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MIDAZOLAM HCL (MIDAZOLAM HCL)
- Preoperative anxiety
- Sedation as adjunct to anesthesia
- Anxiety
- Induce anterograde amnesia
- Sedation in pediatric patients
midazolam 10 mg/5 mL (2 mg/mL) oral syrup
- Dosage information is not available
midazolam 2 mg/mL oral syrup
- Dosage information is not available
midazolam 10 mg/5 mL (2 mg/mL) oral syrup
- Dosage information is not available
midazolam 2 mg/mL oral syrup
- Dosage information is not available
- Aptivus
- atazanavir
- boceprevir
- Crixivan
- darunavir
- delavirdine
- elvitegr-cobicist-emtric-tenof
- fosamprenavir
- Incivek
- indinavir
- Invirase
- itraconazole
- Kaletra
- ketoconazole
- Korlym
- Lexiva
- lopinavir-ritonavir
- Mifeprex
- mifepristone
- nelfinavir
- Norvir
- Norvir Soft Gelatin
- Onmel
- Prezista
- Rescriptor
- Reyataz
- ritonavir
- saquinavir mesylate
- sodium oxybate
- Sporanox
- Sporanox Pulsepak
- Stribild
- telaprevir
- tipranavir
- Victrelis
- Viracept
- Xyrem
Contraindicated
- Calan
- Calan Sr
- Cardizem
- Cardizem Cd
- Cardizem La
- Cartia Xt
- clozapine
- Clozaril
- conivaptan in 5 % dextrose
- Dehydrated Alcohol
- Dilacor Xr
- Dilt-xr
- diltiazem HCl
- ethanol (ethyl alcohol)
- ethyl alcohol-herbal drugs
- Fazaclo
- Lydia Pinkham Herbal
- Matzim La
- Tarka
- Taztia Xt
- Tiazac
- trandolapril-verapamil
- Vaprisol
- verapamil
- Verelan
- Verelan Pm
- Versacloz
Severe
Moderate
- AA#9-carnit-dext-cocoa-hrb#128
- Acid Reducer (cimetidine)
- Acid Relief (cimetidine)
- Alz
- amoxicil-clarithromy-lansopraz
- aprepitant
- argin-niac-yohi-gins-ginkgo-hb
- Biaxin
- Biaxin Xl
- Biaxin Xl Pak
- buprenorphine-naloxone
- Central Vite
- Central-vite Performance
- cimetidine
- clarithromycin
- Daily Multiple
- Daily Multiple For Men 50+
- Diflucan
- Emend
- Erythrocin
- erythromycin
- erythromycin-sulfisoxazole
- Estroblend
- Estroven Mood & Memory
- fluconazole
- fluconazole in dextrose(iso-o)
- fluconazole in NaCl (iso-osm)
- fosaprepitant
- Heartburn Relief
- isoniazid-rifamp-pyrazinamide
- Ketek
- Maximum Daily Green
- Megavite Golden Years 55+
- Memory Complex
- Men's 50+ Daily Formula
- Multivital Performance
- mv with min-FA-lycopene-ginkgo
- mv,Ca,min-FA-herbal comp #223
- mv-FA-D3-K-lycop-lut-herb#220
- mv-iron-FA-Ca-beepoln-hb 101
- mv-iron-min-ginkgo b-ginseng
- mv-mn-FA-herbs190&215-digest#4
- Noxafil
- Omeclamox-pak
- omeprazole-clarith-amoxicillin
- One Daily For Men 50+ Advanced
- One Daily Men's 50+
- One Daily Women 50 Plus
- One-a-day Men's 50+ Advantage
- posaconazole
- Prevpac
- Rifadin
- Rifamate
- rifampin
- rifampin-isoniazid
- Rifater
- Sentra Pm
- Spectravite Performance
- Suboxone
- Tagamet Hb
- telithromycin
- Vfend
- Vfend Iv
- Vigraplex
- vinp-hupe-gink-a-cyst-phos-ace
- vit C-vit E-Se-ginkgo biloba
- voriconazole
- Women's 50+ Daily Formula
- Zubsolv
- Angle-closure glaucoma
Contraindicated
- Acute renal failure
- Coma
- Hemodynamic instability
- Obstructive pulmonary disease
- Pregnancy
- Shock
Severe
Moderate
- Chronic heart failure
- Hepatic cirrhosis
- Peripheral vasoconstriction
MIDAZOLAM HCL (MIDAZOLAM HCL)
- Preoperative anxiety
- Sedation as adjunct to anesthesia
- Anxiety
- Induce anterograde amnesia
- Sedation in pediatric patients
- Respiratory depression
- None
More Frequent
Severe
Less Severe
- Bradycardia
- Hypoxia
- Agitation
- Hiccups
- Nausea
- Vomiting
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Allergic dermatitis
- Apnea
- Cardiac arrhythmia
- Delirium
- Dyspnea
- Excitement
- Hypercapnia
- Hypotension
- Hypoventilation
- Irritability
- Laryngismus
- Nervousness
- Pruritus of skin
- Tachycardia
- Tremor
- Urticaria
- Wheezing
Less Severe
- Aggressive behavior
- Ataxia
- Blurred vision
- Cough
- Dizziness
- Drowsy
- Dysarthria
- Dysphoric mood
- Hallucinations
- Headache disorder
- Mood changes
- Rhinorrhea
- Sialorrhea
- Skin rash
- Sneezing
- Stridor
- Syncope
- Vertigo
- Visual changes
Contraindicated
None
Severe Precaution
Midazolam
Increased risk of hypotension, seizure with rapid injection. Monitor respiration. Decreased clearance.
Respiratory depression risk increases with concurrent opiate use. Use weight based dosing. Monitor closely.
- 1 Day – 29 Days
- Increased risk of hypotension, seizure with rapid injection. Monitor respiration. Decreased clearance.
- Respiratory depression risk increases with concurrent opiate use. Use weight based dosing. Monitor closely.
- 30 Days – 18 Years
- Increased risk of hypotension, seizure with rapid injection. Monitor respiration. Decreased clearance.
- Respiratory depression risk increases with concurrent opiate use. Use weight based dosing. Monitor closely.
Management or Monitoring Precaution
None
Midazolam
- Severity Level:
D
- Additional Notes: Insuff human data; possible risk of congenital malformations w/ benzodiazepines
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Midazolam
Insufficient human data available; manufacturer recommends caution
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Excreted | Not known; no or inclusive data | Insufficient human data available; manufacturer recommends caution |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Midazolam
General-Increased risk for hypoxia, respiratory and cardiac arrest in the elderly. Use reduced dosages and administer with extreme caution. Neuro/Psych-Increased risk of cognitive impairment, delirium, falls, fractures, and motor vehicle crashes.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | Y | Y | Y | Y | N | N |
BEERS: Y HEDIS: Y STOPP: Y
No Known Risk
None
- Midazolam has rarely caused very serious breathing problems (such as rapid/slow/shallow breathing, trouble breathing), especially if used with other medications that cause drowsiness (including opioid medications such as morphine). This medication should be used only in a hospital or medical office under the care of a health professional. See also Side Effects section.
| Anxiety | |
| F06.4 | Anxiety disorder due to known physiological condition |
| F10.180 | Alcohol abuse with alcohol-induced anxiety disorder |
| F10.280 | Alcohol dependence with alcohol-induced anxiety disorder |
| F10.980 | Alcohol use, unspecified with alcohol-induced anxiety disorder |
| F12.180 | Cannabis abuse with cannabis-induced anxiety disorder |
| F12.280 | Cannabis dependence with cannabis-induced anxiety disorder |
| F12.980 | Cannabis use, unspecified with anxiety disorder |
| F14.180 | Cocaine abuse with cocaine-induced anxiety disorder |
| F14.280 | Cocaine dependence with cocaine-induced anxiety disorder |
| F14.980 | Cocaine use, unspecified with cocaine-induced anxiety disorder |
| F15.180 | Other stimulant abuse with stimulant-induced anxiety disorder |
| F15.280 | Other stimulant dependence with stimulant-induced anxiety disorder |
| F15.980 | Other stimulant use, unspecified with stimulant-induced anxiety disorder |
| F16.180 | Hallucinogen abuse with hallucinogen-induced anxiety disorder |
| F16.280 | Hallucinogen dependence with hallucinogen-induced anxiety disorder |
| F16.980 | Hallucinogen use, unspecified with hallucinogen-induced anxiety disorder |
| F18.180 | Inhalant abuse with inhalant-induced anxiety disorder |
| F18.280 | Inhalant dependence with inhalant-induced anxiety disorder |
| F18.980 | Inhalant use, unspecified with inhalant-induced anxiety disorder |
| F19.180 | Other psychoactive substance abuse with psychoactive substance-induced anxiety disorder |
| F19.280 | Other psychoactive substance dependence with psychoactive substance-induced anxiety disorder |
| F19.980 | Other psychoactive substance use, unspecified with psychoactive substance-induced anxiety disorder |
| F40 | Phobic anxiety disorders |
| F40.0 | Agoraphobia |
| F40.00 | Agoraphobia, unspecified |
| F40.01 | Agoraphobia with panic disorder |
| F40.02 | Agoraphobia without panic disorder |
| F40.1 | Social phobias |
| F40.10 | Social phobia, unspecified |
| F40.11 | Social phobia, generalized |
| F40.8 | Other phobic anxiety disorders |
| F40.9 | Phobic anxiety disorder, unspecified |
| F41 | Other anxiety disorders |
| F41.0 | Panic disorder [episodic paroxysmal anxiety] |
| F41.1 | Generalized anxiety disorder |
| F41.3 | Other mixed anxiety disorders |
| F41.8 | Other specified anxiety disorders |
| F41.9 | Anxiety disorder, unspecified |
| F93.0 | Separation anxiety disorder of childhood |
| Preoperative anxiety | |
| R45.0 | Nervousness |
| 0-9 | A-Z |
|---|---|
| F06.4 | Anxiety disorder due to known physiological condition |
| F10.180 | Alcohol abuse with alcohol-induced anxiety disorder |
| F10.280 | Alcohol dependence with alcohol-induced anxiety disorder |
| F10.980 | Alcohol use, unspecified with alcohol-induced anxiety disorder |
| F12.180 | Cannabis abuse with cannabis-induced anxiety disorder |
| F12.280 | Cannabis dependence with cannabis-induced anxiety disorder |
| F12.980 | Cannabis use, unspecified with anxiety disorder |
| F14.180 | Cocaine abuse with cocaine-induced anxiety disorder |
| F14.280 | Cocaine dependence with cocaine-induced anxiety disorder |
| F14.980 | Cocaine use, unspecified with cocaine-induced anxiety disorder |
| F15.180 | Other stimulant abuse with stimulant-induced anxiety disorder |
| F15.280 | Other stimulant dependence with stimulant-induced anxiety disorder |
| F15.980 | Other stimulant use, unspecified with stimulant-induced anxiety disorder |
| F16.180 | Hallucinogen abuse with hallucinogen-induced anxiety disorder |
| F16.280 | Hallucinogen dependence with hallucinogen-induced anxiety disorder |
| F16.980 | Hallucinogen use, unspecified with hallucinogen-induced anxiety disorder |
| F18.180 | Inhalant abuse with inhalant-induced anxiety disorder |
| F18.280 | Inhalant dependence with inhalant-induced anxiety disorder |
| F18.980 | Inhalant use, unspecified with inhalant-induced anxiety disorder |
| F19.180 | Other psychoactive substance abuse with psychoactive substance-induced anxiety disorder |
| F19.280 | Other psychoactive substance dependence with psychoactive substance-induced anxiety disorder |
| F19.980 | Other psychoactive substance use, unspecified with psychoactive substance-induced anxiety disorder |
| F40 | Phobic anxiety disorders |
| F40.0 | Agoraphobia |
| F40.00 | Agoraphobia, unspecified |
| F40.01 | Agoraphobia with panic disorder |
| F40.02 | Agoraphobia without panic disorder |
| F40.1 | Social phobias |
| F40.10 | Social phobia, unspecified |
| F40.11 | Social phobia, generalized |
| F40.8 | Other phobic anxiety disorders |
| F40.9 | Phobic anxiety disorder, unspecified |
| F41 | Other anxiety disorders |
| F41.0 | Panic disorder [episodic paroxysmal anxiety] |
| F41.1 | Generalized anxiety disorder |
| F41.3 | Other mixed anxiety disorders |
| F41.8 | Other specified anxiety disorders |
| F41.9 | Anxiety disorder, unspecified |
| F93.0 | Separation anxiety disorder of childhood |
| R45.0 | Nervousness |
Formulary Reference Tool