiapine 100 mg tablet
- 1 tablet (100 mg) by oral route 2 times per day
quetiapine 200 mg tablet
- 1 tablet (200 mg) by oral route 2 times per day
quetiapine 25 mg tablet
- 1 tablet (25 mg) by oral route 2 times per day
quetiapine 300 mg tablet
- 1 tablet (300 mg) by oral route once daily
quetiapine 400 mg tablet
- 1 tablet (400 mg) by oral route 2 times per day
quetiapine 50 mg tablet
- 1 tablet (50 mg) by oral route 2 times per day
Depression associated with bipolar disorder
- 1 tablet (300 mg) by oral route once daily
- 1 tablet (400 mg) by oral route once daily
- 2 tablets (400 mg) by oral route once daily
- 2 tablets (600 mg) by oral route once daily
Mania associated with bipolar disorder
- 1 tablet (100 mg) by oral route 2 times per day
- 1 tablet (100 mg) by oral route 3 times per day
- 2 tablets (200 mg) by oral route 2 times per day
- 1 tablet (200 mg) by oral route 2 times per day
- 1 tablet (300 mg) by oral route 2 times per day
- 1 tablet (300 mg) by oral route once daily
- 1 tablet (400 mg) by oral route 2 times per day
Schizophrenia
- 1 tablet (25 mg) by oral route 2 times per day
- 1 tablet (25 mg) by oral route 3 times per day
- 1 tablet (50 mg) by oral route 2 times per day
- 1 tablet (50 mg) by oral route 3 times per day
- 2 tablets (50 mg) by oral route 2 times per day
- 2 tablets (50 mg) by oral route 3 times per day
- 2 tablets (100 mg) by oral route 3 times per day
- 2 tablets (100 mg) by oral route 2 times per day
- 1 tablet (100 mg) by oral route 2 times per day
- 1 tablet (100 mg) by oral route 3 times per day
- 2 tablets (200 mg) by oral route 2 times per day
- 1 tablet (200 mg) by oral route 2 times per day
- 1 tablet (300 mg) by oral route 2 times per day
- 1 tablet (300 mg) by oral route once daily
- metoclopramide HCl
- Metozolv Odt
- Reglan
Contraindicated
- Alagesic Lq
- amiodarone
- amiodarone in dextrose,iso-osm
- amobarbital
- amoxicil-clarithromy-lansopraz
- Amytal
- artemether-lumefantrine
- Ascomp With Codeine
- B cplx-C-St.Johnwrt-K.&S.ginsg
- bedaquiline
- Belladonna-phenobarbital
- Biaxin
- Biaxin Xl
- Biaxin Xl Pak
- Bupap
- butabarbital
- Butalbital Compound W/codeine
- Butalbital Compound-codeine
- butalbital-acetaminop-caf-cod
- butalbital-acetaminophen
- butalbital-acetaminophen-caff
- butalbital-aspirin-caffeine
- Butisol
- cabergoline
- calcium-mag-B complex-D3-hrb61
- Capacet
- carbamazepine
- Carbatrol
- Celexa
- Cerebyx
- chloroquine phosphate
- chlorpromazine
- citalopram
- clarithromycin
- Coartem
- codeine-butalbital-ASA-caff
- Cold & Flu Fighter
- Cordarone
- Corvert
- Dilantin
- Dilantin Extended
- Dilantin Infatabs
- Dilantin Kapseal
- Dilantin-125
- disopyramide
- Donnatal
- droperidol
- enzalutamide
- Epitol
- Equetro
- Erythrocin
- erythromycin
- erythromycin-sulfisoxazole
- escitalopram oxalate
- Esgic
- Fatigue Relief Complex
- Fioricet
- Fioricet With Codeine
- Fiorinal
- Fiorinal-codeine #3
- fosphenytoin
- Geodon
- ibutilide fumarate
- isoniazid-rifamp-pyrazinamide
- isradipine
- Ketek
- Lexapro
- Luminal
- Lysodren
- Margesic
- Marten-tab
- mitotane
- Mycobutin
- Mysoline
- Nebupent
- Nembutal Sodium
- Nexterone
- Norpace
- Norpace Cr
- Omeclamox-pak
- omeprazole-clarith-amoxicillin
- Orap
- Pacerone
- pasireotide
- Pentam
- pentamidine
- pentobarbital sodium
- phenobarb-hyoscy-atropine-scop
- phenobarbital
- phenobarbital sodium
- Phenytek
- phenytoin
- phenytoin sodium
- phenytoin sodium extended
- pimozide
- Prevpac
- primidone
- procainamide
- rifabutin
- Rifadin
- Rifamate
- rifampin
- rifampin-isoniazid
- Rifater
- secobarbital sodium
- Seconal Sodium
- Signifor
- Sirturo
- sodium oxybate
- St. John's wort
- Tegretol
- Tegretol Xr
- telithromycin
- Tencon
- thioridazine
- vit C-St. John wort-elder-hb30
- Women's Complex
- Xtandi
- Xyrem
- Zebutal
- ziprasidone HCl
- ziprasidone mesylate
Severe
Moderate
- Ablavar
- Advair Diskus
- Advair Hfa
- alfuzosin
- amantadine HCl
- Anzemet
- Aplenzin
- Apokyn
- apomorphine
- Astagraf Xl
- Avelox
- Avelox Abc Pack
- Avelox In Nacl (iso-osmotic)
- azithromycin
- Betapace
- Betapace Af
- Buproban
- bupropion HBr
- bupropion HCl
- Caprelsa
- carbidopa-levodopa
- carbidopa-levodopa-entacapone
- Cardene Iv
- Cardene Iv In Dextrose
- Cardene Iv In Sodium Chloride
- Cardene Sr
- Cipro
- Cipro In D5W
- Cipro Xr
- ciprofloxacin
- ciprofloxacin (mixture)
- ciprofloxacin in D5W
- clozapine
- Clozaril
- Complera
- Comtan
- crizotinib
- dasatinib
- Diskets
- dofetilide
- dolasetron
- Dolophine
- Edurant
- Effexor Xr
- emtricitab-rilpivirine-tenofov
- entacapone
- eribulin
- ezogabine
- Fareston
- Fazaclo
- felbamate
- Felbatol
- flecainide
- fluticasone-salmeterol
- Forfivo Xl
- foscarnet
- Foscavir
- gadofosveset trisodium
- granisetron
- granisetron (PF)
- Granisol
- Halaven
- Haldol
- Haldol Decanoate
- haloperidol
- haloperidol decanoate
- haloperidol lactate
- Hecoria
- indapamide
- Invega
- Invega Sustenna
- Istodax
- lapatinib
- Levitra
- lithium carbonate
- lithium citrate
- Lithobid
- methadone
- Methadone Intensol
- Methadose
- Mirapex
- Mirapex Er
- moexipril
- moexipril-hydrochlorothiazide
- moxifloxacin
- moxifloxacin in NaCl (iso-osm)
- Nexavar
- nicardipine
- nicardipine in dextrose,iso-os
- nicardipine in NaCl (iso-os)
- norfloxacin
- Noroxin
- Noxafil
- octreotide acetate
- ofloxacin
- ondansetron
- ondansetron HCl
- ondansetron HCl (PF)
- paliperidone
- paliperidone palmitate
- pazopanib
- posaconazole
- Potiga
- pramipexole
- Prograf
- propafenone
- Qualaquin
- quinine sulfate
- Requip
- Requip Xl
- rilpivirine
- romidepsin
- ropinirole
- Rythmol
- salmeterol
- Sancuso
- Sandostatin
- Sandostatin Lar Depot
- Serevent Diskus
- Sinemet
- Sinemet Cr
- Soltamox
- sorafenib
- Sorine
- sotalol
- Sotalol Af
- Sprycel
- Stalevo 100
- Stalevo 125
- Stalevo 150
- Stalevo 200
- Stalevo 50
- Stalevo 75
- sunitinib
- Sutent
- tacrolimus
- tamoxifen
- telavancin
- tetrabenazine
- Tikosyn
- tizanidine
- toremifene
- Tykerb
- Uniretic
- Univasc
- Uroxatral
- vandetanib
- vardenafil
- vemurafenib
- venlafaxine
- Versacloz
- Vibativ
- Votrient
- Wellbutrin
- Wellbutrin Sr
- Wellbutrin Xl
- Xalkori
- Xenazine
- Zanaflex
- Zelboraf
- Zithromax
- Zithromax Tri-pak
- Zithromax Z-pak
- Zmax
- Zofran
- Zofran Odt
- Zuplenz
- Zyban
- Agranulocytosis
- Congenital long QT syndrome
- Neuroleptic malignant syndrome
- Prolonged QT interval
- Torsades de pointes
Contraindicated
- Debilitation
- Disease of liver
- Hypokalemia
- Hypomagnesemia
- Metabolic syndrome X
- Neutropenic disorder
- Orthostatic hypotension
- Senile dementia
Severe
Moderate
- Acquired dystonia
- Acute confusion
- Acute myocardial infarction
- Anemia
- Bradycardia
- Carcinoma of breast
- Cardiac arrhythmia
- Cataracts
- Cerebrovascular disorder
- Chronic heart failure
- Constipation
- Dehydration
- Diabetes mellitus
- Extrapyramidal disease
- Hyperlipidemia
- Hyperprolactinemia
- Hypertension
- Hypothyroidism
- Hypovolemia
- Leukopenia
- Lower seizure threshold
- Myocardial ischemia
- Obesity
- Predisposition to aspiration
- Seizure disorder
- Suicidal ideation
- Tardive dyskinesia
- Weight gain
QUETIAPINE FUMARATE (quetiapine fumarate)
- Schizophrenia
- Bipolar disorder in remission
- Depression associated with bipolar disorder
- Mania associated with bipolar disorder
- None
- Constipation
- Dizziness
- Drowsy
- Dyspepsia
- General weakness
- Headache disorder
- Insomnia
- Lethargy
- Orthostatic hypotension
- Pharyngitis
- Weight gain
- Xerostomia
More Frequent
Severe
Less Severe
- Abnormal hepatic function tests
- Akathisia
- Dysarthria
- Dyspnea
- Hyperglycemia
- Hypotension
- Leukopenia
- Parkinsonism
- Skin rash
- Suicidal ideation
- Acute abdominal pain
- Agitation
- Anorexia
- Cough
- Flu-like symptoms
- Gastroenteritis
- Hypercholesterolemia
- Hyperhidrosis
- Hyperprolactinemia
- Hypertension
- Hypertonia
- Hypertriglyceridemia
- Increased appetite
- Nasal congestion
- Pain
- Palpitations
- Rhinitis
- Tachycardia
- Tremor
- Visual changes
- Vomiting
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Accidental fall
- Agranulocytosis
- Anaphylaxis
- Bradycardia
- Cardiomyopathy
- Cataracts
- Cerebral ischemia
- Cerebrovascular accident
- Depression
- Diabetes mellitus
- Diabetic ketoacidosis
- DRESS syndrome
- Eosinophilia
- Esophageal dysmotility
- Extrapyramidal disease
- Galactorrhea not associated with childbirth
- Gastrointestinal obstruction
- Hepatic failure
- Hepatic necrosis
- Hepatitis
- Hyponatremia
- Hypothermia
- Hypothyroidism
- Ileus
- Menstrual disorder
- Myalgias
- Myocarditis
- Neuroleptic malignant syndrome
- Neutropenic disorder
- Pancreatitis
- Peripheral edema
- Priapism
- Prolonged QT interval
- Rhabdomyolysis
- Seizure disorder
- SIADH syndrome
- Sleep apnea
- Stevens-johnson syndrome
- Tardive dyskinesia
- Thrombocytopenic disorder
- Thrombotic thrombocytopenic purpura
- Toxic epidermal necrolysis
- Urinary retention
Less Severe
- Acquired dystonia
- Complex sleep behavior
- Dysphagia
- Fever
- Memory impairment
- Nightmares
- Nocturnal enuresis
- Sleep walking disorder
- Syncope
- Vasodilation of blood vessels
Contraindicated
None
Severe Precaution
Quetiapine
Possible increased suicidal ideation and attempt. Risk of weight gain, somnolence, tachycardia. Safety and efficacy not established. Not approved age < 10 years per manufacturer.
- 1 Day – 10 Years
- Possible increased suicidal ideation and attempt. Risk of weight gain, somnolence, tachycardia. Safety and efficacy not established. Not approved age < 10 years per manufacturer.
Management or Monitoring Precaution
Quetiapine
Monitor behavior, weight, blood pressure, glucose, lipids. Possible increased risk of suicidal ideation and attempt. Higher incidence of nausea and vomiting. Risk of somnolence, tachycardia, irritability.
- 10 Years – 18 Years
- Monitor behavior, weight, blood pressure, glucose, lipids. Possible increased risk of suicidal ideation and attempt. Higher incidence of nausea and vomiting. Risk of somnolence, tachycardia, irritability.
Quetiapine
- Severity Level:
2
- Additional Notes: Non-teratogenic complications (resp, gi,cns) with exposure during 3rd trimester
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Quetiapine
Limited data suggest minimal amnt excreted ;No observed adv effects on infant
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Excreted | Not known; no or inclusive data | Limited data suggest minimal amnt excreted ;No observed adv effects on infant |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Quetiapine
Neuro/Psych-Inc risk of tardive dyskinesia. CNS effects; sedation, cognit impair, and incr fall risk. Avoid use for behav probs of dementia or delirium unless failed nonpharm options. Inc risk of stroke, cognit decline, and death when used w/senile dementia. Endocrine-May exacerbate or cause SIADH or hyponatremia. Cardiovascular-May cause orthostat hypoten. Start at 50mg/day w/slow titration. Gastrointestinal-May cause or worsen constipation. Urogenital-Avoid in pts w/urinary reten.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | N | Y | Y | Y | N | Y |
BEERS: Y HEDIS: Y STOPP: Y
No Known Risk
None
- There may be a slightly increased risk of serious, possibly fatal side effects (such as stroke, heart failure, fast/irregular heartbeat, pneumonia) when this medication is used by older adults with dementia. This medication is not approved for the treatment of dementia-related behavior problems. Discuss the risks and benefits of this medication, as well as other effective and possibly safer treatments for dementia-related behavior problems, with the doctor.<br /><br /> Quetiapine is used to treat certain mental/mood disorders (such as schizophrenia, bipolar disorder, sudden episodes of mania or depression associated with bipolar disorder). Drugs used to treat depression can help prevent suicidal thoughts/attempts and provide other important benefits. However, studies have shown that a small number of people (especially people younger than 25) who take drugs to treat depression may experience worsening depression, other mental/mood symptoms, or suicidal thoughts/attempts.<br /><br />Therefore, it is very important to talk with the doctor about the risks and benefits of drugs used to treat depression (especially for people younger than 25), even if treatment is not for a mental/mood condition. Tell the doctor right away if you notice worsening depression/other psychiatric conditions, unusual behavior changes (including possible suicidal thoughts/attempts), or other mental/mood changes (including new/worsening anxiety, panic attacks, trouble sleeping, irritability, hostile/angry feelings, impulsive actions, severe restlessness, very rapid speech). Be especially watchful for these symptoms when a new drug to treat depression is started or when the dose is changed. This medication is not approved for use in children under 10 years old.
| Bipolar disorder in remission | |
| F31.7 | Bipolar disorder, currently in remission |
| F31.70 | Bipolar disorder, currently in remission, most recent episode unspecified |
| F31.71 | Bipolar disorder, in partial remission, most recent episode hypomanic |
| F31.72 | Bipolar disorder, in full remission, most recent episode hypomanic |
| F31.73 | Bipolar disorder, in partial remission, most recent episode manic |
| F31.74 | Bipolar disorder, in full remission, most recent episode manic |
| F31.75 | Bipolar disorder, in partial remission, most recent episode depressed |
| F31.76 | Bipolar disorder, in full remission, most recent episode depressed |
| F31.77 | Bipolar disorder, in partial remission, most recent episode mixed |
| F31.78 | Bipolar disorder, in full remission, most recent episode mixed |
| Depression associated with bipolar disorder | |
| F31.3 | Bipolar disorder, current episode depressed, mild or moderate severity |
| F31.30 | Bipolar disorder, current episode depressed, mild or moderate severity, unspecified |
| F31.31 | Bipolar disorder, current episode depressed, mild |
| F31.32 | Bipolar disorder, current episode depressed, moderate |
| F31.4 | Bipolar disorder, current episode depressed, severe, without psychotic features |
| F31.5 | Bipolar disorder, current episode depressed, severe, with psychotic features |
| Mania associated with bipolar disorder | |
| F31.1 | Bipolar disorder, current episode manic without psychotic features |
| F31.10 | Bipolar disorder, current episode manic without psychotic features, unspecified |
| F31.11 | Bipolar disorder, current episode manic without psychotic features, mild |
| F31.12 | Bipolar disorder, current episode manic without psychotic features, moderate |
| F31.13 | Bipolar disorder, current episode manic without psychotic features, severe |
| F31.2 | Bipolar disorder, current episode manic severe with psychotic features |
| F31.73 | Bipolar disorder, in partial remission, most recent episode manic |
| Schizophrenia | |
| F20 | Schizophrenia |
| F20.0 | Paranoid schizophrenia |
| F20.1 | Disorganized schizophrenia |
| F20.2 | Catatonic schizophrenia |
| F20.3 | Undifferentiated schizophrenia |
| F20.5 | Residual schizophrenia |
| F20.8 | Other schizophrenia |
| F20.81 | Schizophreniform disorder |
| F20.89 | Other schizophrenia |
| F20.9 | Schizophrenia, unspecified |
| 0-9 | A-Z |
|---|---|
| F20 | Schizophrenia |
| F20.0 | Paranoid schizophrenia |
| F20.1 | Disorganized schizophrenia |
| F20.2 | Catatonic schizophrenia |
| F20.3 | Undifferentiated schizophrenia |
| F20.5 | Residual schizophrenia |
| F20.8 | Other schizophrenia |
| F20.81 | Schizophreniform disorder |
| F20.89 | Other schizophrenia |
| F20.9 | Schizophrenia, unspecified |
| F31.1 | Bipolar disorder, current episode manic without psychotic features |
| F31.10 | Bipolar disorder, current episode manic without psychotic features, unspecified |
| F31.11 | Bipolar disorder, current episode manic without psychotic features, mild |
| F31.12 | Bipolar disorder, current episode manic without psychotic features, moderate |
| F31.13 | Bipolar disorder, current episode manic without psychotic features, severe |
| F31.2 | Bipolar disorder, current episode manic severe with psychotic features |
| F31.3 | Bipolar disorder, current episode depressed, mild or moderate severity |
| F31.30 | Bipolar disorder, current episode depressed, mild or moderate severity, unspecified |
| F31.31 | Bipolar disorder, current episode depressed, mild |
| F31.32 | Bipolar disorder, current episode depressed, moderate |
| F31.4 | Bipolar disorder, current episode depressed, severe, without psychotic features |
| F31.5 | Bipolar disorder, current episode depressed, severe, with psychotic features |
| F31.7 | Bipolar disorder, currently in remission |
| F31.70 | Bipolar disorder, currently in remission, most recent episode unspecified |
| F31.71 | Bipolar disorder, in partial remission, most recent episode hypomanic |
| F31.72 | Bipolar disorder, in full remission, most recent episode hypomanic |
| F31.73 | Bipolar disorder, in partial remission, most recent episode manic |
| F31.73 | Bipolar disorder, in partial remission, most recent episode manic |
| F31.74 | Bipolar disorder, in full remission, most recent episode manic |
| F31.75 | Bipolar disorder, in partial remission, most recent episode depressed |
| F31.76 | Bipolar disorder, in full remission, most recent episode depressed |
| F31.77 | Bipolar disorder, in partial remission, most recent episode mixed |
| F31.78 | Bipolar disorder, in full remission, most recent episode mixed |
Formulary Reference Tool