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ALISKIREN (aliskiren hemifumarate)
- Hypertension
150 mg tablet
- 1 tablet (150 mg) by oral route once daily
300 mg tablet
- 1 tablet (300 mg) by oral route once daily
150 mg tablet
- 1 tablet (150 mg) by oral route once daily
300 mg tablet
- 1 tablet (300 mg) by oral route once daily
Hypertension
- 1 tablet (150 mg) by oral route once daily
- 2 tablets (300 mg) by oral route once daily
- 1 tablet (300 mg) by oral route once daily
- cyclosporine
- cyclosporine modified
- dextromethorphan-quinidine
- Gengraf
- Neoral
- Nuedexta
- quinidine gluconate
- quinidine sulfate
- Sandimmune
Contraindicated
- Accupril
- Accuretic
- Aceon
- Altace
- amlodipine-benazepril
- amlodipine-olmesartan
- amlodipine-valsartan
- amlodipine-valsartan-hcthiazid
- Atacand
- Atacand Hct
- Avalide
- Avapro
- azilsartan med-chlorthalidone
- azilsartan medoxomil
- Azor
- benazepril
- benazepril-hydrochlorothiazide
- Benicar
- Benicar Hct
- candesartan
- candesartan-hydrochlorothiazid
- captopril
- captopril-hydrochlorothiazide
- Cozaar
- Diovan Hct
- Edarbi
- Edarbyclor
- enalapril maleate
- enalapril-hydrochlorothiazide
- enalaprilat
- Epaned
- eprosartan
- eprosartan-hydrochlorothiazide
- Exforge
- Exforge Hct
- fosinopril
- fosinopril-hydrochlorothiazide
- Hyzaar
- irbesartan
- irbesartan-hydrochlorothiazide
- itraconazole
- lisinopril
- lisinopril-hydrochlorothiazide
- losartan
- losartan-hydrochlorothiazide
- Lotensin
- Lotrel
- Mavik
- Micardis
- Micardis Hct
- moexipril
- moexipril-hydrochlorothiazide
- olmesartan
- olmesartan-amlodipin-hcthiazid
- olmesartan-hydrochlorothiazide
- Onmel
- perindopril erbumine
- Prinivil
- quinapril
- quinapril-hydrochlorothiazide
- ramipril
- Sporanox
- Sporanox Pulsepak
- Tarka
- telmisartan
- telmisartan-amlodipine
- telmisartan-hydrochlorothiazid
- Teveten
- Teveten Hct
- trandolapril
- trandolapril-verapamil
- Tribenzor
- Twynsta
- Uniretic
- Univasc
- valsartan-hydrochlorothiazide
- Vaseretic
- Vasotec
- Zestoretic
- Zestril
Severe
Moderate
- Calan
- Calan Sr
- furosemide
- Lasix
- verapamil
- Verelan
- Verelan Pm
- Angioedema
- Pregnancy
Contraindicated
- Hyperkalemia
- Hyponatremia
- Hypotension
- Hypovolemia
Severe
Moderate
- Renal disease with moderate to severe impairment
ALISKIREN (aliskiren hemifumarate)
- Hypertension
- None
- Diarrhea
More Frequent
Severe
Less Severe
- None
- Cough
- Skin rash
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal hepatic function tests
- Anaphylaxis
- Angioedema
- Hyperkalemia
- Hyperuricemia
- Hyponatremia
- Hypotension
- Kidney stone
- Periorbital edema
- Peripheral edema
- Seizure disorder
- Stevens-johnson syndrome
- Toxic epidermal necrolysis
Less Severe
- Acute abdominal pain
- Dizziness
- Dyspepsia
- Erythema
- Fatigue
- Gastroesophageal reflux disease
- Headache disorder
- Kidney disease with reduction in GFR
- Nausea
- Pruritus of skin
- Urticaria
- Vomiting
Contraindicated
Aliskiren
Risk of increased drug exposure and toxicity. Contraindicated age < 2 years.
- 1 Day – 2 Years
- 1 Risk of increased drug exposure and toxicity. Contraindicated age < 2 years.
Severe Precaution
Aliskiren
Potential risk of increased drug exposure and toxicity. No safety and efficacy age < 6 years.
- 2 Years – 6 Years
- Potential risk of increased drug exposure and toxicity. No safety and efficacy age < 6 years.
Management or Monitoring Precaution
None
Aliskiren
- Severity Level:
1
- Additional Notes: Fetal death/morbidity w/use in 2nd & 3rd trimester, stop when pregnancy detected
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Aliskiren
Caution advised; serious adverse effects possible
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | Caution advised; serious adverse effects possible |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- This drug can cause serious (possibly fatal) harm to an unborn baby if used during pregnancy. Therefore, it is important to prevent pregnancy while taking this medication. Consult your doctor for more details and to discuss the use of reliable forms of birth control while taking this medication. If you are planning pregnancy, become pregnant, or think you may be pregnant, tell your doctor right away.
| Hypertension | |
| I10 | Essential (primary) hypertension |
| I11 | Hypertensive heart disease |
| I11.0 | Hypertensive heart disease with heart failure |
| I11.9 | Hypertensive heart disease without heart failure |
| I12 | Hypertensive chronic kidney disease |
| I12.0 | Hypertensive chronic kidney disease with stage 5 chronic kidney disease or end stage renal disease |
| I12.9 | Hypertensive chronic kidney disease with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13 | Hypertensive heart and chronic kidney disease |
| I13.0 | Hypertensive heart and chronic kidney disease with heart failure and stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13.1 | Hypertensive heart and chronic kidney disease without heart failure |
| I13.10 | Hypertensive heart and chronic kidney disease without heart failure, with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13.11 | Hypertensive heart and chronic kidney disease without heart failure, with stage 5 chronic kidney disease, or end stage renal disease |
| I13.2 | Hypertensive heart and chronic kidney disease with heart failure and with stage 5 chronic kidney disease, or end stage renal disease |
| I15.1 | Hypertension secondary to other renal disorders |
| 0-9 | A-Z |
|---|---|
| I10 | Essential (primary) hypertension |
| I11 | Hypertensive heart disease |
| I11.0 | Hypertensive heart disease with heart failure |
| I11.9 | Hypertensive heart disease without heart failure |
| I12 | Hypertensive chronic kidney disease |
| I12.0 | Hypertensive chronic kidney disease with stage 5 chronic kidney disease or end stage renal disease |
| I12.9 | Hypertensive chronic kidney disease with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13 | Hypertensive heart and chronic kidney disease |
| I13.0 | Hypertensive heart and chronic kidney disease with heart failure and stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13.1 | Hypertensive heart and chronic kidney disease without heart failure |
| I13.10 | Hypertensive heart and chronic kidney disease without heart failure, with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13.11 | Hypertensive heart and chronic kidney disease without heart failure, with stage 5 chronic kidney disease, or end stage renal disease |
| I13.2 | Hypertensive heart and chronic kidney disease with heart failure and with stage 5 chronic kidney disease, or end stage renal disease |
| I15.1 | Hypertension secondary to other renal disorders |
Formulary Reference Tool