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LOTREL (AMLODIPINE BESYLATE/BENAZEPRIL HCL)
- Hypertension
10 mg-20 mg capsule
- 1 capsule by oral route once daily
10 mg-40 mg capsule
- 1 capsule by oral route once daily
5 mg-10 mg capsule
- 1 capsule by oral route once daily
5 mg-20 mg capsule
- 1 capsule by oral route once daily
5 mg-40 mg capsule
- 1 capsule by oral route once daily
amlodipine 10 mg-benazepril 20 mg capsule
- 1 capsule by oral route once daily
amlodipine 10 mg-benazepril 40 mg capsule
- 1 capsule by oral route once daily
amlodipine 2.5 mg-benazepril 10 mg capsule
- 1 capsule by oral route once daily
amlodipine 5 mg-benazepril 10 mg capsule
- 1 capsule by oral route once daily
amlodipine 5 mg-benazepril 20 mg capsule
- 1 capsule by oral route once daily
amlodipine 5 mg-benazepril 40 mg capsule
- 1 capsule by oral route once daily
Hypertension
- 1 capsule by oral route once daily
- ezetimibe-simvastatin
- Vytorin 10-40
- Vytorin 10-80
Contraindicated
- aliskiren
- aliskiren-amlodipin-hcthiazide
- aliskiren-amlodipine
- aliskiren-hydrochlorothiazide
- amoxicil-clarithromy-lansopraz
- Amturnide
- Biaxin
- Biaxin Xl
- Biaxin Xl Pak
- clarithromycin
- conivaptan in 5 % dextrose
- Curad Enema
- Dantrium
- dantrolene
- Disposable Enema
- Enema
- Enema Disposable
- Erythrocin
- erythromycin
- erythromycin-sulfisoxazole
- Fleet Enema
- Fleet Enema Extra
- Fleet Pediatric
- Ketek
- lithium carbonate
- lithium citrate
- Lithobid
- Omeclamox-pak
- omeprazole-clarith-amoxicillin
- Oral Saline Laxative
- Osmoprep
- Phosphate Laxative
- Preparation Cleansing
- Prevpac
- Ready-to-use Enema
- Revonto
- sod phos mono-sod phos dibasic
- sodium phosphates
- Tekamlo
- Tekturna
- Tekturna Hct
- telithromycin
- Vaprisol
Severe
Moderate
- Added Strength Headache Relief
- Added Strength Pain Reliever
- Alka-seltzer
- Alka-seltzer Extra Strength
- Alka-seltzer Original
- Alka-seltzer Plus C/c(pe,dm)
- Alka-seltzer Plus Cold (pe)
- Alka-seltzer Plus Day-night
- Alka-seltzer Plus Night
- Alka-seltzer Pm
- Anacin
- Anacin Maximum Strength
- Analgesic
- Angeliq
- Antacid & Pain Relief
- ASA-acetaminophen-caff-buffers
- ASA-acetaminophen-salicyl-caff
- Ascomp With Codeine
- Aspir-trin
- aspirin
- aspirin, buffered
- aspirin-acetaminophen-caffeine
- aspirin-caffeine
- aspirin-diphenhydramine
- aspirin-diphenhydramine citrat
- aspirin-sod bicarb-citric acid
- Astagraf Xl
- Azasan
- azathioprine
- azathioprine sodium
- Back & Body Pain Reliever
- Bactrim
- Bactrim Ds
- Bayer Advanced
- Bayer Aspirin
- Bayer Aspirin (with Caffeine)
- Bayer Back & Body
- Bayer Plus Extra Strength
- Bayer Pm
- Bc
- Bc Arthritis
- Beyaz
- boceprevir
- Buffered Aspirin
- Bufferin
- bumetanide
- Butalbital Compound W/codeine
- Butalbital Compound-codeine
- butalbital-aspirin-caffeine
- carisoprodol-ASA-codeine
- carisoprodol-aspirin
- chlorphen-phenyleph-DM-aspirin
- chlorphenir-phenylephrn-aspirn
- codeine-butalbital-ASA-caff
- Cold Relief
- Cold Relief Plus
- cyclosporine
- cyclosporine modified
- Demadex
- dihydrocodeine-aspirin-caff
- doxylamine-phenylep-DM-aspirin
- drospirenone-e.estradiol-lm.FA
- drospirenone-estradiol
- drospirenone-ethinyl estradiol
- E.c. Prin
- Ecotrin
- Efferves Pain Relief Antacid
- Effervescent Antacid
- Effervescent Pain Relief
- Effervescent Pain Reliever
- Endodan
- ethacrynate sodium
- Excedrin Extra Strength
- Excedrin Migraine
- Extra Strength Bayer
- Fiorinal
- Fiorinal-codeine #3
- furosemide
- Gengraf
- Gianvi (28)
- Goody's Extra Strength
- Goody's Migraine Relief
- Headache Formula
- Headache Formula Added Str
- Headache Relief
- Hecoria
- Imuran
- Incivek
- isoniazid-rifamp-pyrazinamide
- Juxtapid
- ketoconazole
- Lasix
- Levacet
- Lite Coat Aspirin
- lomitapide
- Loryna (28)
- Medi-seltzer
- mercaptopurine
- Migraine Formula
- Migraine Pain Reliever
- Migraine Relief
- Mycobutin
- Neoral
- niacin-simvastatin
- Ocella
- Orphenadrine Compound Forte
- Orphenadrine Compound-ds
- orphenadrine-ASA-caffeine
- oxycodone-aspirin
- Pain Relief
- Pain Relief Extra Strength
- Pain Reliever
- Pain Reliever Extra Strength
- Pain Reliever Plus
- Pain-off
- Pamprin Max
- PE-DM-ASA/doxyla-PE-DM-ASA
- Percodan
- Priftin
- Primsol
- Prograf
- Purinethol
- rifabutin
- Rifadin
- Rifamate
- rifampin
- rifampin-isoniazid
- rifapentine
- Rifater
- Safyral
- Sandimmune
- Simcor
- simvastatin
- Sodium Edecrin
- sulfamethoxazole-trimethoprim
- Sulfatrim
- Super Pain Relief
- Syeda
- Synalgos-dc
- tacrolimus
- telaprevir
- torsemide
- Tri-buffered Aspirin
- trimethoprim
- Vanquish
- Vestura (28)
- Victrelis
- Vytorin 10-10
- Vytorin 10-20
- Yasmin (28)
- Yaz 28
- Zarah
- Zocor
- Angioedema
- Head and neck angioedema
- Hepatic failure
- Hereditary angioedema
- Intestinal angioedema
- Pregnancy
Contraindicated
- Abnormal hepatic function tests
- Bone marrow depression
- Dehydration
- Hyperkalemia
- Hyponatremia
- Hypotension
- Kidney disease with reduction in GFR
- Neutropenic disorder
- Renal artery stenosis
- Severe aortic valve stenosis
- Severe hepatic disease
- Severe hypotension
Severe
Moderate
- Disease of liver
- Hemodialysis with high-flux membrane
LOTREL (AMLODIPINE BESYLATE/BENAZEPRIL HCL)
- Hypertension
- None
- Acute abdominal pain
- Cough
- Drowsy
- Edema
- Headache disorder
- Nausea
- Peripheral edema
More Frequent
Severe
Less Severe
- Hyperkalemia
- Hypotension
- Dizziness
- Drowsy
- Fatigue
- Flushing
- Nausea
- Orthostatic hypotension
- Palpitations
- Skin rash
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal hepatic function tests
- Acute myocardial infarction
- Acute pancreatitis
- Acute renal failure
- Agranulocytosis
- Anaphylaxis
- Angina
- Angioedema
- Atrial fibrillation
- Black tarry stools
- Bradycardia
- Cardiac arrhythmia
- Depersonalization
- Depression
- Drug-induced hepatitis
- Erythema multiforme
- Extrapyramidal disease
- Head and neck angioedema
- Hemolytic anemia
- Hypertonia
- Hypotension
- Intestinal angioedema
- Jaundice
- Laryngeal edema
- Leukopenia
- Neutropenic disorder
- Obstructive hyperbilirubinemia
- Pancreatitis
- Pemphigus
- Purpura
- Stevens-johnson syndrome
- Thrombocytopenic disorder
- Ventricular tachycardia
Less Severe
- Abnormal sexual function
- Alopecia
- Angina
- Anorexia
- Arthralgias
- Arthritis
- Asthma
- Back pain
- Bronchitis
- Chest pain
- Chills
- Conjunctivitis
- Constipation
- Cramps
- Diarrhea
- Dream disorder
- Drug-induced hot flash
- Dysgeusia
- Dysphagia
- Dyspnea
- Epistaxis
- Erectile dysfunction
- Flatulence
- Flushing
- Gastritis
- General weakness
- Gingival hyperplasia
- Gynecomastia
- Hyperglycemia
- Hyperhidrosis
- Hypesthesia
- Increased urinary frequency
- Infection
- Insomnia
- Libido changes
- Maculopapular rash
- Malaise
- Myalgias
- Nervousness
- Nocturia
- Ocular pain
- Osteoarthritis
- Paresthesia
- Peripheral ischemia
- Peripheral neuropathy
- Polydipsia
- Pruritus of skin
- Sinusitis
- Skin photosensitivity
- Skin rash
- Symptoms of anxiety
- Syncope
- Tachycardia
- Tinnitus
- Tremor
- Urinary tract infection
- Vasculitis
- Vertigo
- Vision loss
- Visual changes
- Vomiting
- Weight gain
- Weight loss
- Xerostomia
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Amlodipine
No safety and efficacy data for age < 6 years.
No safety and efficacy of combination product in pediatrics.
- 1 Day – 6 Years
- No safety and efficacy data for age < 6 years.
- 6 Years – 18 Years
- No safety and efficacy data for age < 6 years.
Amlodipine_Benazepril
No safety and efficacy data for age < 6 years.
No safety and efficacy of combination product in pediatrics.
- 1 Day – 6 Years
- No safety and efficacy of combination product in pediatrics.
- 6 Years – 18 Years
- No safety and efficacy of combination product in pediatrics.
Amlodipine
- Severity Level:
2
- Additional Notes: Uncontrolled htn can result in increased maternal/fetal morbidity and mortality
Benazepril
- Severity Level:
1
- Additional Notes: Fetal death/morbidity w/use in 2nd & 3rd trimester, stop when pregnancy detected
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Amlodipine
Insufficient data avail; consider maternal treatment benefit vs infant risk
Reported amount in breastmilk less than 0. 1% of maternal dose.
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Excreted | Not known; no or inclusive data | Insufficient data avail; consider maternal treatment benefit vs infant risk |
Benazepril
Insufficient data avail; consider maternal treatment benefit vs infant risk
Reported amount in breastmilk less than 0. 1% of maternal dose.
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Excreted | Not known; no or inclusive data | Reported amount in breastmilk less than 0. 1% of maternal dose. |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Amlodipine
General-Not recommended as first line therapy in the elderly. Cardiovascular-Start at 2.5 mg/day and slowly titrate upward. Peripheral edema may be common. Lower drug clearance may result in increased sensitivity to blood pressure lowering effects. Gastrointestinal-May cause or worsen pre-existing constipation.
Renal-Monitor for increased serum creatinine or hyperkalemia. Cardiovascular-Increased risk for hypotension in the elderly.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | N | Y | Y | N | N | N |
BEERS: N HEDIS: N STOPP: Y
Benazepril
General-Not recommended as first line therapy in the elderly. Cardiovascular-Start at 2.5 mg/day and slowly titrate upward. Peripheral edema may be common. Lower drug clearance may result in increased sensitivity to blood pressure lowering effects. Gastrointestinal-May cause or worsen pre-existing constipation.
Renal-Monitor for increased serum creatinine or hyperkalemia. Cardiovascular-Increased risk for hypotension in the elderly.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | Y | N | Y | N | N | N |
BEERS: N HEDIS: N STOPP: Y
No Known Risk
None
- Benazepril (one of the ingredients in this product) can cause serious (possibly fatal) harm to an unborn baby if used during pregnancy. It is important to prevent pregnancy while taking this medication. Consult your doctor for more details and to discuss the use of reliable forms of birth control while taking this medication. If you are planning pregnancy, become pregnant, or think you may be pregnant, tell your doctor right away.
| Hypertension | |
| I10 | Essential (primary) hypertension |
| I11 | Hypertensive heart disease |
| I11.0 | Hypertensive heart disease with heart failure |
| I11.9 | Hypertensive heart disease without heart failure |
| I12 | Hypertensive chronic kidney disease |
| I12.0 | Hypertensive chronic kidney disease with stage 5 chronic kidney disease or end stage renal disease |
| I12.9 | Hypertensive chronic kidney disease with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13 | Hypertensive heart and chronic kidney disease |
| I13.0 | Hypertensive heart and chronic kidney disease with heart failure and stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13.1 | Hypertensive heart and chronic kidney disease without heart failure |
| I13.10 | Hypertensive heart and chronic kidney disease without heart failure, with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13.11 | Hypertensive heart and chronic kidney disease without heart failure, with stage 5 chronic kidney disease, or end stage renal disease |
| I13.2 | Hypertensive heart and chronic kidney disease with heart failure and with stage 5 chronic kidney disease, or end stage renal disease |
| I15.1 | Hypertension secondary to other renal disorders |
| 0-9 | A-Z |
|---|---|
| I10 | Essential (primary) hypertension |
| I11 | Hypertensive heart disease |
| I11.0 | Hypertensive heart disease with heart failure |
| I11.9 | Hypertensive heart disease without heart failure |
| I12 | Hypertensive chronic kidney disease |
| I12.0 | Hypertensive chronic kidney disease with stage 5 chronic kidney disease or end stage renal disease |
| I12.9 | Hypertensive chronic kidney disease with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13 | Hypertensive heart and chronic kidney disease |
| I13.0 | Hypertensive heart and chronic kidney disease with heart failure and stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13.1 | Hypertensive heart and chronic kidney disease without heart failure |
| I13.10 | Hypertensive heart and chronic kidney disease without heart failure, with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13.11 | Hypertensive heart and chronic kidney disease without heart failure, with stage 5 chronic kidney disease, or end stage renal disease |
| I13.2 | Hypertensive heart and chronic kidney disease with heart failure and with stage 5 chronic kidney disease, or end stage renal disease |
| I15.1 | Hypertension secondary to other renal disorders |
Formulary Reference Tool