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TASIGNA (NILOTINIB HCL)
- Accelerated phase philadelphia chromosome (+) CML
- Chronic phase philadelphia chromosome (+) CML
150 mg capsule
- 2 capsules (300 mg) by oral route every 12 hours ; swallow whole. Do not eat any food for at least 2 hrs before or 1 hr after dose
200 mg capsule
- 2 capsules (400 mg) by oral route every 12 hours ; swallow whole. Do not eat any food for at least 2 hrs before or 1 hr after dose
50 mg capsule
- Dosage information is not available
Accelerated phase philadelphia chromosome (+) CML
- 1 capsule (200 mg) by oral route once daily ; swallow whole. Do not eat any food for at least 2 hrs before or 1 hr after dose
- 1 capsule (200 mg) ;Sprinkle and mix entire contents in 1 teaspoonful of applesauce; immediately by oral route once daily
- 2 capsules (400 mg) by oral route once daily ; swallow whole. Donot eat any food for at least 2 hrs before or 1 hr after dose
- 2 capsules (400 mg) by oral route every 12 hours swallowing whole with water on an empty stomach. Do not consume food for at least 2 hrs before or 1 hr after dose is taken
- 2 capsules (400 mg) by oral route every 12 hours ; swallow whole. Do not eat any food for at least 2 hrs before or 1 hr after dose
- 2 capsules (400 mg) ;Sprinkle and mix entire contents in 1 teaspoonful of applesauce; immediately by oral route once daily
- 2 capsules (400 mg) ;Sprinkle and mix entire contents in 1 teaspoonful of applesauce; immediately by oral route every 12 hours
Chronic phase philadelphia chromosome (+) CML
- 1 capsule (200 mg) by oral route once daily ; swallow whole. Do not eat any food for at least 2 hrs before or 1 hr after dose
- 1 capsule (200 mg) ;Sprinkle and mix entire contents in 1 teaspoonful of applesauce; immediately by oral route once daily
- 2 capsules (300 mg) by oral route every 12 hours swallowing whole with water on an empty stomach. Do not consume food for at least 2 hrs before or 1 hr after dose is taken
- 2 capsules (300 mg) by oral route every 12 hours ; swallow whole. Do not eat any food for at least 2 hrs before or 1 hr after dose
- 2 capsules (300 mg) by oral route once daily ; swallow whole. Donot eat any food for at least 2 hrs before or 1 hr after dose
- 2 capsules (300 mg) ;Sprinkle and mix entire contents in 1 teaspoonful of applesauce; immediately by oral route every 12 hours
- 2 capsules (300 mg) ;Sprinkle and mix entire contents in 1 teaspoonful of applesauce; immediately by oral route once daily
- 2 capsules (400 mg) by oral route once daily ; swallow whole. Donot eat any food for at least 2 hrs before or 1 hr after dose
- 2 capsules (400 mg) by oral route every 12 hours swallowing whole with water on an empty stomach. Do not consume food for at least 2 hrs before or 1 hr after dose is taken
- 2 capsules (400 mg) by oral route every 12 hours ; swallow whole. Do not eat any food for at least 2 hrs before or 1 hr after dose
- 2 capsules (400 mg) ;Sprinkle and mix entire contents in 1 teaspoonful of applesauce; immediately by oral route once daily
- 2 capsules (400 mg) ;Sprinkle and mix entire contents in 1 teaspoonful of applesauce; immediately by oral route every 12 hours
- adenovirus vac live type-4 & 7
- adenovirus vaccine live type-4
- adenovirus vaccine live type-7
- amiodarone
- amiodarone in dextrose,iso-osm
- artemether-lumefantrine
- B cplx-C-St.Johnwrt-K.&S.ginsg
- BCG vaccine, live (PF)
- calcium-mag-B complex-D3-hrb61
- Coartem
- Cold & Flu Fighter
- Cordarone
- disopyramide
- dronedarone
- droperidol
- Fatigue Relief Complex
- flu vac,qval 2013-14 (2-49yrs)
- Flumist 2013-2014
- Geodon
- Juxtapid
- lomitapide
- M-m-r Ii (pf)
- measles,mumps&rubella vacc(PF)
- measles,mumps,rub,varicel(PF)
- Multaq
- natalizumab
- Nexterone
- Norpace
- Norpace Cr
- Orap
- Pacerone
- pimozide
- Proquad (pf)
- Rotateq Vaccine
- rotavirus vaccine live, penta
- St. John's wort
- typhoid vaccine
- Tysabri
- varicella virus vacc live (PF)
- Varivax (pf)
- vit C-St. John wort-elder-hb30
- Vivotif Berna Vaccine
- Women's Complex
- yellow fever vaccine live (PF)
- Yf-vax (pf)
- ziprasidone HCl
- ziprasidone mesylate
- Zostavax (pf)
- zoster vaccine live (PF)
Contraindicated
- Acid Control (ranitidine)
- Acid Controller
- Acid Controller Complete
- Acid Reducer (cimetidine)
- Acid Reducer (famotidine)
- Acid Reducer (ranitidine)
- Acid Reducer Complete (famot)
- Acid Relief (cimetidine)
- Aciphex
- Aciphex Sprinkle
- amoxicil-clarithromy-lansopraz
- Apokyn
- apomorphine
- arsenic trioxide
- Avelox
- Avelox Abc Pack
- Avelox In Nacl (iso-osmotic)
- bedaquiline
- Belladonna-phenobarbital
- Betapace
- Betapace Af
- Bosulif
- bosutinib
- Caprelsa
- carbamazepine
- Carbatrol
- Celexa
- Cerebyx
- chloroquine phosphate
- chlorpromazine
- cimetidine
- citalopram
- clozapine
- Clozaril
- colchicine
- colchicine-probenecid
- Colcrys
- Complete
- Corvert
- dasatinib
- deferiprone
- Deprizine
- dexamethasone
- Dexamethasone Intensol
- dexamethasone sodium phos (PF)
- dexamethasone sodium phosphate
- Dexilant
- dexlansoprazole
- Dexpak 10 Day
- Dexpak 13 Day
- Dexpak 6 Day
- Diflucan
- Dilantin
- Dilantin Extended
- Dilantin Infatabs
- Dilantin Kapseal
- Dilantin-125
- Diskets
- dofetilide
- Dolophine
- Donnatal
- Dual Action Complete
- Duexis
- enzalutamide
- Epitol
- Equetro
- escitalopram oxalate
- esomeprazole magnesium
- esomeprazole sodium
- esomeprazole strontium
- famotidine
- famotidine (PF)
- famotidine (PF)-NaCl (iso-os)
- famotidine-Ca carb-mag hydrox
- Fareston
- Fazaclo
- Ferriprox
- First-lansoprazole
- First-omeprazole
- fluconazole
- fluconazole in dextrose(iso-o)
- fluconazole in NaCl (iso-osm)
- fosphenytoin
- guanfacine
- Haldol
- Haldol Decanoate
- haloperidol
- haloperidol decanoate
- haloperidol lactate
- Heartburn Prevention
- Heartburn Relief
- Heartburn Relief (famotidine)
- Heartburn Relief (ranitidine)
- Heartburn Relief 24 Hour
- Heartburn Treatment 24 Hour
- ibrutinib
- ibuprofen-famotidine
- ibutilide fumarate
- Imbruvica
- Intuniv Er
- Invega
- Invega Sustenna
- isoniazid-rifamp-pyrazinamide
- isradipine
- lansoprazole
- Lexapro
- Luminal
- methadone
- Methadone Intensol
- Methadose
- moxifloxacin
- moxifloxacin in NaCl (iso-osm)
- Mycobutin
- Mysoline
- naproxen-esomeprazole
- Nebupent
- Nexium
- Nexium Iv
- Nexium Packet
- nizatidine
- norfloxacin
- Noroxin
- Olysio
- Omeclamox-pak
- omeprazole
- omeprazole magnesium
- Omeprazole+syrspend Sf Alka
- omeprazole-clarith-amoxicillin
- omeprazole-sodium bicarbonate
- paliperidone
- paliperidone palmitate
- pantoprazole
- pasireotide
- Pentam
- pentamidine
- Pepcid
- Pepcid Ac
- Pepcid Complete
- phenobarb-hyoscy-atropine-scop
- phenobarbital
- phenobarbital sodium
- Phenytek
- phenytoin
- phenytoin sodium
- phenytoin sodium extended
- Prevacid
- Prevacid 24Hr
- Prevacid Solutab
- Prevpac
- Prilosec
- Prilosec Otc
- primidone
- procainamide
- propafenone
- Protonix
- Qualaquin
- quinine sulfate
- rabeprazole
- ranitidine HCl
- rifabutin
- Rifadin
- Rifamate
- rifampin
- rifampin-isoniazid
- Rifater
- Rythmol
- Samsca
- Signifor
- simeprevir
- Sirturo
- Sorine
- sotalol
- Sotalol Af
- Sprycel
- Tagamet Hb
- Tegretol
- Tegretol Xr
- Tenex
- tetrabenazine
- thioridazine
- Tikosyn
- tolvaptan
- toremifene
- Trisenox
- Tums Dual Action
- vandetanib
- Versacloz
- Vimovo
- Wal-zan 150
- Xenazine
- Xtandi
- Zantac
- Zantac Maximum Strength
- Zegerid
- Zegerid Otc
Severe
Moderate
- Ablavar
- Abstral
- Acid Gone
- Acid Gone Antacid
- Actiq
- activated charcoal-calcium car
- Advair Diskus
- Advair Hfa
- Advanced Antacid-antigas
- Afinitor
- Afinitor Disperz
- Al hyd-Mg tr-alg ac-sod bicarb
- Alcalak
- Alfenta
- alfentanil
- alfuzosin
- Almacone
- Almacone-2
- Aloxi
- alum-mag hydroxide-simeth
- aluminum hydrox-magnesium carb
- aluminum hydroxide gel
- aluminum-magnesium hydroxide
- amantadine HCl
- Antacid
- Antacid Anti-gas
- Antacid Anti-gas Double Str
- Antacid Calcium
- Antacid Extra Strength
- Antacid Extra-strength
- Antacid Ii Plus Simethicone
- Antacid Liquid
- Antacid M
- Antacid Maximum Strength
- Antacid Multi-symptom
- Antacid Plus Anti-gas
- Antacid Plus Extra Strength
- Antacid Regular Strength
- Antacid Supreme
- Antacid Tablet
- Antacid Ultra Strength
- Antacid With Simethicone
- Antacid-antigas
- Antacid-antigas Ii
- Antacid-simethicone
- Antacid-simethicone Ds
- Anti-diarrhea
- Anti-diarrheal (lope)-anti-gas
- Anti-diarrheal (loperamide)
- Anzemet
- arformoterol
- ASA-acetaminophen-caff-buffers
- aspirin, buffered
- aspirin-calcium carbonate
- Astagraf Xl
- avanafil
- Bayer Plus Extra Strength
- bosentan
- Brovana
- budesonide-formoterol
- Buffered Aspirin
- Bufferin
- cal phos-mag hydrx-C & D3-phos
- Cal-gest Antacid
- calcium & magnesium carbonates
- Calcium Antacid
- Calcium Antacid Tropical
- Calcium Antacid Ultra Max St
- calcium carb-mag hydrox-simeth
- calcium carbonate
- calcium carbonate-mag hydroxid
- calcium-simethicone
- Cardene Iv
- Cardene Iv In Dextrose
- Cardene Iv In Sodium Chloride
- Cardene Sr
- Children's Pepto
- Children's Soothe
- cilostazol
- Comfort Gel
- Comfort Gel Extra Strength
- Complera
- crizotinib
- Diamode
- diosmin complex no.1
- dolasetron
- Dulera
- Duragesic
- Edurant
- Effexor Xr
- emtricitab-rilpivirine-tenofov
- Endocet
- Endodan
- Eovist
- eplerenone
- eribulin
- everolimus
- ezogabine
- felbamate
- Felbatol
- fentanyl
- fentanyl citrate
- fentanyl citrate (PF)
- Fentora
- fingolimod
- Flanax
- flecainide
- fluticasone-salmeterol
- Foaming Antacid
- Foaming Antacid Extra Strength
- Foradil Aerolizer
- formoterol fumarate
- foscarnet
- Foscavir
- gadofosveset trisodium
- gadoxetate
- Gaviscon
- Gaviscon Extra Strength
- Gelusil Antacid & Anti-gas
- Geri-lanta
- Geri-mox Antacid-antigas
- Gilenya
- granisetron
- granisetron (PF)
- Granisol
- Halaven
- Heartburn Antacid
- Hecoria
- ibuprofen-oxycodone
- Imodium Multi-symptom Relief
- indapamide
- Inspra
- Istodax
- ivacaftor
- Kalydeco
- lapatinib
- Lazanda
- Levaquin
- Levaquin In 5 % Dextrose
- Levitra
- levofloxacin
- levofloxacin in D5W
- Liquid Antacid
- lithium carbonate
- lithium citrate
- Lithobid
- Lo-peramide
- loperamide
- loperamide-simethicone
- Maalox Advanced
- Maalox Maximum Strength
- Mag-al
- Mag-al Plus
- Mag-al Plus Extra Strength
- magaldrate
- magaldrate-simethicone
- Maglox
- magnesium hydroxide
- magnesium-aluminum-alginic ac
- Masanti Double Strength
- Mi-acid
- Milk Of Magnesia
- Milk Of Magnesia Concentrated
- Mintox
- Mintox Maximum Strength
- Mintox Plus
- moexipril
- moexipril-hydrochlorothiazide
- mometasone-formoterol
- Nexavar
- nicardipine
- nicardipine in dextrose,iso-os
- nicardipine in NaCl (iso-os)
- Ob Complete One
- octreotide acetate
- ofloxacin
- ondansetron
- ondansetron HCl
- ondansetron HCl (PF)
- Oxecta
- oxycodone
- oxycodone-acetaminophen
- oxycodone-aspirin
- Oxycontin
- palonosetron
- pazopanib
- Pedia-lax
- Percocet
- Percodan
- Perforomist
- Phillips Milk Of Magnesia
- Pletal
- PN85-iron cb&asp g-FA-dha-fish
- Potiga
- Primlev
- Pro-cal
- Prograf
- quetiapine
- Ri-gel
- Ri-gel Ii
- Ri-mag
- Ri-mag Plus
- Ri-mox
- Ri-mox Plus
- Riginic
- rilpivirine
- Risperdal
- Risperdal Consta
- Risperdal M-tab
- risperidone
- risperidone microspheres
- rivaroxaban
- romidepsin
- Roxicet
- Rulox
- salmeterol
- Sancuso
- Sandostatin
- Sandostatin Lar Depot
- Serevent Diskus
- Seroquel
- Seroquel Xr
- Smooth Antacid
- Soltamox
- sorafenib
- Stendra
- Sublimaze (pf)
- Subsys
- sunitinib
- Supreme Antacid
- Sutent
- Symbicort
- tacrolimus
- tamoxifen
- telavancin
- tizanidine
- Toxin Control
- Tracleer
- Tri-buffered Aspirin
- Tums
- Tums E-x
- Tums Extra Strength Smoothies
- Tums Freshers
- Tums Ultra
- Tykerb
- Ultra A-d
- Ultra Strength Antacid
- Ultra Strength Calcium Antacid
- Uniretic
- Univasc
- Uroxatral
- Vanquish
- vardenafil
- Vasculera
- vemurafenib
- venlafaxine
- Vibativ
- Votrient
- Women's Aspirin With Calcium
- Xalkori
- Xarelto
- Xartemis Xr
- Zanaflex
- Zelboraf
- Zofran
- Zofran Odt
- Zortress
- Zuplenz
- Congenital long QT syndrome
- Lactating mother
- Pancreatitis
- Prolonged QT interval
- Torsades de pointes
Contraindicated
- Abnormal hepatic function tests
- Anemia
- Disease of liver
- Elevated serum amylase
- Elevated serum lipase
- Hemorrhage
- Hyperbilirubinemia
- Hyperkalemia
- Hypocalcemia
- Hypokalemia
- Hypomagnesemia
- Hyponatremia
- Hypophosphatemia
- Neutropenic disorder
- Pregnancy
- Thrombocytopenic disorder
Severe
Moderate
- Atherosclerotic cardiovascular disease
- Diabetes mellitus
- History of total gastrectomy
- Hypercholesterolemia
- Hypertension
- Reactivation of hepatitis B
- UGt1a1*28 polymorphism
TASIGNA (NILOTINIB HCL)
- Accelerated phase philadelphia chromosome (+) CML
- Chronic phase philadelphia chromosome (+) CML
- Anemia
- Elevated serum lipase
- Hyperbilirubinemia
- Hyperglycemia
- Hyperkalemia
- Hypertension
- Hypocalcemia
- Hypokalemia
- Hyponatremia
- Leukopenia
- Neutropenic disorder
- Pancytopenia
- Prolonged QT interval
- Skin rash
- Thrombocytopenic disorder
- Abdominal pain with cramps
- Anorexia
- Arthralgias
- Back pain
- Constipation
- Cough
- Diarrhea
- Edema
- Fatigue
- Fever
- Flushing
- General weakness
- Headache disorder
- Hypophosphatemia
- Malaise
- Muscle spasm
- Myalgias
- Nausea
- Night sweats
- Pain
- Palpitations
- Peripheral edema
- Pharyngitis
- Pruritus of skin
- Upper respiratory infection
- Urinary tract infection
- Vertigo
- Vomiting
More Frequent
Severe
Less Severe
- Abnormal ECG
- Abnormal hepatic function tests
- Dyspnea
- Gastrointestinal hemorrhage
- Hemorrhage
- Hypomagnesemia
- Influenza
- Intracranial bleeding
- Lymphopenia
- Ocular hemorrhage
- Pancreatitis
- Pleural effusions
- Urticaria
- Visual changes
- Abdominal distension
- Acne vulgaris
- Allergic dermatitis
- Alopecia
- Body fluid retention
- Bone pain
- Bruising
- Conjunctivitis
- Cutaneous papilloma
- Depression
- Dizziness
- Dry eye
- Dry skin
- Dysgeusia
- Dyspepsia
- Eczema
- Epistaxis
- Erythema
- Flatulence
- Folliculitis
- Hypercholesterolemia
- Hyperhidrosis
- Hypertriglyceridemia
- Hypesthesia
- Increased urinary frequency
- Insomnia
- Muscle weakness
- Musculoskeletal pain
- Non-cardiac chest pain
- Paresthesia
- Peripheral neuropathy
- Symptoms of anxiety
- Voice change
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Acute hepatic failure
- Acute myocardial infarction
- Angina
- Arteriosclerotic vascular disease
- Ascites
- Atrial fibrillation
- Atrial flutter
- Atrioventricular block
- Bacterial sepsis
- Bradycardia
- Cerebral edema
- Cerebral ischemia
- Chest pain
- Extrasystoles
- Hearing loss
- Heart failure
- Hepatitis
- Hypoglycemic disorder
- Infection
- Myocardial ischemia
- Optic neuritis
- Pericardial effusion
- Periorbital edema
- Peripheral arterial occlusive disease
- Pneumonia
- Pulmonary edema
- Reactivation of hepatitis B
- Shock
- Thrombotic disorder
- Thrombotic thrombocytopenic purpura
- Thyroiditis
Less Severe
- Candidiasis
- Chemotherapy-induced hyperuricemia
- Chills
- Earache
- Exfoliative dermatitis
- Facial edema
- Hematoma
- Tachycardia
- Tinnitus
- Urinary incontinence
Contraindicated
None
Severe Precaution
Nilotinib
Possible effects on growth. No safety and efficacy established age < 1 year.
- 1 Day – 364 Days
- Possible effects on growth. No safety and efficacy established age < 1 year.
Management or Monitoring Precaution
Nilotinib
Higher rate of Grade 3-4 hepatotoxicity. Monitor growth and development and monthly hepatic function tests.
- 1 Years – 18 Years
- Higher rate of Grade 3-4 hepatotoxicity. Monitor growth and development and monthly hepatic function tests.
Nilotinib
- Severity Level:
D
- Additional Notes: Based on drug pharmacology developmental toxicity is possible.
Contraindicated
Nilotinib
Insuff human data avail; mfg rec to hold breastfeeding
| General | Excretion Potential | Effect on Infant | Notes |
| Drug should not be given to breast feeding mothers | Unknown | Not known; no or inclusive data | Insuff human data avail; mfg rec to hold breastfeeding |
Precaution Exists
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- This drug can rarely cause serious (possibly fatal) irregular heartbeats (QT prolongation). Nilotinib should not be used in people with low blood levels of certain minerals (potassium, magnesium) or a certain heart problem (long QT syndrome). To lower your risk, your doctor will order certain blood tests (potassium/magnesium levels, liver function tests) before and during treatment with nilotinib.<br /><br />You should have a heart test (EKG) before starting nilotinib. The EKG should be repeated 7 days after your first dose, when your dose is changed, and periodically while you are taking nilotinib. To decrease the risk of this effect, do not eat for 2 hours before or 1 hour after taking your dose.<br /><br />Other drugs/foods may increase the risk of an irregular heartbeat. Therefore, before taking this drug, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. See also How to Use and Drug Interactions sections.
| Accelerated phase philadelphia chromosome (+) CML | |
| C92.1 | Chronic myeloid leukemia, BCr/ABl-positive |
| C92.10 | Chronic myeloid leukemia, BCr/ABl-positive, not having achieved remission |
| C92.12 | Chronic myeloid leukemia, BCr/ABl-positive, in relapse |
| Chronic phase philadelphia chromosome (+) CML | |
| C92.1 | Chronic myeloid leukemia, BCr/ABl-positive |
| C92.10 | Chronic myeloid leukemia, BCr/ABl-positive, not having achieved remission |
| C92.12 | Chronic myeloid leukemia, BCr/ABl-positive, in relapse |
| 0-9 | A-Z |
|---|---|
| C92.1 | Chronic myeloid leukemia, BCr/ABl-positive |
| C92.1 | Chronic myeloid leukemia, BCr/ABl-positive |
| C92.10 | Chronic myeloid leukemia, BCr/ABl-positive, not having achieved remission |
| C92.10 | Chronic myeloid leukemia, BCr/ABl-positive, not having achieved remission |
| C92.12 | Chronic myeloid leukemia, BCr/ABl-positive, in relapse |
| C92.12 | Chronic myeloid leukemia, BCr/ABl-positive, in relapse |
Formulary Reference Tool