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RITALIN (METHYLPHENIDATE HCL)
- Attention-deficit hyperactivity disorder
- Narcolepsy syndrome
10 mg tablet
- 1 tablet (10 mg) by oral route 2 times per day
20 mg tablet
- 1 tablet (20 mg) by oral route 2 times per day
5 mg tablet
- 1 tablet (5 mg) by oral route 2 times per day
10 mg tablet
- 1 tablet (10 mg) by oral route 2 times per day
20 mg tablet
- 1 tablet (20 mg) by oral route 2 times per day
5 mg tablet
- 1 tablet (5 mg) by oral route 2 times per day
methylphenidate 10 mg tablet
- 1 tablet (10 mg) by oral route 2 times per day
methylphenidate 20 mg tablet
- 1 tablet (20 mg) by oral route 2 times per day
methylphenidate 5 mg tablet
- 1 tablet (5 mg) by oral route 2 times per day
Attention-deficit hyperactivity disorder
- 1 tablet (5 mg) by oral route 3 times per day
- 1 tablet (5 mg) by oral route 2 times per day
- 1 tablet (5 mg) by oral route 2 times per day before meals
- 1 tablet (5 mg) by oral route 3 times per day before meals
- 2 tablets (10 mg) by oral route 2 times per day before meals
- 1 tablet (10 mg) by oral route 2 times per day
- 2 tablets (10 mg) by oral route 3 times per day before meals
- 2 tablets (10 mg) by oral route 2 times per day
- 1 tablet (10 mg) by oral route 2 times per day before meals
- 1 tablet (10 mg) by oral route 3 times per day before meals
- 2 tablets (10 mg) by oral route 3 times per day
- 1 tablet (10 mg) by oral route 3 times per day
- 1 tablet (20 mg) by oral route 3 times per day
- 2 tablets (20 mg) by oral route 3 times per day
- 2 tablets (20 mg) by oral route 2 times per day before meals
- 2 tablets (20 mg) by oral route 2 times per day
- 1 tablet (20 mg) by oral route 2 times per day
- 2 tablets (20 mg) by oral route 3 times per day before meals
- 1 tablet (20 mg) by oral route 2 times per day before meals
- 1 tablet (20 mg) by oral route 3 times per day before meals
Narcolepsy syndrome
- 1 tablet (5 mg) by oral route 3 times per day
- 1 tablet (5 mg) by oral route 2 times per day
- 1 tablet (5 mg) by oral route 2 times per day before meals
- 1 tablet (5 mg) by oral route 3 times per day before meals
- 2 tablets (10 mg) by oral route 2 times per day before meals
- 1 tablet (10 mg) by oral route 2 times per day
- 2 tablets (10 mg) by oral route 3 times per day before meals
- 2 tablets (10 mg) by oral route 2 times per day
- 1 tablet (10 mg) by oral route 2 times per day before meals
- 1 tablet (10 mg) by oral route 3 times per day before meals
- 2 tablets (10 mg) by oral route 3 times per day
- 1 tablet (10 mg) by oral route 3 times per day
- 1 tablet (20 mg) by oral route 3 times per day
- 2 tablets (20 mg) by oral route 3 times per day
- 2 tablets (20 mg) by oral route 2 times per day before meals
- 2 tablets (20 mg) by oral route 2 times per day
- 1 tablet (20 mg) by oral route 2 times per day
- 2 tablets (20 mg) by oral route 3 times per day before meals
- 1 tablet (20 mg) by oral route 2 times per day before meals
- 1 tablet (20 mg) by oral route 3 times per day before meals
- isocarboxazid
- Marplan
- Matulane
- methylene blue (antidote)
- Nardil
- Parnate
- phenelzine
- procarbazine
- tranylcypromine
Contraindicated
- amitriptyline
- amitriptyline-chlordiazepoxide
- amoxapine
- Amrix
- Anafranil
- Azilect
- bromocriptine
- cabergoline
- Cafergot
- clomipramine
- Compound 347
- cyclobenzaprine
- cyclobenzaprine with msm
- Cycloset
- D.h.e.45
- Datscan
- desipramine
- dihydroergotamine
- doxepin
- Eldepryl
- enflurane
- ergoloid
- Ergomar
- ergotamine tartrate
- ergotamine-caffeine
- Forane
- imipramine HCl
- imipramine pamoate
- ioflupane I 123
- isoflurane
- linezolid
- maprotiline
- methylergonovine
- Migergot
- Migranal
- Norpramin
- nortriptyline
- Pamelor
- Parlodel
- perphenazine-amitriptyline
- protriptyline
- Prudoxin
- rasagiline
- selegiline HCl
- sevoflurane
- Silenor
- Sojourn
- Surmontil
- Tabradol
- Terrell
- Tofranil
- Tofranil-pm
- trimipramine
- Ultane
- Vivactil
- Zelapar
- Zonalon
- Zyvox
Severe
Moderate
- None
- 30 day risk period post-myocardial infarction
- Angina
- Cardiac arrhythmia
- Cardiomyopathy
- Congenital long QT syndrome
- Coronary artery disease
- Gilles de la tourette syndrome
- Glaucoma
- Hyperthyroidism
- Lower seizure threshold
- Motor tic disorder
- Structural disorder of heart
- Thyrotoxicosis
Contraindicated
- Acrocyanosis
- Alcoholism
- Anxiety disorder
- Bipolar disorder
- Cerebrovascular accident
- Chronic heart failure
- Drug dependence
- Hypertension
- Manic disorder
- Peripheral vascular disease
- Priapism
- Psychotic disorder
- Raynaud's phenomenon
- Suicidal ideation
- Uncontrolled epilepsy
Severe
Moderate
- Abnormal hepatic function tests
- Anemia
- Leukopenia
RITALIN (METHYLPHENIDATE HCL)
- Attention-deficit hyperactivity disorder
- Narcolepsy syndrome
- Hypertension
- Tachycardia
- Acute abdominal pain
- Anorexia
- Excitement
- Headache disorder
- Hyperhidrosis
- Insomnia
- Nausea
- Nervousness
- Upper abdominal pain
- Weight loss
- Xerostomia
More Frequent
Severe
Less Severe
- Angina
- Chest pain
- Dyskinesia
- Motor tic disorder
- Skin rash
- Thrombocytopenic disorder
- Aggressive behavior
- Arthralgias
- Cough
- Dizziness
- Drowsy
- Dyspepsia
- Fever
- Irritability
- Pharyngitis
- Tremor
- Upper respiratory infection
- Urticaria
- Vomiting
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal hepatic function tests
- Acute hepatic failure
- Acute myocardial infarction
- Anaphylaxis
- Anemia
- Angioedema
- Bradycardia
- Bullous dermatitis
- Cerebral vasculitis
- Cerebrovascular accident
- Drug-induced psychosis
- Erythema multiforme
- Exfoliative dermatitis
- Extrasystoles
- Growth failure
- Hallucinations
- Hepatocellular damage
- Hyperbilirubinemia
- Idiopathic thrombocytopenic purpura
- Intracerebral hemorrhage
- Leukopenia
- Manic disorder
- Mood changes
- Pancytopenia
- Priapism
- Raynaud's phenomenon
- Rhabdomyolysis
- Seizure disorder
- Suicidal ideation
- Supraventricular tachycardia
- Tonic clonic seizure
- Toxic psychosis
- Ventricular premature beats
Less Severe
- Acute confusion
- Agitation
- Alopecia
- Blurred vision
- Bruxism
- Constipation
- Diarrhea
- Diplopia
- Dysmenorrhea
- Dyspnea
- Erythema
- Fatigue
- Gynecomastia
- Hematuria
- Libido changes
- Logorrhea
- Migraine
- Motion sickness
- Myalgias
- Mydriasis
- Ocular pain
- Palpitations
- Peripheral vasoconstriction
- Pruritus of skin
- Reversible ischemic neurological defect
- Sore throat
- Visual changes
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
None
Methylphenidate
- Severity Level:
2
- Additional Notes: Insuf human data; cns stimulants cross placental barrier
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Methylphenidate
Insufficient data available, limited data suggest minimal excretion
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Excreted | Not known; no or inclusive data | Insufficient data available, limited data suggest minimal excretion |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Methylphenidate
Neuro/Psych-May exacerbate pre-existing insomnia. Cardiovascular-May exacerbate pre-existing or underlying cardiac abnormality, peripheral vasculopathy. Gastrointestinal-Anorexia may cause significant weight loss.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | N | N | Y | Y | N | N |
BEERS: N HEDIS: N STOPP: N
No Known Risk
None
- Misuse or abuse of methylphenidate can result in serious (possibly fatal) heart and blood pressure problems. This medication can be habit-forming and should be used cautiously by people who have mental/mood disorders or a substance use disorder (such as overuse of or addiction to drugs/alcohol). Before using this medication, tell your doctor if you have a personal or family history of a substance use disorder.<br /><br />Do not increase your dose, use it more often, or use it for a longer time or in a different way than prescribed. Doing so may result in a decrease in the effect of this drug, drug dependence, or abnormal thoughts/behavior. Your doctor may monitor you for a while after the medication is stopped, especially if you have taken this drug for a long time or in high doses. (See also How to Use section.)
| Attention-deficit hyperactivity disorder | |
| F90 | Attention-deficit hyperactivity disorders |
| F90.0 | Attention-deficit hyperactivity disorder, predominantly inattentive type |
| F90.1 | Attention-deficit hyperactivity disorder, predominantly hyperactive type |
| F90.2 | Attention-deficit hyperactivity disorder, combined type |
| F90.8 | Attention-deficit hyperactivity disorder, other type |
| F90.9 | Attention-deficit hyperactivity disorder, unspecified type |
| Narcolepsy syndrome | |
| G47.4 | Narcolepsy and cataplexy |
| G47.41 | Narcolepsy |
| G47.411 | Narcolepsy with cataplexy |
| G47.419 | Narcolepsy without cataplexy |
| G47.42 | Narcolepsy in conditions classified elsewhere |
| G47.421 | Narcolepsy in conditions classified elsewhere with cataplexy |
| G47.429 | Narcolepsy in conditions classified elsewhere without cataplexy |
| 0-9 | A-Z |
|---|---|
| F90 | Attention-deficit hyperactivity disorders |
| F90.0 | Attention-deficit hyperactivity disorder, predominantly inattentive type |
| F90.1 | Attention-deficit hyperactivity disorder, predominantly hyperactive type |
| F90.2 | Attention-deficit hyperactivity disorder, combined type |
| F90.8 | Attention-deficit hyperactivity disorder, other type |
| F90.9 | Attention-deficit hyperactivity disorder, unspecified type |
| G47.4 | Narcolepsy and cataplexy |
| G47.41 | Narcolepsy |
| G47.411 | Narcolepsy with cataplexy |
| G47.419 | Narcolepsy without cataplexy |
| G47.42 | Narcolepsy in conditions classified elsewhere |
| G47.421 | Narcolepsy in conditions classified elsewhere with cataplexy |
| G47.429 | Narcolepsy in conditions classified elsewhere without cataplexy |
Formulary Reference Tool