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ZYKADIA (CERITINIB)
- ALK positive non-small cell lung cancer
150 mg tablet
- 3 tablets (450 mg) by oral route once daily with food
ALK positive non-small cell lung cancer
- 1 tablet (150 mg) by oral route once daily with food
- 2 tablets (300 mg) by oral route once daily with food
- 3 tablets (450 mg) by oral route once daily with food
- alfuzosin
- avanafil
- Brilinta
- bromocriptine
- cabergoline
- Cafergot
- Camptosar
- conivaptan in 5 % dextrose
- Cycloset
- D.h.e.45
- Detrol La
- dihydroergotamine
- dronedarone
- dutasteride-tamsulosin
- eplerenone
- ergoloid
- Ergomar
- ergotamine tartrate
- ergotamine-caffeine
- Flomax
- Inspra
- irinotecan
- Jalyn
- Juxtapid
- Kombiglyze Xr
- Latuda
- Levitra
- lomitapide
- lurasidone
- methylergonovine
- Migergot
- Migranal
- Multaq
- Parlodel
- Rapaflo
- Samsca
- saxagliptin-metformin
- silodosin
- Stendra
- tamsulosin
- ticagrelor
- tolterodine
- tolvaptan
- Uroxatral
- Vaprisol
- vardenafil
Contraindicated
- Abstral
- Actiq
- Afinitor
- Afinitor Disperz
- Alfenta
- alfentanil
- amiodarone
- amiodarone in dextrose,iso-osm
- artemether-lumefantrine
- Astagraf Xl
- B cplx-C-St.Johnwrt-K.&S.ginsg
- Belladonna-phenobarbital
- calcium-mag-B complex-D3-hrb61
- carbamazepine
- Carbatrol
- Cerebyx
- Coartem
- colchicine
- colchicine-probenecid
- Colcrys
- Cold & Flu Fighter
- Cordarone
- cyclosporine
- cyclosporine modified
- dexamethasone
- Dexamethasone Intensol
- dexamethasone sodium phos (PF)
- dexamethasone sodium phosphate
- Dexpak 10 Day
- Dexpak 13 Day
- Dexpak 6 Day
- dextromethorphan-quinidine
- Dilantin
- Dilantin Extended
- Dilantin Infatabs
- Dilantin Kapseal
- Dilantin-125
- disopyramide
- Donnatal
- droperidol
- Duragesic
- enzalutamide
- Epitol
- Equetro
- everolimus
- Fatigue Relief Complex
- fentanyl
- fentanyl citrate
- fentanyl citrate (PF)
- Fentora
- fosphenytoin
- Gengraf
- Geodon
- guanfacine
- Hecoria
- Intuniv Er
- isoniazid-rifamp-pyrazinamide
- Korlym
- Lazanda
- Luminal
- macitentan
- mifepristone
- Mycobutin
- Mysoline
- Neoral
- Nexterone
- Norpace
- Norpace Cr
- Nuedexta
- Olysio
- Opsumit
- Orap
- Pacerone
- phenobarb-hyoscy-atropine-scop
- phenobarbital
- phenobarbital sodium
- Phenytek
- phenytoin
- phenytoin sodium
- phenytoin sodium extended
- pimozide
- primidone
- Prograf
- quetiapine
- quinidine gluconate
- quinidine sulfate
- Rapamune
- rifabutin
- Rifadin
- Rifamate
- rifampin
- rifampin-isoniazid
- Rifater
- Sandimmune
- Seroquel
- Seroquel Xr
- simeprevir
- sirolimus
- St. John's wort
- Sublimaze (pf)
- Subsys
- tacrolimus
- Tegretol
- Tegretol Xr
- Tenex
- vit C-St. John wort-elder-hb30
- Women's Complex
- Xtandi
- ziprasidone HCl
- ziprasidone mesylate
- Zortress
Severe
Moderate
- Abilify
- Abilify Discmelt
- Abilify Maintena
- Ablavar
- Adcirca
- Ambien
- Ambien Cr
- aripiprazole
- bosentan
- buspirone
- Cialis
- cilostazol
- darifenacin
- Detrol
- Edluar
- Enablex
- eszopiclone
- Fareston
- fesoterodine
- gadofosveset trisodium
- Intermezzo
- Istodax
- ivacaftor
- Kalydeco
- Lunesta
- Onglyza
- Pletal
- pomalidomide
- Pomalyst
- Revatio
- romidepsin
- saxagliptin
- sildenafil
- solifenacin
- tadalafil
- toremifene
- Toviaz
- Tracleer
- Vesicare
- Viagra
- zolpidem
- Zolpimist
- Lactating mother
Contraindicated
- Abnormal hepatic function tests
- Bradycardia
- Congenital long QT syndrome
- Hyperbilirubinemia
- Hyperglycemia
- Hypocalcemia
- Hypokalemia
- Hypomagnesemia
- Interstitial lung disease
- Pancreatitis
- Pregnancy
- Prolonged QT interval
- Severe diarrhea
- Severe nausea
- Severe vomiting
Severe
Moderate
- Chronic heart failure
ZYKADIA (CERITINIB)
- ALK positive non-small cell lung cancer
- Abnormal hepatic function tests
- Acute abdominal pain
- Anorexia
- Constipation
- Diarrhea
- Fatigue
- Hyperglycemia
- Nausea
- Vomiting
- Weight loss
More Frequent
Severe
Less Severe
- Bradycardia
- Dehydration
- Interstitial pneumonitis
- Prolonged QT interval
- Renal failure
- Accommodation disorder
- Blurred vision
- Dysesthesia
- Dyspepsia
- Dysphagia
- Dyspnea
- Gait abnormality
- Gastroesophageal reflux disease
- Hyperbilirubinemia
- Hypesthesia
- Hypotonia
- Muscle weakness
- Neuralgia
- Paresthesia
- Peripheral motor neuropathy
- Peripheral neuropathy
- Peripheral sensory neuropathy
- Photopsia
- Polyneuropathy
- Reduced visual acuity
- Skin rash
- Visual changes
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Drug-induced hepatitis
- Gastrointestinal perforation
- Pancreatitis
Less Severe
- None
Contraindicated
None
Severe Precaution
Ceritinib
Potential adverse effect on bone formation. Not studied in pediatrics. No safety and efficacy established.
- 1 Day – 18 Years
- Potential adverse effect on bone formation. Not studied in pediatrics. No safety and efficacy established.
Management or Monitoring Precaution
None
Ceritinib
- Severity Level:
D
- Additional Notes: Based on drug pharmacology and animal data, developmental toxicity is possible.
Contraindicated
Ceritinib
Insuff human data; avoid bf during and for 2 weeks after treatment
| General | Excretion Potential | Effect on Infant | Notes |
| Drug should not be given to breast feeding mothers | Unknown | Not known; no or inclusive data | Insuff human data; avoid bf during and for 2 weeks after treatment |
Precaution Exists
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- None
| ALK positive non-small cell lung cancer | |
| C34 | Malignant neoplasm of bronchus and lung |
| C34.0 | Malignant neoplasm of main bronchus |
| C34.00 | Malignant neoplasm of unspecified main bronchus |
| C34.01 | Malignant neoplasm of right main bronchus |
| C34.02 | Malignant neoplasm of left main bronchus |
| C34.1 | Malignant neoplasm of upper lobe, bronchus or lung |
| C34.10 | Malignant neoplasm of upper lobe, unspecified bronchus or lung |
| C34.11 | Malignant neoplasm of upper lobe, right bronchus or lung |
| C34.12 | Malignant neoplasm of upper lobe, left bronchus or lung |
| C34.2 | Malignant neoplasm of middle lobe, bronchus or lung |
| C34.3 | Malignant neoplasm of lower lobe, bronchus or lung |
| C34.30 | Malignant neoplasm of lower lobe, unspecified bronchus or lung |
| C34.31 | Malignant neoplasm of lower lobe, right bronchus or lung |
| C34.32 | Malignant neoplasm of lower lobe, left bronchus or lung |
| C34.8 | Malignant neoplasm of overlapping sites of bronchus and lung |
| C34.80 | Malignant neoplasm of overlapping sites of unspecified bronchus and lung |
| C34.81 | Malignant neoplasm of overlapping sites of right bronchus and lung |
| C34.82 | Malignant neoplasm of overlapping sites of left bronchus and lung |
| C34.9 | Malignant neoplasm of unspecified part of bronchus or lung |
| C34.90 | Malignant neoplasm of unspecified part of unspecified bronchus or lung |
| C34.91 | Malignant neoplasm of unspecified part of right bronchus or lung |
| C34.92 | Malignant neoplasm of unspecified part of left bronchus or lung |
| C39.9 | Malignant neoplasm of lower respiratory tract, part unspecified |
| 0-9 | A-Z |
|---|---|
| C34 | Malignant neoplasm of bronchus and lung |
| C34.0 | Malignant neoplasm of main bronchus |
| C34.00 | Malignant neoplasm of unspecified main bronchus |
| C34.01 | Malignant neoplasm of right main bronchus |
| C34.02 | Malignant neoplasm of left main bronchus |
| C34.1 | Malignant neoplasm of upper lobe, bronchus or lung |
| C34.10 | Malignant neoplasm of upper lobe, unspecified bronchus or lung |
| C34.11 | Malignant neoplasm of upper lobe, right bronchus or lung |
| C34.12 | Malignant neoplasm of upper lobe, left bronchus or lung |
| C34.2 | Malignant neoplasm of middle lobe, bronchus or lung |
| C34.3 | Malignant neoplasm of lower lobe, bronchus or lung |
| C34.30 | Malignant neoplasm of lower lobe, unspecified bronchus or lung |
| C34.31 | Malignant neoplasm of lower lobe, right bronchus or lung |
| C34.32 | Malignant neoplasm of lower lobe, left bronchus or lung |
| C34.8 | Malignant neoplasm of overlapping sites of bronchus and lung |
| C34.80 | Malignant neoplasm of overlapping sites of unspecified bronchus and lung |
| C34.81 | Malignant neoplasm of overlapping sites of right bronchus and lung |
| C34.82 | Malignant neoplasm of overlapping sites of left bronchus and lung |
| C34.9 | Malignant neoplasm of unspecified part of bronchus or lung |
| C34.90 | Malignant neoplasm of unspecified part of unspecified bronchus or lung |
| C34.91 | Malignant neoplasm of unspecified part of right bronchus or lung |
| C34.92 | Malignant neoplasm of unspecified part of left bronchus or lung |
| C39.9 | Malignant neoplasm of lower respiratory tract, part unspecified |
Formulary Reference Tool