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NAPROTIN (naproxen/capsicum oleoresin)
500 mg-0.025 % kit
- Dosage information is not available
- cidofovir
- ketorolac
- Sprix
- Vistide
Contraindicated
- Alimta
- apixaban
- colistin (colistimethate Na)
- Coly-mycin M Parenteral
- Coumadin
- Curad Enema
- Disposable Enema
- Eliquis
- Enema
- Enema Disposable
- Fleet Enema
- Fleet Enema Extra
- Fleet Pediatric
- Folotyn
- Jantoven
- Methotrexate (anti-rheumatic)
- methotrexate sodium
- methotrexate sodium (PF)
- Oral Saline Laxative
- Osmoprep
- pemetrexed
- Phosphate Laxative
- pralatrexate
- Preparation Cleansing
- Ready-to-use Enema
- Rheumatrex
- rivaroxaban
- sod phos mono-sod phos dibasic
- sodium phosphates
- Trexall
- warfarin
- Xarelto
Severe
Moderate
- A-hydrocort
- A-methapred
- abciximab
- Accolate
- Accupril
- Accuretic
- acebutolol
- Aceon
- adefovir
- Adult Low Dose Aspirin
- Aggrenox
- Alka-seltzer
- Alka-seltzer Extra Strength
- Alka-seltzer Original
- Alka-seltzer Pm
- Altace
- amiloride
- amiloride-hydrochlorothiazide
- amiodarone
- amiodarone in dextrose,iso-osm
- amlodipine-benazepril
- amlodipine-olmesartan
- amlodipine-valsartan
- amlodipine-valsartan-hcthiazid
- Angeliq
- Antacid & Pain Relief
- Anucort-hc
- Anusol-hc
- Aristospan Intra-articular
- Aristospan Intralesional
- Arixtra
- ASA-acetaminophen-caff-buffers
- Aspir-81
- Aspir-low
- Aspir-trin
- aspirin
- Aspirin Childrens
- Aspirin Low Dose
- Aspirin Low-strength
- aspirin, buffered
- aspirin-calcium carbonate
- aspirin-diphenhydramine
- aspirin-sod bicarb-citric acid
- Astagraf Xl
- Atacand
- Atacand Hct
- atenolol
- atenolol-chlorthalidone
- Atripla
- Avalide
- Avapro
- azilsartan med-chlorthalidone
- azilsartan medoxomil
- Azor
- Bayer Advanced
- Bayer Aspirin
- Bayer Chewable Aspirin
- Bayer Childrens Aspirin
- Bayer Plus Extra Strength
- benazepril
- benazepril-hydrochlorothiazide
- Benicar
- Benicar Hct
- betamethasone acet & sod phos
- Betapace
- Betapace Af
- betaxolol
- Beyaz
- bisoprolol fumarate
- bisoprolol-hydrochlorothiazide
- Brevibloc
- Brevibloc In Nacl (iso-osm)
- Brilinta
- Brintellix
- Brisdelle
- budesonide
- Buffered Aspirin
- Bufferin
- bumetanide
- Bystolic
- candesartan
- candesartan-hydrochlorothiazid
- captopril
- captopril-hydrochlorothiazide
- Celestone Soluspan
- Celexa
- Child Aspirin
- Children's Aspirin
- cilostazol
- cisplatin
- citalopram
- clopidogrel
- colchicine-probenecid
- Colocort
- Complera
- Cordarone
- Corgard
- Cortef
- Cortenema
- Cortifoam
- cortisone
- Corzide
- Cozaar
- cyclosporine
- cyclosporine modified
- Cymbalta
- Daflonex-xl
- dalteparin (porcine)
- Demadex
- Depo-medrol
- desvenlafaxine
- desvenlafaxine fumarate
- desvenlafaxine succinate
- dexamethasone
- Dexamethasone Intensol
- dexamethasone sodium phos (PF)
- dexamethasone sodium phosphate
- Dexpak 10 Day
- Dexpak 13 Day
- Dexpak 6 Day
- Diflucan
- diosmin complex no.1
- Diovan Hct
- dipyridamole-aspirin
- drospirenone-e.estradiol-lm.FA
- drospirenone-estradiol
- drospirenone-ethinyl estradiol
- duloxetine
- Dutoprol
- Dyazide
- Dyrenium
- E.c. Prin
- Ecotrin
- Ecotrin Low Strength
- Edarbi
- Edarbyclor
- efavirenz-emtricitabin-tenofov
- Efferves Pain Relief Antacid
- Effervescent Antacid
- Effervescent Pain Relief
- Effervescent Pain Reliever
- Effexor Xr
- Elmiron
- elvitegr-cobicist-emtric-tenof
- emtricitab-rilpivirine-tenofov
- emtricitabine-tenofovir
- enalapril maleate
- enalapril-hydrochlorothiazide
- enalaprilat
- enoxaparin
- Enteric Coated Aspirin
- Entocort Ec
- Epaned
- eprosartan
- eprosartan-hydrochlorothiazide
- eptifibatide
- erlotinib
- escitalopram oxalate
- esmolol
- esmolol in NaCl (iso-osm)
- ethacrynate sodium
- Exforge
- Exforge Hct
- Extra Strength Bayer
- Ez Use Joint-tunnel-trigger
- Fetzima
- First-duke's
- First-mary's Mouthwash
- Flo-pred
- fluconazole
- fluconazole in dextrose(iso-o)
- fluconazole in NaCl (iso-osm)
- fludrocortisone
- fluoxetine
- fluvoxamine
- fondaparinux
- fosinopril
- fosinopril-hydrochlorothiazide
- Fragmin
- furosemide
- Gengraf
- Gianvi (28)
- Grx Hicort 25
- Hecoria
- Hemril-30
- heparin (porcine)
- heparin (porcine) in D5W
- heparin(porcine) in 0.45% NaCl
- heparin, porcine (PF)
- Hepsera
- hesp-diosm hyd-Ca dobe-diosmin
- hesperid-diosmin-grape seed xt
- hydrocortisone
- hydrocortisone acetate
- hydrocortisone sod succ (PF)
- hydrocortisone sod succinate
- Hyzaar
- Inderal La
- Inderal Xl
- Innopran Xl
- Integrilin
- irbesartan
- irbesartan-hydrochlorothiazide
- Kenalog
- ketoconazole
- Khedezla
- Lasix
- Levatol
- levomilnacipran
- Lexapro
- lisinopril
- lisinopril-hydrochlorothiazide
- Lite Coat Aspirin
- lithium carbonate
- lithium citrate
- Lithobid
- Lo-dose Aspirin
- Lopressor
- Lopressor Hct
- Loryna (28)
- losartan
- losartan-hydrochlorothiazide
- Lotensin
- Lotrel
- Lovenox
- Luvox Cr
- Mavik
- Maxzide
- Maxzide-25Mg
- Medi-seltzer
- Medrol
- Medrol (pak)
- methylprednisolone
- methylprednisolone acetate
- methylprednisolone sod suc(PF)
- methylprednisolone sodium succ
- methylprednisolone-bupivacaine
- metoprolol su-hydrochlorothiaz
- metoprolol succinate
- metoprolol ta-hydrochlorothiaz
- metoprolol tartrate
- Micardis
- Micardis Hct
- miconazole
- Millipred
- Millipred Dp
- milnacipran
- moexipril
- moexipril-hydrochlorothiazide
- nadolol
- nadolol-bendroflumethiazide
- nebivolol
- Neoral
- Nexterone
- nystatin-hydrocortisone-diphen
- nystatin-TCN-HC-diphenhydramin
- Ocella
- olanzapine-fluoxetine
- olmesartan
- olmesartan-amlodipin-hcthiazid
- olmesartan-hydrochlorothiazide
- Orapred
- Orapred Odt
- Oravig
- Oxandrin
- oxandrolone
- Pacerone
- paroxetine HCl
- paroxetine mesylate
- Paxil
- Paxil Cr
- Pediapred
- penbutolol
- pentosan polysulfate sodium
- perindopril erbumine
- Pexeva
- Physicians Ez Use M-pred
- pindolol
- Plavix
- Pletal
- prednisolone
- prednisolone acetate
- prednisolone sodium phosphate
- prednisone
- Prednisone Intensol
- Prinivil
- Pristiq
- probenecid
- Proctocort
- Prograf
- propranolol
- propranolol-hydrochlorothiazid
- Prozac
- Prozac Weekly
- quinapril
- quinapril-hydrochlorothiazide
- ramipril
- Rapamune
- Rayos
- Rectacort-hc
- Reopro
- Safyral
- Sandimmune
- Sarafem
- Savella
- Sectral
- sertraline
- sirolimus
- Sodium Edecrin
- Solu-cortef
- Solu-cortef (pf)
- Solu-medrol
- Solu-medrol (pf)
- Sorine
- sotalol
- Sotalol Af
- St Joseph Aspirin
- St. Joseph Aspirin
- Stribild
- Syeda
- Symbyax
- tacrolimus
- Tarceva
- Tarka
- telmisartan
- telmisartan-amlodipine
- telmisartan-hydrochlorothiazid
- tenofovir disoproxil fumarate
- Tenoretic 100
- Tenoretic 50
- Tenormin
- Teveten
- Teveten Hct
- ticagrelor
- timolol maleate
- Toprol Xl
- torsemide
- trandolapril
- trandolapril-verapamil
- Tri-buffered Aspirin
- triamcinolone acetonide
- triamcinolone hexacetonide
- triamcinolone-lidocaine
- triamterene
- triamterene-hydrochlorothiazid
- Tribenzor
- Trombonex-d
- Truvada
- Twynsta
- Uceris
- Uniretic
- Univasc
- valsartan-hydrochlorothiazide
- Vanquish
- Vasculera
- Vaseretic
- Vasoflex Hd
- Vasotec
- Venaliv
- venlafaxine
- Veripred 20
- Vestura (28)
- Vfend
- Vfend Iv
- Viibryd
- vilazodone
- Viread
- vit C-but.broom-hesperidn-dios
- vit C-dios-rut-bioflav-butc br
- voriconazole
- vortioxetine
- Women's Aspirin With Calcium
- Yasmin (28)
- Yaz 28
- zafirlukast
- Zarah
- Zebeta
- Zestoretic
- Zestril
- Ziac
- Zoloft
- Aspirin exacerbated respiratory disease
- Cerebrovascular accident
- Chronic kidney disease stage 4 (severe) GFR 15-29 ml/min
- Chronic kidney disease stage 5 (failure) GFr<15 ml/min
- History of kidney donation
- History of roux-en-Y gastric bypass
- Post-operative from CABG surgery
- Pregnancy
- Renal transplant
Contraindicated
- Acute myocardial infarction
- Alcoholism
- Anemia
- Chronic heart failure
- Disease of liver
- Edema
- Esophageal dysmotility
- Gastrointestinal hemorrhage
- Gastrointestinal perforation
- Gastrointestinal ulcer
- Hypertension
- Increased risk of bleeding
- Kidney disease with likely reduction in GFR
- Systemic mastocytosis
- Thrombotic disorder
- Tobacco smoker
Severe
Moderate
- Abnormal hepatic function tests
- Gastritis
- Gastrointestinal ulcer
- Increased risk of bleeding due to coagulation disorder
NAPROTIN (naproxen/capsicum oleoresin)
- Abnormal hepatic function tests
- Body fluid retention
- Skin rash
- Tinnitus
- Urticaria
- Blistering skin
- Constipation
- Contact dermatitis
- Dizziness
- Drowsy
- Edema
- Headache disorder
- Heartburn
- Nausea
More Frequent
Severe
Less Severe
- Blurred vision
- Bruising
- Ecchymosis
- Hemorrhage
- Polydipsia
- Purpura
- Visual changes
- Acute pain at drug application site
- Diarrhea
- Dyspepsia
- Erythema
- Hearing loss
- Hyperhidrosis
- Palpitations
- Pruritus of skin
- Upper abdominal pain
- Vertigo
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Acute confusion
- Acute myocardial infarction
- Acute pancreatitis
- Agranulocytosis
- Allergic dermatitis
- Anaphylaxis
- Anemia
- Angioedema
- Aplastic anemia
- Bacterial sepsis
- Bloody vomit
- Bronchospastic pulmonary disease
- Burns
- Cardiac arrhythmia
- Cerebrovascular accident
- Chest tightness
- Chronic heart failure
- Colitis
- Coma
- Corneal opacity
- Cystitis
- Depression
- Dyspnea
- Eosinophilia
- Eosinophilic pneumonia
- Erythema multiforme
- Exfoliative dermatitis
- Fever
- Gastric ulcer
- Gastrointestinal hemorrhage
- Gastrointestinal obstruction
- Gastrointestinal perforation
- Gastrointestinal ulcer
- Glomerulonephritis
- Heart failure
- Hematuria
- Hemolytic anemia
- Hepatic failure
- Hepatitis
- Hyperglycemia
- Hyperkalemia
- Hypertension
- Hypoglycemic disorder
- Hypotension
- Interstitial nephritis
- Jaundice
- Kidney disease with reduction in GFR
- Leukopenia
- Loffler syndrome
- Lupus-like syndrome
- Lymphadenopathy
- Myalgia
- Nephrotic syndrome
- Non-infective meningitis
- Optic neuritis
- Pancytopenia
- Peptic ulcer
- Pneumonia
- Polyuria
- Proteinuria
- Pruritus of skin
- Pulmonary edema
- Rectal bleeding
- Renal failure
- Renal papillary necrosis
- Renal tubular necrosis
- Respiratory depression
- Seizure disorder
- Stevens-johnson syndrome
- Syncope
- Tachycardia
- Thrombocytopenic disorder
- Thrombotic disorder
- Toxic epidermal necrolysis
- Vasculitis
- Wheezing
Less Severe
- Alopecia
- Appetite changes
- Black tarry stools
- Concentration difficulty
- Conjunctivitis
- Cough
- Dysgeusia
- Dysuria
- Eructation
- Erythema nodosum
- Esophagitis
- Fatigue
- Gastritis
- General weakness
- Glossitis
- Hallucinations
- Headache disorder
- Insomnia
- Lichen planus
- Menstrual disorder
- Muscle weakness
- Nervousness
- Ocular pain
- Oliguria
- Papilledema
- Paresthesia
- Reduced sensation of skin
- Skin photosensitivity
- Stinging of skin
- Stomatitis
- Symptoms of anxiety
- Tremor
- Vomiting
- Weight gain
- Weight loss
- Xerostomia
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Capsaicin 0.025, 0.033% (Top)
Consult clinician for use if age < 8 years.
Safety and efficacy not established in children age less than 2 years.
- 1 Day – 8 Years
- Consult clinician for use if age < 8 years.
- 1 Day – 2 Years
- Consult clinician for use if age < 8 years.
Naproxen
Consult clinician for use if age < 8 years.
Safety and efficacy not established in children age less than 2 years.
- 1 Day – 8 Years
- Safety and efficacy not established in children age less than 2 years.
- 1 Day – 2 Years
- Safety and efficacy not established in children age less than 2 years.
Capsicum
- Severity Level:
2
- Additional Notes: Insufficient human data available on developmental toxicity risk.
Naproxen
- Severity Level:
1
- Additional Notes: Not recommended near or after 20 weeks gestation
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Capsicum (systemic)
Insufficient human data available
Insufficient data available; low levels found in breastmilk
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | Insufficient human data available |
Naproxen
Insufficient human data available
Insufficient data available; low levels found in breastmilk
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Excreted | Not known; no or inclusive data | Insufficient data available; low levels found in breastmilk |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Naproxen
Gastrointestinal-Risk for ulceration or serious GI bleed; highest with history of PUD or GI bleed. Renal-Risk of AKI and exacerbation of CKD. Avoid with CrCl <30 mL/min. Cardiovascular-May exacerbate pre-existing hypertension or CHF. Risk of MI and stroke. This risk may occur early in treatment and increases with duration of use. Risk for reinfarction with minimal NSAID use post-MI. Contraindicated with CABG. Hepatic-Elevated hepatic transaminases may occur with chronic use.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | Y | Y | Y | N | N | N |
BEERS: Y HEDIS: Y STOPP: Y
No Known Risk
None
- Nonsteroidal anti-inflammatory drugs (including naproxen) may rarely increase the risk for a heart attack or stroke. This effect can happen at any time while taking this drug but is more likely if you take it for a long time. The risk may be greater in older adults or if you have heart disease or increased risk for heart disease (for example, due to smoking, family history of heart disease, or conditions such as high blood pressure or diabetes).<br /><br />Do not take this drug right before or after heart bypass surgery (CABG). This drug may rarely cause serious (rarely fatal) bleeding from the stomach or intestines. This effect can occur without warning at any time while taking this drug.<br /><br />Older adults may be at higher risk for this effect. Stop taking naproxen and get medical help right away if you notice any of these rare but serious side effects: stomach/abdominal pain that doesn't go away, black/tarry stools, vomit that looks like coffee grounds, chest/jaw/left arm pain, shortness of breath, unusual sweating, confusion, weakness on one side of the body, trouble speaking, sudden vision changes. Talk to your doctor or pharmacist about the benefits and risks of taking this drug.
Formulary Reference Tool