DESMOPRESSIN ACETATE (DESMOPRESSIN ACETATE)
- Partial central diabetes insipidus
- Partial central diabetes insipidus
- Hemophilia A
- Von willebrand's disease
0.83 mcg/spray (0.1 mL) nasal spray
- Inhale 1 spray (0.83 mcg) in either the left or right nostril by intranasal route once daily approximately 30 minutes before bedtime
1.66 mcg/spray (0.1 mL) nasal spray
- Inhale 1 spray (1.66 mcg) in either the left or right nostril by intranasal route once daily approximately 30 minutes before bedtime
10 mcg/spray (0.1 mL) nasal spray
- Spray 1 spray (10 mcg) by intranasal route 2 times per day
150 mcg/spray (0.1 mL) nasal spray
- Spray 2 sprays (300 mcg) by intranasal route once daily
desmopressin 0.83 mcg/spray (0.1 mL) nasal spray
- Inhale 1 spray (0.83 mcg) in either the left or right nostril by intranasal route once daily approximately 30 minutes before bedtime
desmopressin 1.66 mcg/spray (0.1 mL) nasal spray
- Inhale 1 spray (1.66 mcg) in either the left or right nostril by intranasal route once daily approximately 30 minutes before bedtime
desmopressin 10 mcg/spray (0.1 mL) nasal spray
- Spray 1 spray (10 mcg) by intranasal route 2 times per day
desmopressin 150 mcg/spray (0.1 mL) nasal spray
- Spray 2 sprays (300 mcg) by intranasal route once daily
Hemophilia A
- Infuse 0.3 mcg/kg by intravenous route once 30 minutes prior to procedure
- Infuse 0.3 mcg/kg slowly over 15-30 minute(s) by intravenous route once
Partial central diabetes insipidus
- Inject 0.25 milliliter (1 mcg) by subcutaneous route 2 times per day
- Inject 0.25 milliliter (1 mcg) by intravenous route 2 times per day
- Inject 0.5 milliliter (2 mcg) by intravenous route 2 times per day
- Inject 0.5 milliliter (2 mcg) by subcutaneous route 2 times per day
- Spray 1 spray (10 mcg) by intranasal route once daily
- Spray 1 spray (10 mcg) by intranasal route 2 times per day
- Spray 1 spray (10 mcg) by intranasal route 3 times per day
- Spray 2 sprays (20 mcg) by intranasal route 2 times per day
- Spray 2 sprays (20 mcg) by intranasal route once daily
Von willebrand's disease
- Infuse 0.3 mcg/kg over 15-30 minute(s) by intravenous route
- None
Contraindicated
- None
Severe
Moderate
- None
- Chronic kidney disease stage 3A (moderate) GFR 45-59
- Chronic kidney disease stage 3B (moderate) GFR 30-44
- Chronic kidney disease stage 4 (severe) GFR 15-29 ml/min
- Chronic kidney disease stage 5 (failure) GFr<15 ml/min
- Hyponatremia
- Renal disease with moderate to severe impairment
Contraindicated
- Hyponatremia
- Kidney disease with likely reduction in GFR
- Psychogenic polydipsia
- Severe allergic rhinitis
Severe
Moderate
- Allergic rhinitis
- Chronic heart failure
- Coronary artery disease
- Cystic fibrosis
- Hypertension
- Water intoxication
DESMOPRESSIN ACETATE (DESMOPRESSIN ACETATE)
- Partial central diabetes insipidus
- Partial central diabetes insipidus
- Hemophilia A
- Von willebrand's disease
- None
- None
More Frequent
Severe
Less Severe
- Hypertension
- Abdominal pain with cramps
- Back pain
- Body fluid retention
- Bronchitis
- Chills
- Dizziness
- Epistaxis
- Headache disorder
- Nasal passage irritation
- Nausea
- Sneezing
- Vulvodynia
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal hepatic function tests
- Acute respiratory insufficiency
- Anaphylaxis
- Atrial fibrillation
- Chest pain
- Hypertension
- Hyponatremia
- Hypotension
- Seizure disorder
- Water intoxication
Less Severe
- Agitation
- Balanitis
- Cough
- Diarrhea
- Disturbance in thinking
- Drowsy
- Dyspepsia
- Dysuria
- Edema
- Flushing
- Insomnia
- Nasal congestion
- Ocular itching
- Palpitations
- Rhinitis
- Sore throat
- Tachycardia
- Upper respiratory infection
- Vomiting
- Vulvodynia
- Weight gain
Contraindicated
None
Severe Precaution
Desmopressin (Nasal)
Contraindicated for treatment of primary nocturnal enuresis. Risk of water intoxication, hyponatremia and seizure. Monitor fluid intake.
- 1 Day – 18 Years
- Contraindicated for treatment of primary nocturnal enuresis. Risk of water intoxication, hyponatremia and seizure. Monitor fluid intake.
Management or Monitoring Precaution
Desmopressin (select)
Risk of water intoxication, hyponatremia and seizure. Monitor fluid intake.
- 1 Day – 18 Years
- Risk of water intoxication, hyponatremia and seizure. Monitor fluid intake.
Desmopressin Acetate
- Severity Level:
2
- Additional Notes: Limited human data do not suggest a clear association for development toxicity.
Contraindicated
None
General | Excretion Potential | Effect on Infant | Notes |
None |
Precaution Exists
None
General | Excretion Potential | Effect on Infant | Notes |
None |
No Known Risk
Desmopressin
Limited data suggest negligible amount in breastmilk and poor oral absorption
General | Excretion Potential | Effect on Infant | Notes |
No known risks; does not adversely affect lactation | Excreted | Not known; no or inclusive data | Limited data suggest negligible amount in breastmilk and poor oral absorption |
Contraindicated
None
Precaution Exists
Desmopressin Acetate
General-Avoid for treatment of nocturia or nocturnal polyuria due to risk for hyponatremia. Safer alternatives exist. Use in geriatric patients requires careful fluid intake restriction to prevent possible water intoxication with hyponatremia.
Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
Increased Risk / Adverse Effects | Y | N | N | N | N | N |
BEERS: Y HEDIS: N STOPP: Y
No Known Risk
None
- None
Hemophilia A | |
D66 | Hereditary factor VIII deficiency |
Z14.02 | Symptomatic hemophilia A carrier |
Partial central diabetes insipidus | |
E23.2 | Diabetes insipidus |
Von willebrand's disease | |
D68.0 | Von willebrand's disease |
0-9 | A-Z |
---|---|
D66 | Hereditary factor VIII deficiency |
D68.0 | Von willebrand's disease |
E23.2 | Diabetes insipidus |
Z14.02 | Symptomatic hemophilia A carrier |