EPLERENONE (EPLERENONE)

Moderate

• Accupril

• Accuretic

• Aceon

• Altace

• amlodipine-benazepril

• amlodipine-olmesartan

• amlodipine-valsartan

• amlodipine-valsartan-hcthiazid

• Angeliq

• aprepitant

• Atacand

• Atacand Hct

• atazanavir

• Avalide

• Avapro

• azilsartan med-chlorthalidone

• azilsartan medoxomil

• Azor

• benazepril

• benazepril-hydrochlorothiazide

• Benicar

• Benicar Hct

• Beyaz

• Calan

• Calan Sr

• candesartan

• candesartan-hydrochlorothiazid

• captopril

• captopril-hydrochlorothiazide

• Cardizem

• Cardizem Cd

• Cardizem La

• Cartia Xt

• Cipro

• Cipro In D5W

• Cipro Xr

• ciprofloxacin

• ciprofloxacin (mixture)

• ciprofloxacin in D5W

• Cozaar

• crizotinib

• darunavir

• Diflucan

• Dilacor Xr

• Dilt-xr

• diltiazem HCl

• Diovan Hct

• drospirenone-e.estradiol-lm.FA

• drospirenone-estradiol

• drospirenone-ethinyl estradiol

• Edarbi

• Edarbyclor

• Emend

• enalapril maleate

• enalapril-hydrochlorothiazide

• enalaprilat

• Epaned

• eprosartan

• eprosartan-hydrochlorothiazide

• Erythrocin

• erythromycin

• erythromycin-sulfisoxazole

• Exforge

• Exforge Hct

• fluconazole

• fluconazole in dextrose(iso-o)

• fluconazole in NaCl (iso-osm)

• fosamprenavir

• fosaprepitant

• fosinopril

• fosinopril-hydrochlorothiazide

• Gianvi (28)

• Gleevec

• Hyzaar

• imatinib

• Invirase

• irbesartan

• irbesartan-hydrochlorothiazide

• Lexiva

• lisinopril

• lisinopril-hydrochlorothiazide

• lithium carbonate

• lithium citrate

• Lithobid

• Loryna (28)

• losartan

• losartan-hydrochlorothiazide

• Lotensin

• Lotrel

• Matzim La

• Mavik

• Micardis

• Micardis Hct

• moexipril

• moexipril-hydrochlorothiazide

• Ocella

• olmesartan

• olmesartan-amlodipin-hcthiazid

• olmesartan-hydrochlorothiazide

• perindopril erbumine

• Prezista

• Prinivil

• quinapril

• quinapril-hydrochlorothiazide

• ramipril

• Reyataz

• Safyral

• saquinavir mesylate

• Syeda

• Tarka

• Taztia Xt

• telmisartan

• telmisartan-amlodipine

• telmisartan-hydrochlorothiazid

• Teveten

• Teveten Hct

• Tiazac

• trandolapril

• trandolapril-verapamil

• Tribenzor

• Twynsta

• Uniretic

• Univasc

• valsartan-hydrochlorothiazide

• Vaseretic

• Vasotec

• verapamil

• Verelan

• Verelan Pm

• Vestura (28)

• Xalkori

• Yasmin (28)

• Yaz 28

• Zarah

• Zestoretic

• Zestril

Moderate

• Disease of liver

Eplerenone

• Severity Level:

  2

• Additional Notes: Insufficient human data available.

Contraindicated

None

General	Excretion Potential	Effect on Infant	Notes
			None

Precaution Exists

Eplerenone

Insufficient data available.

General	Excretion Potential	Effect on Infant	Notes
Evaluate use carefully	Unknown	Not known; no or inclusive data	Insufficient data available.

No Known Risk

None

General	Excretion Potential	Effect on Infant	Notes
			None

Contraindicated

None

Precaution Exists

Eplerenone

Cardiovascular-In the EPHESUS study, patients over 75 years of age with heart failure post-acute myocardial infarction did not benefit from treatment with eplerenone. Metabolic-Treated elderly have a higher incidence of drug induced hyperkalemia. Renal-Manufacturer recommends that patients treated for hypertension with CrCl <51 mL/min and all patients with CrCl <31 mL/min should not be treated with eplerenone.

Organ / System	HEP	REN	CARD	ENDO	NEURO / PSYCH	PULM
Increased Risk / Adverse Effects	Y	N	N	N	N	Y

BEERS: N     HEDIS: N     STOPP: Y

No Known Risk

None

0-9	A-Z
I10	Essential (primary) hypertension
I11	Hypertensive heart disease
I11.0	Hypertensive heart disease with heart failure
I11.9	Hypertensive heart disease without heart failure
I12	Hypertensive chronic kidney disease
I12.0	Hypertensive chronic kidney disease with stage 5 chronic kidney disease or end stage renal disease
I12.9	Hypertensive chronic kidney disease with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease
I13	Hypertensive heart and chronic kidney disease
I13.0	Hypertensive heart and chronic kidney disease with heart failure and stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease
I13.1	Hypertensive heart and chronic kidney disease without heart failure
I13.10	Hypertensive heart and chronic kidney disease without heart failure, with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease
I13.11	Hypertensive heart and chronic kidney disease without heart failure, with stage 5 chronic kidney disease, or end stage renal disease
I13.2	Hypertensive heart and chronic kidney disease with heart failure and with stage 5 chronic kidney disease, or end stage renal disease
I15.1	Hypertension secondary to other renal disorders
I50.22	Chronic systolic (congestive) heart failure
I50.32	Chronic diastolic (congestive) heart failure
I50.42	Chronic combined systolic (congestive) and diastolic (congestive) heart failure
I50.812	Chronic right heart failure