EPLERENONE (EPLERENONE)
- Chronic heart failure following myocardial infarction
- Hypertension
25 mg tablet
- 1 tablet (25 mg) by oral route once daily
50 mg tablet
- 1 tablet (50 mg) by oral route once daily
25 mg tablet
- 1 tablet (25 mg) by oral route once daily
50 mg tablet
- 1 tablet (50 mg) by oral route once daily
Chronic heart failure following myocardial infarction
- 1 tablet (25 mg) by oral route once daily
- 1 tablet (50 mg) by oral route once daily
- 2 tablets (50 mg) by oral route once daily
Hypertension
- 1 tablet (25 mg) by oral route once daily
- 1 tablet (50 mg) by oral route 2 times per day
- 1 tablet (50 mg) by oral route once daily
- 2 tablets (50 mg) by oral route once daily
- Sporanox
- Sporanox Pulsepak
- Stribild
- telaprevir
- telithromycin
- ritonavir
- Prevpac
- posaconazole
- Onmel
- omeprazole-clarith-amoxicillin
- Omeclamox-pak
- Noxafil
- Norvir Soft Gelatin
- Norvir
- nelfinavir
- nefazodone
- lopinavir-ritonavir
- ketoconazole
- Ketek
- Kaletra
- itraconazole
- indinavir
- Incivek
- elvitegr-cobicist-emtric-tenof
- Crixivan
- conivaptan in 5 % dextrose
- clarithromycin
- boceprevir
- Biaxin Xl Pak
- Biaxin Xl
- Biaxin
- amoxicil-clarithromy-lansopraz
- Vaprisol
- Vfend
- Vfend Iv
- Victrelis
- Viracept
- voriconazole
Contraindicated
- sodium-K+-mag-Ca-chlor-acetate
- sodium-potas-chloride-dextrose
- Sorbutuss
- spironolacton-hydrochlorothiaz
- spironolactone
- Suclear
- sulfamethoxazole-trimethoprim
- Sulfatrim
- Taron-crystals
- Theralith Xr
- Thermotabs
- Tpn Electrolytes
- Tpn Electrolytes Ii
- triamterene
- triamterene-hydrochlorothiazid
- sodium phosphates
- sodium Cl-potassium chloride
- sodium & potassium bicarbonate
- sod phos,di & mono-K phos mono
- sod phos mono-sod phos dibasic
- sod & pot chlorid-sod cit-rice
- Reclast
- Ready-to-use Enema
- Primsol
- Preparation Cleansing
- potassium&sodium monobas phos
- potassium phosphate, monobasic
- potassium phosphate dibasic
- potassium gluconate
- potassium Cl-calcium phos-mag
- potassium citrate-citric acid
- potassium citrate
- potassium chloride-D5-0.9%NaCl
- potassium chloride-D5-0.3%NaCl
- potassium chloride-D5-0.2%NaCl
- potassium chloride-0.45 % NaCl
- potassium chloride in LR-D5
- potassium chloride in D5W
- potassium chloride in 0.9%NaCl
- potassium chloride
- potassium chlorid-D5-0.45%NaCl
- potassium bicarb-citric acid
- potassium bicarb & chloride
- potassium & sodium phosphates
- potassium
- pot & sod citrate-citric acid
- Phosphate Laxative
- Phospha 250 Neutral
- Phos-nak
- PEG 3350-bowel 2,two part prep
- pediatric multivit #18-iron-FA
- Pediatric Electrolyte
- Pedialyte
- Osmoprep
- Oral Saline Laxative
- Nutrilyte Ii
- Nano Vm T/f
- Medi-lyte
- Maxzide-25Mg
- Maxzide
- Klor-con/ef
- Klor-con M20
- Klor-con M15
- Klor-con M10
- Klor-con 10
- Klor-con
- Kaochlor
- K-tab
- K-phos-neutral
- K-phos Original
- K-phos No 2
- K-effervescent
- Hyperlyte Cr
- Fleet Pediatric
- Fleet Enema Extra
- Fleet Enema
- Enema Disposable
- Enema
- Effer-k
- Dyrenium
- Dyazide
- DM-GG-potassium citrate
- Disposable Enema
- Cytra-k
- Cytra-3
- Cytra K Crystals
- Curad Enema
- Cerasport Ex1
- Cerasport
- Ceraors 75
- Ceralyte-70
- Bactrim Ds
- Bactrim
- amiloride-hydrochlorothiazide
- amiloride
- Alka-seltzer Gold
- Aldactone
- Aldactazide
- Tricitrates
- trimethoprim
- Urocit-k 10
- Urocit-k 15
- Urocit-k 5
- vit B6-mag cit & ox-potass cit
- zoledronic acid
- zoledronic acid-mannitol-water
- Zometa
Severe
Moderate
- Syeda
- Tarka
- Taztia Xt
- telmisartan
- telmisartan-amlodipine
- telmisartan-hydrochlorothiazid
- Teveten
- Teveten Hct
- Tiazac
- trandolapril
- trandolapril-verapamil
- saquinavir mesylate
- Safyral
- Reyataz
- ramipril
- quinapril-hydrochlorothiazide
- quinapril
- Prinivil
- Prezista
- perindopril erbumine
- olmesartan-hydrochlorothiazide
- olmesartan-amlodipin-hcthiazid
- olmesartan
- Ocella
- moexipril-hydrochlorothiazide
- moexipril
- Micardis Hct
- Micardis
- Mavik
- Matzim La
- Lotrel
- Lotensin
- losartan-hydrochlorothiazide
- losartan
- Loryna (28)
- Lithobid
- lithium citrate
- lithium carbonate
- lisinopril-hydrochlorothiazide
- lisinopril
- Lexiva
- irbesartan-hydrochlorothiazide
- irbesartan
- Invirase
- imatinib
- Hyzaar
- Gleevec
- Gianvi (28)
- fosinopril-hydrochlorothiazide
- fosinopril
- fosaprepitant
- fosamprenavir
- fluconazole in NaCl (iso-osm)
- fluconazole in dextrose(iso-o)
- fluconazole
- Exforge Hct
- Exforge
- erythromycin-sulfisoxazole
- erythromycin
- Erythrocin
- eprosartan-hydrochlorothiazide
- eprosartan
- Epaned
- enalaprilat
- enalapril-hydrochlorothiazide
- enalapril maleate
- Emend
- Edarbyclor
- Edarbi
- drospirenone-ethinyl estradiol
- drospirenone-estradiol
- drospirenone-e.estradiol-lm.FA
- Diovan Hct
- diltiazem HCl
- Dilt-xr
- Dilacor Xr
- Diflucan
- darunavir
- crizotinib
- Cozaar
- ciprofloxacin in D5W
- ciprofloxacin (mixture)
- ciprofloxacin
- Cipro Xr
- Cipro In D5W
- Cipro
- Cartia Xt
- Cardizem La
- Cardizem Cd
- Cardizem
- captopril-hydrochlorothiazide
- captopril
- candesartan-hydrochlorothiazid
- candesartan
- Calan Sr
- Calan
- Beyaz
- Benicar Hct
- Benicar
- benazepril-hydrochlorothiazide
- benazepril
- Azor
- azilsartan medoxomil
- azilsartan med-chlorthalidone
- Avapro
- Avalide
- atazanavir
- Atacand Hct
- Atacand
- aprepitant
- Angeliq
- amlodipine-valsartan-hcthiazid
- amlodipine-valsartan
- amlodipine-olmesartan
- amlodipine-benazepril
- Altace
- Aceon
- Accuretic
- Accupril
- Tribenzor
- Twynsta
- Uniretic
- Univasc
- valsartan-hydrochlorothiazide
- Vaseretic
- Vasotec
- verapamil
- Verelan
- Verelan Pm
- Vestura (28)
- Xalkori
- Yasmin (28)
- Yaz 28
- Zarah
- Zestoretic
- Zestril
- Diabetic nephropathy
- Hyperkalemia
- Severe renal impairment
Contraindicated
- None
Severe
Moderate
- Disease of liver
EPLERENONE (EPLERENONE)
- Chronic heart failure following myocardial infarction
- Hypertension
- Hyperkalemia
- None
More Frequent
Severe
Less Severe
- Dizziness
- Headache disorder
- Kidney disease with reduction in GFR
- Abnormal vaginal bleeding
- Gynecomastia
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Acute myocardial infarction
- Angina
- Angioedema
Less Severe
- Skin rash
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Eplerenone
No efficacy for hypertension in pediatric studies ages 4 to 17 years.
- 1 Day – 17 Years
- No efficacy for hypertension in pediatric studies ages 4 to 17 years.
Eplerenone
- Severity Level:
2
- Additional Notes: Insufficient human data available.
Contraindicated
None
General | Excretion Potential | Effect on Infant | Notes |
None |
Precaution Exists
Eplerenone
Insufficient data available.
General | Excretion Potential | Effect on Infant | Notes |
Evaluate use carefully | Unknown | Not known; no or inclusive data | Insufficient data available. |
No Known Risk
None
General | Excretion Potential | Effect on Infant | Notes |
None |
Contraindicated
None
Precaution Exists
Eplerenone
Cardiovascular-In the EPHESUS study, patients over 75 years of age with heart failure post-acute myocardial infarction did not benefit from treatment with eplerenone. Metabolic-Treated elderly have a higher incidence of drug induced hyperkalemia. Renal-Manufacturer recommends that patients treated for hypertension with CrCl <51 mL/min and all patients with CrCl <31 mL/min should not be treated with eplerenone.
Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
Increased Risk / Adverse Effects | Y | N | N | N | N | Y |
BEERS: N HEDIS: N STOPP: Y
No Known Risk
None
- None
Chronic heart failure following myocardial infarction | |
I50.22 | Chronic systolic (congestive) heart failure |
I50.32 | Chronic diastolic (congestive) heart failure |
I50.42 | Chronic combined systolic (congestive) and diastolic (congestive) heart failure |
I50.812 | Chronic right heart failure |
Hypertension | |
I10 | Essential (primary) hypertension |
I11 | Hypertensive heart disease |
I11.0 | Hypertensive heart disease with heart failure |
I11.9 | Hypertensive heart disease without heart failure |
I12 | Hypertensive chronic kidney disease |
I12.0 | Hypertensive chronic kidney disease with stage 5 chronic kidney disease or end stage renal disease |
I12.9 | Hypertensive chronic kidney disease with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
I13 | Hypertensive heart and chronic kidney disease |
I13.0 | Hypertensive heart and chronic kidney disease with heart failure and stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
I13.1 | Hypertensive heart and chronic kidney disease without heart failure |
I13.10 | Hypertensive heart and chronic kidney disease without heart failure, with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
I13.11 | Hypertensive heart and chronic kidney disease without heart failure, with stage 5 chronic kidney disease, or end stage renal disease |
I13.2 | Hypertensive heart and chronic kidney disease with heart failure and with stage 5 chronic kidney disease, or end stage renal disease |
I15.1 | Hypertension secondary to other renal disorders |
0-9 | A-Z |
---|---|
I10 | Essential (primary) hypertension |
I11 | Hypertensive heart disease |
I11.0 | Hypertensive heart disease with heart failure |
I11.9 | Hypertensive heart disease without heart failure |
I12 | Hypertensive chronic kidney disease |
I12.0 | Hypertensive chronic kidney disease with stage 5 chronic kidney disease or end stage renal disease |
I12.9 | Hypertensive chronic kidney disease with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
I13 | Hypertensive heart and chronic kidney disease |
I13.0 | Hypertensive heart and chronic kidney disease with heart failure and stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
I13.1 | Hypertensive heart and chronic kidney disease without heart failure |
I13.10 | Hypertensive heart and chronic kidney disease without heart failure, with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
I13.11 | Hypertensive heart and chronic kidney disease without heart failure, with stage 5 chronic kidney disease, or end stage renal disease |
I13.2 | Hypertensive heart and chronic kidney disease with heart failure and with stage 5 chronic kidney disease, or end stage renal disease |
I15.1 | Hypertension secondary to other renal disorders |
I50.22 | Chronic systolic (congestive) heart failure |
I50.32 | Chronic diastolic (congestive) heart failure |
I50.42 | Chronic combined systolic (congestive) and diastolic (congestive) heart failure |
I50.812 | Chronic right heart failure |