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SANDIMMUNE (CYCLOSPORINE)
- Prevention of cardiac transplant rejection
- Prevention of kidney transplant rejection
- Prevention of liver transplant rejection
- Sandimmune Oral Solution
- Sandimmune Intravenous Solution
- Sandimmune Capsule
- Cyclosporine Oral Soln
- Cyclosporine Intravenous Solution
- Cyclosporine Capsule
- By Indication
100 mg/mL oral solution
- 5 mg/kg by oral route once daily diluted with milk, chocolate milk or orange juice at room temperature
250 mg/5 mL intravenous solution
- Infuse 2 mg/kg over 2-6 hour(s) by intravenous route once daily
100 mg capsule
- 5 mg/kg by oral route once daily
25 mg capsule
- 5 mg/kg by oral route once daily
100 mg/mL oral solution
- 5 mg/kg by oral route once daily diluted with milk, chocolate milk or orange juice at room temperature
250 mg/5 mL intravenous solution
- Infuse 2 mg/kg over 2-6 hour(s) by intravenous route once daily
100 mg capsule
- 5 mg/kg by oral route once daily
25 mg capsule
- 5 mg/kg by oral route once daily
Prevention of cardiac transplant rejection
- 5 mg/kg by oral route once daily
- 10 mg/kg by oral route once daily
- 5 mg/kg by oral route once daily diluted with milk, chocolate milk or orange juice at room temperature
- 10 mg/kg by oral route once daily diluted with milk, chocolate milk or orange juice at room temperature
- Infuse 2 mg/kg over 2-6 hour(s) by intravenous route once daily
- Infuse 10 mg/kg over 2-6 hour(s) by intravenous route once daily
- Infuse 1 mg/kg over 2-6 hour(s) by intravenous route every 12 hours
- Infuse 5 mg/kg over 2-6 hour(s) by intravenous route every 12 hours
- Infuse 0.66 mg/kg over 2-6 hour(s) by intravenous route every 8 hours
- Infuse 3.3 mg/kg over 2-6 hour(s) by intravenous route every 8 hours
- Infuse 5 mg/kg over 2-6 hour(s) by intravenous route once daily
- Infuse 6 mg/kg over 2-6 hour(s) by intravenous route once daily
Prevention of kidney transplant rejection
- 5 mg/kg by oral route once daily
- 10 mg/kg by oral route once daily
- 5 mg/kg by oral route once daily diluted with milk, chocolate milk or orange juice at room temperature
- 10 mg/kg by oral route once daily diluted with milk, chocolate milk or orange juice at room temperature
- Infuse 2 mg/kg over 2-6 hour(s) by intravenous route once daily
- Infuse 10 mg/kg over 2-6 hour(s) by intravenous route once daily
- Infuse 1 mg/kg over 2-6 hour(s) by intravenous route every 12 hours
- Infuse 5 mg/kg over 2-6 hour(s) by intravenous route every 12 hours
- Infuse 0.66 mg/kg over 2-6 hour(s) by intravenous route every 8 hours
- Infuse 3.3 mg/kg over 2-6 hour(s) by intravenous route every 8 hours
- Infuse 5 mg/kg over 2-6 hour(s) by intravenous route once daily
- Infuse 6 mg/kg over 2-6 hour(s) by intravenous route once daily
Prevention of liver transplant rejection
- 5 mg/kg by oral route once daily
- 10 mg/kg by oral route once daily
- 5 mg/kg by oral route once daily diluted with milk, chocolate milk or orange juice at room temperature
- 10 mg/kg by oral route once daily diluted with milk, chocolate milk or orange juice at room temperature
- Infuse 2 mg/kg over 2-6 hour(s) by intravenous route once daily
- Infuse 10 mg/kg over 2-6 hour(s) by intravenous route once daily
- Infuse 1 mg/kg over 2-6 hour(s) by intravenous route every 12 hours
- Infuse 5 mg/kg over 2-6 hour(s) by intravenous route every 12 hours
- Infuse 0.66 mg/kg over 2-6 hour(s) by intravenous route every 8 hours
- Infuse 3.3 mg/kg over 2-6 hour(s) by intravenous route every 8 hours
- Infuse 5 mg/kg over 2-6 hour(s) by intravenous route once daily
- Infuse 6 mg/kg over 2-6 hour(s) by intravenous route once daily
- adenovirus vac live type-4 & 7
- adenovirus vaccine live type-4
- adenovirus vaccine live type-7
- Aldactazide
- Aldactone
- aliskiren
- aliskiren-amlodipin-hcthiazide
- aliskiren-amlodipine
- aliskiren-hydrochlorothiazide
- amiloride
- amiloride-hydrochlorothiazide
- Amturnide
- Astagraf Xl
- BCG vaccine, live (PF)
- bosentan
- Crestor
- Detrol La
- dronedarone
- Dyazide
- Dyrenium
- ezetimibe-simvastatin
- flu vac,qval 2013-14 (2-49yrs)
- Flumist 2013-2014
- fluvastatin
- Hecoria
- Juxtapid
- Korlym
- Lescol Xl
- Livalo
- lomitapide
- M-m-r Ii (pf)
- Maxzide
- Maxzide-25Mg
- measles,mumps&rubella vacc(PF)
- measles,mumps,rub,varicel(PF)
- Mifeprex
- mifepristone
- Multaq
- natalizumab
- niacin-simvastatin
- pitavastatin
- Prograf
- Proquad (pf)
- rosuvastatin
- Rotateq Vaccine
- rotavirus vaccine live, penta
- Simcor
- simvastatin
- spironolacton-hydrochlorothiaz
- spironolactone
- tacrolimus
- Tekamlo
- Tekturna
- Tekturna Hct
- tofacitinib
- tolterodine
- Tracleer
- triamterene
- triamterene-hydrochlorothiazid
- typhoid vaccine
- Tysabri
- varicella virus vacc live (PF)
- Varivax (pf)
- Vivotif Berna Vaccine
- Vytorin 10-10
- Vytorin 10-20
- Vytorin 10-40
- Vytorin 10-80
- Xeljanz
- yellow fever vaccine live (PF)
- Yf-vax (pf)
- Zocor
- Zostavax (pf)
- zoster vaccine live (PF)
Contraindicated
- 1-day
- 3 Day Vaginal
- 3-day Vaginal
- Abelcet
- Advicor
- Afinitor
- Afinitor Disperz
- Ala-seb-t
- Alagesic Lq
- Altoprev
- Ambisome
- amlodipine-atorvastatin
- amobarbital
- amoxicil-clarithromy-lansopraz
- amphotericin B lipid complex
- amphotericin B liposome
- Amytal
- Android
- Anti-dandruff (coal Tar)
- Aptivus
- Ascomp With Codeine
- atazanavir
- atorvastatin
- Azulfidine
- Azulfidine En-tabs
- B cplx-C-St.Johnwrt-K.&S.ginsg
- Bactrim
- Bactrim Ds
- Belladonna-phenobarbital
- Betatar Gel
- Biaxin
- Biaxin Xl
- Biaxin Xl Pak
- boceprevir
- Bosulif
- bosutinib
- Bupap
- butabarbital
- Butalbital Compound W/codeine
- Butalbital Compound-codeine
- butalbital-acetaminop-caf-cod
- butalbital-acetaminophen
- butalbital-acetaminophen-caff
- butalbital-aspirin-caffeine
- Butisol
- butoconazole nitrate
- Caduet
- calcium-mag-B complex-D3-hrb61
- Cancidas
- Capacet
- carbamazepine
- Carbatrol
- caspofungin
- Cerebyx
- clarithromycin
- clotrimazole
- Clotrimazole 3 Day
- Clotrimazole-3
- Clotrimazole-7
- coal tar
- coal tar-salicylic acid
- codeine-butalbital-ASA-caff
- colchicine
- colchicine-probenecid
- Colcrys
- Cold & Flu Fighter
- Covaryx
- Covaryx H.s.
- Crixivan
- crizotinib
- Cutar
- danazol
- darunavir
- Dhs Tar
- Dhs Tar Gel
- Diflucan
- Digox
- digoxin
- Dilantin
- Dilantin Extended
- Dilantin Infatabs
- Dilantin Kapseal
- Dilantin-125
- Donnatal
- Eemt
- Eemt Hs
- Elta Tar
- enzalutamide
- Epitol
- Equetro
- Erythrocin
- erythromycin
- erythromycin-sulfisoxazole
- Esgic
- estrogens-methyltestosterone
- ethotoin
- everolimus
- ezetimibe-atorvastatin
- Fatigue Relief Complex
- Fioricet
- Fioricet With Codeine
- Fiorinal
- Fiorinal-codeine #3
- fluconazole
- fluconazole in dextrose(iso-o)
- fluconazole in NaCl (iso-osm)
- fosamprenavir
- fosphenytoin
- guanfacine
- Gynazole-1
- Gyne-lotrimin
- Gyne-lotrimin 7
- Hycamtin
- ibrutinib
- Imbruvica
- Incivek
- indinavir
- Intuniv Er
- Invirase
- Ionil T
- isoniazid-rifamp-pyrazinamide
- itraconazole
- Kaletra
- Ketek
- ketoconazole
- Lanoxin
- Lanoxin Pediatric
- Lexiva
- Lipitor
- Liptruzet
- lopinavir-ritonavir
- lovastatin
- Luminal
- Margesic
- Marten-tab
- Methitest
- Methotrexate (anti-rheumatic)
- methotrexate sodium
- methotrexate sodium (PF)
- methyltestosterone
- Mevacor
- Mg217 Psoriasis
- miconazole
- Miconazole 7
- miconazole nitrate
- Miconazole-3
- Miconazole-3 Prefil,cream,wipe
- miconazole-skin clnsr17
- Monistat 1 Combo Pack
- Monistat 3
- Monistat 7
- Monistat 7 Cream, Appl, Wipes
- Mycobutin
- Mysoline
- nafcillin
- nafcillin in dextrose iso-osm
- nelfinavir
- Nembutal Sodium
- Neutrogena T-gel
- Neutrogena T-gel Conditioner
- Neutrogena T/gel Ex-str
- niacin-lovastatin
- Norvir
- Norvir Soft Gelatin
- Noxafil
- Olysio
- Omeclamox-pak
- omeprazole-clarith-amoxicillin
- Onmel
- Orap
- Oravig
- Oxipor Vhc
- Pazol Xs
- Pc-tar
- Peganone
- pentobarbital sodium
- phenobarb-hyoscy-atropine-scop
- phenobarbital
- phenobarbital sodium
- Phenytek
- phenytoin
- phenytoin sodium
- phenytoin sodium extended
- pimozide
- posaconazole
- Prevpac
- Prezista
- Priftin
- primidone
- quinupristin-dalfopristin
- Reyataz
- Rheumatrex
- rifabutin
- Rifadin
- Rifamate
- rifampin
- rifampin-isoniazid
- rifapentine
- Rifater
- ritonavir
- salicylic acid-coal tar-sulfur
- saquinavir mesylate
- Scytera
- secobarbital sodium
- Seconal Sodium
- simeprevir
- Sporanox
- Sporanox Pulsepak
- St. John's wort
- sulfadiazine
- sulfamethoxazole-trimethoprim
- sulfasalazine
- Sulfatrim
- Sulfazine
- Sulfazine Ec
- Synercid
- T+plus
- Tarsum
- Tegretol
- Tegretol Xr
- telaprevir
- telithromycin
- Tencon
- Tenex
- Tera-gel Tar Shampoo
- Testred
- Thera-gel
- Therapeutic Shampoo
- tioconazole
- Tioconazole-1
- tipranavir
- topotecan
- Trexall
- Vagistat-1
- Vagistat-3
- Vfend
- Vfend Iv
- Victrelis
- Viracept
- vit C-St. John wort-elder-hb30
- voriconazole
- Women's Complex
- X-seb T Pearl
- X-seb T Plus
- Xalkori
- Xtandi
- Zebutal
- Zortress
Severe
Moderate
- Advil
- Advil Allergy Sinus
- Advil Allergy-congestion Rlf
- Advil Cold & Sinus
- Advil Congestion Relief
- Advil Liqui-gel
- Advil Migraine
- Advil Pm
- Advil Pm Liqui-gels
- afatinib
- Aleve
- Aleve Cold & Sinus
- Aleve Sinus & Headache
- Aleve-d Sinus & Cold
- Aleve-d Sinus & Headache
- All Day Pain Relief
- All Day Pain Relief Sinus & Co
- All Day Relief
- ambrisentan
- amiodarone
- amiodarone in dextrose,iso-osm
- amlodipine
- amlodipine-benazepril
- amlodipine-olmesartan
- amlodipine-valsartan
- amlodipine-valsartan-hcthiazid
- Anaprox
- Anaprox Ds
- Ansaid
- Arthrotec 50
- Atripla
- avanafil
- Azor
- Calan
- Calan Sr
- Caldolor
- Cambia
- Cardene Iv
- Cardene Iv In Dextrose
- Cardene Iv In Sodium Chloride
- Cardene Sr
- Cardizem
- Cardizem Cd
- Cardizem La
- Cartia Xt
- Cataflam
- Child Ibuprofen
- Children's Advil
- Children's Ibu-drops
- Children's Ibuprofen
- Children's Medi-profen
- Children's Motrin
- Children's Profen Ib
- chlorphen-phenyleph-ibuprofen
- chlorphen-pseudoeph-ibuprofen
- cilostazol
- Cipro
- Cipro In D5W
- Cipro Xr
- ciprofloxacin
- ciprofloxacin (mixture)
- ciprofloxacin in D5W
- Cold & Sinus Pain Relief
- Cold-sinus Relief
- colesevelam
- Complera
- Cordarone
- Daypro
- Detrol
- diclofenac epolamine
- diclofenac potassium
- diclofenac sodium
- diclofenac submicronized
- diclofenac-misoprostol
- Dilacor Xr
- Dilt-xr
- diltiazem HCl
- Duexis
- Ec-naprosyn
- efavirenz-emtricitabin-tenofov
- elvitegr-cobicist-emtric-tenof
- emtricitab-rilpivirine-tenofov
- emtricitabine-tenofovir
- etodolac
- Etopophos
- etoposide
- etoposide phosphate
- Exforge
- Exforge Hct
- ezetimibe
- Feldene
- fenoprofen
- Flanax
- Flector
- flurbiprofen
- Gilotrif
- hydrocodone-ibuprofen
- I-prin
- Ibu-drops
- Ibudone
- ibuprofen
- Ibuprofen Cold
- Ibuprofen Cold-sinus(with Pse)
- Ibuprofen Ib
- Ibuprofen Jr Strength
- ibuprofen lysine (PF)
- Ibuprofen Pm
- ibuprofen-diphenhydramine
- ibuprofen-diphenhydramine HCl
- ibuprofen-famotidine
- ibuprofen-oxycodone
- ibuprofen-phenylephrine HCl
- Indocin
- indomethacin
- indomethacin sodium
- Infant's Ibuprofen
- Infant's Medi-profen
- Infant's Motrin
- Infants Ibu-drops
- Infants Profenib
- ivacaftor
- Kalydeco
- ketoprofen
- ketorolac
- Lescol
- Letairis
- Lotrel
- Matzim La
- Medi-profen
- Mediproxen
- mefenamic acid
- metoclopramide HCl
- Metozolv Odt
- Midol (naproxen)
- Motrin Ib
- Motrin Pm
- nabumetone
- Nalfon
- Naprelan Cr
- Naprosyn
- naproxen
- naproxen sodium
- naproxen-esomeprazole
- naproxen-pseudoephedrine
- nefazodone
- Neoprofen (ibuprofen Lysn)(pf)
- Nexterone
- nicardipine
- nicardipine in dextrose,iso-os
- nicardipine in NaCl (iso-os)
- norfloxacin
- Noroxin
- Norvasc
- octreotide acetate
- olmesartan-amlodipin-hcthiazid
- oxaprozin
- Pacerone
- Pennsaid
- piroxicam
- Pletal
- Ponstel
- Prandimet
- Prandin
- Pravachol
- pravastatin
- Provil
- pseudoephedrine-ibuprofen
- Rapamune
- Reglan
- repaglinide
- repaglinide-metformin
- Reprexain
- Sandostatin
- Sandostatin Lar Depot
- Sinus & Cold-d
- sirolimus
- Solaraze
- Sprix
- Stendra
- Stribild
- sulindac
- Tarka
- Taztia Xt
- telmisartan-amlodipine
- temsirolimus
- tenofovir disoproxil fumarate
- Tiazac
- tolmetin
- Toposar
- Torisel
- trandolapril-verapamil
- Tribenzor
- Truvada
- Twynsta
- verapamil
- Verelan
- Verelan Pm
- Vicoprofen
- Vimovo
- Viread
- Voltaren-xr
- Wal-profen
- Wal-profen Cold-sinus
- Wal-proxen
- Welchol
- Zetia
- Zipsor
- Zorvolex
- Lactating mother
- Posterior reversible encephalopathy syndrome
- Progressive multifocal leukoencephalopathy
- Severe uncontrolled hypertension
Contraindicated
- BK polyomavirus reactivation nephropathy
- Disease of liver
- Hyperchloremic acidosis
- Hyperkalemia
- Hyperuricemia
- Hypomagnesemia
- Idiopathic intracranial hypertension
- Infection
- Kidney disease with reduction in GFR
- Malignancy
- Malignant lymphoma
- Nephrotoxicity
- Thrombotic thrombocytopenic purpura
Severe
Moderate
- Abnormal hepatic function tests
- Hyperbilirubinemia
- Hypercholesterolemia
- Hypertension
- Hypertriglyceridemia
- Seizure disorder
SANDIMMUNE (CYCLOSPORINE)
- Prevention of cardiac transplant rejection
- Prevention of kidney transplant rejection
- Prevention of liver transplant rejection
- Gingival hyperplasia
- Hypertension
- Nephrotoxicity
- Abdominal pain with cramps
- Dizziness
- Dyspepsia
- Edema
- Flu-like symptoms
- Headache disorder
- Hirsutism
- Pain
- Tremor
- Vomiting
More Frequent
Severe
Less Severe
- Bacterial sepsis
- Chest pain
- Dyspnea
- Fungal infection
- Hypomagnesemia
- Infection
- Jaundice
- Seizure disorder
- Skin rash
- Abdominal distension
- Acne vulgaris
- Cramps in legs
- Diarrhea
- Dyschromia
- Flatulence
- Gastritis
- Migraine
- Nausea
- Paresthesia
- Tinnitus
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Acute myocardial infarction
- Anaphylaxis
- Anemia
- Angioedema
- BK polyomavirus reactivation nephropathy
- Cholestasis
- Encephalopathy
- Hearing loss
- Hematuria
- Hepatic failure
- Hepatitis
- Hyperglycemia
- Hyperkalemia
- Hyperuricemia
- Interstitial nephritis
- Malignant lymphoma
- Neoplasm
- Pancreatitis
- Parasitic infection
- Peptic ulcer
- Posterior reversible encephalopathy syndrome
- Progressive multifocal leukoencephalopathy
- Renal failure
- Thrombocytopenic disorder
- Thrombotic thrombocytopenic purpura
- Upper GI bleed
- Viral infection
- Visual changes
Less Severe
- Acute confusion
- Anorexia
- Arthralgias
- Constipation
- Depression
- Dysgeusia
- Dysphagia
- Fever
- General weakness
- Gynecomastia
- Hiccups
- Hyperkeratosis
- Lethargy
- Myalgias
- Night sweats
- Onychia sicca
- Pruritus of skin
- Sinusitis
- Stomatitis
- Symptoms of anxiety
- Weight loss
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
None
Cyclosporine
- Severity Level:
C
- Additional Notes: Limited data show incr risk of pre-mature birth in transplant pts on immunosupp.
Contraindicated
Cyclosporine
Use not recommended, potential for immune suppression and neutropenia
| General | Excretion Potential | Effect on Infant | Notes |
| Drug should not be given to breast feeding mothers | Excreted | Not known; no or inclusive data | Use not recommended, potential for immune suppression and neutropenia |
Precaution Exists
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Cyclosporine
Cardiovascular-Increased risk for systolic hypertension. Renal-Increased risk for renal impairment in elderly.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | Y | N | Y | N | N | N |
BEERS: N HEDIS: N STOPP: N
No Known Risk
None
- Cyclosporine lowers your ability to fight infections. This may make you more likely to get a serious (rarely fatal) infection or make any infection you have worse. This effect may also increase your risk of getting certain types of cancer (such as skin cancer, lymphoma).<br /><br />Tell your doctor right away if you have any signs of infection or cancer such as sore throat that doesn't go away, fever, chills, cough, burning/frequent urination, unusual skin changes, change in appearance or size of moles, unusual weight loss, swollen lymph glands, unusual lumps, night sweats. Cyclosporine can also cause high blood pressure and kidney problems. The risk of both problems increases with higher doses and longer treatment with this drug.<br /><br />Your doctor will monitor your blood pressure and kidney function while you take this medication. Psoriasis patients who have had certain previous treatments (such as coal tar, methotrexate, radiation treatment, light treatment with PUVA/UVB) are at increased risk to develop skin cancer. Talk to your doctor of the risks and benefits of this medication.<br /><br /> Different brands of this medication may deliver different amounts of medication. Do not switch brands of cyclosporine without your doctor's permission and directions.
| Prevention of cardiac transplant rejection | |
| Z94.1 | Heart transplant status |
| Z94.3 | Heart and lungs transplant status |
| Prevention of kidney transplant rejection | |
| Z94.0 | Kidney transplant status |
| Prevention of liver transplant rejection | |
| Z94.4 | Liver transplant status |
| 0-9 | A-Z |
|---|---|
| Z94.0 | Kidney transplant status |
| Z94.1 | Heart transplant status |
| Z94.3 | Heart and lungs transplant status |
| Z94.4 | Liver transplant status |
Formulary Reference Tool