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CAPTOPRIL (CAPTOPRIL)
- Chronic heart failure
- Diabetic nephropathy
- Hypertension
- Left ventricular dysfunction following MI
100 mg tablet
- 1 tablet (100 mg) by oral route 3 times per day
12.5 mg tablet
- 1 tablet (12.5 mg) by oral route 3 times per day
25 mg tablet
- 1 tablet (25 mg) by oral route 2 times per day
50 mg tablet
- 1 tablet (50 mg) by oral route 2 times per day
Chronic heart failure
- 2 tablets (25 mg) by oral route 3 times per day
- 1 tablet (100 mg) by oral route 3 times per day
- 1 tablet (12.5 mg) by oral route 3 times per day
- one-half tablet (6.25 mg) by oral route 3 times per day
Diabetic nephropathy
- 1 tablet (25 mg) by oral route 3 times per day
- 2 tablets (25 mg) by oral route 3 times per day
Hypertension
- 1 tablet (25 mg) by oral route 2 times per day
- 1 tablet (25 mg) by oral route 3 times per day
- 2 tablets (25 mg) by oral route 3 times per day
- 2 tablets (25 mg) by oral route 2 times per day
- 1 tablet (50 mg) by oral route 2 times per day
- 2 tablets (50 mg) by oral route 2 times per day
- 1 tablet (100 mg) by oral route 2 times per day
- 1 tablet (100 mg) by oral route 3 times per day
- 1 tablet (12.5 mg) by oral route 3 times per day
- 1 tablet (12.5 mg) by oral route 2 times per day
- one-half tablet (6.25 mg) by oral route 3 times per day
- one-half tablet (6.25 mg) by oral route 2 times per day
- None
Contraindicated
- aliskiren
- aliskiren-amlodipin-hcthiazide
- aliskiren-amlodipine
- aliskiren-hydrochlorothiazide
- Amturnide
- Curad Enema
- Disposable Enema
- Enema
- Enema Disposable
- Fleet Enema
- Fleet Enema Extra
- Fleet Pediatric
- Hycamtin
- lithium carbonate
- lithium citrate
- Lithobid
- Oral Saline Laxative
- Osmoprep
- Phosphate Laxative
- Preparation Cleansing
- Ready-to-use Enema
- sod phos mono-sod phos dibasic
- sodium phosphates
- Tekamlo
- Tekturna
- Tekturna Hct
- topotecan
Severe
Moderate
- Added Strength Headache Relief
- Added Strength Pain Reliever
- Alka-seltzer
- Alka-seltzer Extra Strength
- Alka-seltzer Original
- Alka-seltzer Plus C/c(pe,dm)
- Alka-seltzer Plus Cold (pe)
- Alka-seltzer Plus Day-night
- Alka-seltzer Plus Night
- Alka-seltzer Pm
- Anacin
- Anacin Maximum Strength
- Analgesic
- Angeliq
- Antacid & Pain Relief
- ASA-acetaminophen-caff-buffers
- ASA-acetaminophen-salicyl-caff
- Ascomp With Codeine
- Aspir-trin
- aspirin
- aspirin, buffered
- aspirin-acetaminophen-caffeine
- aspirin-caffeine
- aspirin-diphenhydramine
- aspirin-diphenhydramine citrat
- aspirin-sod bicarb-citric acid
- Azasan
- azathioprine
- azathioprine sodium
- Back & Body Pain Reliever
- Bactrim
- Bactrim Ds
- Bayer Advanced
- Bayer Aspirin
- Bayer Aspirin (with Caffeine)
- Bayer Back & Body
- Bayer Plus Extra Strength
- Bayer Pm
- Bc
- Bc Arthritis
- Beyaz
- Buffered Aspirin
- Bufferin
- bumetanide
- Butalbital Compound W/codeine
- Butalbital Compound-codeine
- butalbital-aspirin-caffeine
- carisoprodol-ASA-codeine
- carisoprodol-aspirin
- chlorphen-phenyleph-DM-aspirin
- chlorphenir-phenylephrn-aspirn
- codeine-butalbital-ASA-caff
- Cold Relief
- Cold Relief Plus
- Demadex
- dihydrocodeine-aspirin-caff
- doxylamine-phenylep-DM-aspirin
- drospirenone-e.estradiol-lm.FA
- drospirenone-estradiol
- drospirenone-ethinyl estradiol
- E.c. Prin
- Ecotrin
- Efferves Pain Relief Antacid
- Effervescent Antacid
- Effervescent Pain Relief
- Effervescent Pain Reliever
- Endodan
- ethacrynate sodium
- Excedrin Extra Strength
- Excedrin Migraine
- Extra Strength Bayer
- Fiorinal
- Fiorinal-codeine #3
- furosemide
- Gianvi (28)
- Goody's Extra Strength
- Goody's Migraine Relief
- Headache Formula
- Headache Formula Added Str
- Headache Relief
- Imuran
- Lasix
- Levacet
- Lite Coat Aspirin
- Loryna (28)
- Medi-seltzer
- mercaptopurine
- Migraine Formula
- Migraine Pain Reliever
- Migraine Relief
- Ocella
- Orphenadrine Compound Forte
- Orphenadrine Compound-ds
- orphenadrine-ASA-caffeine
- oxycodone-aspirin
- Pain Relief
- Pain Relief Extra Strength
- Pain Reliever
- Pain Reliever Extra Strength
- Pain Reliever Plus
- Pain-off
- Pamprin Max
- PE-DM-ASA/doxyla-PE-DM-ASA
- Percodan
- Primsol
- Purinethol
- Safyral
- Sodium Edecrin
- sulfamethoxazole-trimethoprim
- Sulfatrim
- Super Pain Relief
- Syeda
- Synalgos-dc
- torsemide
- Tri-buffered Aspirin
- trimethoprim
- Vanquish
- Vestura (28)
- Yasmin (28)
- Yaz 28
- Zarah
- Angioedema
- Hypotension
- Pregnancy
Contraindicated
- Hemodialysis with high-flux membrane
- Hereditary angioedema
- Hyperkalemia
- Hyponatremia
Severe
Moderate
- Aortic valve stenosis
- Bone marrow depression
- Cerebrovascular insufficiency
- Cough
- Immunosuppression
- Kidney disease with reduction in GFR
- Neutropenic disorder
- Recipient of organ transplant
- Renal artery stenosis
CAPTOPRIL (CAPTOPRIL)
- Chronic heart failure
- Diabetic nephropathy
- Hypertension
- Left ventricular dysfunction following MI
- None
- Cough
More Frequent
Severe
Less Severe
- Angina
- Arthralgias
- Fever
- Hyperkalemia
- Hypotension
- Kidney disease with reduction in GFR
- Skin rash
- Dysgeusia
- Eosinophilia
- Nausea
- Pruritus of skin
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Acute myocardial infarction
- Acute pancreatitis
- Acute renal failure
- Agranulocytosis
- Anemia
- Angioedema
- Bronchospastic pulmonary disease
- Chest pain
- Cholestasis
- Chronic heart failure
- Eosinophilic pneumonia
- Flushing
- Head and neck angioedema
- Hepatic necrosis
- Hepatitis
- Hyponatremia
- Interstitial nephritis
- Intestinal angioedema
- Neutropenic disorder
- Obstructive hyperbilirubinemia
- Pancytopenia
- Pemphigus
- Proteinuria
- Raynaud's phenomenon
- Tachycardia
- Thrombocytopenic disorder
- Vasculitis
Less Severe
- Acute confusion
- Ataxia
- Blurred vision
- Depression
- Drowsy
- Dyspepsia
- Erectile dysfunction
- General weakness
- Glossitis
- Gynecomastia
- Muscle weakness
- Myalgias
- Nervousness
- Palpitations
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Captopril
Monitor for excessive and prolonged decrease in blood pressure, urine output, especially neonates. Reports of prolonged hypotension, oliguria and seizures. No established safety and efficacy.
- 1 Day – 364 Days
- Monitor for excessive and prolonged decrease in blood pressure, urine output, especially neonates. Reports of prolonged hypotension, oliguria and seizures. No established safety and efficacy.
Captopril
- Severity Level:
1
- Additional Notes: Fetal death/morbidity w/use in 2nd & 3rd trimester, stop when pregnancy detected
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Captopril
Limited data suggest amt excreted minimal, no adverse effects in infant
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Excreted | Not known; no or inclusive data | Limited data suggest amt excreted minimal, no adverse effects in infant |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Captopril
Cardiovascular-Monitor for hypotension more closely in the elderly. Metabolic-Monitor for hyperkalemia which has a higher incidence in the elderly. Renal-Increased risk for neutropenia in patients with renal impairment.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | Y | N | Y | N | N | N |
BEERS: N HEDIS: N STOPP: Y
No Known Risk
None
- This drug can cause serious (possibly fatal) harm to an unborn baby if used during pregnancy. Therefore, it is important to prevent pregnancy while taking this medication. Consult your doctor for more details and to discuss the use of reliable forms of birth control while taking this medication. If you are planning pregnancy, become pregnant, or think you may be pregnant, contact your doctor right away.
| Chronic heart failure | |
| I50.22 | Chronic systolic (congestive) heart failure |
| I50.32 | Chronic diastolic (congestive) heart failure |
| I50.42 | Chronic combined systolic (congestive) and diastolic (congestive) heart failure |
| I50.812 | Chronic right heart failure |
| I50.814 | Right heart failure due to left heart failure |
| Diabetic nephropathy | |
| E08.21 | Diabetes mellitus due to underlying condition with diabetic nephropathy |
| E09.21 | Drug or chemical induced diabetes mellitus with diabetic nephropathy |
| E10.21 | Type 1 diabetes mellitus with diabetic nephropathy |
| E11.21 | Type 2 diabetes mellitus with diabetic nephropathy |
| E13.21 | Other specified diabetes mellitus with diabetic nephropathy |
| Hypertension | |
| I10 | Essential (primary) hypertension |
| I11 | Hypertensive heart disease |
| I11.0 | Hypertensive heart disease with heart failure |
| I11.9 | Hypertensive heart disease without heart failure |
| I12 | Hypertensive chronic kidney disease |
| I12.0 | Hypertensive chronic kidney disease with stage 5 chronic kidney disease or end stage renal disease |
| I12.9 | Hypertensive chronic kidney disease with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13 | Hypertensive heart and chronic kidney disease |
| I13.0 | Hypertensive heart and chronic kidney disease with heart failure and stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13.1 | Hypertensive heart and chronic kidney disease without heart failure |
| I13.10 | Hypertensive heart and chronic kidney disease without heart failure, with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13.11 | Hypertensive heart and chronic kidney disease without heart failure, with stage 5 chronic kidney disease, or end stage renal disease |
| I13.2 | Hypertensive heart and chronic kidney disease with heart failure and with stage 5 chronic kidney disease, or end stage renal disease |
| I15.1 | Hypertension secondary to other renal disorders |
| Left ventricular dysfunction following MI | |
| I23.8 | Other current complications following acute myocardial infarction |
| I50.1 | Left ventricular failure, unspecified |
| 0-9 | A-Z |
|---|---|
| E08.21 | Diabetes mellitus due to underlying condition with diabetic nephropathy |
| E09.21 | Drug or chemical induced diabetes mellitus with diabetic nephropathy |
| E10.21 | Type 1 diabetes mellitus with diabetic nephropathy |
| E11.21 | Type 2 diabetes mellitus with diabetic nephropathy |
| E13.21 | Other specified diabetes mellitus with diabetic nephropathy |
| I10 | Essential (primary) hypertension |
| I11 | Hypertensive heart disease |
| I11.0 | Hypertensive heart disease with heart failure |
| I11.9 | Hypertensive heart disease without heart failure |
| I12 | Hypertensive chronic kidney disease |
| I12.0 | Hypertensive chronic kidney disease with stage 5 chronic kidney disease or end stage renal disease |
| I12.9 | Hypertensive chronic kidney disease with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13 | Hypertensive heart and chronic kidney disease |
| I13.0 | Hypertensive heart and chronic kidney disease with heart failure and stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13.1 | Hypertensive heart and chronic kidney disease without heart failure |
| I13.10 | Hypertensive heart and chronic kidney disease without heart failure, with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13.11 | Hypertensive heart and chronic kidney disease without heart failure, with stage 5 chronic kidney disease, or end stage renal disease |
| I13.2 | Hypertensive heart and chronic kidney disease with heart failure and with stage 5 chronic kidney disease, or end stage renal disease |
| I15.1 | Hypertension secondary to other renal disorders |
| I23.8 | Other current complications following acute myocardial infarction |
| I50.1 | Left ventricular failure, unspecified |
| I50.22 | Chronic systolic (congestive) heart failure |
| I50.32 | Chronic diastolic (congestive) heart failure |
| I50.42 | Chronic combined systolic (congestive) and diastolic (congestive) heart failure |
| I50.812 | Chronic right heart failure |
| I50.814 | Right heart failure due to left heart failure |
Formulary Reference Tool