VOQUEZNA TRIPLE PAK (vonoprazan fumarate/amoxicillin trihydrate/clarithromycin)
- inflammation of the stomach lining caused by H. pylori
- ulcer of duodenum caused by bacteria Helicobacter pylori
20 mg-500 mg-500 mg oral pack
- Dosage information is not available
- Advicor
- alfuzosin
- Altoprev
- amiodarone
- amiodarone in dextrose,iso-osm
- avanafil
- Brilinta
- bromocriptine
- cabergoline
- Cafergot
- Camptosar
- Complera
- conivaptan in 5 % dextrose
- Cordarone
- Cycloset
- D.h.e.45
- Detrol La
- dihydroergotamine
- disopyramide
- dronedarone
- droperidol
- dutasteride-tamsulosin
- Edurant
- eletriptan HBr
- emtricitab-rilpivirine-tenofov
- eplerenone
- ergoloid
- Ergomar
- ergotamine tartrate
- ergotamine-caffeine
- ezetimibe-simvastatin
- Flomax
- Inspra
- irinotecan
- Jalyn
- Juxtapid
- Kombiglyze Xr
- Latuda
- Levitra
- lomitapide
- lovastatin
- lurasidone
- methylergonovine
- Mevacor
- Migergot
- Migranal
- Multaq
- Nexterone
- niacin-lovastatin
- niacin-simvastatin
- Norpace
- Norpace Cr
- Orap
- Pacerone
- Parlodel
- pimozide
- Rapaflo
- Relpax
- rilpivirine
- Samsca
- saxagliptin-metformin
- silodosin
- Simcor
- simvastatin
- Stendra
- tamsulosin
- ticagrelor
- tolterodine
- tolvaptan
- typhoid vaccine
- Uroxatral
- Vaprisol
- vardenafil
- Vivotif Berna Vaccine
- Vytorin 10-10
- Vytorin 10-20
- Vytorin 10-40
- Vytorin 10-80
- Zocor
Contraindicated
- Abstral
- Actiq
- Adalat Cc
- Adempas
- Advair Diskus
- Advair Hfa
- Afeditab Cr
- Afinitor
- Afinitor Disperz
- Alfenta
- alfentanil
- aliskiren
- aliskiren-amlodipin-hcthiazide
- aliskiren-amlodipine
- aliskiren-hydrochlorothiazide
- amlodipine
- amlodipine-atorvastatin
- amlodipine-benazepril
- amlodipine-olmesartan
- amlodipine-valsartan
- amlodipine-valsartan-hcthiazid
- Amturnide
- Astagraf Xl
- Azor
- Caduet
- Calan
- Calan Sr
- Caprelsa
- Cardene Iv
- Cardene Iv In Dextrose
- Cardene Iv In Sodium Chloride
- Cardene Sr
- Cardizem
- Cardizem Cd
- Cardizem La
- Cartia Xt
- Cellcept
- Cellcept Intravenous
- colchicine
- colchicine-probenecid
- Colcrys
- Coumadin
- cyclosporine
- cyclosporine modified
- Digox
- digoxin
- Dilacor Xr
- Dilt-xr
- diltiazem HCl
- dofetilide
- Duragesic
- Endocet
- Endodan
- everolimus
- Exforge
- Exforge Hct
- felodipine
- fentanyl
- fentanyl citrate
- fentanyl citrate (PF)
- Fentora
- fluticasone-salmeterol
- Gengraf
- Geodon
- guanfacine
- Hecoria
- Hycamtin
- ibuprofen-oxycodone
- Intuniv Er
- Invega
- Invega Sustenna
- isradipine
- itraconazole
- Jantoven
- ketoconazole
- Korlym
- Lanoxin
- Lazanda
- Lotrel
- macitentan
- Matzim La
- Methotrexate (anti-rheumatic)
- methotrexate sodium
- methotrexate sodium (PF)
- mifepristone
- mycophenolate mofetil
- mycophenolate mofetil HCl
- Neoral
- nicardipine
- nicardipine in dextrose,iso-os
- nicardipine in NaCl (iso-os)
- Nifedical Xl
- nifedipine
- nimodipine
- nisoldipine
- Norvasc
- Nymalize
- olmesartan-amlodipin-hcthiazid
- Olysio
- Onmel
- Opsumit
- Oxecta
- oxycodone
- oxycodone-acetaminophen
- oxycodone-aspirin
- Oxycontin
- paliperidone
- paliperidone palmitate
- Percocet
- Percodan
- Primlev
- Procardia
- Procardia Xl
- Prograf
- propafenone
- quinupristin-dalfopristin
- Rapamune
- Rheumatrex
- riociguat
- Roxicet
- Rythmol
- salmeterol
- Sandimmune
- Serevent Diskus
- simeprevir
- sirolimus
- Sporanox
- Sporanox Pulsepak
- Sublimaze (pf)
- Subsys
- Sular
- Synercid
- tacrolimus
- Tarka
- Taztia Xt
- Tekamlo
- Tekturna
- Tekturna Hct
- telmisartan-amlodipine
- temsirolimus
- Tenex
- Tiazac
- Tikosyn
- topotecan
- Torisel
- trandolapril-verapamil
- Trexall
- Tribenzor
- Twynsta
- vandetanib
- verapamil
- Verelan
- Verelan Pm
- warfarin
- Xartemis Xr
- ziprasidone HCl
- ziprasidone mesylate
- Zortress
Severe
Moderate
- A-hydrocort
- A-methapred
- Abilify
- Abilify Discmelt
- Abilify Maintena
- Adcirca
- Adderall
- Adderall Xr
- Aerospan
- afatinib
- Altavera (28)
- Alvesco
- Alyacen 1/35 (28)
- Alyacen 7/7/7 (28)
- Ambien
- Ambien Cr
- Amethia
- Amethia Lo
- Amethyst
- aminophylline
- Amphetamine Salt Combo
- Anti-diarrhea
- Anti-diarrheal (lope)-anti-gas
- Anti-diarrheal (loperamide)
- Anucort-hc
- Anusol-hc
- Apri
- Aranelle (28)
- aripiprazole
- Aristospan Intra-articular
- Aristospan Intralesional
- Asmanex Twisthaler
- atorvastatin
- Aubra
- Aviane
- azelastine-fluticasone
- Azurette (28)
- Balziva (28)
- beclomethasone diprop (AQ)
- beclomethasone dipropionate
- Beconase Aq
- betamethasone acet & sod phos
- Beyaz
- Breo Ellipta
- Brevicon (28)
- Briellyn
- budesonide
- budesonide-formoterol
- Burn Calories
- buspirone
- Camila
- Camrese
- Camrese Lo
- Caziant (28)
- Celestone Soluspan
- Chateal
- Cialis
- ciclesonide
- cilostazol
- cinacalcet
- Colocort
- Cortef
- Cortenema
- Cortifoam
- cortisone
- Cryselle (28)
- Cyclafem 1/35 (28)
- Cyclafem 7/7/7 (28)
- Cyclessa (28)
- Daily Energy
- darifenacin
- Dasetta 1/35 (28)
- Dasetta 7/7/7 (28)
- Daysee
- Depo-medrol
- Depo-provera
- Depo-subq Provera 104
- desog-e.estradiol/e.estradiol
- Desogen
- desogestrel-ethinyl estradiol
- Detrol
- dexamethasone
- Dexamethasone Intensol
- dexamethasone sodium phos (PF)
- dexamethasone sodium phosphate
- Dexedrine Spansule
- Dexpak 10 Day
- Dexpak 13 Day
- Dexpak 6 Day
- dextroamphetamine
- dextroamphetamine-amphetamine
- Diabeta
- Diamode
- Dietex Forte
- drospirenone-e.estradiol-lm.FA
- drospirenone-ethinyl estradiol
- Dulera
- Dymista
- Edluar
- Elinest
- Elixophyllin
- Emoquette
- Enablex
- Enpresse
- Enskyce
- Entocort Ec
- Errin
- Estarylla
- estradiol valerate-dienogest
- Estrostep Fe-28
- eszopiclone
- ethynodiol diac-eth estradiol
- etonogestrel
- etonogestrel-ethinyl estradiol
- Etopophos
- etoposide
- etoposide phosphate
- Ez Use Joint-tunnel-trigger
- ezetimibe-atorvastatin
- Falmina (28)
- Femcon Fe
- fesoterodine
- Fetzima
- fingolimod
- First-duke's
- First-mary's Mouthwash
- Flo-pred
- Flonase
- Flovent Diskus
- Flovent Hfa
- fludrocortisone
- flunisolide
- fluticasone
- fluticasone furoate
- fluticasone-vilanterol
- Generess Fe
- Gianvi (28)
- Gildagia
- Gildess
- Gildess Fe
- Gilenya
- Gilotrif
- glipizide
- glipizide-metformin
- Glucotrol
- Glucotrol Xl
- Glucovance
- glyburide
- glyburide micronized
- glyburide-metformin
- Glynase
- Grx Hicort 25
- Guarana
- guarana-calcium-amino acid cmb
- guarana-calcium-phosphorus
- guarana-Cr-citaurantium-hrb109
- guarana-Cr-gr tea-yrb mat-hb39
- Heather
- Hemril-30
- hydrocortisone
- hydrocortisone acetate
- hydrocortisone sod succ (PF)
- hydrocortisone sod succinate
- Imodium Multi-symptom Relief
- Intermezzo
- Introvale
- ivacaftor
- Jencycla
- Jolessa
- Jolivette
- Junel 1.5/30 (21)
- Junel 1/20 (21)
- Junel Fe 1.5/30 (28)
- Junel Fe 1/20 (28)
- Kalydeco
- Kariva (28)
- Kelnor 1/35 (28)
- Kenalog
- Kurvelo
- L norgest&E estradiol-E estrad
- Larin 1/20 (21)
- Larin Fe
- Leena 28
- Lessina
- levomilnacipran
- Levonest (28)
- levonorg-eth estrad triphasic
- levonorgestrel
- levonorgestrel-ethinyl estrad
- Levora 0.15/30 (28)
- Levora-28
- Lipitor
- Liptruzet
- Livalo
- Lo Loestrin Fe
- Lo-peramide
- Loestrin 1.5/30 (21)
- Loestrin 1/20 (21)
- Loestrin Fe 1.5/30 (28)
- Loestrin Fe 1/20 (28)
- Lomedia 24 Fe
- loperamide
- loperamide-simethicone
- Loryna (28)
- Loseasonique
- Low-ogestrel (28)
- Lunesta
- Lutera (28)
- Lyza
- Marlissa
- Medrol
- Medrol (pak)
- medroxyprogesterone
- methylprednisolone
- methylprednisolone acetate
- methylprednisolone sod suc(PF)
- methylprednisolone sodium succ
- methylprednisolone-bupivacaine
- Microgestin 1.5/30 (21)
- Microgestin 1/20 (21)
- Microgestin Fe 1.5/30 (28)
- Microgestin Fe 1/20 (28)
- midazolam
- midazolam (PF)
- Millipred
- Millipred Dp
- Minastrin 24 Fe
- Mircette (28)
- Modicon (28)
- mometasone
- mometasone-formoterol
- Mono-linyah
- Mononessa (28)
- mv,Ca,Fe,min-FA-guarana-caff
- mv,Ca,Fe,min-FA-hrb cmplx145
- mv,Ca,Fe,min-FA-hrb cmplx146
- mv,Ca,min-iron-FA-guarana-caff
- My Way
- Myzilra
- Nasacort
- Nasacort Aq
- Nasonex
- Natazia
- Necon 0.5/35 (28)
- Necon 1/35 (28)
- Necon 1/50 (28)
- Necon 10/11 (28)
- Necon 7/7/7 (28)
- Nexplanon
- Next Choice One Dose
- Nor-qd
- Nora-be
- norelgestrom-ethinyl estradiol
- noreth-ethinyl estradiol-iron
- norethin-e.estradiol triphasic
- norethin-eth estrad biphasic
- norethindrone (contraceptive)
- norethindrone ac-eth estradiol
- norethindrone-e.estradiol-iron
- norethindrone-ethin estradiol
- norethindrone-mestranol
- norgestimate-ethinyl estradiol
- norgestrel-ethinyl estradiol
- Norinyl 1+35 (28)
- Norinyl 1+50 (28)
- Nortrel 0.5/35 (28)
- Nortrel 1/35 (21)
- Nortrel 1/35 (28)
- Nortrel 7/7/7 (28)
- Nuvaring
- nystatin-hydrocortisone-diphen
- nystatin-TCN-HC-diphenhydramin
- Ocella
- Ogestrel (28)
- Omnaris
- One Daily
- One Daily Energy
- One Daily Healthy Weight
- One Daily Women's Metabolism
- One-a-day Weightsmart
- One-a-day Women's Active
- Onglyza
- Orapred
- Orapred Odt
- Orsythia
- Ortho Evra
- Ortho Micronor
- Ortho Tri-cyclen (28)
- Ortho Tri-cyclen Lo (28)
- Ortho-cept (28)
- Ortho-cyclen (28)
- Ortho-novum 1/35 (28)
- Ortho-novum 7/7/7 (28)
- Ovcon-35 (28)
- Pediapred
- Philith
- Physicians Ez Use M-pred
- Pimtrea (28)
- Pirmella
- pitavastatin
- Plan B One-step
- Pletal
- Portia
- Prandimet
- Prandin
- Pravachol
- pravastatin
- prednisolone
- prednisolone acetate
- prednisolone sodium phosphate
- prednisone
- Prednisone Intensol
- Previfem
- probenecid
- Procentra
- Proctocort
- Pulmicort
- Pulmicort Flexhaler
- Qnasl
- Quartette
- Quasense
- Qvar
- Rayos
- Reclipsen (28)
- Rectacort-hc
- regorafenib
- repaglinide
- repaglinide-metformin
- Revatio
- Rhinocort Aqua
- Safyral
- saxagliptin
- Seasonique
- Sensipar
- sildenafil
- solifenacin
- Solu-cortef
- Solu-cortef (pf)
- Solu-medrol
- Solu-medrol (pf)
- Sprintec (28)
- Sronyx
- Stivarga
- Syeda
- Symbicort
- tadalafil
- Theo-24
- Theochron
- theophylline
- theophylline in dextrose 5 %
- Tilia Fe
- Toposar
- Toviaz
- Tri-estarylla
- Tri-legest Fe
- Tri-linyah
- Tri-norinyl (28)
- Tri-previfem (28)
- Tri-sprintec (28)
- triamcinolone acetonide
- triamcinolone hexacetonide
- triamcinolone-lidocaine
- triazolam
- Trinessa (28)
- Trivora (28)
- Uceris
- Ultra A-d
- Ultra Energy
- Velivet Triphasic Regimen (28)
- Veramyst
- Veripred 20
- Vesicare
- Vestura (28)
- Viagra
- Viorele (28)
- Vyfemla (28)
- Wera (28)
- Women's Active
- Wymzya Fe
- Yasmin (28)
- Yaz 28
- Zarah
- Zenchent (28)
- Zenchent Fe
- Zenzedi
- Zeosa
- Zetonna
- zolpidem
- Zolpimist
- Zovia 1/35E (28)
- Zovia 1/50E (28)
- Child-pugh class B hepatic impairment
- Child-pugh class C hepatic impairment
- Congenital long QT syndrome
- Lactation
- Torsades de pointes
- Ventricular tachycardia
Contraindicated
- Cholestatic hepatitis
- Chronic kidney disease stage 3A (moderate) GFR 45-59
- Chronic kidney disease stage 3B (moderate) GFR 30-44
- Chronic kidney disease stage 4 (severe) GFR 15-29 ml/min
- Chronic kidney disease stage 5 (failure) GFr<15 ml/min
- Clostridioides difficile infection
- Coronary artery disease
- Hypokalemia
- Hypomagnesemia
- Infectious mononucleosis
- Prolonged QT interval
Severe
Moderate
- Bradycardia
- Kidney disease with likely reduction in GFR
- Myasthenia gravis
VOQUEZNA TRIPLE PAK (vonoprazan fumarate/amoxicillin trihydrate/clarithromycin)
- inflammation of the stomach lining caused by H. pylori
- ulcer of duodenum caused by bacteria Helicobacter pylori
- None
- Acute abdominal pain
- Diarrhea
- Dysgeusia
- Nausea
- Skin rash
- Vomiting
- Vulvovaginal candidiasis
More Frequent
Severe
Less Severe
- Anaphylaxis
- Exfoliative dermatitis
- Urticaria
- Abdominal pain with cramps
- Dyspepsia
- Flatulence
- Headache disorder
- Insomnia
- Pruritus of skin
- Skin rash
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal hepatic function tests
- Acute generalized exanthematous pustulosis
- Acute hepatic failure
- Acute pancreatitis
- Agranulocytosis
- Anaphylaxis
- Angioedema
- Atrial fibrillation
- Autoimmune hemolytic anemia
- Bullous dermatitis
- Cardiac arrest
- Cellulitis
- Chest pain
- Cholestasis
- Cholestatic hepatitis
- Clostridioides difficile infection
- Crystalluria
- DRESS syndrome
- Drowsy
- Drug-induced hepatitis
- Drug-induced psychosis
- Dyskinesia
- Eosinophilia
- Erythema multiforme
- Esophagitis
- Extrasystoles
- Furred tongue
- Gastroenteritis
- General weakness
- Hallucinations
- Hemorrhage
- Hepatic failure
- Hepatitis
- Hepatocellular damage
- Hyperbilirubinemia
- Hypersensitivity angiitis
- Hypersensitivity drug reaction
- Idiopathic thrombocytopenic purpura
- IgA vasculitis
- Interstitial nephritis
- Jaundice
- Laryngeal edema
- Leukopenia
- Maculopapular rash
- Muscle spasm
- Myopathy
- Neuromuscular blockade
- Neutropenic disorder
- Obstructive hyperbilirubinemia
- Prolonged QT interval
- Pulmonary thromboembolism
- Renal failure
- Rhabdomyolysis
- Seizure disorder
- Serum sickness
- Stevens-johnson syndrome
- Thrombocytopenic disorder
- Thrombocytosis
- Torsades de pointes
- Toxic epidermal necrolysis
- Unconsciousness
- Urticaria
- Ventricular arrhythmias
- Ventricular tachycardia
Less Severe
- Abdominal distension
- Acne vulgaris
- Acute confusion
- Agitation
- Anemia
- Anorexia
- Asthma
- Behavioral disorders
- Candidiasis
- Chills
- Constipation
- Dental discoloration
- Depersonalization
- Depression
- Dizziness
- Dream disorder
- Epistaxis
- Eructation
- Fatigue
- Fever
- Gastritis
- Gastroesophageal reflux disease
- Glossitis
- Hearing loss
- Hyperhidrosis
- Insomnia
- Loss of sense of smell
- Loss of taste
- Malaise
- Manic disorder
- Mucocutaneous candidiasis
- Muscle weakness
- Myalgia
- Nervousness
- Palpitations
- Paresthesia
- Parosmia
- Pruritus of skin
- Rectal pain
- Skin rash
- Stomatitis
- Symptoms of anxiety
- Tinnitus
- Tongue discoloration
- Tremor
- Vertigo
- Xerostomia
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Amoxicillin, vonoprazan (comb)
Safety and efficacy not established in pediatrics. Rare reports of tooth discoloration or staining with amoxicillin.
- 1 Day – 18 Years
- Safety and efficacy not established in pediatrics. Rare reports of tooth discoloration or staining with amoxicillin.
Amoxicillin
- Severity Level:
2
- Additional Notes: Insufficient human data available on developmental toxicity risk.
Clarithromycin
- Severity Level:
2
- Additional Notes: Available human data suggest developmental toxicity risk is low
Vonoprazan
- Severity Level:
2
- Additional Notes: Mfg does not recommend, insufficient data available
Contraindicated
Vonoprazan
Mfr recs to avoid breastfeeding during therapy and 2 days after therapy ends.
General | Excretion Potential | Effect on Infant | Notes |
Drug should not be given to breast feeding mothers | Unknown | Not known; no or inclusive data | Mfr recs to avoid breastfeeding during therapy and 2 days after therapy ends. |
Precaution Exists
Amoxicillin
May cause sensitization, diarrhea or rash in nursing infant.
Low amount excreted unlikely to affect nursing infant;Monitor for diarrhea
General | Excretion Potential | Effect on Infant | Notes |
Evaluate use carefully | Excreted | Drug shown to have adverse effect | May cause sensitization, diarrhea or rash in nursing infant. |
Clarithromycin
May cause sensitization, diarrhea or rash in nursing infant.
Low amount excreted unlikely to affect nursing infant;Monitor for diarrhea
General | Excretion Potential | Effect on Infant | Notes |
Evaluate use carefully | Excreted | Not known; no or inclusive data | Low amount excreted unlikely to affect nursing infant;Monitor for diarrhea |
No Known Risk
None
General | Excretion Potential | Effect on Infant | Notes |
None |
Contraindicated
None
Precaution Exists
Amoxicillin
Renal-May need to adjust dosage for renal impairment.
Renal-May require dosage adjustment with severe renal impairment to minimize risk of QT-prolongation. Cardiovascular-Contraindicated in patients with pre-existing QT prolongation. Elderly may be more susceptible to Torsades de Pointes.
Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
Increased Risk / Adverse Effects | Y | N | N | N | N | N |
BEERS: N HEDIS: N STOPP: N
Clarithromycin
Renal-May need to adjust dosage for renal impairment.
Renal-May require dosage adjustment with severe renal impairment to minimize risk of QT-prolongation. Cardiovascular-Contraindicated in patients with pre-existing QT prolongation. Elderly may be more susceptible to Torsades de Pointes.
Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
Increased Risk / Adverse Effects | Y | Y | N | N | N | N |
BEERS: N HEDIS: N STOPP: N
No Known Risk
None
- None
Duodenal ulcer due to h. pylori | |
B96.81 | Helicobacter pylori [h. pylori] as the cause of diseases classified elsewhere |
Helicobacter pylori gastritis | |
B96.81 | Helicobacter pylori [h. pylori] as the cause of diseases classified elsewhere |
0-9 | A-Z |
---|---|
B96.81 | Helicobacter pylori [h. pylori] as the cause of diseases classified elsewhere |
B96.81 | Helicobacter pylori [h. pylori] as the cause of diseases classified elsewhere |