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OXALIPLATIN (OXALIPLATIN)
- Lymph node positive colorectal carcinoma
- Metastatic colorectal cancer
- Oxaliplatin Iv Solution
- Oxaliplatin Intravenous Solution
- Oxaliplatin Intravenous Powder For Solution
100 mg intravenous solution
- Dosage information is not available
50 mg intravenous solution
- Dosage information is not available
100 mg/20 mL intravenous solution
- Dosage information is not available
50 mg/10 mL (5 mg/mL) intravenous solution
- Dosage information is not available
100 mg intravenous solution
- Dosage information is not available
50 mg intravenous solution
- Dosage information is not available
- adenovirus vac live type-4 & 7
- adenovirus vaccine live type-4
- adenovirus vaccine live type-7
- BCG vaccine, live (PF)
- flu vac,qval 2013-14 (2-49yrs)
- Flumist 2013-2014
- M-m-r Ii (pf)
- measles,mumps&rubella vacc(PF)
- measles,mumps,rub,varicel(PF)
- natalizumab
- Proquad (pf)
- Rotateq Vaccine
- rotavirus vaccine live, penta
- typhoid vaccine
- Tysabri
- varicella virus vacc live (PF)
- Varivax (pf)
- Vivotif Berna Vaccine
- yellow fever vaccine live (PF)
- Yf-vax (pf)
- Zostavax (pf)
- zoster vaccine live (PF)
Contraindicated
- clozapine
- Clozaril
- deferiprone
- Fazaclo
- Ferriprox
- Versacloz
Severe
Moderate
- None
- Congenital long QT syndrome
- Lactating mother
- Myopathy with CK elevation
Contraindicated
- Abnormal hepatic function tests
- Anemia
- Hypokalemia
- Hypomagnesemia
- Interstitial pneumonitis
- Neutropenic disorder
- Peripheral neuropathy
- Posterior reversible encephalopathy syndrome
- Pregnancy
- Pulmonary fibrosis
- Severe renal impairment
- Thrombocytopenic disorder
Severe
Moderate
- Disease of liver
OXALIPLATIN (OXALIPLATIN)
- Lymph node positive colorectal carcinoma
- Metastatic colorectal cancer
- Abnormal hepatic function tests
- Anemia
- Arthralgias
- Chest pain
- Cough
- Dyspnea
- Edema
- Injection site sequelae
- Leukopenia
- Neutropenic disorder
- Palmar-plantar erythrodysesthesia
- Peripheral sensory neuropathy
- Stomatitis
- Thrombocytopenic disorder
- Thromboembolic disorder
- Acute abdominal pain
- Alopecia
- Anorexia
- Back pain
- Chills
- Constipation
- Diarrhea
- Dizziness
- Dysesthesia
- Dysgeusia
- Dyspepsia
- Fatigue
- Fever
- Headache disorder
- Hyperglycemia
- Insomnia
- Myalgias
- Nausea
- Paresthesia
- Pharyngitis
- Rhinitis
- Vomiting
More Frequent
Severe
Less Severe
- Bronchospastic pulmonary disease
- Dehydration
- Depression
- Hypersensitivity drug reaction
- Hypoalbuminemia
- Hypocalcemia
- Hypokalemia
- Hyponatremia
- Infection
- Dry skin
- Dysuria
- Epistaxis
- Eye tearing
- Flatulence
- Flushing
- Gastroesophageal reflux disease
- Hiccups
- Hyperhidrosis
- Increased urinary frequency
- Peripheral edema
- Pruritus of skin
- Skin rash
- Symptoms of anxiety
- Urticaria
- Xerostomia
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Acute pancreatitis
- Acute renal failure
- Anaphylaxis
- Angioedema
- Clostridium difficile infection
- Cranial nerve disorder
- Dysarthria
- Gastrointestinal obstruction
- Granulocytopenic disorder
- Hearing loss
- Hemolytic uremic syndrome
- Hepatic veno-occlusive disease
- Hyporeflexia
- Hypotension
- Ileus
- Interstitial nephritis
- Kidney disease with reduction in GFR
- Laryngismus
- Lhermitte's sign
- Metabolic acidosis
- Muscle weakness
- Optic neuritis
- Peliosis hepatis
- Posterior reversible encephalopathy syndrome
- Prolonged QT interval
- Pulmonary fibrosis
- Reduced visual acuity
- Renal tubular necrosis
- Rhabdomyolysis
- Seizure disorder
- Septic shock
- Severe diarrhea
- Torsades de pointes
- Twitching
- Ventricular arrhythmias
- Vision loss
- Visual field defect
Less Severe
- Hypesthesia
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Oxaliplatin
Limited efficacy demonstrated for solid tumors in pediatric studies. Risk of paresthesia, thrombocytopenia.
- 1 Day – 18 Years
- Limited efficacy demonstrated for solid tumors in pediatric studies. Risk of paresthesia, thrombocytopenia.
Oxaliplatin
- Severity Level:
D
- Additional Notes:
Contraindicated
Oxaliplatin
Potential for serious adverse reaction in nursing infant
| General | Excretion Potential | Effect on Infant | Notes |
| Drug should not be given to breast feeding mothers | Unknown | Not known; no or inclusive data | Potential for serious adverse reaction in nursing infant |
Precaution Exists
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Oxaliplatin
General-Increased risk for fatigue, dehydration, hypokalemia and syncope. Gastrointestinal-Increased risk for diarrhea. Hematologic-Increased risk for leukopenia Pulmonary-Monitor for interstitial lung disease/fibrosis. Hepatic-Monitor LFTs. Renal-Monitor serum creatinine. Neuro/Psych-Monitor for peripheral neuropathy and RPLS.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | Y | Y | N | Y | Y | N |
BEERS: N HEDIS: N STOPP: N
No Known Risk
None
- Oxaliplatin may rarely cause a severe (possibly fatal) allergic reaction within minutes after a dose. Get medical help right away if you develop any signs of an allergic reaction (such as rash, itching, swelling, trouble breathing, swelling of throat, dizziness).
| Lymph node positive colorectal carcinoma | |
| C18 | Malignant neoplasm of colon |
| C18.0 | Malignant neoplasm of cecum |
| C18.1 | Malignant neoplasm of appendix |
| C18.2 | Malignant neoplasm of ascending colon |
| C18.3 | Malignant neoplasm of hepatic flexure |
| C18.4 | Malignant neoplasm of transverse colon |
| C18.5 | Malignant neoplasm of splenic flexure |
| C18.6 | Malignant neoplasm of descending colon |
| C18.7 | Malignant neoplasm of sigmoid colon |
| C18.8 | Malignant neoplasm of overlapping sites of colon |
| C18.9 | Malignant neoplasm of colon, unspecified |
| C19 | Malignant neoplasm of rectosigmoid junction |
| C20 | Malignant neoplasm of rectum |
| Metastatic colorectal cancer | |
| C18 | Malignant neoplasm of colon |
| C18.0 | Malignant neoplasm of cecum |
| C18.1 | Malignant neoplasm of appendix |
| C18.2 | Malignant neoplasm of ascending colon |
| C18.3 | Malignant neoplasm of hepatic flexure |
| C18.4 | Malignant neoplasm of transverse colon |
| C18.5 | Malignant neoplasm of splenic flexure |
| C18.6 | Malignant neoplasm of descending colon |
| C18.7 | Malignant neoplasm of sigmoid colon |
| C18.8 | Malignant neoplasm of overlapping sites of colon |
| C18.9 | Malignant neoplasm of colon, unspecified |
| C19 | Malignant neoplasm of rectosigmoid junction |
| C20 | Malignant neoplasm of rectum |
| C21.8 | Malignant neoplasm of overlapping sites of rectum, anus and anal canal |
| 0-9 | A-Z |
|---|---|
| C18 | Malignant neoplasm of colon |
| C18 | Malignant neoplasm of colon |
| C18.0 | Malignant neoplasm of cecum |
| C18.0 | Malignant neoplasm of cecum |
| C18.1 | Malignant neoplasm of appendix |
| C18.1 | Malignant neoplasm of appendix |
| C18.2 | Malignant neoplasm of ascending colon |
| C18.2 | Malignant neoplasm of ascending colon |
| C18.3 | Malignant neoplasm of hepatic flexure |
| C18.3 | Malignant neoplasm of hepatic flexure |
| C18.4 | Malignant neoplasm of transverse colon |
| C18.4 | Malignant neoplasm of transverse colon |
| C18.5 | Malignant neoplasm of splenic flexure |
| C18.5 | Malignant neoplasm of splenic flexure |
| C18.6 | Malignant neoplasm of descending colon |
| C18.6 | Malignant neoplasm of descending colon |
| C18.7 | Malignant neoplasm of sigmoid colon |
| C18.7 | Malignant neoplasm of sigmoid colon |
| C18.8 | Malignant neoplasm of overlapping sites of colon |
| C18.8 | Malignant neoplasm of overlapping sites of colon |
| C18.9 | Malignant neoplasm of colon, unspecified |
| C18.9 | Malignant neoplasm of colon, unspecified |
| C19 | Malignant neoplasm of rectosigmoid junction |
| C19 | Malignant neoplasm of rectosigmoid junction |
| C20 | Malignant neoplasm of rectum |
| C20 | Malignant neoplasm of rectum |
| C21.8 | Malignant neoplasm of overlapping sites of rectum, anus and anal canal |
Formulary Reference Tool