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TOBREX (tobramycin)
- bacterial infection of the eyelid
- combined inflammation of cornea and conjunctiva of eye
- inflammation of eyelid edges and the lining of the eye
- inflammation of one of the glands of the eyelids
- inflammation of the sac in which tears are collected
- pink eye from bacterial infection
0.3 % eye ointment
- Apply a small amount (1/2 inch) to the lower lid of the affected eye(s) by ophthalmic route 2 times per day
Bacterial blepharitis
- Apply a small amount (1/2 inch) to the lower lid of the right eye by ophthalmic route 2 times per day
- Apply a small amount (1/2 inch) to the lower lid of the left eye by ophthalmic route 2 times per day
- Apply a small amount (1/2 inch) to the lower lid of the affected eye(s) by ophthalmic route 2 times per day
- Apply a small amount (1/2 inch) to the lower lid of both eyes by ophthalmic route 2 times per day
- Apply a small amount (1/2 inch) to the lower lid of the right eye by ophthalmic route 3 times per day
- Apply a small amount (1/2 inch) to the lower lid of the left eye by ophthalmic route 3 times per day
- Apply a small amount (1/2 inch) to the lower lid of the affected eye(s) by ophthalmic route 3 times per day
- Apply a small amount (1/2 inch) to the lower lid of both eyes by ophthalmic route 3 times per day
- Apply a small amount (1/2 inch) to the lower lid of the right eye by ophthalmic route 2-3 times daily
- Apply a small amount (1/2 inch) to the lower lid of the left eye by ophthalmic route 2-3 times daily
- Apply a small amount (1/2 inch) to the lower lid of the affected eye(s) by ophthalmic route 2-3 times daily
- Apply a small amount (1/2 inch) to the lower lid of both eyes by ophthalmic route 2-3 times daily
Bacterial conjunctivitis
- Apply a small amount (1/2 inch) to the lower lid of the right eye by ophthalmic route 2 times per day
- Apply a small amount (1/2 inch) to the lower lid of the left eye by ophthalmic route 2 times per day
- Apply a small amount (1/2 inch) to the lower lid of the affected eye(s) by ophthalmic route 2 times per day
- Apply a small amount (1/2 inch) to the lower lid of both eyes by ophthalmic route 2 times per day
- Apply a small amount (1/2 inch) to the lower lid of the right eye by ophthalmic route 3 times per day
- Apply a small amount (1/2 inch) to the lower lid of the left eye by ophthalmic route 3 times per day
- Apply a small amount (1/2 inch) to the lower lid of the affected eye(s) by ophthalmic route 3 times per day
- Apply a small amount (1/2 inch) to the lower lid of both eyes by ophthalmic route 3 times per day
- Apply a small amount (1/2 inch) to the lower lid of the right eye by ophthalmic route 2-3 times daily
- Apply a small amount (1/2 inch) to the lower lid of the left eye by ophthalmic route 2-3 times daily
- Apply a small amount (1/2 inch) to the lower lid of the affected eye(s) by ophthalmic route 2-3 times daily
- Apply a small amount (1/2 inch) to the lower lid of both eyes by ophthalmic route 2-3 times daily
Blepharoconjunctivitis
- Apply a small amount (1/2 inch) to the lower lid of the right eye by ophthalmic route 2 times per day
- Apply a small amount (1/2 inch) to the lower lid of the left eye by ophthalmic route 2 times per day
- Apply a small amount (1/2 inch) to the lower lid of the affected eye(s) by ophthalmic route 2 times per day
- Apply a small amount (1/2 inch) to the lower lid of both eyes by ophthalmic route 2 times per day
- Apply a small amount (1/2 inch) to the lower lid of the right eye by ophthalmic route 3 times per day
- Apply a small amount (1/2 inch) to the lower lid of the left eye by ophthalmic route 3 times per day
- Apply a small amount (1/2 inch) to the lower lid of the affected eye(s) by ophthalmic route 3 times per day
- Apply a small amount (1/2 inch) to the lower lid of both eyes by ophthalmic route 3 times per day
- Apply a small amount (1/2 inch) to the lower lid of the right eye by ophthalmic route 2-3 times daily
- Apply a small amount (1/2 inch) to the lower lid of the left eye by ophthalmic route 2-3 times daily
- Apply a small amount (1/2 inch) to the lower lid of the affected eye(s) by ophthalmic route 2-3 times daily
- Apply a small amount (1/2 inch) to the lower lid of both eyes by ophthalmic route 2-3 times daily
Dacryocystitis
- Apply a small amount (1/2 inch) to the lower lid of the right eye by ophthalmic route 2 times per day
- Apply a small amount (1/2 inch) to the lower lid of the left eye by ophthalmic route 2 times per day
- Apply a small amount (1/2 inch) to the lower lid of the affected eye(s) by ophthalmic route 2 times per day
- Apply a small amount (1/2 inch) to the lower lid of both eyes by ophthalmic route 2 times per day
- Apply a small amount (1/2 inch) to the lower lid of the right eye by ophthalmic route 3 times per day
- Apply a small amount (1/2 inch) to the lower lid of the left eye by ophthalmic route 3 times per day
- Apply a small amount (1/2 inch) to the lower lid of the affected eye(s) by ophthalmic route 3 times per day
- Apply a small amount (1/2 inch) to the lower lid of both eyes by ophthalmic route 3 times per day
- Apply a small amount (1/2 inch) to the lower lid of the right eye by ophthalmic route 2-3 times daily
- Apply a small amount (1/2 inch) to the lower lid of the left eye by ophthalmic route 2-3 times daily
- Apply a small amount (1/2 inch) to the lower lid of the affected eye(s) by ophthalmic route 2-3 times daily
- Apply a small amount (1/2 inch) to the lower lid of both eyes by ophthalmic route 2-3 times daily
Keratoconjunctivitis
- Apply a small amount (1/2 inch) to the lower lid of the right eye by ophthalmic route 2 times per day
- Apply a small amount (1/2 inch) to the lower lid of the left eye by ophthalmic route 2 times per day
- Apply a small amount (1/2 inch) to the lower lid of the affected eye(s) by ophthalmic route 2 times per day
- Apply a small amount (1/2 inch) to the lower lid of both eyes by ophthalmic route 2 times per day
- Apply a small amount (1/2 inch) to the lower lid of the right eye by ophthalmic route 3 times per day
- Apply a small amount (1/2 inch) to the lower lid of the left eye by ophthalmic route 3 times per day
- Apply a small amount (1/2 inch) to the lower lid of the affected eye(s) by ophthalmic route 3 times per day
- Apply a small amount (1/2 inch) to the lower lid of both eyes by ophthalmic route 3 times per day
- Apply a small amount (1/2 inch) to the lower lid of the right eye by ophthalmic route 2-3 times daily
- Apply a small amount (1/2 inch) to the lower lid of the left eye by ophthalmic route 2-3 times daily
- Apply a small amount (1/2 inch) to the lower lid of the affected eye(s) by ophthalmic route 2-3 times daily
- Apply a small amount (1/2 inch) to the lower lid of both eyes by ophthalmic route 2-3 times daily
Meibomianitis
- Apply a small amount (1/2 inch) to the lower lid of the right eye by ophthalmic route 2 times per day
- Apply a small amount (1/2 inch) to the lower lid of the left eye by ophthalmic route 2 times per day
- Apply a small amount (1/2 inch) to the lower lid of the affected eye(s) by ophthalmic route 2 times per day
- Apply a small amount (1/2 inch) to the lower lid of both eyes by ophthalmic route 2 times per day
- Apply a small amount (1/2 inch) to the lower lid of the right eye by ophthalmic route 3 times per day
- Apply a small amount (1/2 inch) to the lower lid of the left eye by ophthalmic route 3 times per day
- Apply a small amount (1/2 inch) to the lower lid of the affected eye(s) by ophthalmic route 3 times per day
- Apply a small amount (1/2 inch) to the lower lid of both eyes by ophthalmic route 3 times per day
- Apply a small amount (1/2 inch) to the lower lid of the right eye by ophthalmic route 2-3 times daily
- Apply a small amount (1/2 inch) to the lower lid of the left eye by ophthalmic route 2-3 times daily
- Apply a small amount (1/2 inch) to the lower lid of the affected eye(s) by ophthalmic route 2-3 times daily
- Apply a small amount (1/2 inch) to the lower lid of both eyes by ophthalmic route 2-3 times daily
- None
Contraindicated
- None
Severe
Moderate
- None
- None
Contraindicated
- None
Severe
Moderate
- No disease contraindications
TOBREX (tobramycin)
- bacterial infection of the eyelid
- combined inflammation of cornea and conjunctiva of eye
- inflammation of eyelid edges and the lining of the eye
- inflammation of one of the glands of the eyelids
- inflammation of the sac in which tears are collected
- pink eye from bacterial infection
- None
- None
More Frequent
Severe
Less Severe
- Ocular inflammation
- Ocular itching
- Ocular redness
- Blurred vision
- Conjunctival hyperemia
- Ocular irritation
- Ocular pain
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Anaphylaxis
- Erythema multiforme
- Hypersensitivity drug reaction
- Punctate keratitis
- Stevens-johnson syndrome
Less Severe
- Eyelid edema
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Tobramycin (Ophth)
Safety and efficacy below the age of 2 months not established.
- 1 Day – 59 Days
- Safety and efficacy below the age of 2 months not established.
Tobramycin Sulfate (ophthalmic)
- Severity Level:
2
- Additional Notes: Insuff human data avail; animal data do not suggest risk
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Tobramycin
Poor oral absorption; unlikely clinically significant levels in infant
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Excreted | Not known; no or inclusive data | Poor oral absorption; unlikely clinically significant levels in infant |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- None
| Bacterial blepharitis | |
| H01.0 | Blepharitis |
| H01.00 | Unspecified blepharitis |
| H01.001 | Unspecified blepharitis right upper eyelid |
| H01.002 | Unspecified blepharitis right lower eyelid |
| H01.003 | Unspecified blepharitis right eye, unspecified eyelid |
| H01.004 | Unspecified blepharitis left upper eyelid |
| H01.005 | Unspecified blepharitis left lower eyelid |
| H01.006 | Unspecified blepharitis left eye, unspecified eyelid |
| H01.009 | Unspecified blepharitis unspecified eye, unspecified eyelid |
| H01.00A | Unspecified blepharitis right eye, upper and lower eyelids |
| H01.00B | Unspecified blepharitis left eye, upper and lower eyelids |
| H01.01 | Ulcerative blepharitis |
| H01.011 | Ulcerative blepharitis right upper eyelid |
| H01.012 | Ulcerative blepharitis right lower eyelid |
| H01.013 | Ulcerative blepharitis right eye, unspecified eyelid |
| H01.014 | Ulcerative blepharitis left upper eyelid |
| H01.015 | Ulcerative blepharitis left lower eyelid |
| H01.016 | Ulcerative blepharitis left eye, unspecified eyelid |
| H01.019 | Ulcerative blepharitis unspecified eye, unspecified eyelid |
| H01.01A | Ulcerative blepharitis right eye, upper and lower eyelids |
| H01.01B | Ulcerative blepharitis left eye, upper and lower eyelids |
| H01.02 | Squamous blepharitis |
| H01.021 | Squamous blepharitis right upper eyelid |
| H01.022 | Squamous blepharitis right lower eyelid |
| H01.023 | Squamous blepharitis right eye, unspecified eyelid |
| H01.024 | Squamous blepharitis left upper eyelid |
| H01.025 | Squamous blepharitis left lower eyelid |
| H01.026 | Squamous blepharitis left eye, unspecified eyelid |
| H01.029 | Squamous blepharitis unspecified eye, unspecified eyelid |
| H01.02A | Squamous blepharitis right eye, upper and lower eyelids |
| H01.02B | Squamous blepharitis left eye, upper and lower eyelids |
| Bacterial conjunctivitis | |
| H10.02 | Other mucopurulent conjunctivitis |
| H10.021 | Other mucopurulent conjunctivitis, right eye |
| H10.022 | Other mucopurulent conjunctivitis, left eye |
| H10.023 | Other mucopurulent conjunctivitis, bilateral |
| H10.029 | Other mucopurulent conjunctivitis, unspecified eye |
| H10.3 | Unspecified acute conjunctivitis |
| H10.30 | Unspecified acute conjunctivitis, unspecified eye |
| H10.31 | Unspecified acute conjunctivitis, right eye |
| H10.32 | Unspecified acute conjunctivitis, left eye |
| H10.33 | Unspecified acute conjunctivitis, bilateral |
| Blepharoconjunctivitis | |
| H10.5 | Blepharoconjunctivitis |
| H10.50 | Unspecified blepharoconjunctivitis |
| H10.501 | Unspecified blepharoconjunctivitis, right eye |
| H10.502 | Unspecified blepharoconjunctivitis, left eye |
| H10.503 | Unspecified blepharoconjunctivitis, bilateral |
| H10.509 | Unspecified blepharoconjunctivitis, unspecified eye |
| H10.52 | Angular blepharoconjunctivitis |
| H10.521 | Angular blepharoconjunctivitis, right eye |
| H10.522 | Angular blepharoconjunctivitis, left eye |
| H10.523 | Angular blepharoconjunctivitis, bilateral |
| H10.529 | Angular blepharoconjunctivitis, unspecified eye |
| Dacryocystitis | |
| H04.30 | Unspecified dacryocystitis |
| H04.301 | Unspecified dacryocystitis of right lacrimal passage |
| H04.302 | Unspecified dacryocystitis of left lacrimal passage |
| H04.303 | Unspecified dacryocystitis of bilateral lacrimal passages |
| H04.309 | Unspecified dacryocystitis of unspecified lacrimal passage |
| H04.31 | Phlegmonous dacryocystitis |
| H04.311 | Phlegmonous dacryocystitis of right lacrimal passage |
| H04.312 | Phlegmonous dacryocystitis of left lacrimal passage |
| H04.313 | Phlegmonous dacryocystitis of bilateral lacrimal passages |
| H04.319 | Phlegmonous dacryocystitis of unspecified lacrimal passage |
| H04.32 | Acute dacryocystitis |
| H04.321 | Acute dacryocystitis of right lacrimal passage |
| H04.322 | Acute dacryocystitis of left lacrimal passage |
| H04.323 | Acute dacryocystitis of bilateral lacrimal passages |
| H04.329 | Acute dacryocystitis of unspecified lacrimal passage |
| H04.41 | Chronic dacryocystitis |
| H04.411 | Chronic dacryocystitis of right lacrimal passage |
| H04.412 | Chronic dacryocystitis of left lacrimal passage |
| H04.413 | Chronic dacryocystitis of bilateral lacrimal passages |
| H04.419 | Chronic dacryocystitis of unspecified lacrimal passage |
| P39.1 | Neonatal conjunctivitis and dacryocystitis |
| Keratoconjunctivitis | |
| H16.20 | Unspecified keratoconjunctivitis |
| H16.201 | Unspecified keratoconjunctivitis, right eye |
| H16.202 | Unspecified keratoconjunctivitis, left eye |
| H16.203 | Unspecified keratoconjunctivitis, bilateral |
| H16.209 | Unspecified keratoconjunctivitis, unspecified eye |
| Meibomianitis | |
| H00.02 | Hordeolum internum |
| H00.021 | Hordeolum internum right upper eyelid |
| H00.022 | Hordeolum internum right lower eyelid |
| H00.023 | Hordeolum internum right eye, unspecified eyelid |
| H00.024 | Hordeolum internum left upper eyelid |
| H00.025 | Hordeolum internum left lower eyelid |
| H00.026 | Hordeolum internum left eye, unspecified eyelid |
| H00.029 | Hordeolum internum unspecified eye, unspecified eyelid |
| 0-9 | A-Z |
|---|---|
| H00.02 | Hordeolum internum |
| H00.021 | Hordeolum internum right upper eyelid |
| H00.022 | Hordeolum internum right lower eyelid |
| H00.023 | Hordeolum internum right eye, unspecified eyelid |
| H00.024 | Hordeolum internum left upper eyelid |
| H00.025 | Hordeolum internum left lower eyelid |
| H00.026 | Hordeolum internum left eye, unspecified eyelid |
| H00.029 | Hordeolum internum unspecified eye, unspecified eyelid |
| H01.0 | Blepharitis |
| H01.00 | Unspecified blepharitis |
| H01.001 | Unspecified blepharitis right upper eyelid |
| H01.002 | Unspecified blepharitis right lower eyelid |
| H01.003 | Unspecified blepharitis right eye, unspecified eyelid |
| H01.004 | Unspecified blepharitis left upper eyelid |
| H01.005 | Unspecified blepharitis left lower eyelid |
| H01.006 | Unspecified blepharitis left eye, unspecified eyelid |
| H01.009 | Unspecified blepharitis unspecified eye, unspecified eyelid |
| H01.00A | Unspecified blepharitis right eye, upper and lower eyelids |
| H01.00B | Unspecified blepharitis left eye, upper and lower eyelids |
| H01.01 | Ulcerative blepharitis |
| H01.011 | Ulcerative blepharitis right upper eyelid |
| H01.012 | Ulcerative blepharitis right lower eyelid |
| H01.013 | Ulcerative blepharitis right eye, unspecified eyelid |
| H01.014 | Ulcerative blepharitis left upper eyelid |
| H01.015 | Ulcerative blepharitis left lower eyelid |
| H01.016 | Ulcerative blepharitis left eye, unspecified eyelid |
| H01.019 | Ulcerative blepharitis unspecified eye, unspecified eyelid |
| H01.01A | Ulcerative blepharitis right eye, upper and lower eyelids |
| H01.01B | Ulcerative blepharitis left eye, upper and lower eyelids |
| H01.02 | Squamous blepharitis |
| H01.021 | Squamous blepharitis right upper eyelid |
| H01.022 | Squamous blepharitis right lower eyelid |
| H01.023 | Squamous blepharitis right eye, unspecified eyelid |
| H01.024 | Squamous blepharitis left upper eyelid |
| H01.025 | Squamous blepharitis left lower eyelid |
| H01.026 | Squamous blepharitis left eye, unspecified eyelid |
| H01.029 | Squamous blepharitis unspecified eye, unspecified eyelid |
| H01.02A | Squamous blepharitis right eye, upper and lower eyelids |
| H01.02B | Squamous blepharitis left eye, upper and lower eyelids |
| H04.30 | Unspecified dacryocystitis |
| H04.301 | Unspecified dacryocystitis of right lacrimal passage |
| H04.302 | Unspecified dacryocystitis of left lacrimal passage |
| H04.303 | Unspecified dacryocystitis of bilateral lacrimal passages |
| H04.309 | Unspecified dacryocystitis of unspecified lacrimal passage |
| H04.31 | Phlegmonous dacryocystitis |
| H04.311 | Phlegmonous dacryocystitis of right lacrimal passage |
| H04.312 | Phlegmonous dacryocystitis of left lacrimal passage |
| H04.313 | Phlegmonous dacryocystitis of bilateral lacrimal passages |
| H04.319 | Phlegmonous dacryocystitis of unspecified lacrimal passage |
| H04.32 | Acute dacryocystitis |
| H04.321 | Acute dacryocystitis of right lacrimal passage |
| H04.322 | Acute dacryocystitis of left lacrimal passage |
| H04.323 | Acute dacryocystitis of bilateral lacrimal passages |
| H04.329 | Acute dacryocystitis of unspecified lacrimal passage |
| H04.41 | Chronic dacryocystitis |
| H04.411 | Chronic dacryocystitis of right lacrimal passage |
| H04.412 | Chronic dacryocystitis of left lacrimal passage |
| H04.413 | Chronic dacryocystitis of bilateral lacrimal passages |
| H04.419 | Chronic dacryocystitis of unspecified lacrimal passage |
| H10.02 | Other mucopurulent conjunctivitis |
| H10.021 | Other mucopurulent conjunctivitis, right eye |
| H10.022 | Other mucopurulent conjunctivitis, left eye |
| H10.023 | Other mucopurulent conjunctivitis, bilateral |
| H10.029 | Other mucopurulent conjunctivitis, unspecified eye |
| H10.3 | Unspecified acute conjunctivitis |
| H10.30 | Unspecified acute conjunctivitis, unspecified eye |
| H10.31 | Unspecified acute conjunctivitis, right eye |
| H10.32 | Unspecified acute conjunctivitis, left eye |
| H10.33 | Unspecified acute conjunctivitis, bilateral |
| H10.5 | Blepharoconjunctivitis |
| H10.50 | Unspecified blepharoconjunctivitis |
| H10.501 | Unspecified blepharoconjunctivitis, right eye |
| H10.502 | Unspecified blepharoconjunctivitis, left eye |
| H10.503 | Unspecified blepharoconjunctivitis, bilateral |
| H10.509 | Unspecified blepharoconjunctivitis, unspecified eye |
| H10.52 | Angular blepharoconjunctivitis |
| H10.521 | Angular blepharoconjunctivitis, right eye |
| H10.522 | Angular blepharoconjunctivitis, left eye |
| H10.523 | Angular blepharoconjunctivitis, bilateral |
| H10.529 | Angular blepharoconjunctivitis, unspecified eye |
| H16.20 | Unspecified keratoconjunctivitis |
| H16.201 | Unspecified keratoconjunctivitis, right eye |
| H16.202 | Unspecified keratoconjunctivitis, left eye |
| H16.203 | Unspecified keratoconjunctivitis, bilateral |
| H16.209 | Unspecified keratoconjunctivitis, unspecified eye |
| P39.1 | Neonatal conjunctivitis and dacryocystitis |
Formulary Reference Tool