BUTALBITAL-ASPIRIN-CAFFEINE (BUTALBITAL/ASPIRIN/CAFFEINE)
- Tension-type headache
50 mg-325 mg-40 mg capsule
- 1 capsule by oral route every 4 hours as needed not to exceed 6 capsules per 24Hrs
50 mg-325 mg-40 mg capsule
- 1 capsule by oral route every 4 hours as needed not to exceed 6 capsules per 24Hrs
Tension-type headache
- 1 capsule by oral route every 4 hours as needed not to exceed 6 capsules per 24Hrs
- 2 capsules by oral route every 4 hours as needed not to exceed 6Capsules per 24Hrs
- 1 - 2 capsules by oral route every 4 hours as needed not to exceed 6 capsules per 24Hrs
- dipyridamole
- ketorolac
- Mifeprex
- mifepristone
- sodium oxybate
- Sprix
- Xyrem
Contraindicated
- Acid Reducer (cimetidine)
- Acid Relief (cimetidine)
- Adenocard
- Adenoscan
- adenosine
- adenosine (diagnostic)
- Afinitor
- Afinitor Disperz
- Agrylin
- Alimta
- Altavera (28)
- Alyacen 1/35 (28)
- Alyacen 7/7/7 (28)
- Amethia
- Amethia Lo
- Amethyst
- anagrelide
- apixaban
- Apri
- Aranelle (28)
- Astagraf Xl
- Aubra
- Aviane
- Azurette (28)
- Balziva (28)
- Beyaz
- Brevicon (28)
- Briellyn
- Brilinta
- Camila
- Camrese
- Camrese Lo
- Caziant (28)
- Chateal
- cimetidine
- Coumadin
- Cryselle (28)
- Cyclafem 1/35 (28)
- Cyclafem 7/7/7 (28)
- Cyclessa (28)
- cyclosporine
- cyclosporine modified
- Dasetta 1/35 (28)
- Dasetta 7/7/7 (28)
- Daysee
- desog-e.estradiol/e.estradiol
- Desogen
- desogestrel-ethinyl estradiol
- drospirenone-e.estradiol-lm.FA
- drospirenone-ethinyl estradiol
- Elinest
- Eliquis
- Emoquette
- Enpresse
- Enskyce
- Errin
- Estarylla
- estradiol valerate-dienogest
- Estrostep Fe-28
- ethynodiol diac-eth estradiol
- etonogestrel
- etonogestrel-ethinyl estradiol
- everolimus
- Falmina (28)
- Femcon Fe
- flu vac,qval 2013-14 (2-49yrs)
- Flumist 2013-2014
- Generess Fe
- Gengraf
- Gianvi (28)
- Gildagia
- Gildess
- Gildess Fe
- Heartburn Relief
- Heather
- Hecoria
- Introvale
- Jantoven
- Jencycla
- Jolessa
- Jolivette
- Junel 1.5/30 (21)
- Junel 1/20 (21)
- Junel Fe 1.5/30 (28)
- Junel Fe 1/20 (28)
- Kariva (28)
- Kelnor 1/35 (28)
- Kurvelo
- L norgest&E estradiol-E estrad
- Larin 1/20 (21)
- Larin Fe
- Leena 28
- Lessina
- Levonest (28)
- levonorg-eth estrad triphasic
- levonorgestrel
- levonorgestrel-ethinyl estrad
- Levora 0.15/30 (28)
- Levora-28
- Lexiscan
- Lo Loestrin Fe
- Loestrin 1.5/30 (21)
- Loestrin 1/20 (21)
- Loestrin Fe 1.5/30 (28)
- Loestrin Fe 1/20 (28)
- Lomedia 24 Fe
- Loryna (28)
- Loseasonique
- Low-ogestrel (28)
- Lutera (28)
- Lyza
- Marlissa
- Methotrexate (anti-rheumatic)
- methotrexate sodium
- methotrexate sodium (PF)
- Microgestin 1.5/30 (21)
- Microgestin 1/20 (21)
- Microgestin Fe 1.5/30 (28)
- Microgestin Fe 1/20 (28)
- Minastrin 24 Fe
- Mircette (28)
- Mirena
- Modicon (28)
- Mono-linyah
- Mononessa (28)
- My Way
- Myzilra
- Natazia
- Necon 0.5/35 (28)
- Necon 1/35 (28)
- Necon 1/50 (28)
- Necon 10/11 (28)
- Necon 7/7/7 (28)
- Neoral
- Nexplanon
- Next Choice One Dose
- Nor-qd
- Nora-be
- norelgestrom-ethinyl estradiol
- noreth-ethinyl estradiol-iron
- norethin-e.estradiol triphasic
- norethin-eth estrad biphasic
- norethindrone (contraceptive)
- norethindrone ac-eth estradiol
- norethindrone-e.estradiol-iron
- norethindrone-ethin estradiol
- norethindrone-mestranol
- norgestimate-ethinyl estradiol
- norgestrel-ethinyl estradiol
- Norinyl 1+35 (28)
- Norinyl 1+50 (28)
- Nortrel 0.5/35 (28)
- Nortrel 1/35 (21)
- Nortrel 1/35 (28)
- Nortrel 7/7/7 (28)
- Nuvaring
- Ocella
- Ogestrel (28)
- Orsythia
- Ortho Evra
- Ortho Micronor
- Ortho Tri-cyclen (28)
- Ortho Tri-cyclen Lo (28)
- Ortho-cept (28)
- Ortho-cyclen (28)
- Ortho-novum 1/35 (28)
- Ortho-novum 7/7/7 (28)
- Ovcon-35 (28)
- pemetrexed
- Philith
- Pimtrea (28)
- Pirmella
- Plan B One-step
- Portia
- Previfem
- Prograf
- Quartette
- Quasense
- quetiapine
- Rapamune
- Reclipsen (28)
- regadenoson
- Rheumatrex
- rivaroxaban
- Safyral
- Samsca
- Sandimmune
- Seasonique
- Seroquel Xr
- sirolimus
- Skyla
- Sprintec (28)
- Sronyx
- Syeda
- tacrolimus
- Tagamet Hb
- temsirolimus
- ticagrelor
- Tilia Fe
- tolvaptan
- Torisel
- Trexall
- Tri-estarylla
- Tri-legest Fe
- Tri-linyah
- Tri-norinyl (28)
- Tri-previfem (28)
- Tri-sprintec (28)
- Trinessa (28)
- Trivora (28)
- varicella virus vacc live (PF)
- Varivax (pf)
- Velivet Triphasic Regimen (28)
- Vestura (28)
- Viorele (28)
- Vyfemla (28)
- warfarin
- Wera (28)
- Wymzya Fe
- Xarelto
- Yasmin (28)
- Yaz 28
- Zarah
- Zenchent (28)
- Zenchent Fe
- Zeosa
- Zortress
- Zovia 1/35E (28)
- Zovia 1/50E (28)
Severe
Moderate
- A-hydrocort
- A-methapred
- Abilify
- Abilify Discmelt
- Abilify Maintena
- Accupril
- Accuretic
- acebutolol
- Aceon
- acetazolamide
- acetazolamide sodium
- Activella
- Adasuve
- Adoxa
- Alora
- Altace
- Amaryl
- aminophylline
- amlodipine-benazepril
- Angeliq
- Anucort-hc
- Anusol-hc
- aripiprazole
- Aristospan Intra-articular
- Aristospan Intralesional
- Arixtra
- Avidoxy
- benazepril
- benazepril-hydrochlorothiazide
- betamethasone acet & sod phos
- betaxolol
- Brintellix
- Brisdelle
- budesonide
- captopril
- captopril-hydrochlorothiazide
- Celestone Soluspan
- Celexa
- Cenestin
- chlorpromazine
- citalopram
- Climara
- Climara Pro
- colchicine-probenecid
- Colocort
- Combipatch
- Compazine
- Compro
- conj estrogens-bazedoxifene
- conjugated estrogens
- Cortef
- Cortenema
- Cortifoam
- cortisone
- Covaryx
- Covaryx H.s.
- Cymbalta
- dalteparin (porcine)
- Delestrogen
- Depacon
- Depakene
- Depakote
- Depakote Er
- Depakote Sprinkles
- Depo-estradiol
- Depo-medrol
- desvenlafaxine
- desvenlafaxine fumarate
- desvenlafaxine succinate
- dexamethasone
- Dexamethasone Intensol
- dexamethasone sodium phos (PF)
- dexamethasone sodium phosphate
- Dexpak 10 Day
- Dexpak 13 Day
- Dexpak 6 Day
- dextromethorphan-quinidine
- Diabeta
- Diamox Sequels
- divalproex
- Divigel
- Doryx
- Doxy-100
- doxycycline calcium
- doxycycline hyclate
- doxycycline monohydrate
- drospirenone-estradiol
- Duavee
- Duetact
- duloxetine
- Dutoprol
- Eemt
- Eemt Hs
- Effexor Xr
- Elestrin
- Elixophyllin
- Elmiron
- enalapril maleate
- enalapril-hydrochlorothiazide
- enalaprilat
- Enjuvia
- enoxaparin
- Entocort Ec
- Epaned
- escitalopram oxalate
- esterified estrogens
- Estrace
- estradiol
- estradiol acetate
- estradiol cypionate
- Estradiol Transdermal Patch
- estradiol valerate
- estradiol-levonorgestrel
- estradiol-norethindrone acet
- estradiol-norgestimate
- Estrasorb
- Estring
- Estrogel
- estrogens-methyltestosterone
- estropipate
- Evamist
- Ez Use Joint-tunnel-trigger
- felodipine
- Femhrt Low Dose
- Femring
- Fetzima
- First-duke's
- First-mary's Mouthwash
- Flagyl
- Flagyl Er
- Flo-pred
- fludrocortisone
- fluoxetine
- fluphenazine decanoate
- fluphenazine HCl
- fluvoxamine
- fondaparinux
- fosinopril
- fosinopril-hydrochlorothiazide
- Fragmin
- glimepiride
- glipizide
- glipizide-metformin
- Glucotrol
- Glucotrol Xl
- Glucovance
- glyburide
- glyburide micronized
- glyburide-metformin
- Glynase
- Grx Hicort 25
- Haldol
- Haldol Decanoate
- haloperidol
- haloperidol decanoate
- haloperidol lactate
- Hemril-30
- heparin (porcine)
- heparin (porcine) in D5W
- heparin(porcine) in 0.45% NaCl
- heparin, porcine (PF)
- hydrocortisone
- hydrocortisone acetate
- hydrocortisone sod succ (PF)
- hydrocortisone sod succinate
- Inderal La
- Inderal Xl
- Innopran Xl
- Jinteli
- Kenalog
- Khedezla
- lepirudin
- levomilnacipran
- Lexapro
- lisinopril
- lisinopril-hydrochlorothiazide
- lithium carbonate
- lithium citrate
- Lithobid
- Lopressor
- Lopressor Hct
- Lotensin
- Lotrel
- Lovenox
- loxapine
- loxapine succinate
- Loxitane
- Luvox Cr
- Mavik
- Medrol
- Medrol (pak)
- Menest
- Menostar
- methazolamide
- methylprednisolone
- methylprednisolone acetate
- methylprednisolone sod suc(PF)
- methylprednisolone sodium succ
- methylprednisolone-bupivacaine
- metoprolol su-hydrochlorothiaz
- metoprolol succinate
- metoprolol ta-hydrochlorothiaz
- metoprolol tartrate
- Metro I.v.
- Metrogel Vaginal
- metronidazole
- metronidazole in NaCl (iso-os)
- Millipred
- Millipred Dp
- milnacipran
- Mimvey
- Minivelle
- moexipril
- moexipril-hydrochlorothiazide
- Monodox
- Morgidox
- nateglinide
- Neptazane
- Nuedexta
- nystatin-hydrocortisone-diphen
- nystatin-TCN-HC-diphenhydramin
- Ogen 2.5
- olanzapine-fluoxetine
- Oracea
- Orapred
- Orapred Odt
- paroxetine HCl
- paroxetine mesylate
- Paxil
- Paxil Cr
- Pediapred
- pentosan polysulfate sodium
- perindopril erbumine
- perphenazine
- perphenazine-amitriptyline
- Pexeva
- Phenadoz
- Phenergan
- Physicians Ez Use M-pred
- pioglitazone-glimepiride
- prednisolone
- prednisolone acetate
- prednisolone sodium phosphate
- prednisone
- Prednisone Intensol
- Prefest
- Premarin
- Prinivil
- Pristiq
- probenecid
- prochlorperazine
- prochlorperazine Edisylate
- prochlorperazine maleate
- Proctocort
- promethazine
- Promethazine Vc
- Promethazine Vc-codeine
- promethazine-codeine
- promethazine-DM
- promethazine-phenyleph-codeine
- promethazine-phenylephrine
- Promethegan
- propranolol
- propranolol-hydrochlorothiazid
- Prozac
- Prozac Weekly
- quinapril
- quinapril-hydrochlorothiazide
- quinidine gluconate
- quinidine sulfate
- ramipril
- Rayos
- Rectacort-hc
- Refludan
- Risperdal
- Risperdal Consta
- Risperdal M-tab
- risperidone
- risperidone microspheres
- Sarafem
- Savella
- Sectral
- Seroquel
- sertraline
- Solu-cortef
- Solu-cortef (pf)
- Solu-medrol
- Solu-medrol (pf)
- Starlix
- Stavzor
- Symbyax
- synthetic conj estrogens A
- synthetic conj estrogens B
- Tarka
- Theo-24
- Theochron
- theophylline
- theophylline in dextrose 5 %
- thioridazine
- ticlopidine
- tolazamide
- tolbutamide
- Toprol Xl
- trandolapril
- trandolapril-verapamil
- triamcinolone acetonide
- triamcinolone hexacetonide
- triamcinolone-lidocaine
- trifluoperazine
- Uceris
- Uniretic
- Univasc
- Vagifem
- valproate sodium
- valproic acid
- valproic acid (as sodium salt)
- Vandazole
- Vaseretic
- Vasotec
- venlafaxine
- Veripred 20
- Vibramycin
- Viibryd
- vilazodone
- Vivelle-dot
- vortioxetine
- Zestoretic
- Zestril
- Zoloft
- 30 day risk period post-myocardial infarction
- Acute asthma attack
- Alcoholism
- Aspirin exacerbated respiratory disease
- Gastrointestinal hemorrhage
- Hemolytic anemia from PK and g6PD deficiencies
- Hemophilia
- Lactating mother
- Peptic ulcer
- Porphyria
- Pregnancy
- Reye's syndrome
- Sleep apnea
- Von willebrand's disease
Contraindicated
- Acute respiratory insufficiency
- Alcoholism
- Chronic obstructive pulmonary disease
- Depression
- Drug abuse
- Erosive gastritis
- Gastrointestinal ulcer
- Gout
- Hepatic coma
- Hepatic encephalopathy
- Hyperammonemia
- Hypoprothrombinemia
- Necrotizing enterocolitis
- Peptic ulcer
- Suicidal ideation
- Systemic mastocytosis
- Thrombocytopenic disorder
- Thrombotic thrombocytopenic purpura
Severe
Moderate
- Anemia
- Cardiac arrhythmia
- Complex sleep behavior
- Disease of liver
- Hyperkinesis
- Hypertension
- Insomnia
- Kidney disease with reduction in GFR
- Nasal polyp
- Neutropenic disorder
- Renal disease with moderate to severe impairment
- Seizure disorder
- Severe hepatic disease
- Thrombocytopenic disorder
- Vitamin K deficiency
BUTALBITAL-ASPIRIN-CAFFEINE (BUTALBITAL/ASPIRIN/CAFFEINE)
- Tension-type headache
- None
- Abdominal pain with cramps
- Dizziness
- Drowsy
- Gastric acid hypersecretory conditions
- Gastrointestinal irritation
- Heartburn
- Insomnia
- Nausea
- Nervousness
- Vomiting
More Frequent
Severe
Less Severe
- Acute confusion
- Excitement
- Lethargy
- Constipation
- Depression
- Excitement
- Headache disorder
- Insomnia
- Irritability
- Nausea
- Nervousness
- Nightmares
- Symptoms of anxiety
- Syncope
- Vertigo
- Vomiting
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Accidental fall
- Agranulocytosis
- Allergic dermatitis
- Altered consciousness
- Anaphylaxis
- Anemia
- Angioedema
- Apnea
- Blistering skin
- Bradycardia
- Bronchospastic pulmonary disease
- Drug-induced hepatitis
- Dyspnea
- Exfoliative dermatitis
- Extrasystoles
- Gastrointestinal hemorrhage
- Gastrointestinal perforation
- Gastrointestinal ulcer
- Hallucinations
- Hemolytic anemia
- Hemorrhage
- Hypersensitivity drug reaction
- Hypotension
- Hypoventilation
- Interstitial nephritis
- Intracranial bleeding
- Leukopenia
- Megaloblastic anemia
- Memory impairment
- Osteopenia
- Platelet aggregation inhibition
- Psychiatric disorder
- Purpura
- Rectal bleeding
- Rickets
- Seizure disorder
- Skin rash
- Stevens-johnson syndrome
- Throat constriction
- Thrombocytopenic disorder
- Urticaria
- Wheezing
Less Severe
- Abnormal hepatic function tests
- Agitation
- Anorexia
- Ataxia
- Black tarry stools
- CNS depression
- Complex sleep behavior
- Disturbance in thinking
- Drowsy
- Drug dependence
- Dyspepsia
- Epistaxis
- Erythema
- Gastritis
- Gingival bleeding
- Hematoma
- Hyperesthesia
- Hyperglycemia
- Hyperkinesis
- Irritability
- Nausea
- Nephrotoxicity
- Pruritus of skin
- Scotomata
- Skin rash
- Symptoms of anxiety
- Tachycardia
- Tinnitus
- Tremor
- Vomiting
Contraindicated
None
Severe Precaution
Aspirin
Reye syndrome risk with viral illness, fever, and/or flu symptoms.
Safety and effectiveness not established age < 12 years.
- 1 Day – 16 Years
- Reye syndrome risk with viral illness, fever, and/or flu symptoms.
- 1 Day – 12 Years
- Reye syndrome risk with viral illness, fever, and/or flu symptoms.
Butalbital
Reye syndrome risk with viral illness, fever, and/or flu symptoms.
Safety and effectiveness not established age < 12 years.
- 1 Day – 16 Years
- Safety and effectiveness not established age < 12 years.
- 1 Day – 12 Years
- Safety and effectiveness not established age < 12 years.
Management or Monitoring Precaution
Caffeine
Caution in: seizure disorder, cardiovascular disease, or in premature neonates with renal or hepatic impairment.
Adverse CNS effects of insomnia, restlessness, nervousness, and mild delirium, more severe in children.
- 1 Day – 364 Days
- Caution in: seizure disorder, cardiovascular disease, or in premature neonates with renal or hepatic impairment.
- Adverse CNS effects of insomnia, restlessness, nervousness, and mild delirium, more severe in children.
- 1 Years – 13 Years
- Caution in: seizure disorder, cardiovascular disease, or in premature neonates with renal or hepatic impairment.
- Adverse CNS effects of insomnia, restlessness, nervousness, and mild delirium, more severe in children.
Aspirin (>150Mg)
- Severity Level:
1
- Additional Notes: No fda category; not recommended especially in 3rd trimester or near term
Butalbital
- Severity Level:
C
- Additional Notes: Case report of neonatal withdrawal seizures with butalbital combo product
Caffeine
- Severity Level:
C
- Additional Notes: Reports of miscarriage,poor fetal growth possibly assoc w/high doses of caffeine
Contraindicated
Aspirin (>150Mg)
One report of metabolic acidosis; risk of reye's synd in viral illness.
General | Excretion Potential | Effect on Infant | Notes |
Drug should not be given to breast feeding mothers | Excreted | Drug shown to have adverse effect | One report of metabolic acidosis; risk of reye's synd in viral illness. |
Precaution Exists
Butalbital
Possibility of central nervous system depression in nursing infant.
High doses may cause hyperactivity and wakefulness in infant.
General | Excretion Potential | Effect on Infant | Notes |
Evaluate use carefully | Excreted | Drug shown to have adverse effect | Possibility of central nervous system depression in nursing infant. |
Caffeine
Possibility of central nervous system depression in nursing infant.
High doses may cause hyperactivity and wakefulness in infant.
General | Excretion Potential | Effect on Infant | Notes |
Evaluate use carefully | Excreted | Drug shown to have adverse effect | High doses may cause hyperactivity and wakefulness in infant. |
No Known Risk
None
General | Excretion Potential | Effect on Infant | Notes |
None |
Contraindicated
None
Precaution Exists
Butalbital
General-Not recommended in the elderly due to sedation which may predispose to falls. May exacerbate depression. Renal-Renal excretion may increase adverse events with renal impairment. Monitor renal function.
Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
Increased Risk / Adverse Effects | Y | Y | N | Y | N | N |
BEERS: Y HEDIS: Y STOPP: Y
No Known Risk
None
- None
Tension-type headache | |
G44.2 | Tension-type headache |
G44.20 | Tension-type headache, unspecified |
G44.201 | Tension-type headache, unspecified, intractable |
G44.209 | Tension-type headache, unspecified, not intractable |
G44.21 | Episodic tension-type headache |
G44.211 | Episodic tension-type headache, intractable |
G44.219 | Episodic tension-type headache, not intractable |
G44.22 | Chronic tension-type headache |
G44.221 | Chronic tension-type headache, intractable |
G44.229 | Chronic tension-type headache, not intractable |
0-9 | A-Z |
---|---|
G44.2 | Tension-type headache |
G44.20 | Tension-type headache, unspecified |
G44.201 | Tension-type headache, unspecified, intractable |
G44.209 | Tension-type headache, unspecified, not intractable |
G44.21 | Episodic tension-type headache |
G44.211 | Episodic tension-type headache, intractable |
G44.219 | Episodic tension-type headache, not intractable |
G44.22 | Chronic tension-type headache |
G44.221 | Chronic tension-type headache, intractable |
G44.229 | Chronic tension-type headache, not intractable |