AMLODIPINE-VALSARTAN-HCTZ (AMLODIPINE BESYLATE/VALSARTAN/HYDROCHLOROTHIAZIDE)
- Hypertension
10 mg-160 mg-12.5 mg tablet
- 1 tablet by oral route once daily
10 mg-160 mg-25 mg tablet
- 1 tablet by oral route once daily
10 mg-320 mg-25 mg tablet
- 1 tablet by oral route once daily
5 mg-160 mg-12.5 mg tablet
- 1 tablet by oral route once daily
5 mg-160 mg-25 mg tablet
- 1 tablet by oral route once daily
amlodipine 10 mg-valsartan 160 mg-hydrochlorothiazide 12.5 mg tablet
- 1 tablet by oral route once daily
amlodipine 10 mg-valsartan 160 mg-hydrochlorothiazide 25 mg tablet
- 1 tablet by oral route once daily
amlodipine 10 mg-valsartan 320 mg-hydrochlorothiazide 25 mg tablet
- 1 tablet by oral route once daily
amlodipine 5 mg-valsartan 160 mg-hydrochlorothiazide 12.5 mg tablet
- 1 tablet by oral route once daily
amlodipine 5 mg-valsartan 160 mg-hydrochlorothiazide 25 mg tablet
- 1 tablet by oral route once daily
Hypertension
- 1 tablet by oral route once daily
- 2 tablets by oral route once daily
- dofetilide
- ezetimibe-simvastatin
- Tikosyn
- Vytorin 10-40
- Vytorin 10-80
Contraindicated
- aliskiren
- aliskiren-amlodipin-hcthiazide
- aliskiren-amlodipine
- aliskiren-hydrochlorothiazide
- amoxicil-clarithromy-lansopraz
- Amturnide
- Biaxin
- Biaxin Xl
- Biaxin Xl Pak
- clarithromycin
- conivaptan in 5 % dextrose
- Curad Enema
- Dantrium
- dantrolene
- Disposable Enema
- Enema
- Enema Disposable
- Erythrocin
- erythromycin
- erythromycin-sulfisoxazole
- Fleet Enema
- Fleet Enema Extra
- Fleet Pediatric
- Ketek
- lithium carbonate
- lithium citrate
- Lithobid
- methenamine mand-sod biphos
- Omeclamox-pak
- omeprazole-clarith-amoxicillin
- Oral Saline Laxative
- Osmoprep
- Phosphate Laxative
- Preparation Cleansing
- Prevpac
- Ready-to-use Enema
- Reclast
- Revonto
- sod phos mono-sod phos dibasic
- sodium phosphates
- Tekamlo
- Tekturna
- Tekturna Hct
- telithromycin
- Uroqid-acid No.2
- Vaprisol
- zoledronic acid
- zoledronic acid-mannitol-water
- Zometa
Severe
Moderate
- acarbose
- Advil
- Advil Allergy Sinus
- Advil Allergy-congestion Rlf
- Advil Cold & Sinus
- Advil Congestion Relief
- Advil Liqui-gel
- Advil Migraine
- Advil Pm
- Advil Pm Liqui-gels
- Aldactazide
- Aldactone
- Aleve
- Aleve Cold & Sinus
- Aleve Sinus & Headache
- Aleve-d Sinus & Cold
- Aleve-d Sinus & Headache
- Alka-seltzer Gold
- All Day Pain Relief
- All Day Pain Relief Sinus & Co
- All Day Relief
- Amaryl
- amiloride
- amiloride-hydrochlorothiazide
- Anaprox
- Anaprox Ds
- Angeliq
- Ansaid
- Apidra
- Apidra Solostar
- Arthrotec 50
- Astagraf Xl
- Bactrim
- Bactrim Ds
- Beyaz
- boceprevir
- bumetanide
- Caldolor
- Cambia
- Cataflam
- Celebrex
- celecoxib
- Ceralyte-70
- Ceraors 75
- Cerasport
- Cerasport Ex1
- Child Ibuprofen
- Children's Advil
- Children's Ibu-drops
- Children's Ibuprofen
- Children's Medi-profen
- Children's Motrin
- Children's Profen Ib
- chlorphen-phenyleph-ibuprofen
- chlorphen-pseudoeph-ibuprofen
- cholestyramine (with sugar)
- Cholestyramine Light
- cholestyramine-aspartame
- Cold & Sinus Pain Relief
- Cold-sinus Relief
- Colestid
- Colestid Flavored
- colestipol
- cyclosporine
- cyclosporine modified
- Cytra K Crystals
- Cytra-3
- Cytra-k
- Daypro
- Demadex
- Diabeta
- diazoxide
- diclofenac epolamine
- diclofenac potassium
- diclofenac sodium
- diclofenac submicronized
- diclofenac-misoprostol
- Digox
- digoxin
- DM-GG-potassium citrate
- drospirenone-e.estradiol-lm.FA
- drospirenone-estradiol
- drospirenone-ethinyl estradiol
- Duetact
- Duexis
- Dyazide
- Dyrenium
- Ec-naprosyn
- Effer-k
- eplerenone
- ethacrynate sodium
- etodolac
- Feldene
- fenoprofen
- Flanax
- Flector
- flurbiprofen
- furosemide
- Gengraf
- Gianvi (28)
- glimepiride
- glipizide
- glipizide-metformin
- Glucotrol
- Glucotrol Xl
- Glucovance
- glyburide
- glyburide micronized
- glyburide-metformin
- Glynase
- Glyset
- Hecoria
- Humalog
- Humalog Kwikpen
- Humalog Mix 50-50
- Humalog Mix 50-50 Kwikpen
- Humalog Mix 75-25
- Humalog Mix 75-25 Kwikpen
- Humulin 70/30
- Humulin N
- Humulin N Kwikpen
- Humulin R
- Humulin R U-500 "Concentrated"
- hydrocodone-ibuprofen
- Hyperlyte Cr
- I-prin
- Ibu-drops
- Ibudone
- ibuprofen
- Ibuprofen Cold
- Ibuprofen Cold-sinus(with Pse)
- Ibuprofen Ib
- Ibuprofen Jr Strength
- ibuprofen lysine (PF)
- Ibuprofen Pm
- ibuprofen-diphenhydramine
- ibuprofen-diphenhydramine HCl
- ibuprofen-famotidine
- ibuprofen-oxycodone
- ibuprofen-phenylephrine HCl
- Incivek
- Indocin
- indomethacin
- indomethacin sodium
- Infant's Ibuprofen
- Infant's Medi-profen
- Infant's Motrin
- Infants Ibu-drops
- Infants Profenib
- Inspra
- insulin asp prt-insulin aspart
- insulin aspart
- insulin detemir
- insulin glargine
- insulin glulisine
- insulin lispro
- insulin lispro protam-lispro
- insulin NPH and regular human
- insulin regular hum U-500 conc
- insulin regular human
- isoniazid-rifamp-pyrazinamide
- Juxtapid
- K-effervescent
- K-phos No 2
- K-phos Original
- K-phos-neutral
- K-tab
- Kaochlor
- ketoconazole
- ketoprofen
- ketorolac
- Klor-con
- Klor-con 10
- Klor-con M10
- Klor-con M15
- Klor-con M20
- Klor-con/ef
- Lanoxin
- Lanoxin Pediatric
- Lantus
- Lantus Solostar
- Lasix
- Levemir
- Levemir Flexpen
- lomitapide
- Loryna (28)
- Maxzide
- Maxzide-25Mg
- Medi-lyte
- Medi-profen
- Mediproxen
- mefenamic acid
- meloxicam
- Midol (naproxen)
- miglitol
- Mobic
- Motrin Ib
- Motrin Pm
- Mycobutin
- nabumetone
- Nalfon
- Nano Vm T/f
- Naprelan Cr
- Naprosyn
- naproxen
- naproxen sodium
- naproxen-esomeprazole
- naproxen-pseudoephedrine
- nateglinide
- Neoprofen (ibuprofen Lysn)(pf)
- Neoral
- niacin-simvastatin
- Novolin 70/30
- Novolin N
- Novolin R
- Novolog
- Novolog Flexpen
- Novolog Mix 70-30
- Novolog Mix 70-30 Flexpen
- Novolog Penfill
- NPH insulin human recomb
- Nutrilyte Ii
- Ocella
- oxaprozin
- Pedialyte
- Pediatric Electrolyte
- pediatric multivit #18-iron-FA
- PEG 3350-bowel 2,two part prep
- Pennsaid
- Phos-nak
- Phospha 250 Neutral
- pioglitazone-glimepiride
- piroxicam
- Ponstel
- pot & sod citrate-citric acid
- potassium
- potassium & sodium phosphates
- potassium bicarb & chloride
- potassium bicarb-citric acid
- potassium chlorid-D5-0.45%NaCl
- potassium chloride
- potassium chloride in 0.9%NaCl
- potassium chloride in D5W
- potassium chloride in LR-D5
- potassium chloride-0.45 % NaCl
- potassium chloride-D5-0.2%NaCl
- potassium chloride-D5-0.3%NaCl
- potassium chloride-D5-0.9%NaCl
- potassium citrate
- potassium citrate-citric acid
- potassium Cl-calcium phos-mag
- potassium gluconate
- potassium phosphate dibasic
- potassium phosphate, monobasic
- potassium&sodium monobas phos
- Precose
- Prevalite
- Priftin
- Primsol
- Proglycem
- Prograf
- Provil
- pseudoephedrine-ibuprofen
- Questran
- Questran Light
- Reprexain
- rifabutin
- Rifadin
- Rifamate
- rifampin
- rifampin-isoniazid
- rifapentine
- Rifater
- Safyral
- Sandimmune
- Simcor
- simvastatin
- Sinus & Cold-d
- sod & pot chlorid-sod cit-rice
- sod phos,di & mono-K phos mono
- sodium & potassium bicarbonate
- sodium Cl-potassium chloride
- Sodium Edecrin
- sodium-K+-mag-Ca-chlor-acetate
- sodium-potas-chloride-dextrose
- Solaraze
- Sorbutuss
- spironolacton-hydrochlorothiaz
- spironolactone
- Sprix
- Starlix
- Suclear
- sulfamethoxazole-trimethoprim
- Sulfatrim
- sulindac
- Syeda
- tacrolimus
- Taron-crystals
- telaprevir
- Theralith Xr
- Thermotabs
- tolazamide
- tolbutamide
- tolmetin
- torsemide
- Tpn Electrolytes
- Tpn Electrolytes Ii
- triamterene
- triamterene-hydrochlorothiazid
- Tricitrates
- trimethoprim
- Urocit-k 10
- Urocit-k 15
- Urocit-k 5
- Vestura (28)
- Vicoprofen
- Victrelis
- Vimovo
- vit B6-mag cit & ox-potass cit
- Voltaren-xr
- Vytorin 10-10
- Vytorin 10-20
- Wal-profen
- Wal-profen Cold-sinus
- Wal-proxen
- Yasmin (28)
- Yaz 28
- Zarah
- Zipsor
- Zocor
- Zorvolex
- Anuria
- Pregnancy
Contraindicated
- Acute pancreatitis
- Azotemia
- Dehydration
- Gout
- Hepatic failure
- Hyperkalemia
- Hyperuricemia
- Hypochloremic alkalosis
- Hypokalemia
- Hypomagnesemia
- Hyponatremia
- Hypotension
- Hypovolemia
- Neonatal hyperbilirubinemia
- Renal artery stenosis
- Secondary angle-closure glaucoma
- Severe aortic valve stenosis
- Severe hepatic disease
- Severe hypotension
- Severe renal impairment
Severe
Moderate
- Basal cell carcinoma of skin
- Diabetes mellitus
- Disease of liver
- Hypercalcemia
- Hypercholesterolemia
- Hyperparathyroidism
- Neutropenic disorder
- Squamous cell carcinoma of skin
- Sympathectomy
- Systemic lupus erythematosus
AMLODIPINE-VALSARTAN-HCTZ (AMLODIPINE BESYLATE/VALSARTAN/HYDROCHLOROTHIAZIDE)
- Hypertension
- Hyperkalemia
- Hypochloremic alkalosis
- Hypokalemia
- Hyponatremia
- Hypotension
- Acute abdominal pain
- Arthralgias
- Back pain
- Diarrhea
- Dizziness
- Drowsy
- Edema
- Fatigue
- Headache disorder
- Nausea
- Peripheral edema
- Viral infection
More Frequent
Severe
Less Severe
- Hyperglycemia
- Hypomagnesemia
- Kidney disease with reduction in GFR
- Abdominal pain with cramps
- Abnormal sexual function
- Anorexia
- Cough
- Diarrhea
- Dizziness
- Erectile dysfunction
- Fatigue
- Flushing
- Nausea
- Orthostatic hypotension
- Palpitations
- Upper respiratory infection
- Vomiting
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal hepatic function tests
- Acute myocardial infarction
- Acute pancreatitis
- Agranulocytosis
- Anaphylaxis
- Angina
- Angioedema
- Aplastic anemia
- Atrial fibrillation
- Blurred vision
- Bradycardia
- Bullous dermatitis
- Chest pain
- Depersonalization
- Depression
- Dyspnea
- Erythema multiforme
- Exfoliative dermatitis
- Extrapyramidal disease
- Gout
- Hemolytic anemia
- Hepatitis
- Hypercalcemia
- Hyperparathyroidism
- Hypersensitivity angiitis
- Hyperuricemia
- Hypotension
- Interstitial nephritis
- Interstitial pneumonitis
- Jaundice
- Leukopenia
- Myopia
- Neutropenic disorder
- Obstructive hyperbilirubinemia
- Pancreatitis
- Purpura
- Renal failure
- Rhabdomyolysis
- Secondary angle-closure glaucoma
- Squamous cell carcinoma of skin
- Stevens-johnson syndrome
- Syncope
- Systemic lupus erythematosus
- Thrombocytopenic disorder
- Toxic epidermal necrolysis
- Vasculitis
- Ventricular tachycardia
Less Severe
- Abnormal sexual function
- Alopecia
- Anorexia
- Arthralgias
- Back pain
- Basal cell carcinoma of skin
- Blurred vision
- Chest pain
- Chills
- Conjunctivitis
- Constipation
- Cramps
- Diarrhea
- Dream disorder
- Drowsy
- Drug-induced hot flash
- Dyspepsia
- Dysphagia
- Dyspnea
- Epistaxis
- Erectile dysfunction
- Fever
- Flatulence
- Gastrointestinal irritation
- General weakness
- Gingival hyperplasia
- Gynecomastia
- Headache disorder
- Hypercholesterolemia
- Hyperglycemia
- Hyperhidrosis
- Hypertriglyceridemia
- Hypesthesia
- Increased urinary frequency
- Insomnia
- Maculopapular rash
- Malaise
- Muscle spasm
- Myalgias
- Nervousness
- Nocturia
- Ocular pain
- Osteoarthritis
- Palpitations
- Paresthesia
- Peripheral ischemia
- Peripheral neuropathy
- Pharyngitis
- Polydipsia
- Pruritus of skin
- Sialoadenitis
- Skin rash
- Symptoms of anxiety
- Syncope
- Tachycardia
- Tinnitus
- Tremor
- Urticaria
- Vasculitis
- Vertigo
- Visual changes
- Vomiting
- Weight gain
- Weight loss
- Xanthopsia
- Xerostomia
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Amlodipine_Valsartan
Safety and efficacy of combination products not established in pediatrics.
- 1 Day – 18 Years
- Safety and efficacy of combination products not established in pediatrics.
Amlodipine
- Severity Level:
2
- Additional Notes: Uncontrolled htn can result in increased maternal/fetal morbidity and mortality
Hydrochlorothiazide
- Severity Level:
B
- Additional Notes: Not recommended in pre-eclampsia and other pregnancy-induced hypertension.
Valsartan
- Severity Level:
1
- Additional Notes: Fetal death/morbidity w/use in 2nd & 3rd trimester, stop when pregnancy detected
Contraindicated
None
General | Excretion Potential | Effect on Infant | Notes |
None |
Precaution Exists
Amlodipine
Insufficient data avail; consider maternal treatment benefit vs infant risk
Limited amounts excreted with no known adverse effects in infant.
Insufficient human data; manufacturer does not rec
General | Excretion Potential | Effect on Infant | Notes |
Evaluate use carefully | Excreted | Not known; no or inclusive data | Insufficient data avail; consider maternal treatment benefit vs infant risk |
Hydrochlorothiazide
Insufficient data avail; consider maternal treatment benefit vs infant risk
Limited amounts excreted with no known adverse effects in infant.
Insufficient human data; manufacturer does not rec
General | Excretion Potential | Effect on Infant | Notes |
Evaluate use carefully | Excreted | Not known; no or inclusive data | Limited amounts excreted with no known adverse effects in infant. |
Valsartan
Insufficient data avail; consider maternal treatment benefit vs infant risk
Limited amounts excreted with no known adverse effects in infant.
Insufficient human data; manufacturer does not rec
General | Excretion Potential | Effect on Infant | Notes |
Evaluate use carefully | Unknown | Not known; no or inclusive data | Insufficient human data; manufacturer does not rec |
No Known Risk
None
General | Excretion Potential | Effect on Infant | Notes |
None |
Contraindicated
None
Precaution Exists
Amlodipine
General-Not recommended as first line therapy in the elderly. Cardiovascular-Start at 2.5 mg/day and slowly titrate upward. Peripheral edema may be common. Lower drug clearance may result in increased sensitivity to blood pressure lowering effects. Gastrointestinal-May cause or worsen pre-existing constipation.
Cardiovascular-Increased sensitivity to effects on blood pressure. Metabolic-More likely to develop hypokalemia, hypomagnesemia, or hyponatremia. Endocrine-May exacerbate SIADH. May worsen glucose control in patients with diabetes. Renal-Not effective with CrCL < 30mL/min.
Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
Increased Risk / Adverse Effects | N | Y | Y | N | N | N |
BEERS: N HEDIS: N STOPP: Y
Hydrochlorothiazide
General-Not recommended as first line therapy in the elderly. Cardiovascular-Start at 2.5 mg/day and slowly titrate upward. Peripheral edema may be common. Lower drug clearance may result in increased sensitivity to blood pressure lowering effects. Gastrointestinal-May cause or worsen pre-existing constipation.
Cardiovascular-Increased sensitivity to effects on blood pressure. Metabolic-More likely to develop hypokalemia, hypomagnesemia, or hyponatremia. Endocrine-May exacerbate SIADH. May worsen glucose control in patients with diabetes. Renal-Not effective with CrCL < 30mL/min.
Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
Increased Risk / Adverse Effects | Y | N | Y | N | N | Y |
BEERS: Y HEDIS: N STOPP: Y
No Known Risk
None
- Valsartan can cause serious (possibly fatal) harm to an unborn baby if used during pregnancy. It is important to prevent pregnancy while taking this medication. Consult your doctor for more details and to discuss the use of reliable forms of birth control while taking this medication. If you are planning pregnancy, become pregnant, or think you may be pregnant, tell your doctor right away.
Hypertension | |
I10 | Essential (primary) hypertension |
I11 | Hypertensive heart disease |
I11.0 | Hypertensive heart disease with heart failure |
I11.9 | Hypertensive heart disease without heart failure |
I12 | Hypertensive chronic kidney disease |
I12.0 | Hypertensive chronic kidney disease with stage 5 chronic kidney disease or end stage renal disease |
I12.9 | Hypertensive chronic kidney disease with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
I13 | Hypertensive heart and chronic kidney disease |
I13.0 | Hypertensive heart and chronic kidney disease with heart failure and stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
I13.1 | Hypertensive heart and chronic kidney disease without heart failure |
I13.10 | Hypertensive heart and chronic kidney disease without heart failure, with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
I13.11 | Hypertensive heart and chronic kidney disease without heart failure, with stage 5 chronic kidney disease, or end stage renal disease |
I13.2 | Hypertensive heart and chronic kidney disease with heart failure and with stage 5 chronic kidney disease, or end stage renal disease |
I15.1 | Hypertension secondary to other renal disorders |
0-9 | A-Z |
---|---|
I10 | Essential (primary) hypertension |
I11 | Hypertensive heart disease |
I11.0 | Hypertensive heart disease with heart failure |
I11.9 | Hypertensive heart disease without heart failure |
I12 | Hypertensive chronic kidney disease |
I12.0 | Hypertensive chronic kidney disease with stage 5 chronic kidney disease or end stage renal disease |
I12.9 | Hypertensive chronic kidney disease with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
I13 | Hypertensive heart and chronic kidney disease |
I13.0 | Hypertensive heart and chronic kidney disease with heart failure and stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
I13.1 | Hypertensive heart and chronic kidney disease without heart failure |
I13.10 | Hypertensive heart and chronic kidney disease without heart failure, with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
I13.11 | Hypertensive heart and chronic kidney disease without heart failure, with stage 5 chronic kidney disease, or end stage renal disease |
I13.2 | Hypertensive heart and chronic kidney disease with heart failure and with stage 5 chronic kidney disease, or end stage renal disease |
I15.1 | Hypertension secondary to other renal disorders |