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CLADRIBINE (CLADRIBINE)
- Hairy cell leukemia
10 mg/10 mL intravenous solution
- Infuse 0.09 mg/kg daily by continuous infusion route for 7 days
10 mg/10 mL intravenous solution
- Infuse 0.09 mg/kg daily by continuous infusion route for 7 days
Hairy cell leukemia
- Infuse 0.09 mg/kg daily by continuous infusion route for 7 days
- adenovirus vac live type-4 & 7
- adenovirus vaccine live type-4
- adenovirus vaccine live type-7
- BCG vaccine, live (PF)
- flu vac,qval 2013-14 (2-49yrs)
- Flumist 2013-2014
- M-m-r Ii (pf)
- measles,mumps&rubella vacc(PF)
- measles,mumps,rub,varicel(PF)
- natalizumab
- Proquad (pf)
- Rotateq Vaccine
- rotavirus vaccine live, penta
- typhoid vaccine
- Tysabri
- varicella virus vacc live (PF)
- Varivax (pf)
- Vivotif Berna Vaccine
- yellow fever vaccine live (PF)
- Yf-vax (pf)
- Zostavax (pf)
- zoster vaccine live (PF)
Contraindicated
- clozapine
- Clozaril
- deferiprone
- Fazaclo
- Ferriprox
- Versacloz
Severe
Moderate
- None
- Lactating mother
Contraindicated
- Anemia
- Bone marrow depression
- Kidney disease with reduction in GFR
- Neutropenic disorder
- Peripheral neuropathy
- Pregnancy
- Severe infection
- Thrombocytopenic disorder
Severe
Moderate
- Hyperuricemia
CLADRIBINE (CLADRIBINE)
- Hairy cell leukemia
- Bone marrow depression
- Cough
- Fever
- Infection
- Neutropenic disorder
- Severe anemia
- Skin rash
- Thrombocytopenic disorder
- Anorexia
- Fatigue
- Headache disorder
- Nausea
- Vomiting
More Frequent
Severe
Less Severe
- Dyspnea
- Edema
- Injection site sequelae
- Tachycardia
- Acute abdominal pain
- Arthralgias
- Constipation
- Diarrhea
- Dizziness
- Flatulence
- Hyperhidrosis
- Insomnia
- Myalgias
- Petechiae
- Pruritus of skin
- Rales
- Symptoms of anxiety
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Aplastic anemia
- Bacterial sepsis
- Eosinophilia
- Hemolytic anemia
- Hyperbilirubinemia
- Lymphopenia
- Myelodysplastic syndrome
- Nephrotoxicity
- Peripheral motor neuropathy
- Peripheral neuropathy
- Pneumonia
- Progressive multifocal leukoencephalopathy
- Pulmonary infiltrates
- Renal failure
- Stevens-johnson syndrome
- Urticaria
Less Severe
- Acute confusion
- Altered consciousness
- Conjunctivitis
- Ecchymosis
- Peripheral sensory neuropathy
- Phlebitis after infusion
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Cladribine (IV, antineoplastic)
Safety and effectiveness have not been established.
- 1 Day – 18 Years
- Safety and effectiveness have not been established.
Cladribine
- Severity Level:
D
- Additional Notes: Inhibits dna synthesis; teratogenic in animals
Contraindicated
Cladribine
Potential for serious adverse effects
| General | Excretion Potential | Effect on Infant | Notes |
| Drug should not be given to breast feeding mothers | Unknown | Not known; no or inclusive data | Potential for serious adverse effects |
Precaution Exists
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- This medication may cause very serious blood disorders (decreased bone marrow function leading to low number of blood cells such as white cells, red cells, and platelets). This effect can weaken the immune system/increase the risk of infection, cause anemia, or cause your body to bruise or bleed easier. Tell your doctor right away if you develop any of the following: signs of infection (fever, persistent sore throat), easy bruising/bleeding, unusual tiredness, fast/pounding heartbeat.<br /><br /> When used in high doses, cladribine may cause very serious kidney or nerve problems. Nerve problems may also rarely occur in patients taking the normal dose of cladribine. Get medical help right away if you develop any of the following: change in the amount of urine, weakness/numbness/tingling in your hands/feet, or inability to move your arms/legs.<br /><br /> Cladribine may increase your risk of getting a rare but very serious (possibly fatal) brain infection (progressive multifocal leukoencephalopathy-PML). Get medical help right away if you have any of these side effects: clumsiness, loss of coordination/balance, weakness, sudden change in your thinking (such as confusion, difficulty concentrating, memory loss), difficulty talking, seizures, or sudden vision changes. See also Side Effects section.
| Hairy cell leukemia | |
| C91.4 | Hairy cell leukemia |
| C91.40 | Hairy cell leukemia not having achieved remission |
| C91.42 | Hairy cell leukemia, in relapse |
| 0-9 | A-Z |
|---|---|
| C91.4 | Hairy cell leukemia |
| C91.40 | Hairy cell leukemia not having achieved remission |
| C91.42 | Hairy cell leukemia, in relapse |
Formulary Reference Tool