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VOTRIENT (PAZOPANIB HCL)
- Renal cell carcinoma
- Soft or connective tissue sarcoma
200 mg tablet
- 4 tablets (800 mg) by oral route once daily
Renal cell carcinoma
- 2 tablets (400 mg) by oral route once daily
- 4 tablets (800 mg) by oral route once daily
Soft or connective tissue sarcoma
- 2 tablets (400 mg) by oral route once daily
- 4 tablets (800 mg) by oral route once daily
- adenovirus vac live type-4 & 7
- adenovirus vaccine live type-4
- adenovirus vaccine live type-7
- BCG vaccine, live (PF)
- flu vac,qval 2013-14 (2-49yrs)
- Flumist 2013-2014
- M-m-r Ii (pf)
- measles,mumps&rubella vacc(PF)
- measles,mumps,rub,varicel(PF)
- natalizumab
- Proquad (pf)
- Rotateq Vaccine
- rotavirus vaccine live, penta
- typhoid vaccine
- Tysabri
- varicella virus vacc live (PF)
- Varivax (pf)
- Vivotif Berna Vaccine
- yellow fever vaccine live (PF)
- Yf-vax (pf)
- Zostavax (pf)
- zoster vaccine live (PF)
Contraindicated
- Acid Control (ranitidine)
- Acid Controller
- Acid Controller Complete
- Acid Reducer (cimetidine)
- Acid Reducer (famotidine)
- Acid Reducer (ranitidine)
- Acid Reducer Complete (famot)
- Acid Relief (cimetidine)
- Aciphex
- Aciphex Sprinkle
- amoxicil-clarithromy-lansopraz
- artemether-lumefantrine
- B cplx-C-St.Johnwrt-K.&S.ginsg
- Belladonna-phenobarbital
- calcium-mag-B complex-D3-hrb61
- carbamazepine
- Carbatrol
- Cerebyx
- cimetidine
- clozapine
- Clozaril
- Coartem
- Cold & Flu Fighter
- Complete
- deferiprone
- Deprizine
- dexamethasone
- Dexamethasone Intensol
- dexamethasone sodium phos (PF)
- dexamethasone sodium phosphate
- Dexilant
- dexlansoprazole
- Dexpak 10 Day
- Dexpak 13 Day
- Dexpak 6 Day
- Diflucan
- Dilantin
- Dilantin Extended
- Dilantin Infatabs
- Dilantin Kapseal
- Dilantin-125
- disopyramide
- Donnatal
- droperidol
- Dual Action Complete
- Duexis
- enzalutamide
- Epitol
- Equetro
- esomeprazole magnesium
- esomeprazole sodium
- esomeprazole strontium
- famotidine
- famotidine (PF)
- famotidine (PF)-NaCl (iso-os)
- famotidine-Ca carb-mag hydrox
- Fatigue Relief Complex
- Fazaclo
- Ferriprox
- First-lansoprazole
- First-omeprazole
- fluconazole
- fluconazole in dextrose(iso-o)
- fluconazole in NaCl (iso-osm)
- fosphenytoin
- Geodon
- Heartburn Prevention
- Heartburn Relief
- Heartburn Relief (famotidine)
- Heartburn Relief (ranitidine)
- Heartburn Relief 24 Hour
- Heartburn Treatment 24 Hour
- ibuprofen-famotidine
- isoniazid-rifamp-pyrazinamide
- lansoprazole
- Luminal
- Mycobutin
- Mysoline
- naproxen-esomeprazole
- Nexium
- Nexium Iv
- Nexium Packet
- nizatidine
- Norpace
- Norpace Cr
- Omeclamox-pak
- omeprazole
- omeprazole magnesium
- Omeprazole+syrspend Sf Alka
- omeprazole-clarith-amoxicillin
- omeprazole-sodium bicarbonate
- Orap
- pantoprazole
- Pepcid
- Pepcid Ac
- Pepcid Complete
- phenobarb-hyoscy-atropine-scop
- phenobarbital
- phenobarbital sodium
- Phenytek
- phenytoin
- phenytoin sodium
- phenytoin sodium extended
- pimozide
- Prevacid
- Prevacid 24Hr
- Prevacid Solutab
- Prevpac
- Prilosec
- Prilosec Otc
- primidone
- Protonix
- rabeprazole
- ranitidine HCl
- rifabutin
- Rifadin
- Rifamate
- rifampin
- rifampin-isoniazid
- Rifater
- St. John's wort
- Tagamet Hb
- Tegretol
- Tegretol Xr
- Tums Dual Action
- Versacloz
- Vimovo
- vit C-St. John wort-elder-hb30
- Wal-zan 150
- Women's Complex
- Xtandi
- Zantac
- Zantac Maximum Strength
- Zegerid
- Zegerid Otc
- ziprasidone HCl
- ziprasidone mesylate
Severe
Moderate
- Ablavar
- Acid Gone
- Acid Gone Antacid
- activated charcoal-calcium car
- Advair Diskus
- Advair Hfa
- Advanced Antacid-antigas
- Al hyd-Mg tr-alg ac-sod bicarb
- Alcalak
- alfuzosin
- Almacone
- Almacone-2
- Aloxi
- alum-mag hydroxide-simeth
- aluminum hydrox-magnesium carb
- aluminum hydroxide gel
- aluminum-magnesium hydroxide
- amantadine HCl
- Antacid
- Antacid Anti-gas
- Antacid Anti-gas Double Str
- Antacid Calcium
- Antacid Extra Strength
- Antacid Extra-strength
- Antacid Ii Plus Simethicone
- Antacid Liquid
- Antacid M
- Antacid Maximum Strength
- Antacid Multi-symptom
- Antacid Plus Anti-gas
- Antacid Plus Extra Strength
- Antacid Regular Strength
- Antacid Supreme
- Antacid Tablet
- Antacid Ultra Strength
- Antacid With Simethicone
- Antacid-antigas
- Antacid-antigas Ii
- Antacid-simethicone
- Antacid-simethicone Ds
- Anzemet
- Apokyn
- apomorphine
- arsenic trioxide
- ASA-acetaminophen-caff-buffers
- asenapine
- aspirin, buffered
- aspirin-calcium carbonate
- Astagraf Xl
- Avelox
- Avelox Abc Pack
- Avelox In Nacl (iso-osmotic)
- azithromycin
- Bayer Plus Extra Strength
- bedaquiline
- Betapace
- Betapace Af
- budesonide-formoterol
- Buffered Aspirin
- Bufferin
- cal phos-mag hydrx-C & D3-phos
- Cal-gest Antacid
- calcium & magnesium carbonates
- Calcium Antacid
- Calcium Antacid Tropical
- Calcium Antacid Ultra Max St
- calcium carb-mag hydrox-simeth
- calcium carbonate
- calcium carbonate-mag hydroxid
- calcium-simethicone
- Caprelsa
- Cardene Iv
- Cardene Iv In Dextrose
- Cardene Iv In Sodium Chloride
- Cardene Sr
- Celexa
- Children's Pepto
- Children's Soothe
- chloroquine phosphate
- chlorpromazine
- Cipro
- Cipro In D5W
- Cipro Xr
- ciprofloxacin
- ciprofloxacin (mixture)
- ciprofloxacin in D5W
- citalopram
- Comfort Gel
- Comfort Gel Extra Strength
- Complera
- Corvert
- crizotinib
- dasatinib
- diosmin complex no.1
- Diskets
- dofetilide
- dolasetron
- Dolophine
- Dulera
- Edurant
- Effexor Xr
- emtricitab-rilpivirine-tenofov
- Eovist
- eribulin
- escitalopram oxalate
- ezogabine
- Fareston
- felbamate
- Felbatol
- Flanax
- flecainide
- fluticasone-salmeterol
- Foaming Antacid
- Foaming Antacid Extra Strength
- Foradil Aerolizer
- formoterol fumarate
- foscarnet
- Foscavir
- gadofosveset trisodium
- gadoxetate
- Gaviscon
- Gaviscon Extra Strength
- Gelusil Antacid & Anti-gas
- Geri-lanta
- Geri-mox Antacid-antigas
- granisetron
- granisetron (PF)
- Granisol
- Halaven
- Haldol
- Haldol Decanoate
- haloperidol
- haloperidol decanoate
- haloperidol lactate
- Heartburn Antacid
- Hecoria
- ibutilide fumarate
- indapamide
- Invega
- Invega Sustenna
- isradipine
- Istodax
- Juxtapid
- Kaletra
- lapatinib
- Levaquin
- Levaquin In 5 % Dextrose
- Levitra
- levofloxacin
- levofloxacin in D5W
- Lexapro
- Liquid Antacid
- lithium carbonate
- lithium citrate
- Lithobid
- lomitapide
- lopinavir-ritonavir
- Maalox Advanced
- Maalox Maximum Strength
- Mag-al
- Mag-al Plus
- Mag-al Plus Extra Strength
- magaldrate
- magaldrate-simethicone
- Maglox
- magnesium hydroxide
- magnesium-aluminum-alginic ac
- Masanti Double Strength
- methadone
- Methadone Intensol
- Methadose
- Mi-acid
- Milk Of Magnesia
- Milk Of Magnesia Concentrated
- Mintox
- Mintox Maximum Strength
- Mintox Plus
- moexipril
- moexipril-hydrochlorothiazide
- mometasone-formoterol
- moxifloxacin
- moxifloxacin in NaCl (iso-osm)
- Nebupent
- Nexavar
- nicardipine
- nicardipine in dextrose,iso-os
- nicardipine in NaCl (iso-os)
- nilotinib
- norfloxacin
- Noroxin
- Noxafil
- Ob Complete One
- octreotide acetate
- ofloxacin
- ondansetron
- ondansetron HCl
- ondansetron HCl (PF)
- paliperidone
- paliperidone palmitate
- palonosetron
- pasireotide
- Pedia-lax
- Pentam
- pentamidine
- Perforomist
- Phillips Milk Of Magnesia
- PN85-iron cb&asp g-FA-dha-fish
- posaconazole
- Potiga
- Pro-cal
- procainamide
- Prograf
- propafenone
- Qualaquin
- quetiapine
- quinine sulfate
- Ri-gel
- Ri-gel Ii
- Ri-mag
- Ri-mag Plus
- Ri-mox
- Ri-mox Plus
- Riginic
- rilpivirine
- Risperdal
- Risperdal Consta
- Risperdal M-tab
- risperidone
- risperidone microspheres
- romidepsin
- Rulox
- Rythmol
- salmeterol
- Sancuso
- Sandostatin
- Sandostatin Lar Depot
- Saphris
- Saphris (black Cherry)
- Serevent Diskus
- Seroquel
- Seroquel Xr
- Signifor
- Sirturo
- Smooth Antacid
- Soltamox
- sorafenib
- Sorine
- sotalol
- Sotalol Af
- Sprycel
- sunitinib
- Supreme Antacid
- Sutent
- Symbicort
- tacrolimus
- tamoxifen
- Tasigna
- telavancin
- tetrabenazine
- thioridazine
- Tikosyn
- tizanidine
- toremifene
- Toxin Control
- Tri-buffered Aspirin
- Trisenox
- Tums
- Tums E-x
- Tums Extra Strength Smoothies
- Tums Freshers
- Tums Ultra
- Tykerb
- Ultra Strength Antacid
- Ultra Strength Calcium Antacid
- Uniretic
- Univasc
- Uroxatral
- vandetanib
- Vanquish
- vardenafil
- Vasculera
- vemurafenib
- venlafaxine
- Vibativ
- Women's Aspirin With Calcium
- Xalkori
- Xenazine
- Zanaflex
- Zelboraf
- Zithromax
- Zithromax Tri-pak
- Zithromax Z-pak
- Zmax
- Zofran
- Zofran Odt
- Zuplenz
- Arterial aneurysm
- Arterial dissection
- Congenital long QT syndrome
- Hemolytic uremic syndrome
- Lactating mother
- Posterior reversible encephalopathy syndrome
- Thrombotic thrombocytopenic purpura
- Torsades de pointes
Contraindicated
- Abnormal hepatic function tests
- Acute myocardial infarction
- Acute thromboembolic stroke
- Angina
- Disease of liver
- Drug-induced hepatitis
- Gastrointestinal fistula
- Gastrointestinal hemorrhage
- Gastrointestinal perforation
- Hemorrhage
- Hyperbilirubinemia
- Hypocalcemia
- Hypokalemia
- Hypomagnesemia
- Interstitial lung disease
- Intracerebral hemorrhage
- Invasive surgical procedure
- Left ventricular failure
- Pancreatitis
- Pregnancy
- Prolonged QT interval
- Severe infection
- Severe uncontrolled hypertension
- Thromboembolic disorder
Severe
Moderate
- Diarrhea
- Hypothyroidism
- Impaired wound healing
- Proteinuria
- UGt1a1*28 polymorphism
VOTRIENT (PAZOPANIB HCL)
- Renal cell carcinoma
- Soft or connective tissue sarcoma
- Bradycardia
- Hemorrhage
- Hypertension
- Leukopenia
- Neutropenic disorder
- Thrombocytopenic disorder
- Thrombotic disorder
- Alopecia
- Anorexia
- Diarrhea
- Dyspnea
- Elevated serum lipase
- Fatigue
- General weakness
- Hair bleaching
- Headache disorder
- Myalgias
- Nausea
- Pain
- Proteinuria
- Skin rash
- Stomatitis
- Vomiting
- Weight loss
More Frequent
Severe
Less Severe
- Acute myocardial infarction
- Arterial thrombosis
- Hyperbilirubinemia
- Hypothyroidism
- Infection
- Lymphopenia
- Acute abdominal pain
- Blurred vision
- Chest pain
- Chills
- Dry skin
- Dyschromia
- Dysgeusia
- Dyspepsia
- Epistaxis
- Flatulence
- Hyperhidrosis
- Insomnia
- Nail disorders
- Palmar-plantar erythrodysesthesia
- Paresthesia
- Skin hypopigmentation
- Urinary tract infection
- Voice change
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Cerebrovascular accident
- Chronic heart failure
- Erythrocytosis
- Gastrointestinal fistula
- Gastrointestinal hemorrhage
- Gastrointestinal perforation
- Hemolytic uremic syndrome
- Hepatic failure
- Hepatitis
- Hypertensive crisis
- Impaired wound healing
- Interstitial lung disease
- Interstitial pneumonitis
- Intracerebral hemorrhage
- Left ventricular failure
- New fistula formation involving an internal organ
- Pancreatitis
- Pneumothorax
- Posterior reversible encephalopathy syndrome
- Prolonged QT interval
- Pulmonary hemorrhage
- Reactivation of hepatitis B
- Retinal detachment
- Thrombotic thrombocytopenic purpura
- Torsades de pointes
- Venous thrombosis
Less Severe
- Angina
- Arthralgias
- Facial edema
- Hematuria
- Muscle spasm
Contraindicated
None
Severe Precaution
Pazopanib
May affect organ development. Unknown effects on growth. Safety and efficacy not established and not indicated in pediatrics.
- 1 Day – 2 Years
- May affect organ development. Unknown effects on growth. Safety and efficacy not established and not indicated in pediatrics.
Management or Monitoring Precaution
Pazopanib
Unknown effects on growth and development. Safety and efficacy not established.
- 2 Years – 18 Years
- Unknown effects on growth and development. Safety and efficacy not established.
Pazopanib
- Severity Level:
D
- Additional Notes: Based on drug pharmacology developmental toxicity is possible.
Contraindicated
Pazopanib
Nursing infant potential tox; avoid bf during and 2 wks after treatment
| General | Excretion Potential | Effect on Infant | Notes |
| Drug should not be given to breast feeding mothers | Unknown | Not known; no or inclusive data | Nursing infant potential tox; avoid bf during and 2 wks after treatment |
Precaution Exists
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Pazopanib
General-Increased risk of fatigue and decreased appetite. Hepatic-Increased risk for potentially severe and fatal hepatotoxicity associated with elevated AST, ALT and bilirubin. Cardiovascular-Increased incidence of hypertension. Risk of QT prolongation.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | N | Y | Y | N | N | N |
BEERS: N HEDIS: N STOPP: N
No Known Risk
None
- Pazopanib can rarely cause very serious (possibly fatal) liver disease. Your doctor will order blood tests to check your liver before you start and while you are taking pazopanib. During the first 2 months of treatment, liver tests will be done frequently, usually every 2 weeks.<br /><br />After 2 months, liver testing will be less frequent. Tell your doctor right away if you develop symptoms of liver disease such as dark urine, yellow eyes/skin, persistent nausea/vomiting, stomach/abdominal pain. Your doctor may need to change your dosage or discontinue the drug.
| Renal cell carcinoma | |
| C64 | Malignant neoplasm of kidney, except renal pelvis |
| C64.1 | Malignant neoplasm of right kidney, except renal pelvis |
| C64.2 | Malignant neoplasm of left kidney, except renal pelvis |
| C64.9 | Malignant neoplasm of unspecified kidney, except renal pelvis |
| Soft or connective tissue sarcoma | |
| C49 | Malignant neoplasm of other connective and soft tissue |
| C49.0 | Malignant neoplasm of connective and soft tissue of head, face and neck |
| C49.1 | Malignant neoplasm of connective and soft tissue of upper limb, including shoulder |
| C49.10 | Malignant neoplasm of connective and soft tissue of unspecified upper limb, including shoulder |
| C49.11 | Malignant neoplasm of connective and soft tissue of right upper limb, including shoulder |
| C49.12 | Malignant neoplasm of connective and soft tissue of left upper limb, including shoulder |
| C49.2 | Malignant neoplasm of connective and soft tissue of lower limb, including hip |
| C49.20 | Malignant neoplasm of connective and soft tissue of unspecified lower limb, including hip |
| C49.21 | Malignant neoplasm of connective and soft tissue of right lower limb, including hip |
| C49.22 | Malignant neoplasm of connective and soft tissue of left lower limb, including hip |
| C49.3 | Malignant neoplasm of connective and soft tissue of thorax |
| C49.4 | Malignant neoplasm of connective and soft tissue of abdomen |
| C49.5 | Malignant neoplasm of connective and soft tissue of pelvis |
| C49.6 | Malignant neoplasm of connective and soft tissue of trunk, unspecified |
| C49.8 | Malignant neoplasm of overlapping sites of connective and soft tissue |
| C49.9 | Malignant neoplasm of connective and soft tissue, unspecified |
| 0-9 | A-Z |
|---|---|
| C49 | Malignant neoplasm of other connective and soft tissue |
| C49.0 | Malignant neoplasm of connective and soft tissue of head, face and neck |
| C49.1 | Malignant neoplasm of connective and soft tissue of upper limb, including shoulder |
| C49.10 | Malignant neoplasm of connective and soft tissue of unspecified upper limb, including shoulder |
| C49.11 | Malignant neoplasm of connective and soft tissue of right upper limb, including shoulder |
| C49.12 | Malignant neoplasm of connective and soft tissue of left upper limb, including shoulder |
| C49.2 | Malignant neoplasm of connective and soft tissue of lower limb, including hip |
| C49.20 | Malignant neoplasm of connective and soft tissue of unspecified lower limb, including hip |
| C49.21 | Malignant neoplasm of connective and soft tissue of right lower limb, including hip |
| C49.22 | Malignant neoplasm of connective and soft tissue of left lower limb, including hip |
| C49.3 | Malignant neoplasm of connective and soft tissue of thorax |
| C49.4 | Malignant neoplasm of connective and soft tissue of abdomen |
| C49.5 | Malignant neoplasm of connective and soft tissue of pelvis |
| C49.6 | Malignant neoplasm of connective and soft tissue of trunk, unspecified |
| C49.8 | Malignant neoplasm of overlapping sites of connective and soft tissue |
| C49.9 | Malignant neoplasm of connective and soft tissue, unspecified |
| C64 | Malignant neoplasm of kidney, except renal pelvis |
| C64.1 | Malignant neoplasm of right kidney, except renal pelvis |
| C64.2 | Malignant neoplasm of left kidney, except renal pelvis |
| C64.9 | Malignant neoplasm of unspecified kidney, except renal pelvis |
Formulary Reference Tool