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CYPROHEPTADINE HCL (CYPROHEPTADINE HCL)
- Allergic rhinitis
- Pruritus of skin
- Allergic conjunctivitis
- Anaphylaxis adjunct
- Dermatographic urticaria
- Nasal congestion
- Rhinorrhea
- Sneezing
- Urticaria
- Vasomotor rhinitis
2 mg/5 mL oral syrup
- 10 milliliters (4 mg) by oral route 3 times per day
cyproheptadine 2 mg/5 mL oral syrup
- 10 milliliters (4 mg) by oral route 3 times per day
2 mg/5 mL oral syrup
- 10 milliliters (4 mg) by oral route 3 times per day
cyproheptadine 2 mg/5 mL oral syrup
- 10 milliliters (4 mg) by oral route 3 times per day
Allergic conjunctivitis
- 10 milliliters (4 mg) by oral route 3 times per day
- 10 milliliters (4 mg) by oral route 4 times per day
- 20 milliliters (8 mg) by oral route 4 times per day
- 20 milliliters (8 mg) by oral route 3 times per day
Allergic rhinitis
- 10 milliliters (4 mg) by oral route 3 times per day
- 10 milliliters (4 mg) by oral route 4 times per day
- 20 milliliters (8 mg) by oral route 4 times per day
- 20 milliliters (8 mg) by oral route 3 times per day
Dermatographic urticaria
- 10 milliliters (4 mg) by oral route 3 times per day
- 10 milliliters (4 mg) by oral route 4 times per day
- 20 milliliters (8 mg) by oral route 4 times per day
- 20 milliliters (8 mg) by oral route 3 times per day
Nasal congestion
- 10 milliliters (4 mg) by oral route 3 times per day
- 10 milliliters (4 mg) by oral route 4 times per day
- 20 milliliters (8 mg) by oral route 4 times per day
- 20 milliliters (8 mg) by oral route 3 times per day
Pruritus of skin
- 10 milliliters (4 mg) by oral route 3 times per day
- 10 milliliters (4 mg) by oral route 4 times per day
- 10 milliliters (4 mg) by oral route every 8 hours as needed
- 20 milliliters (8 mg) by oral route 4 times per day
- 20 milliliters (8 mg) by oral route 3 times per day
Sneezing
- 10 milliliters (4 mg) by oral route 3 times per day
- 10 milliliters (4 mg) by oral route 4 times per day
- 20 milliliters (8 mg) by oral route 4 times per day
- 20 milliliters (8 mg) by oral route 3 times per day
Urticaria
- 10 milliliters (4 mg) by oral route 3 times per day
- 10 milliliters (4 mg) by oral route 4 times per day
- 20 milliliters (8 mg) by oral route 4 times per day
- 20 milliliters (8 mg) by oral route 3 times per day
Vasomotor rhinitis
- 10 milliliters (4 mg) by oral route 3 times per day
- 10 milliliters (4 mg) by oral route 4 times per day
- 20 milliliters (8 mg) by oral route 4 times per day
- 20 milliliters (8 mg) by oral route 3 times per day
- Azilect
- Eldepryl
- isocarboxazid
- linezolid
- Marplan
- Matulane
- methylene blue (antidote)
- Nardil
- Parnate
- phenelzine
- procarbazine
- rasagiline
- selegiline HCl
- tranylcypromine
- Zelapar
- Zyvox
Contraindicated
- Metopirone
- metyrapone
Severe
Moderate
- None
- None
Contraindicated
- Angle-closure glaucoma
- Benign prostatic hyperplasia
- Bladder outflow obstruction
- Chronic idiopathic constipation
- Stenosing peptic ulcer
- Urinary retention
Severe
Moderate
- Hypertension
- Hyperthyroidism
- Ocular hypertension
CYPROHEPTADINE HCL (CYPROHEPTADINE HCL)
- Allergic rhinitis
- Pruritus of skin
- Allergic conjunctivitis
- Anaphylaxis adjunct
- Dermatographic urticaria
- Nasal congestion
- Rhinorrhea
- Sneezing
- Urticaria
- Vasomotor rhinitis
- None
- Drowsy
- Thick bronchial secretions
More Frequent
Severe
Less Severe
- None
- None
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal hepatic function tests
- Blood dyscrasias
- Cholestasis
- Drug-induced hepatitis
Less Severe
- Abdominal pain with cramps
- Acute confusion
- Blurred vision
- Dizziness
- Dry nose
- Dry throat
- Dysuria
- Excitement
- Hyperhidrosis
- Increased appetite
- Nervousness
- Nightmares
- Skin photosensitivity
- Skin rash
- Tachycardia
- Tinnitus
- Visual changes
- Weight gain
- Xerostomia
Contraindicated
Cyproheptadine
Contraindicated in newborn and premature infants. Possible CNS excitation, seizure and respiratory arrest.
- 1 Day – 29 Days
- 1 Contraindicated in newborn and premature infants. Possible CNS excitation, seizure and respiratory arrest.
Severe Precaution
Cyproheptadine
Possible CNS excitation, hallucinations, seizure and respiratory arrest. No safety and efficacy age < 2 years.
- 30 Days – 2 Years
- Possible CNS excitation, hallucinations, seizure and respiratory arrest. No safety and efficacy age < 2 years.
Management or Monitoring Precaution
None
Cyproheptadine Hydrochloride
- Severity Level:
B
- Additional Notes:
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Cyproheptadine
Insuff data avail; other antihistamines reported to cause sedation
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | Insuff data avail; other antihistamines reported to cause sedation |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Cyproheptadine
Neuro/Psych-Anticholinergic effects may cause significant sedation, worsen cognitive impairment and increase fall risk. Gastrointestinal-May cause or worsen pre-existing constipation. Genitourinary-Best avoided in patients with urinary retention from any cause.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | N | N | N | Y | N | N |
BEERS: Y HEDIS: Y STOPP: Y
No Known Risk
None
- None
| Allergic conjunctivitis | |
| H10.1 | Acute atopic conjunctivitis |
| H10.10 | Acute atopic conjunctivitis, unspecified eye |
| H10.11 | Acute atopic conjunctivitis, right eye |
| H10.12 | Acute atopic conjunctivitis, left eye |
| H10.13 | Acute atopic conjunctivitis, bilateral |
| H10.44 | Vernal conjunctivitis |
| H10.45 | Other chronic allergic conjunctivitis |
| H16.26 | Vernal keratoconjunctivitis, with limbar and corneal involvement |
| H16.261 | Vernal keratoconjunctivitis, with limbar and corneal involvement, right eye |
| H16.262 | Vernal keratoconjunctivitis, with limbar and corneal involvement, left eye |
| H16.263 | Vernal keratoconjunctivitis, with limbar and corneal involvement, bilateral |
| H16.269 | Vernal keratoconjunctivitis, with limbar and corneal involvement, unspecified eye |
| Allergic rhinitis | |
| J30.1 | Allergic rhinitis due to pollen |
| J30.2 | Other seasonal allergic rhinitis |
| J30.5 | Allergic rhinitis due to food |
| J30.8 | Other allergic rhinitis |
| J30.81 | Allergic rhinitis due to animal (cat) (dog) hair and dander |
| J30.89 | Other allergic rhinitis |
| J30.9 | Allergic rhinitis, unspecified |
| Anaphylaxis adjunct | |
| T78.00xA | Anaphylactic reaction due to unspecified food, initial encounter |
| T78.01xA | Anaphylactic reaction due to peanuts, initial encounter |
| T78.02xA | Anaphylactic reaction due to shellfish (crustaceans), initial encounter |
| T78.03xA | Anaphylactic reaction due to other fish, initial encounter |
| T78.04xA | Anaphylactic reaction due to fruits and vegetables, initial encounter |
| T78.05xA | Anaphylactic reaction due to tree nuts and seeds, initial encounter |
| T78.06xA | Anaphylactic reaction due to food additives, initial encounter |
| T78.07xA | Anaphylactic reaction due to milk and dairy products, initial encounter |
| T78.08xA | Anaphylactic reaction due to eggs, initial encounter |
| T78.09xA | Anaphylactic reaction due to other food products, initial encounter |
| T78.2xxA | Anaphylactic shock, unspecified, initial encounter |
| T80.51 | Anaphylactic reaction due to administration of blood and blood products |
| T80.52xA | Anaphylactic reaction due to vaccination, initial encounter |
| T80.59xA | Anaphylactic reaction due to other serum, initial encounter |
| T88.6xxA | Anaphylactic reaction due to adverse effect of correct drug or medicament properly administered, initial encounter |
| Dermatographic urticaria | |
| L50.3 | Dermatographic urticaria |
| Nasal congestion | |
| R09.81 | Nasal congestion |
| Pruritus of skin | |
| L29.8 | Other pruritus |
| L29.9 | Pruritus, unspecified |
| Rhinorrhea | |
| R09.82 | Postnasal drip |
| Sneezing | |
| R06.7 | Sneezing |
| Urticaria | |
| L50 | Urticaria |
| L50.0 | Allergic urticaria |
| L50.1 | Idiopathic urticaria |
| L50.2 | Urticaria due to cold and heat |
| L50.3 | Dermatographic urticaria |
| L50.4 | Vibratory urticaria |
| L50.5 | Cholinergic urticaria |
| L50.6 | Contact urticaria |
| L50.8 | Other urticaria |
| L50.9 | Urticaria, unspecified |
| L56.3 | Solar urticaria |
| O26.86 | Pruritic urticarial papules and plaques of pregnancy (PUPPp) |
| Vasomotor rhinitis | |
| J30.0 | Vasomotor rhinitis |
| 0-9 | A-Z |
|---|---|
| H10.1 | Acute atopic conjunctivitis |
| H10.10 | Acute atopic conjunctivitis, unspecified eye |
| H10.11 | Acute atopic conjunctivitis, right eye |
| H10.12 | Acute atopic conjunctivitis, left eye |
| H10.13 | Acute atopic conjunctivitis, bilateral |
| H10.44 | Vernal conjunctivitis |
| H10.45 | Other chronic allergic conjunctivitis |
| H16.26 | Vernal keratoconjunctivitis, with limbar and corneal involvement |
| H16.261 | Vernal keratoconjunctivitis, with limbar and corneal involvement, right eye |
| H16.262 | Vernal keratoconjunctivitis, with limbar and corneal involvement, left eye |
| H16.263 | Vernal keratoconjunctivitis, with limbar and corneal involvement, bilateral |
| H16.269 | Vernal keratoconjunctivitis, with limbar and corneal involvement, unspecified eye |
| J30.0 | Vasomotor rhinitis |
| J30.1 | Allergic rhinitis due to pollen |
| J30.2 | Other seasonal allergic rhinitis |
| J30.5 | Allergic rhinitis due to food |
| J30.8 | Other allergic rhinitis |
| J30.81 | Allergic rhinitis due to animal (cat) (dog) hair and dander |
| J30.89 | Other allergic rhinitis |
| J30.9 | Allergic rhinitis, unspecified |
| L29.8 | Other pruritus |
| L29.9 | Pruritus, unspecified |
| L50 | Urticaria |
| L50.0 | Allergic urticaria |
| L50.1 | Idiopathic urticaria |
| L50.2 | Urticaria due to cold and heat |
| L50.3 | Dermatographic urticaria |
| L50.3 | Dermatographic urticaria |
| L50.4 | Vibratory urticaria |
| L50.5 | Cholinergic urticaria |
| L50.6 | Contact urticaria |
| L50.8 | Other urticaria |
| L50.9 | Urticaria, unspecified |
| L56.3 | Solar urticaria |
| O26.86 | Pruritic urticarial papules and plaques of pregnancy (PUPPp) |
| R06.7 | Sneezing |
| R09.81 | Nasal congestion |
| R09.82 | Postnasal drip |
| T78.00xA | Anaphylactic reaction due to unspecified food, initial encounter |
| T78.01xA | Anaphylactic reaction due to peanuts, initial encounter |
| T78.02xA | Anaphylactic reaction due to shellfish (crustaceans), initial encounter |
| T78.03xA | Anaphylactic reaction due to other fish, initial encounter |
| T78.04xA | Anaphylactic reaction due to fruits and vegetables, initial encounter |
| T78.05xA | Anaphylactic reaction due to tree nuts and seeds, initial encounter |
| T78.06xA | Anaphylactic reaction due to food additives, initial encounter |
| T78.07xA | Anaphylactic reaction due to milk and dairy products, initial encounter |
| T78.08xA | Anaphylactic reaction due to eggs, initial encounter |
| T78.09xA | Anaphylactic reaction due to other food products, initial encounter |
| T78.2xxA | Anaphylactic shock, unspecified, initial encounter |
| T80.51 | Anaphylactic reaction due to administration of blood and blood products |
| T80.52xA | Anaphylactic reaction due to vaccination, initial encounter |
| T80.59xA | Anaphylactic reaction due to other serum, initial encounter |
| T88.6xxA | Anaphylactic reaction due to adverse effect of correct drug or medicament properly administered, initial encounter |
Formulary Reference Tool