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TEKTURNA HCT (ALISKIREN HEMIFUMARATE/HYDROCHLOROTHIAZIDE)
- Hypertension
150 mg-12.5 mg tablet
- 1 tablet by oral route once daily
150 mg-25 mg tablet
- 1 tablet by oral route once daily
300 mg-12.5 mg tablet
- 1 tablet by oral route once daily
300 mg-25 mg tablet
- 1 tablet by oral route once daily
Hypertension
- 1 tablet by oral route once daily
- cyclosporine
- cyclosporine modified
- dextromethorphan-quinidine
- dofetilide
- Gengraf
- Neoral
- Nuedexta
- quinidine gluconate
- quinidine sulfate
- Sandimmune
- Tikosyn
Contraindicated
- Accupril
- Accuretic
- Aceon
- Altace
- amlodipine-benazepril
- amlodipine-olmesartan
- amlodipine-valsartan
- amlodipine-valsartan-hcthiazid
- Atacand
- Atacand Hct
- Avalide
- Avapro
- azilsartan med-chlorthalidone
- azilsartan medoxomil
- Azor
- benazepril
- benazepril-hydrochlorothiazide
- Benicar
- Benicar Hct
- candesartan
- candesartan-hydrochlorothiazid
- captopril
- captopril-hydrochlorothiazide
- Cozaar
- Curad Enema
- Diovan Hct
- Disposable Enema
- Edarbi
- Edarbyclor
- enalapril maleate
- enalapril-hydrochlorothiazide
- enalaprilat
- Enema
- Enema Disposable
- Epaned
- eprosartan
- eprosartan-hydrochlorothiazide
- Exforge
- Exforge Hct
- Fleet Enema
- Fleet Enema Extra
- Fleet Pediatric
- fosinopril
- fosinopril-hydrochlorothiazide
- Hyzaar
- irbesartan
- irbesartan-hydrochlorothiazide
- itraconazole
- lisinopril
- lisinopril-hydrochlorothiazide
- lithium carbonate
- lithium citrate
- Lithobid
- losartan
- losartan-hydrochlorothiazide
- Lotensin
- Lotrel
- Mavik
- methenamine mand-sod biphos
- Micardis
- Micardis Hct
- moexipril
- moexipril-hydrochlorothiazide
- olmesartan
- olmesartan-amlodipin-hcthiazid
- olmesartan-hydrochlorothiazide
- Onmel
- Oral Saline Laxative
- Osmoprep
- perindopril erbumine
- Phosphate Laxative
- Preparation Cleansing
- Prinivil
- quinapril
- quinapril-hydrochlorothiazide
- ramipril
- Ready-to-use Enema
- Reclast
- sod phos mono-sod phos dibasic
- sodium phosphates
- Sporanox
- Sporanox Pulsepak
- Tarka
- telmisartan
- telmisartan-amlodipine
- telmisartan-hydrochlorothiazid
- Teveten
- Teveten Hct
- trandolapril
- trandolapril-verapamil
- Tribenzor
- Twynsta
- Uniretic
- Univasc
- Uroqid-acid No.2
- valsartan-hydrochlorothiazide
- Vaseretic
- Vasotec
- Zestoretic
- Zestril
- zoledronic acid
- zoledronic acid-mannitol-water
- Zometa
Severe
Moderate
- acarbose
- Amaryl
- Apidra
- Apidra Solostar
- Calan
- Calan Sr
- cholestyramine (with sugar)
- Cholestyramine Light
- cholestyramine-aspartame
- Colestid
- Colestid Flavored
- colestipol
- Diabeta
- diazoxide
- Digox
- digoxin
- Duetact
- furosemide
- glimepiride
- glipizide
- glipizide-metformin
- Glucotrol
- Glucotrol Xl
- Glucovance
- glyburide
- glyburide micronized
- glyburide-metformin
- Glynase
- Glyset
- Humalog
- Humalog Kwikpen
- Humalog Mix 50-50
- Humalog Mix 50-50 Kwikpen
- Humalog Mix 75-25
- Humalog Mix 75-25 Kwikpen
- Humulin 70/30
- Humulin N
- Humulin N Kwikpen
- Humulin R
- Humulin R U-500 "Concentrated"
- insulin asp prt-insulin aspart
- insulin aspart
- insulin detemir
- insulin glargine
- insulin glulisine
- insulin lispro
- insulin lispro protam-lispro
- insulin NPH and regular human
- insulin regular hum U-500 conc
- insulin regular human
- Lanoxin
- Lanoxin Pediatric
- Lantus
- Lantus Solostar
- Lasix
- Levemir
- Levemir Flexpen
- miglitol
- nateglinide
- Novolin 70/30
- Novolin N
- Novolin R
- Novolog
- Novolog Flexpen
- Novolog Mix 70-30
- Novolog Mix 70-30 Flexpen
- Novolog Penfill
- NPH insulin human recomb
- pioglitazone-glimepiride
- Precose
- Prevalite
- Proglycem
- Questran
- Questran Light
- Starlix
- tolazamide
- tolbutamide
- verapamil
- Verelan
- Verelan Pm
- Angioedema
- Anuria
- Pregnancy
Contraindicated
- Acute pancreatitis
- Azotemia
- Dehydration
- Gout
- Hepatic failure
- Hyperkalemia
- Hyperuricemia
- Hypochloremic alkalosis
- Hypokalemia
- Hypomagnesemia
- Hyponatremia
- Hypotension
- Hypovolemia
- Neonatal hyperbilirubinemia
- Secondary angle-closure glaucoma
Severe
Moderate
- Basal cell carcinoma of skin
- Diabetes mellitus
- Hypercalcemia
- Hypercholesterolemia
- Hyperparathyroidism
- Renal disease with moderate to severe impairment
- Squamous cell carcinoma of skin
- Sympathectomy
- Systemic lupus erythematosus
TEKTURNA HCT (ALISKIREN HEMIFUMARATE/HYDROCHLOROTHIAZIDE)
- Hypertension
- Hypochloremic alkalosis
- Hypokalemia
- Hyponatremia
- Hypotension
- Diarrhea
More Frequent
Severe
Less Severe
- Hyperglycemia
- Hypomagnesemia
- Kidney disease with reduction in GFR
- Abdominal pain with cramps
- Abnormal sexual function
- Anorexia
- Cough
- Diarrhea
- Dizziness
- Fatigue
- Nausea
- Orthostatic hypotension
- Skin rash
- Vomiting
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal hepatic function tests
- Acute pancreatitis
- Agranulocytosis
- Anaphylaxis
- Angioedema
- Aplastic anemia
- Erythema multiforme
- Exfoliative dermatitis
- Gout
- Hemolytic anemia
- Hepatitis
- Hypercalcemia
- Hyperkalemia
- Hyperparathyroidism
- Hypersensitivity angiitis
- Hyperuricemia
- Hyponatremia
- Hypotension
- Interstitial nephritis
- Interstitial pneumonitis
- Jaundice
- Kidney stone
- Leukopenia
- Myopia
- Neutropenic disorder
- Obstructive hyperbilirubinemia
- Periorbital edema
- Peripheral edema
- Purpura
- Secondary angle-closure glaucoma
- Seizure disorder
- Squamous cell carcinoma of skin
- Stevens-johnson syndrome
- Systemic lupus erythematosus
- Thrombocytopenic disorder
- Toxic epidermal necrolysis
- Vasculitis
Less Severe
- Acute abdominal pain
- Basal cell carcinoma of skin
- Blurred vision
- Constipation
- Dizziness
- Dyspepsia
- Erectile dysfunction
- Erythema
- Fatigue
- Fever
- Gastroesophageal reflux disease
- Gastrointestinal irritation
- General weakness
- Headache disorder
- Hypercholesterolemia
- Hypertriglyceridemia
- Kidney disease with reduction in GFR
- Muscle spasm
- Nausea
- Nervousness
- Paresthesia
- Pruritus of skin
- Sialoadenitis
- Skin rash
- Urticaria
- Vertigo
- Vomiting
- Xanthopsia
Contraindicated
Aliskiren
Risk of increased drug exposure and toxicity. Contraindicated age < 2 years.
- 1 Day – 2 Years
- 1 Risk of increased drug exposure and toxicity. Contraindicated age < 2 years.
Severe Precaution
Aliskiren
Potential risk of increased drug exposure and toxicity. No safety and efficacy age < 6 years.
- 2 Years – 6 Years
- Potential risk of increased drug exposure and toxicity. No safety and efficacy age < 6 years.
Management or Monitoring Precaution
None
Aliskiren
- Severity Level:
1
- Additional Notes: Fetal death/morbidity w/use in 2nd & 3rd trimester, stop when pregnancy detected
Hydrochlorothiazide
- Severity Level:
B
- Additional Notes: Not recommended in pre-eclampsia and other pregnancy-induced hypertension.
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Aliskiren
Caution advised; serious adverse effects possible
Limited amounts excreted with no known adverse effects in infant.
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | Caution advised; serious adverse effects possible |
Hydrochlorothiazide
Caution advised; serious adverse effects possible
Limited amounts excreted with no known adverse effects in infant.
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Excreted | Not known; no or inclusive data | Limited amounts excreted with no known adverse effects in infant. |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- This drug can cause serious (possibly fatal) harm to an unborn baby if used during pregnancy. Therefore, it is important to prevent pregnancy while taking this medication. Consult your doctor for more details and to discuss the use of reliable forms of birth control while taking this medication. If you are planning pregnancy, become pregnant, or think you may be pregnant, tell your doctor right away.
| Hypertension | |
| I10 | Essential (primary) hypertension |
| I11 | Hypertensive heart disease |
| I11.0 | Hypertensive heart disease with heart failure |
| I11.9 | Hypertensive heart disease without heart failure |
| I12 | Hypertensive chronic kidney disease |
| I12.0 | Hypertensive chronic kidney disease with stage 5 chronic kidney disease or end stage renal disease |
| I12.9 | Hypertensive chronic kidney disease with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13 | Hypertensive heart and chronic kidney disease |
| I13.0 | Hypertensive heart and chronic kidney disease with heart failure and stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13.1 | Hypertensive heart and chronic kidney disease without heart failure |
| I13.10 | Hypertensive heart and chronic kidney disease without heart failure, with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13.11 | Hypertensive heart and chronic kidney disease without heart failure, with stage 5 chronic kidney disease, or end stage renal disease |
| I13.2 | Hypertensive heart and chronic kidney disease with heart failure and with stage 5 chronic kidney disease, or end stage renal disease |
| I15.1 | Hypertension secondary to other renal disorders |
| 0-9 | A-Z |
|---|---|
| I10 | Essential (primary) hypertension |
| I11 | Hypertensive heart disease |
| I11.0 | Hypertensive heart disease with heart failure |
| I11.9 | Hypertensive heart disease without heart failure |
| I12 | Hypertensive chronic kidney disease |
| I12.0 | Hypertensive chronic kidney disease with stage 5 chronic kidney disease or end stage renal disease |
| I12.9 | Hypertensive chronic kidney disease with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13 | Hypertensive heart and chronic kidney disease |
| I13.0 | Hypertensive heart and chronic kidney disease with heart failure and stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13.1 | Hypertensive heart and chronic kidney disease without heart failure |
| I13.10 | Hypertensive heart and chronic kidney disease without heart failure, with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13.11 | Hypertensive heart and chronic kidney disease without heart failure, with stage 5 chronic kidney disease, or end stage renal disease |
| I13.2 | Hypertensive heart and chronic kidney disease with heart failure and with stage 5 chronic kidney disease, or end stage renal disease |
| I15.1 | Hypertension secondary to other renal disorders |
Formulary Reference Tool