ZOLEDRONIC ACID (ZOLEDRONIC ACID)
- Humoral hypercalcemia of malignancy
- Prevention of skeletal related event in multiple myeloma
- Prevention of skeletal related events in bone metastases
4 mg/5 mL intravenous solution
- Dosage information is not available
4 mg intravenous solution
- Dosage information is not available
Prevention of skeletal related event in multiple myeloma
- Infuse 5 milliliters (4 mg) over 15 minute(s) by intravenous route every 3 weeks
- Infuse 5 milliliters (4 mg) over 15 minute(s) by intravenous route every 4 weeks
- Infuse 4 mg over 15 minute(s) by intravenous route every 3 weeks
- Infuse 4 mg over 15 minute(s) by intravenous route every 4 weeks
Prevention of skeletal related events in bone metastases
- Infuse 5 milliliters (4 mg) over 15 minute(s) by intravenous route every 3 weeks
- Infuse 5 milliliters (4 mg) over 15 minute(s) by intravenous route every 4 weeks
- Infuse 4 mg over 15 minute(s) by intravenous route every 3 weeks
- Infuse 4 mg over 15 minute(s) by intravenous route every 4 weeks
- None
Contraindicated
- Accuretic
- acetaminophen-mag sal-pamabrom
- acetaminophen-pamabrom
- acetaminophen-pamabrom-pyrilam
- Aldactazide
- Aldactone
- aliskiren-amlodipin-hcthiazide
- aliskiren-hydrochlorothiazide
- amiloride
- amiloride-hydrochlorothiazide
- amlodipine-valsartan-hcthiazid
- Amturnide
- Atacand Hct
- atenolol-chlorthalidone
- Avalide
- azilsartan med-chlorthalidone
- benazepril-hydrochlorothiazide
- Benicar Hct
- bisoprolol-hydrochlorothiazide
- bumetanide
- candesartan-hydrochlorothiazid
- captopril-hydrochlorothiazide
- chlorothiazide
- chlorothiazide sodium
- chlorthalidone
- clonidine-chlorthalidone
- Clorpres
- Corzide
- Cramp Tabs
- Demadex
- Diovan Hct
- Diuril
- Diuril Iv
- Dutoprol
- Dyazide
- Dyrenium
- Edarbyclor
- enalapril-hydrochlorothiazide
- eplerenone
- eprosartan-hydrochlorothiazide
- ethacrynate sodium
- Exforge Hct
- fosinopril-hydrochlorothiazide
- furosemide
- hydrochlorothiazide
- Hyzaar
- indapamide
- Inspra
- irbesartan-hydrochlorothiazide
- Lasix
- lisinopril-hydrochlorothiazide
- Lopressor Hct
- losartan-hydrochlorothiazide
- mannitol 10 %
- mannitol 15 %
- mannitol 20 %
- mannitol 25 %
- mannitol 5 %
- Maxzide
- Maxzide-25Mg
- methyclothiazide
- methyldopa-hydrochlorothiazide
- metolazone
- metoprolol su-hydrochlorothiaz
- metoprolol ta-hydrochlorothiaz
- Micardis Hct
- Microzide
- Midol
- moexipril-hydrochlorothiazide
- Multi-symptom Pms
- nadolol-bendroflumethiazide
- olmesartan-amlodipin-hcthiazid
- olmesartan-hydrochlorothiazide
- Osmitrol 10 %
- Osmitrol 15 %
- Osmitrol 20 %
- Osmitrol 5 %
- Pamprin (with Mag Salicylate)
- Pamprin Multi-symptom
- Pms Maximum Strength
- Pre-menstrual Relief
- Premsyn Pms
- propranolol-hydrochlorothiazid
- quinapril-hydrochlorothiazide
- Sodium Edecrin
- spironolacton-hydrochlorothiaz
- spironolactone
- Tekturna Hct
- telmisartan-hydrochlorothiazid
- Tenoretic 100
- Tenoretic 50
- Teveten Hct
- torsemide
- triamterene
- triamterene-hydrochlorothiazid
- Tribenzor
- Uniretic
- valsartan-hydrochlorothiazide
- Vaseretic
- Women's Menstrual Relief
- Zaroxolyn
- Zestoretic
- Ziac
Severe
Moderate
- None
- Acute renal failure
- Chronic kidney disease stage 4 (severe) GFR 15-29 ml/min
- Chronic kidney disease stage 5 (failure) GFr<15 ml/min
- Lactating mother
Contraindicated
- Aseptic necrosis of jaw bone
- Atypical femoral fracture
- Dehydration
- Hypocalcemia
- Hypomagnesemia
- Hypophosphatemia
- Invasive dental procedure
- Periodontitis
- Pregnancy
Severe
Moderate
- Arthralgias
- Kidney disease with likely reduction in GFR
- Myalgias
ZOLEDRONIC ACID (ZOLEDRONIC ACID)
- Humoral hypercalcemia of malignancy
- Prevention of skeletal related event in multiple myeloma
- Prevention of skeletal related events in bone metastases
- Bone pain
- Dyspnea
- General weakness
- Hypertension
- Hypokalemia
- Hypomagnesemia
- Hypophosphatemia
- Acute abdominal pain
- Allergic dermatitis
- Arthralgias
- Back pain
- Chills
- Constipation
- Cough
- Diarrhea
- Dizziness
- Fatigue
- Fever
- Flu-like symptoms
- Headache disorder
- Insomnia
- Myalgias
- Nausea
- Ocular inflammation
- Pain
- Peripheral edema
- Urinary tract infection
- Vomiting
More Frequent
Severe
Less Severe
- Anemia
- Atrial fibrillation
- Granulocytopenic disorder
- Hypotension
- Infection
- Thrombocytopenic disorder
- Acute confusion
- Agitation
- Anorexia
- Cramps
- Drowsy
- Dysgeusia
- Dyspepsia
- Dysphagia
- Hyperhidrosis
- Paresthesia
- Stomatitis
- Upper abdominal pain
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Acute renal failure
- Anaphylaxis
- Angioedema
- Aseptic necrosis of bone in orofacial region
- Aseptic necrosis of jaw bone
- Asthma exacerbation
- Atypical femoral fracture
- Avascular necrosis of bone
- Blurred vision
- Bradycardia
- Bronchospastic pulmonary disease
- Fanconi syndrome
- Hyperkalemia
- Hypersensitivity drug reaction
- Hypocalcemia
- Injection site sequelae
- Interstitial lung disease
- Iritis
- Kidney disease with reduction in GFR
- Pancytopenia
- Scleritis
- Seizure disorder
- Stevens-johnson syndrome
- Toxic epidermal necrolysis
- Urticaria
- Uveitis
Less Severe
- Arthritis
- Chest pain
- Conjunctivitis
- Cramps in legs
- Dehydration
- Hematuria
- Hyperesthesia
- Hypesthesia
- Malaise
- Muscle spasm
- Proteinuria
- Pruritus of skin
- Skin rash
- Symptoms of anxiety
- Tremor
- Xerostomia
Contraindicated
None
Severe Precaution
Zoledronic Acid
Increased risk of fever, arthralgia, hypocalcemia. Weigh risk-benefit. Not indicated per manufacturer.
- 1 Day – 18 Years
- Increased risk of fever, arthralgia, hypocalcemia. Weigh risk-benefit. Not indicated per manufacturer.
Management or Monitoring Precaution
None
Zoledronic Acid
- Severity Level:
D
- Additional Notes: Developmental tox in animals; binds to maternal bone & is released over wks-yrs
Contraindicated
Zoledronic Acid
Should not be administered in lactation, binds to bone long-term
General | Excretion Potential | Effect on Infant | Notes |
Drug should not be given to breast feeding mothers | Unknown | Not known; no or inclusive data | Should not be administered in lactation, binds to bone long-term |
Precaution Exists
None
General | Excretion Potential | Effect on Infant | Notes |
None |
No Known Risk
None
General | Excretion Potential | Effect on Infant | Notes |
None |
Contraindicated
None
Precaution Exists
Zoledronic Acid
Renal-Nephrotoxicity risk is higher in the elderly; monitor renal function prior to giving dose. Avoid in severe impairment (CrCL<30 mL/min) and correct dehydration before administering dose.
Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
Increased Risk / Adverse Effects | Y | N | N | N | N | N |
BEERS: N HEDIS: N STOPP: N
No Known Risk
None
- None
Humoral hypercalcemia of malignancy | |
E83.52 | Hypercalcemia |
Prevention of skeletal related event in multiple myeloma | |
C90.0 | Multiple myeloma |
C90.00 | Multiple myeloma not having achieved remission |
C90.02 | Multiple myeloma in relapse |
Prevention of skeletal related events in bone metastases | |
C79.51 | Secondary malignant neoplasm of bone |
0-9 | A-Z |
---|---|
C79.51 | Secondary malignant neoplasm of bone |
C90.0 | Multiple myeloma |
C90.00 | Multiple myeloma not having achieved remission |
C90.02 | Multiple myeloma in relapse |
E83.52 | Hypercalcemia |