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ILARIS (CANAKINUMAB/PF)
- Familial cold autoinflammatory syndrome
- Muckle-wells syndrome
- Systemic-onset juvenile idiopathic arthritis
- Familial mediterranean fever
- Hyper-igD periodic fever syndrome
- TNF receptor-associated periodic fever syndrome
(PF) 150 mg/mL subcutaneous solution
- Inject 1 milliliter (150 mg) by subcutaneous route every 8 weeks
Familial cold autoinflammatory syndrome
- Inject 1 milliliter (150 mg) by subcutaneous route every 8 weeks
Familial mediterranean fever
- Inject 1 milliliter (150 mg) by subcutaneous route every 4 weeks
- Inject 2 milliliters (300 mg) by subcutaneous route every 4 weeks
Hyper-igD periodic fever syndrome
- Inject 1 milliliter (150 mg) by subcutaneous route every 4 weeks
- Inject 2 milliliters (300 mg) by subcutaneous route every 4 weeks
Muckle-wells syndrome
- Inject 1 milliliter (150 mg) by subcutaneous route every 8 weeks
TNF receptor-associated periodic fever syndrome
- Inject 1 milliliter (150 mg) by subcutaneous route every 4 weeks
- Inject 2 milliliters (300 mg) by subcutaneous route every 4 weeks
- adenovirus vac live type-4 & 7
- adenovirus vaccine live type-4
- adenovirus vaccine live type-7
- BCG vaccine, live (PF)
- flu vac,qval 2013-14 (2-49yrs)
- Flumist 2013-2014
- M-m-r Ii (pf)
- measles,mumps&rubella vacc(PF)
- measles,mumps,rub,varicel(PF)
- natalizumab
- Proquad (pf)
- Rotateq Vaccine
- rotavirus vaccine live, penta
- typhoid vaccine
- Tysabri
- varicella virus vacc live (PF)
- Varivax (pf)
- Vivotif Berna Vaccine
- yellow fever vaccine live (PF)
- Yf-vax (pf)
- Zostavax (pf)
- zoster vaccine live (PF)
Contraindicated
- adalimumab
- certolizumab pegol
- Cimzia
- Cimzia Powder For Reconst
- Cimzia Starter Kit
- Enbrel
- Enbrel Sureclick
- etanercept
- golimumab
- Humira
- Humira Crohn's Dis Start Pck
- Humira Pen
- Humira Psoriasis Starter Pack
- infliximab
- Remicade
- Simponi
- Simponi Aria
Severe
Moderate
- None
- None
Contraindicated
- Inactive tuberculosis
- Severe infection
Severe
Moderate
- Malignancy
ILARIS (CANAKINUMAB/PF)
- Familial cold autoinflammatory syndrome
- Muckle-wells syndrome
- Systemic-onset juvenile idiopathic arthritis
- Familial mediterranean fever
- Hyper-igD periodic fever syndrome
- TNF receptor-associated periodic fever syndrome
- Systemic infection
- Acute abdominal pain
- Diarrhea
- Headache disorder
- Injection site sequelae
- Nausea
- Pharyngitis
- Rhinitis
- Upper respiratory infection
More Frequent
Severe
Less Severe
- Malignancy
- Reactivated tuberculosis
- Gastroenteritis
- Influenza
- Musculoskeletal pain
- Vertigo
- Weight gain
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal hepatic function tests
- Active tuberculosis
- Atypical mycobacterial infection
- Cytomegalovirus disease
- Dysphagia
- Dyspnea
- Herpes zoster
- Hypotension
- Macrophage activation syndrome
- Neutropenic disorder
- Opportunistic fungal infection
- Thrombocytopenic disorder
Less Severe
- Palpitations
- Pruritus of skin
- Skin rash
- Urticaria
Contraindicated
None
Severe Precaution
Canakinumab
Risk of infection, possible malignancy, and macrophage activation syndrome. No established safety and efficacy age < 2 years.
- 1 Day – 2 Years
- Risk of infection, possible malignancy, and macrophage activation syndrome. No established safety and efficacy age < 2 years.
Management or Monitoring Precaution
Canakinumab
Monitor for infection, possible malignancy, and macrophage activation syndrome.
- 2 Years – 18 Years
- Monitor for infection, possible malignancy, and macrophage activation syndrome.
Canakinumab
- Severity Level:
2
- Additional Notes: Insuff human data avail; animal data sug dev tox at doses >10x mrhd
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Canakinumab
Insufficient human data
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | Insufficient human data |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- None
| Familial cold autoinflammatory syndrome | |
| M04.2 | Cryopyrin-associated periodic syndromes |
| Familial mediterranean fever | |
| M04.1 | Periodic fever syndromes |
| Muckle-wells syndrome | |
| M04.2 | Cryopyrin-associated periodic syndromes |
| Systemic-onset juvenile idiopathic arthritis | |
| M08.2 | Juvenile rheumatoid arthritis with systemic onset |
| M08.20 | Juvenile rheumatoid arthritis with systemic onset, unspecified site |
| M08.21 | Juvenile rheumatoid arthritis with systemic onset, shoulder |
| M08.211 | Juvenile rheumatoid arthritis with systemic onset, right shoulder |
| M08.212 | Juvenile rheumatoid arthritis with systemic onset, left shoulder |
| M08.219 | Juvenile rheumatoid arthritis with systemic onset, unspecified shoulder |
| M08.22 | Juvenile rheumatoid arthritis with systemic onset, elbow |
| M08.221 | Juvenile rheumatoid arthritis with systemic onset, right elbow |
| M08.222 | Juvenile rheumatoid arthritis with systemic onset, left elbow |
| M08.229 | Juvenile rheumatoid arthritis with systemic onset, unspecified elbow |
| M08.23 | Juvenile rheumatoid arthritis with systemic onset, wrist |
| M08.231 | Juvenile rheumatoid arthritis with systemic onset, right wrist |
| M08.232 | Juvenile rheumatoid arthritis with systemic onset, left wrist |
| M08.239 | Juvenile rheumatoid arthritis with systemic onset, unspecified wrist |
| M08.24 | Juvenile rheumatoid arthritis with systemic onset, hand |
| M08.241 | Juvenile rheumatoid arthritis with systemic onset, right hand |
| M08.242 | Juvenile rheumatoid arthritis with systemic onset, left hand |
| M08.249 | Juvenile rheumatoid arthritis with systemic onset, unspecified hand |
| M08.25 | Juvenile rheumatoid arthritis with systemic onset, hip |
| M08.251 | Juvenile rheumatoid arthritis with systemic onset, right hip |
| M08.252 | Juvenile rheumatoid arthritis with systemic onset, left hip |
| M08.259 | Juvenile rheumatoid arthritis with systemic onset, unspecified hip |
| M08.26 | Juvenile rheumatoid arthritis with systemic onset, knee |
| M08.261 | Juvenile rheumatoid arthritis with systemic onset, right knee |
| M08.262 | Juvenile rheumatoid arthritis with systemic onset, left knee |
| M08.269 | Juvenile rheumatoid arthritis with systemic onset, unspecified knee |
| M08.27 | Juvenile rheumatoid arthritis with systemic onset, ankle and foot |
| M08.271 | Juvenile rheumatoid arthritis with systemic onset, right ankle and foot |
| M08.272 | Juvenile rheumatoid arthritis with systemic onset, left ankle and foot |
| M08.279 | Juvenile rheumatoid arthritis with systemic onset, unspecified ankle and foot |
| M08.28 | Juvenile rheumatoid arthritis with systemic onset, vertebrae |
| M08.29 | Juvenile rheumatoid arthritis with systemic onset, multiple sites |
| 0-9 | A-Z |
|---|---|
| M04.1 | Periodic fever syndromes |
| M04.2 | Cryopyrin-associated periodic syndromes |
| M04.2 | Cryopyrin-associated periodic syndromes |
| M08.2 | Juvenile rheumatoid arthritis with systemic onset |
| M08.20 | Juvenile rheumatoid arthritis with systemic onset, unspecified site |
| M08.21 | Juvenile rheumatoid arthritis with systemic onset, shoulder |
| M08.211 | Juvenile rheumatoid arthritis with systemic onset, right shoulder |
| M08.212 | Juvenile rheumatoid arthritis with systemic onset, left shoulder |
| M08.219 | Juvenile rheumatoid arthritis with systemic onset, unspecified shoulder |
| M08.22 | Juvenile rheumatoid arthritis with systemic onset, elbow |
| M08.221 | Juvenile rheumatoid arthritis with systemic onset, right elbow |
| M08.222 | Juvenile rheumatoid arthritis with systemic onset, left elbow |
| M08.229 | Juvenile rheumatoid arthritis with systemic onset, unspecified elbow |
| M08.23 | Juvenile rheumatoid arthritis with systemic onset, wrist |
| M08.231 | Juvenile rheumatoid arthritis with systemic onset, right wrist |
| M08.232 | Juvenile rheumatoid arthritis with systemic onset, left wrist |
| M08.239 | Juvenile rheumatoid arthritis with systemic onset, unspecified wrist |
| M08.24 | Juvenile rheumatoid arthritis with systemic onset, hand |
| M08.241 | Juvenile rheumatoid arthritis with systemic onset, right hand |
| M08.242 | Juvenile rheumatoid arthritis with systemic onset, left hand |
| M08.249 | Juvenile rheumatoid arthritis with systemic onset, unspecified hand |
| M08.25 | Juvenile rheumatoid arthritis with systemic onset, hip |
| M08.251 | Juvenile rheumatoid arthritis with systemic onset, right hip |
| M08.252 | Juvenile rheumatoid arthritis with systemic onset, left hip |
| M08.259 | Juvenile rheumatoid arthritis with systemic onset, unspecified hip |
| M08.26 | Juvenile rheumatoid arthritis with systemic onset, knee |
| M08.261 | Juvenile rheumatoid arthritis with systemic onset, right knee |
| M08.262 | Juvenile rheumatoid arthritis with systemic onset, left knee |
| M08.269 | Juvenile rheumatoid arthritis with systemic onset, unspecified knee |
| M08.27 | Juvenile rheumatoid arthritis with systemic onset, ankle and foot |
| M08.271 | Juvenile rheumatoid arthritis with systemic onset, right ankle and foot |
| M08.272 | Juvenile rheumatoid arthritis with systemic onset, left ankle and foot |
| M08.279 | Juvenile rheumatoid arthritis with systemic onset, unspecified ankle and foot |
| M08.28 | Juvenile rheumatoid arthritis with systemic onset, vertebrae |
| M08.29 | Juvenile rheumatoid arthritis with systemic onset, multiple sites |
Formulary Reference Tool