DULOXETINE HCL (duloxetine HCl)

Moderate

• abciximab

• Abilify

• Abilify Discmelt

• Abilify Maintena

• Abstral

• Actiq

• Activase

• Added Strength Headache Relief

• Added Strength Pain Reliever

• Adderall

• Adderall Xr

• Adipex-p

• Adult Low Dose Aspirin

• Advil

• Advil Allergy Sinus

• Advil Allergy-congestion Rlf

• Advil Cold & Sinus

• Advil Congestion Relief

• Advil Liqui-gel

• Advil Migraine

• Advil Pm

• Advil Pm Liqui-gels

• Aggrastat In Sodium Chloride

• Aggrenox

• Aleve

• Aleve Cold & Sinus

• Aleve Sinus & Headache

• Aleve-d Sinus & Cold

• Aleve-d Sinus & Headache

• Alka-seltzer

• Alka-seltzer Extra Strength

• Alka-seltzer Original

• Alka-seltzer Plus C/c(pe,dm)

• Alka-seltzer Plus Cold (pe)

• Alka-seltzer Plus Day-night

• Alka-seltzer Plus Night

• Alka-seltzer Pm

• All Day Pain Relief

• All Day Pain Relief Sinus & Co

• All Day Relief

• almotriptan malate

• Alsuma

• alteplase

• Amerge

• amitriptyline

• amitriptyline-chlordiazepoxide

• amoxapine

• Amphetamine Salt Combo

• Amrix

• Anacin

• Anacin Maximum Strength

• Anafranil

• Analgesic

• Anaprox

• Anaprox Ds

• Ansaid

• Antacid & Pain Relief

• aripiprazole

• Arthri-flex

• Arthrotec 50

• ASA-acetaminophen-caff-buffers

• ASA-acetaminophen-salicyl-caff

• Ascomp With Codeine

• Aspir-81

• Aspir-low

• Aspir-trin

• aspirin

• Aspirin Childrens

• Aspirin Low Dose

• Aspirin Low-strength

• aspirin, buffered

• aspirin-acetaminophen-caffeine

• aspirin-caffeine

• aspirin-calcium carbonate

• aspirin-diphenhydramine

• aspirin-diphenhydramine citrat

• aspirin-sod bicarb-citric acid

• Axert

• Back & Body Pain Reliever

• Bayer Advanced

• Bayer Aspirin

• Bayer Aspirin (with Caffeine)

• Bayer Back & Body

• Bayer Chewable Aspirin

• Bayer Childrens Aspirin

• Bayer Plus Extra Strength

• Bayer Pm

• Bc

• Bc Arthritis

• Brilinta

• Brisdelle

• Buffered Aspirin

• Bufferin

• Butalbital Compound W/codeine

• Butalbital Compound-codeine

• butalbital-aspirin-caffeine

• Caldolor

• Cambia

• carisoprodol-ASA-codeine

• carisoprodol-aspirin

• Cataflam

• Celebrex

• celecoxib

• Child Aspirin

• Child Ibuprofen

• Children's Advil

• Children's Aspirin

• Children's Ibu-drops

• Children's Ibuprofen

• Children's Medi-profen

• Children's Motrin

• Children's Profen Ib

• chlorphen-phenyleph-DM-aspirin

• chlorphen-phenyleph-ibuprofen

• chlorphen-pseudoeph-ibuprofen

• chlorphenir-phenylephrn-aspirn

• cilostazol

• clomipramine

• clopidogrel

• codeine-butalbital-ASA-caff

• Cold & Sinus Pain Relief

• Cold Relief

• Cold Relief Plus

• Cold-sinus Relief

• Conzip

• cyclobenzaprine

• cyclobenzaprine with msm

• Daypro

• desipramine

• Desoxyn

• Dexedrine Spansule

• dextroamphetamine

• dextroamphetamine-amphetamine

• diclofenac epolamine

• diclofenac potassium

• diclofenac sodium

• diclofenac submicronized

• diclofenac-misoprostol

• dihydrocodeine-aspirin-caff

• dipyridamole-aspirin

• doxepin

• doxylamine-phenylep-DM-aspirin

• Duexis

• Duragesic

• E.c. Prin

• Ec-naprosyn

• Ecotrin

• Ecotrin Low Strength

• Efferves Pain Relief Antacid

• Effervescent Antacid

• Effervescent Pain Relief

• Effervescent Pain Reliever

• eletriptan HBr

• Endodan

• Enteric Coated Aspirin

• eptifibatide

• etodolac

• Excedrin Extra Strength

• Excedrin Migraine

• Extra Strength Bayer

• Feldene

• fenoprofen

• fentanyl

• fentanyl citrate

• fentanyl citrate (PF)

• Fentora

• Fiorinal

• Fiorinal-codeine #3

• Flanax

• Flector

• fluoxetine

• flurbiprofen

• Frova

• frovatriptan

• gluc-msm-coll2-hyal-antiarthr3

• glucos-msm-C-Mn-ginger-willow

• glucos-msm-C-Mn-herb#21

• glucos-msm-collagen-C-Mn-hrb21

• Glucosamine-msm Complex

• Goody's Extra Strength

• Goody's Migraine Relief

• Headache Formula

• Headache Formula Added Str

• Headache Relief

• heparin (porcine)

• heparin (porcine) in D5W

• heparin(porcine) in 0.45% NaCl

• heparin, porcine (PF)

• hydrocodone-ibuprofen

• I-prin

• Ibu-drops

• Ibudone

• ibuprofen

• Ibuprofen Cold

• Ibuprofen Cold-sinus(with Pse)

• Ibuprofen Ib

• Ibuprofen Jr Strength

• ibuprofen lysine (PF)

• Ibuprofen Pm

• ibuprofen-diphenhydramine

• ibuprofen-diphenhydramine HCl

• ibuprofen-famotidine

• ibuprofen-oxycodone

• ibuprofen-phenylephrine HCl

• imipramine HCl

• imipramine pamoate

• Imitrex

• Imitrex Statdose Kit Refill

• Imitrex Statdose Pen

• Indocin

• indomethacin

• indomethacin sodium

• Infant's Ibuprofen

• Infant's Medi-profen

• Infant's Motrin

• Infants Ibu-drops

• Infants Profenib

• Integrilin

• ketoprofen

• ketorolac

• Lazanda

• Levacet

• levmetamfetamine

• lisdexamfetamine

• Lite Coat Aspirin

• lithium carbonate

• lithium citrate

• Lithobid

• Lo-dose Aspirin

• Maxalt

• Maxalt-mlt

• Medi-profen

• Medi-seltzer

• Mediproxen

• mefenamic acid

• meloxicam

• methamphetamine

• Midol (naproxen)

• Migraine Formula

• Migraine Pain Reliever

• Migraine Relief

• mirabegron

• Mobic

• Motrin Ib

• Motrin Pm

• Msm Glucosamine Complex

• Myrbetriq

• nabumetone

• Nalfon

• Naprelan Cr

• Naprosyn

• naproxen

• naproxen sodium

• naproxen-esomeprazole

• naproxen-pseudoephedrine

• naratriptan

• Neoprofen (ibuprofen Lysn)(pf)

• Norpramin

• nortriptyline

• Nucynta

• Nucynta Er

• olanzapine-fluoxetine

• Oleptro Er

• Orphenadrine Compound Forte

• Orphenadrine Compound-ds

• orphenadrine-ASA-caffeine

• oxaprozin

• oxycodone-aspirin

• Pain Relief

• Pain Relief Extra Strength

• Pain Reliever

• Pain Reliever Extra Strength

• Pain Reliever Plus

• Pain-off

• Pamelor

• Pamprin Max

• paroxetine HCl

• paroxetine mesylate

• Paxil

• Paxil Cr

• PE-DM-ASA/doxyla-PE-DM-ASA

• Pennsaid

• Percodan

• perphenazine-amitriptyline

• Pexeva

• phentermine

• phentermine-topiramate

• piroxicam

• Plavix

• Pletal

• Ponstel

• Procentra

• protriptyline

• Provil

• Prozac

• Prozac Weekly

• Prudoxin

• pseudoephedrine-ibuprofen

• Qsymia

• Relpax

• Reopro

• Reprexain

• Retavase

• reteplase

• Risperdal

• Risperdal Consta

• Risperdal M-tab

• risperidone

• risperidone microspheres

• rizatriptan

• Sarafem

• Silenor

• Sinus & Cold-d

• Solaraze

• Sprix

• St Joseph Aspirin

• St. Joseph Aspirin

• Sublimaze (pf)

• Subsys

• sulindac

• sumatriptan

• sumatriptan succinate

• Sumavel Dosepro

• Super Pain Relief

• Suprenza

• Surmontil

• Symbyax

• Synalgos-dc

• Synapryn

• Tabradol

• tapentadol

• tenecteplase

• ticagrelor

• ticlopidine

• tirofiban-0.9% sodium chloride

• Tnkase

• Tofranil

• Tofranil-pm

• tolmetin

• tramadol

• tramadol-acetaminophen

• tramadol-glucosamine

• trazodone

• Tri-buffered Aspirin

• trimipramine

• Ultracet

• Ultram

• Ultram Er

• Vanquish

• Vapor Inhaler

• Vicoprofen

• Vimovo

• Vivactil

• Voltaren-xr

• Vyvanse

• Wal-profen

• Wal-profen Cold-sinus

• Wal-proxen

• Women's Aspirin With Calcium

• Zenzedi

• Zipsor

• zolmitriptan

• Zomig

• Zomig Zmt

• Zonalon

• Zorvolex

Moderate

• Bipolar disorder

• Gastrointestinal hypomotility

• Hyperglycemia

• Hypertension

• Hypomania

• Hyponatremia

• Increased risk of bleeding

• Kidney disease with likely reduction in GFR

• Manic disorder

• Orthostatic hypotension

• Seizure disorder

• SIADH syndrome

• Urinary retention

Duloxetine

• Severity Level:

  C

• Additional Notes: Non-teratogenic complications (resp, gi,cns) and post partum hemorrhage possible

Contraindicated

None

General	Excretion Potential	Effect on Infant	Notes
			None

Precaution Exists

Duloxetine

Monitor infant for drowsiness, adequate weight gain and development

General	Excretion Potential	Effect on Infant	Notes
Evaluate use carefully	Excreted	Not known; no or inclusive data	Monitor infant for drowsiness, adequate weight gain and development

No Known Risk

None

General	Excretion Potential	Effect on Infant	Notes
			None

Contraindicated

None

Precaution Exists

Duloxetine

Hepatic-May need to adjust dose especially in combination with renal impairment. Renal-Avoid use with CrCl < 30 mL/min. Endocrine-Increased risk of SIADH and hyponatremia resulting in an increased risk of falls. Cardiovascular-Elderly may be at increased risk for orthostatic hypotension, syncope and falls.

Organ / System	HEP	REN	CARD	ENDO	NEURO / PSYCH	PULM
Increased Risk / Adverse Effects	Y	Y	Y	N	N	Y

BEERS: Y     HEDIS: Y     STOPP: Y

No Known Risk

None

0-9	A-Z
E08.40	Diabetes mellitus due to underlying condition with diabetic neuropathy, unspecified
E08.42	Diabetes mellitus due to underlying condition with diabetic polyneuropathy
E09.40	Drug or chemical induced diabetes mellitus with neurological complications with diabetic neuropathy, unspecified
E09.42	Drug or chemical induced diabetes mellitus with neurological complications with diabetic polyneuropathy
E10.40	Type 1 diabetes mellitus with diabetic neuropathy, unspecified
E10.42	Type 1 diabetes mellitus with diabetic polyneuropathy
E11.40	Type 2 diabetes mellitus with diabetic neuropathy, unspecified
E11.42	Type 2 diabetes mellitus with diabetic polyneuropathy
E13.40	Other specified diabetes mellitus with diabetic neuropathy, unspecified
E13.42	Other specified diabetes mellitus with diabetic polyneuropathy
F32	Major depressive disorder, single episode
F32.0	Major depressive disorder, single episode, mild
F32.1	Major depressive disorder, single episode, moderate
F32.2	Major depressive disorder, single episode, severe without psychotic features
F32.3	Major depressive disorder, single episode, severe with psychotic features
F32.4	Major depressive disorder, single episode, in partial remission
F32.5	Major depressive disorder, single episode, in full remission
F32.9	Major depressive disorder, single episode, unspecified
F33	Major depressive disorder, recurrent
F33.0	Major depressive disorder, recurrent, mild
F33.1	Major depressive disorder, recurrent, moderate
F33.2	Major depressive disorder, recurrent severe without psychotic features
F33.3	Major depressive disorder, recurrent, severe with psychotic symptoms
F33.4	Major depressive disorder, recurrent, in remission
F33.40	Major depressive disorder, recurrent, in remission, unspecified
F33.41	Major depressive disorder, recurrent, in partial remission
F33.42	Major depressive disorder, recurrent, in full remission
F33.9	Major depressive disorder, recurrent, unspecified
F41.1	Generalized anxiety disorder
F41.8	Other specified anxiety disorders
G89.2	Chronic pain, not elsewhere classified
G89.21	Chronic pain due to trauma
G89.22	Chronic post-thoracotomy pain
G89.28	Other chronic postprocedural pain
G89.29	Other chronic pain
M25.5	Pain in joint
M25.50	Pain in unspecified joint
M25.51	Pain in shoulder
M25.511	Pain in right shoulder
M25.512	Pain in left shoulder
M25.519	Pain in unspecified shoulder
M25.52	Pain in elbow
M25.521	Pain in right elbow
M25.522	Pain in left elbow
M25.529	Pain in unspecified elbow
M25.53	Pain in wrist
M25.531	Pain in right wrist
M25.532	Pain in left wrist
M25.539	Pain in unspecified wrist
M25.55	Pain in hip
M25.551	Pain in right hip
M25.552	Pain in left hip
M25.559	Pain in unspecified hip
M25.56	Pain in knee
M25.561	Pain in right knee
M25.562	Pain in left knee
M25.569	Pain in unspecified knee
M25.57	Pain in ankle and joints of foot
M25.571	Pain in right ankle and joints of right foot
M25.572	Pain in left ankle and joints of left foot
M25.579	Pain in unspecified ankle and joints of unspecified foot
M54.2	Cervicalgia
M54.4	Lumbago with sciatica
M54.40	Lumbago with sciatica, unspecified side
M54.41	Lumbago with sciatica, right side
M54.42	Lumbago with sciatica, left side
M54.5	Low back pain
M54.6	Pain in thoracic spine
M54.89	Other dorsalgia
M54.9	Dorsalgia, unspecified
M60.9	Myositis, unspecified
M79.1	Myalgia
M79.10	Myalgia, unspecified site
M79.11	Myalgia of mastication muscle
M79.12	Myalgia of auxiliary muscles, head and neck
M79.18	Myalgia, other site
M79.6	Pain in limb, hand, foot, fingers and toes
M79.60	Pain in limb, unspecified
M79.601	Pain in right arm
M79.602	Pain in left arm
M79.603	Pain in arm, unspecified
M79.604	Pain in right leg
M79.605	Pain in left leg
M79.606	Pain in leg, unspecified
M79.609	Pain in unspecified limb
M79.62	Pain in upper arm
M79.621	Pain in right upper arm
M79.622	Pain in left upper arm
M79.629	Pain in unspecified upper arm
M79.63	Pain in forearm
M79.631	Pain in right forearm
M79.632	Pain in left forearm
M79.639	Pain in unspecified forearm
M79.64	Pain in hand and fingers
M79.641	Pain in right hand
M79.642	Pain in left hand
M79.643	Pain in unspecified hand
M79.644	Pain in right finger(s)
M79.645	Pain in left finger(s)
M79.646	Pain in unspecified finger(s)
M79.65	Pain in thigh
M79.651	Pain in right thigh
M79.652	Pain in left thigh
M79.659	Pain in unspecified thigh
M79.66	Pain in lower leg
M79.661	Pain in right lower leg
M79.662	Pain in left lower leg
M79.669	Pain in unspecified lower leg
M79.67	Pain in foot and toes
M79.671	Pain in right foot
M79.672	Pain in left foot
M79.673	Pain in unspecified foot
M79.674	Pain in right toe(s)
M79.675	Pain in left toe(s)
M79.676	Pain in unspecified toe(s)
M79.7	Fibromyalgia