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ACYCLOVIR (ACYCLOVIR)
- Mucocutaneous herpes simplex
- Chickenpox
- Genital herpes simplex
- Herpes labialis
- Herpes simplex encephalitis
- Herpes simplex infection
- Herpes zoster
- Mucocutaneous herpes simplex
- Recurrent herpes genitalis
- Recurrent herpes simplex labialis
- Recurrent mucocutaneous herpes simplex
- Suppression of recurrent herpes simplex infection
- Zovirax Topical Ointment
- Zovirax Topical Cream
- Zovirax Tablet
- Zovirax Oral Suspension
- Zovirax Oral Susp
- Zovirax Capsule
- Acyclovir Topical Ointment
- Acyclovir Topical Cream
- Acyclovir Tablet
- Acyclovir Oral Suspension
- Acyclovir Oral Susp
- Acyclovir Capsule
- By Indication
5 % topical ointment
- Apply to the affected area(s) by topical route every 3 hours 6 times per day
5 % topical cream
- Apply to the affected area(s) by topical route 5 times per day
400 mg tablet
- 1 tablet (400 mg) by oral route every 8 hours
800 mg tablet
- 1 tablet (800 mg) by oral route 5 times per day for 10 days
200 mg/5 mL oral suspension
- 20 milliliters (800 mg) by oral route every 4 hours while awake for 10 days
200 mg/5 mL oral suspension
- 20 milliliters (800 mg) by oral route every 4 hours while awake for 10 days
200 mg capsule
- 1 capsule (200 mg) by oral route every 4 hours 5 times per day
5 % topical ointment
- Apply to the affected area(s) by topical route every 3 hours 6 times per day
5 % topical cream
- Apply to the affected area(s) by topical route 5 times per day
400 mg tablet
- 1 tablet (400 mg) by oral route every 8 hours
800 mg tablet
- 1 tablet (800 mg) by oral route 5 times per day for 10 days
200 mg/5 mL (5 mL) oral suspension
- 20 milliliters (800 mg) by oral route every 4 hours while awake for 10 days
200 mg/5 mL oral suspension
- 20 milliliters (800 mg) by oral route every 4 hours while awake for 10 days
200 mg/5 mL (5 mL) oral suspension
- 20 milliliters (800 mg) by oral route every 4 hours while awake for 10 days
200 mg/5 mL oral suspension
- 20 milliliters (800 mg) by oral route every 4 hours while awake for 10 days
200 mg capsule
- 1 capsule (200 mg) by oral route every 4 hours 5 times per day
Chickenpox
- 2 tablets (800 mg) by oral route 4 times per day
- 2 tablets (800 mg) by oral route 4 times per day for 5 days
- 1 tablet (800 mg) by oral route 4 times per day
- 20 milliliters (800 mg) by oral route 4 times per day for 5 days
- 20 milliliters (800 mg) by oral route 4 times per day
- 1 tablet (800 mg) by oral route 4 times per day for 5 days
Genital herpes simplex
- Apply to the affected area(s) by topical route every 3 hours 6 times per day for 7 days
- Apply to the affected area(s) by topical route every 3 hours 6 times per day
- 5 milliliters (200 mg) by oral route every 4 hours 5 times per day for 7 days
- 5 milliliters (200 mg) by oral route every 4 hours 5 times per day for 10 days
- 5 milliliters (200 mg) by oral route every 4 hours 5 times per day
- 1 capsule (200 mg) by oral route every 4 hours 5 times per day for 7 days
- 1 capsule (200 mg) by oral route every 4 hours 5 times per day for 10 days
- 1 capsule (200 mg) by oral route every 4 hours 5 times per day
Herpes zoster
- 1 tablet (800 mg) by oral route every 4 hours 5 times per day for 10 days
- 1 tablet (800 mg) by oral route every 4 hours 5 times per day for 7 days
- 2 tablets (800 mg) by oral route every 4 hours 5 times per day for 10 days
- 2 tablets (800 mg) by oral route every 4 hours 5 times per day for 7 days
- 2 tablets (800 mg) by oral route every 4 hours 5 times per day while awake for 10 days
- 2 tablets (800 mg) by oral route every 4 hours 5 times per day while awake for 7 days
- 1 tablet (800 mg) by oral route every 4 hours 5 times per day while awake for 10 days
- 1 tablet (800 mg) by oral route every 4 hours 5 times per day while awake for 7 days
- 1 tablet (800 mg) by oral route 5 times per day for 7 days
- 2 tablets (800 mg) by oral route 5 times per day for 7 days
- 2 tablets (800 mg) by oral route every 4 hours while awake for 10 days
- 2 tablets (800 mg) by oral route 5 times per day for 10 days
- 1 tablet (800 mg) by oral route every 4 hours while awake for 10Days
- 1 tablet (800 mg) by oral route 5 times per day for 10 days
- 2 tablets (800 mg) by oral route every 4 hours while awake for 7Days
- 1 tablet (800 mg) by oral route every 4 hours while awake for 7 days
- 20 milliliters (800 mg) by oral route every 4 hours while awake for 7 days
- 20 milliliters (800 mg) by oral route every 4 hours while awake for 10 days
- 20 milliliters (800 mg) by oral route 5 times per day for 10 days
Herpes zoster ophthalmicus
- 2 tablets (800 mg) by oral route every 4 hours 5 times per day for 10 days
- 2 tablets (800 mg) by oral route every 4 hours 5 times per day while awake for 10 days
- 2 tablets (800 mg) by oral route 5 times per day for 7 days
- 2 tablets (800 mg) by oral route every 4 hours while awake for 10 days
- 2 tablets (800 mg) by oral route 5 times per day for 10 days
- 20 milliliters (800 mg) by oral route every 4 hours while awake for 7 days
- 20 milliliters (800 mg) by oral route every 4 hours while awake for 10 days
- 20 milliliters (800 mg) by oral route 5 times per day for 10 days
Recurrent herpes genitalis
- 5 milliliters (200 mg) by oral route every 4 hours 5 times per day
- 5 milliliters (200 mg) by oral route every 4 hours 5 times per day for 5 days
- 1 capsule (200 mg) by oral route every 4 hours 5 times per day
- 1 capsule (200 mg) by oral route every 4 hours 5 times per day for 5 days
- 10 milliliters (400 mg) by oral route every 8 hours
- 1 tablet (400 mg) by oral route every 8 hours
- 2 capsules (400 mg) by oral route every 8 hours for 5 days
- 2 capsules (400 mg) by oral route every 8 hours
- 1 tablet (400 mg) by oral route every 8 hours for 5 days
- 10 milliliters (400 mg) by oral route every 8 hours for 5 days
- 20 milliliters (800 mg) by oral route 2 times per day for 5 days
- 20 milliliters (800 mg) by oral route 2 times per day
- 2 tablets (800 mg) by oral route 2 times per day for 5 days
- 2 tablets (800 mg) by oral route 2 times per day
Recurrent herpes simplex labialis
- Apply to the affected area(s) by topical route 5 times per day
- Apply to the affected area(s) by topical route 5 times per day for 4 days
Suppression of recurrent herpes simplex infection
- 5 milliliters (200 mg) by oral route 3 times per day for 12 months
- 5 milliliters (200 mg) by oral route 5 times per day for 12 months
- 5 milliliters (200 mg) by oral route 5 times per day
- 1 capsule (200 mg) by oral route 3 times per day for 12 months
- 1 capsule (200 mg) by oral route 5 times per day for 12 months
- 1 capsule (200 mg) by oral route 5 times per day
- 1 capsule (200 mg) by oral route 3 times per day
- 5 milliliters (200 mg) by oral route 3 times per day
- 10 milliliters (400 mg) by oral route 2 times per day
- 2 capsules (400 mg) by oral route 2 times per day
- 1 tablet (400 mg) by oral route 2 times per day
- 2 capsules (400 mg) by oral route 2 times per day for 12 months
- 1 tablet (400 mg) by oral route 2 times per day for 12 months
- 10 milliliters (400 mg) by oral route 2 times per day for 12 months
- measles,mumps,rub,varicel(PF)
- Proquad (pf)
- varicella virus vacc live (PF)
- Varivax (pf)
- Zostavax (pf)
- zoster vaccine live (PF)
Contraindicated
- tizanidine
- Zanaflex
Severe
Moderate
- Atripla
- Complera
- efavirenz-emtricitabin-tenofov
- elvitegr-cobicist-emtric-tenof
- emtricitab-rilpivirine-tenofov
- emtricitabine-tenofovir
- Stribild
- tenofovir disoproxil fumarate
- Truvada
- Viread
- None
Contraindicated
- Dehydration
- Kidney disease with reduction in GFR
Severe
Moderate
- No disease contraindications
ACYCLOVIR (ACYCLOVIR)
- Mucocutaneous herpes simplex
- Chickenpox
- Genital herpes simplex
- Herpes labialis
- Herpes simplex encephalitis
- Herpes simplex infection
- Herpes zoster
- Mucocutaneous herpes simplex
- Recurrent herpes genitalis
- Recurrent herpes simplex labialis
- Recurrent mucocutaneous herpes simplex
- Suppression of recurrent herpes simplex infection
- None
- Abnormal desquamation
- Dry skin
- Malaise
- Skin irritation
- Stinging of skin
More Frequent
Severe
Less Severe
- None
- Abdominal pain with cramps
- Agitation
- Alopecia
- Cheilosis
- Diarrhea
- Dizziness
- Drowsy
- Gastrointestinal irritation
- Headache disorder
- Myalgias
- Nausea
- Paresthesia
- Pruritus of skin
- Vomiting
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal hepatic function tests
- Acute confusion
- Aggressive behavior
- Anaphylaxis
- Anemia
- Angioedema
- Coma
- Delirium
- Drug-induced psychosis
- Dysarthria
- Encephalopathy
- Erythema multiforme
- Fever
- Hallucinations
- Hematuria
- Hepatitis
- Hyperbilirubinemia
- Jaundice
- Leukopenia
- Lymphadenopathy
- Peripheral edema
- Pruritus of skin
- Renal failure
- Seizure disorder
- Skin rash
- Stevens-johnson syndrome
- Thrombocytopenic disorder
- Toxic epidermal necrolysis
- Urticaria
- Visual changes
Less Severe
- Ataxia
- Contact dermatitis
- Eczema
- Pain
- Renal pain
- Skin photosensitivity
- Tremor
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Acyclovir (Oral)
IV route preferred. Safety and efficacy of oral route not established age < 2 years. Rare use for immunocompromised patients in treating zoster or varicella.
Safety and efficacy not established age < 6 years.
- 1 Day – 2 Years
- IV route preferred. Safety and efficacy of oral route not established age < 2 years. Rare use for immunocompromised patients in treating zoster or varicella.
- 1 Day – 6 Years
- IV route preferred. Safety and efficacy of oral route not established age < 2 years. Rare use for immunocompromised patients in treating zoster or varicella.
Acyclovir (Topical)
IV route preferred. Safety and efficacy of oral route not established age < 2 years. Rare use for immunocompromised patients in treating zoster or varicella.
Safety and efficacy not established age < 6 years.
- 1 Day – 2 Years
- Safety and efficacy not established age < 6 years.
- 1 Day – 6 Years
- Safety and efficacy not established age < 6 years.
Acyclovir
- Severity Level:
B
- Additional Notes:
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
No Known Risk
Acyclovir (oral, Inj)
Limited data suggest low levels excreted resulting in no adverse effects
Unlikely to be excreted since dose is small & systemic absorption is minimal
| General | Excretion Potential | Effect on Infant | Notes |
| No known risks; does not adversely affect lactation | Excreted | No adverse effect | Limited data suggest low levels excreted resulting in no adverse effects |
Acyclovir (topical, Buccal)
Limited data suggest low levels excreted resulting in no adverse effects
Unlikely to be excreted since dose is small & systemic absorption is minimal
| General | Excretion Potential | Effect on Infant | Notes |
| No known risks; does not adversely affect lactation | Unknown | No adverse effect | Unlikely to be excreted since dose is small & systemic absorption is minimal |
Contraindicated
None
Precaution Exists
Acyclovir
Renal-Dose interval adjustment necessary for CrCL<25 mL/min. for high dose (800 mg oral) treatment. For IV therapy: CrCL >25-50 mL/min, adjust interval to 12 hours; CrCL>10-25mL/min, adjust interval to 24 hours; CrCL<11mL/min, decrease dose by half and use a 24 hour interval. Renal toxicity more common in the elderly. Neuro/Psych-Dizziness, somnolence, hallucinations, confusion and coma are reported more commonly in the elderly.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | Y | N | N | Y | N | N |
BEERS: N HEDIS: N STOPP: N
No Known Risk
None
- None
| Chickenpox | |
| B01 | Varicella [chickenpox] |
| B01.9 | Varicella without complication |
| Genital herpes simplex | |
| A60 | Anogenital herpesviral [herpes simplex] infections |
| A60.0 | Herpesviral infection of genitalia and urogenital tract |
| A60.00 | Herpesviral infection of urogenital system, unspecified |
| A60.01 | Herpesviral infection of penis |
| A60.02 | Herpesviral infection of other male genital organs |
| A60.03 | Herpesviral cervicitis |
| A60.04 | Herpesviral vulvovaginitis |
| A60.09 | Herpesviral infection of other urogenital tract |
| A60.9 | Anogenital herpesviral infection, unspecified |
| Herpes labialis | |
| B00.1 | Herpesviral vesicular dermatitis |
| Herpes simplex encephalitis | |
| B00.4 | Herpesviral encephalitis |
| Herpes simplex infection | |
| A60 | Anogenital herpesviral [herpes simplex] infections |
| A60.0 | Herpesviral infection of genitalia and urogenital tract |
| A60.00 | Herpesviral infection of urogenital system, unspecified |
| A60.01 | Herpesviral infection of penis |
| A60.02 | Herpesviral infection of other male genital organs |
| A60.03 | Herpesviral cervicitis |
| A60.04 | Herpesviral vulvovaginitis |
| A60.09 | Herpesviral infection of other urogenital tract |
| A60.1 | Herpesviral infection of perianal skin and rectum |
| A60.9 | Anogenital herpesviral infection, unspecified |
| B00 | Herpesviral [herpes simplex] infections |
| B00.1 | Herpesviral vesicular dermatitis |
| B00.2 | Herpesviral gingivostomatitis and pharyngotonsillitis |
| B00.9 | Herpesviral infection, unspecified |
| Herpes zoster | |
| B02 | Zoster [herpes zoster] |
| B02.0 | Zoster encephalitis |
| B02.1 | Zoster meningitis |
| B02.3 | Zoster ocular disease |
| B02.30 | Zoster ocular disease, unspecified |
| B02.31 | Zoster conjunctivitis |
| B02.32 | Zoster iridocyclitis |
| B02.33 | Zoster keratitis |
| B02.34 | Zoster scleritis |
| B02.39 | Other herpes zoster eye disease |
| B02.7 | Disseminated zoster |
| B02.8 | Zoster with other complications |
| B02.9 | Zoster without complications |
| Mucocutaneous herpes simplex | |
| A60 | Anogenital herpesviral [herpes simplex] infections |
| A60.0 | Herpesviral infection of genitalia and urogenital tract |
| A60.00 | Herpesviral infection of urogenital system, unspecified |
| A60.01 | Herpesviral infection of penis |
| A60.02 | Herpesviral infection of other male genital organs |
| A60.03 | Herpesviral cervicitis |
| A60.04 | Herpesviral vulvovaginitis |
| A60.09 | Herpesviral infection of other urogenital tract |
| A60.1 | Herpesviral infection of perianal skin and rectum |
| A60.9 | Anogenital herpesviral infection, unspecified |
| B00.1 | Herpesviral vesicular dermatitis |
| B00.2 | Herpesviral gingivostomatitis and pharyngotonsillitis |
| B00.89 | Other herpesviral infection |
| Recurrent herpes genitalis | |
| A60 | Anogenital herpesviral [herpes simplex] infections |
| A60.0 | Herpesviral infection of genitalia and urogenital tract |
| A60.00 | Herpesviral infection of urogenital system, unspecified |
| A60.01 | Herpesviral infection of penis |
| A60.02 | Herpesviral infection of other male genital organs |
| A60.03 | Herpesviral cervicitis |
| A60.04 | Herpesviral vulvovaginitis |
| A60.09 | Herpesviral infection of other urogenital tract |
| A60.9 | Anogenital herpesviral infection, unspecified |
| Recurrent herpes simplex labialis | |
| B00.9 | Herpesviral infection, unspecified |
| Recurrent mucocutaneous herpes simplex | |
| A60 | Anogenital herpesviral [herpes simplex] infections |
| A60.0 | Herpesviral infection of genitalia and urogenital tract |
| A60.00 | Herpesviral infection of urogenital system, unspecified |
| A60.01 | Herpesviral infection of penis |
| A60.02 | Herpesviral infection of other male genital organs |
| A60.03 | Herpesviral cervicitis |
| A60.04 | Herpesviral vulvovaginitis |
| A60.09 | Herpesviral infection of other urogenital tract |
| A60.1 | Herpesviral infection of perianal skin and rectum |
| A60.9 | Anogenital herpesviral infection, unspecified |
| B00.1 | Herpesviral vesicular dermatitis |
| B00.2 | Herpesviral gingivostomatitis and pharyngotonsillitis |
| B00.89 | Other herpesviral infection |
| Suppression of recurrent herpes simplex infection | |
| A60 | Anogenital herpesviral [herpes simplex] infections |
| A60.0 | Herpesviral infection of genitalia and urogenital tract |
| A60.00 | Herpesviral infection of urogenital system, unspecified |
| A60.01 | Herpesviral infection of penis |
| A60.02 | Herpesviral infection of other male genital organs |
| A60.03 | Herpesviral cervicitis |
| A60.04 | Herpesviral vulvovaginitis |
| A60.09 | Herpesviral infection of other urogenital tract |
| A60.1 | Herpesviral infection of perianal skin and rectum |
| A60.9 | Anogenital herpesviral infection, unspecified |
| B00.2 | Herpesviral gingivostomatitis and pharyngotonsillitis |
| B00.89 | Other herpesviral infection |
| B00.9 | Herpesviral infection, unspecified |
| 0-9 | A-Z |
|---|---|
| A60 | Anogenital herpesviral [herpes simplex] infections |
| A60 | Anogenital herpesviral [herpes simplex] infections |
| A60 | Anogenital herpesviral [herpes simplex] infections |
| A60 | Anogenital herpesviral [herpes simplex] infections |
| A60 | Anogenital herpesviral [herpes simplex] infections |
| A60 | Anogenital herpesviral [herpes simplex] infections |
| A60.0 | Herpesviral infection of genitalia and urogenital tract |
| A60.0 | Herpesviral infection of genitalia and urogenital tract |
| A60.0 | Herpesviral infection of genitalia and urogenital tract |
| A60.0 | Herpesviral infection of genitalia and urogenital tract |
| A60.0 | Herpesviral infection of genitalia and urogenital tract |
| A60.0 | Herpesviral infection of genitalia and urogenital tract |
| A60.00 | Herpesviral infection of urogenital system, unspecified |
| A60.00 | Herpesviral infection of urogenital system, unspecified |
| A60.00 | Herpesviral infection of urogenital system, unspecified |
| A60.00 | Herpesviral infection of urogenital system, unspecified |
| A60.00 | Herpesviral infection of urogenital system, unspecified |
| A60.00 | Herpesviral infection of urogenital system, unspecified |
| A60.01 | Herpesviral infection of penis |
| A60.01 | Herpesviral infection of penis |
| A60.01 | Herpesviral infection of penis |
| A60.01 | Herpesviral infection of penis |
| A60.01 | Herpesviral infection of penis |
| A60.01 | Herpesviral infection of penis |
| A60.02 | Herpesviral infection of other male genital organs |
| A60.02 | Herpesviral infection of other male genital organs |
| A60.02 | Herpesviral infection of other male genital organs |
| A60.02 | Herpesviral infection of other male genital organs |
| A60.02 | Herpesviral infection of other male genital organs |
| A60.02 | Herpesviral infection of other male genital organs |
| A60.03 | Herpesviral cervicitis |
| A60.03 | Herpesviral cervicitis |
| A60.03 | Herpesviral cervicitis |
| A60.03 | Herpesviral cervicitis |
| A60.03 | Herpesviral cervicitis |
| A60.03 | Herpesviral cervicitis |
| A60.04 | Herpesviral vulvovaginitis |
| A60.04 | Herpesviral vulvovaginitis |
| A60.04 | Herpesviral vulvovaginitis |
| A60.04 | Herpesviral vulvovaginitis |
| A60.04 | Herpesviral vulvovaginitis |
| A60.04 | Herpesviral vulvovaginitis |
| A60.09 | Herpesviral infection of other urogenital tract |
| A60.09 | Herpesviral infection of other urogenital tract |
| A60.09 | Herpesviral infection of other urogenital tract |
| A60.09 | Herpesviral infection of other urogenital tract |
| A60.09 | Herpesviral infection of other urogenital tract |
| A60.09 | Herpesviral infection of other urogenital tract |
| A60.1 | Herpesviral infection of perianal skin and rectum |
| A60.1 | Herpesviral infection of perianal skin and rectum |
| A60.1 | Herpesviral infection of perianal skin and rectum |
| A60.1 | Herpesviral infection of perianal skin and rectum |
| A60.9 | Anogenital herpesviral infection, unspecified |
| A60.9 | Anogenital herpesviral infection, unspecified |
| A60.9 | Anogenital herpesviral infection, unspecified |
| A60.9 | Anogenital herpesviral infection, unspecified |
| A60.9 | Anogenital herpesviral infection, unspecified |
| A60.9 | Anogenital herpesviral infection, unspecified |
| B00 | Herpesviral [herpes simplex] infections |
| B00.1 | Herpesviral vesicular dermatitis |
| B00.1 | Herpesviral vesicular dermatitis |
| B00.1 | Herpesviral vesicular dermatitis |
| B00.1 | Herpesviral vesicular dermatitis |
| B00.2 | Herpesviral gingivostomatitis and pharyngotonsillitis |
| B00.2 | Herpesviral gingivostomatitis and pharyngotonsillitis |
| B00.2 | Herpesviral gingivostomatitis and pharyngotonsillitis |
| B00.2 | Herpesviral gingivostomatitis and pharyngotonsillitis |
| B00.4 | Herpesviral encephalitis |
| B00.89 | Other herpesviral infection |
| B00.89 | Other herpesviral infection |
| B00.89 | Other herpesviral infection |
| B00.9 | Herpesviral infection, unspecified |
| B00.9 | Herpesviral infection, unspecified |
| B00.9 | Herpesviral infection, unspecified |
| B01 | Varicella [chickenpox] |
| B01.9 | Varicella without complication |
| B02 | Zoster [herpes zoster] |
| B02.0 | Zoster encephalitis |
| B02.1 | Zoster meningitis |
| B02.3 | Zoster ocular disease |
| B02.30 | Zoster ocular disease, unspecified |
| B02.31 | Zoster conjunctivitis |
| B02.32 | Zoster iridocyclitis |
| B02.33 | Zoster keratitis |
| B02.34 | Zoster scleritis |
| B02.39 | Other herpes zoster eye disease |
| B02.7 | Disseminated zoster |
| B02.8 | Zoster with other complications |
| B02.9 | Zoster without complications |
Formulary Reference Tool