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PRAMIPEXOLE DIHYDROCHLORIDE (PRAMIPEXOLE DI-HCL)
- Idiopathic parkinsonism
- Restless legs syndrome
0.125 mg tablet
- 1 tablet (0.125 mg) by oral route 3 times per day
0.25 mg tablet
- 1 tablet (0.25 mg) by oral route 3 times per day
0.5 mg tablet
- 1 tablet (0.5 mg) by oral route 3 times per day
0.75 mg tablet
- 1 tablet (0.75 mg) by oral route 3 times per day
1 mg tablet
- 1 tablet (1 mg) by oral route 3 times per day
1.5 mg tablet
- 1 tablet (1.5 mg) by oral route 3 times per day
pramipexole 0.125 mg tablet
- 1 tablet (0.125 mg) by oral route 3 times per day
pramipexole 0.25 mg tablet
- 1 tablet (0.25 mg) by oral route 3 times per day
pramipexole 0.5 mg tablet
- 1 tablet (0.5 mg) by oral route 3 times per day
pramipexole 0.75 mg tablet
- 1 tablet (0.75 mg) by oral route 3 times per day
pramipexole 1 mg tablet
- 1 tablet (1 mg) by oral route 3 times per day
pramipexole 1.5 mg tablet
- 1 tablet (1.5 mg) by oral route 3 times per day
0.125 mg tablet
- 1 tablet (0.125 mg) by oral route 3 times per day
0.25 mg tablet
- 1 tablet (0.25 mg) by oral route 3 times per day
0.5 mg tablet
- 1 tablet (0.5 mg) by oral route 3 times per day
0.75 mg tablet
- 1 tablet (0.75 mg) by oral route 3 times per day
1 mg tablet
- 1 tablet (1 mg) by oral route 3 times per day
1.5 mg tablet
- 1 tablet (1.5 mg) by oral route 3 times per day
0.125 mg tablet
- 1 tablet (0.125 mg) by oral route 3 times per day
0.25 mg tablet
- 1 tablet (0.25 mg) by oral route 3 times per day
0.5 mg tablet
- 1 tablet (0.5 mg) by oral route 3 times per day
0.75 mg tablet
- 1 tablet (0.75 mg) by oral route 3 times per day
1 mg tablet
- 1 tablet (1 mg) by oral route 3 times per day
1.5 mg tablet
- 1 tablet (1.5 mg) by oral route 3 times per day
Idiopathic parkinsonism
- 1 tablet (0.125 mg) by oral route 3 times per day
- 2 tablets (0.25 mg) by oral route 3 times per day
- 1 tablet (0.25 mg) by oral route 3 times per day
- 2 tablets (0.5 mg) by oral route 3 times per day
- 1 tablet (0.5 mg) by oral route 3 times per day
- 1 tablet (0.75 mg) by oral route 3 times per day
- 2 tablets (1 mg) by oral route 3 times per day
- 1 tablet (1 mg) by oral route 3 times per day
- 2 tablets (1.5 mg) by oral route 3 times per day
- 1 tablet (1.5 mg) by oral route 3 times per day
Restless legs syndrome
- 1 tablet (0.125 mg) by oral route 2-3 hours before bedtime
- 2 tablets (0.25 mg) by oral route 2-3 hours before bedtime
- 1 tablet (0.25 mg) by oral route 2-3 hours before bedtime
- 2 tablets (0.5 mg) by oral route 2-3 hours before bedtime
- 1 tablet (0.5 mg) by oral route 2-3 hours before bedtime
- None
Contraindicated
- Abilify
- Abilify Discmelt
- Abilify Maintena
- Adasuve
- aripiprazole
- chlorpromazine
- Compazine
- Compro
- droperidol
- fluphenazine decanoate
- fluphenazine HCl
- Haldol
- Haldol Decanoate
- haloperidol
- haloperidol decanoate
- haloperidol lactate
- loxapine
- loxapine succinate
- Loxitane
- olanzapine
- olanzapine pamoate
- olanzapine-fluoxetine
- Orap
- perphenazine
- perphenazine-amitriptyline
- Phenadoz
- Phenergan
- pimozide
- prochlorperazine
- prochlorperazine Edisylate
- prochlorperazine maleate
- promethazine
- Promethazine Vc
- Promethazine Vc-codeine
- promethazine-codeine
- promethazine-DM
- promethazine-phenyleph-codeine
- promethazine-phenylephrine
- Promethegan
- Symbyax
- thioridazine
- thiothixene
- trifluoperazine
- Zyprexa
- Zyprexa Relprevv
- Zyprexa Zydis
Severe
Moderate
- asenapine
- Geodon
- Invega
- Invega Sustenna
- Latuda
- lurasidone
- paliperidone
- paliperidone palmitate
- quetiapine
- Risperdal
- Risperdal Consta
- Risperdal M-tab
- risperidone
- risperidone microspheres
- Saphris
- Saphris (black Cherry)
- Seroquel
- Seroquel Xr
- ziprasidone HCl
- ziprasidone mesylate
- Lactating mother
Contraindicated
- Chronic kidney disease stage 3A (moderate) GFR 45-59
- Chronic kidney disease stage 3B (moderate) GFR 30-44
- Chronic kidney disease stage 4 (severe) GFR 15-29 ml/min
- Hallucinations
- Narcolepsy syndrome
- Rhabdomyolysis
- Sleep apnea
- Symptomatic orthostatic hypotension
Severe
Moderate
- Drowsy
- Dyskinesia
- Heart failure
- Impulse control disorder
- Kidney disease with likely reduction in GFR
PRAMIPEXOLE DIHYDROCHLORIDE (PRAMIPEXOLE DI-HCL)
- Idiopathic parkinsonism
- Restless legs syndrome
- Dyskinesia
- Extrapyramidal disease
- General weakness
- Nausea
- Orthostatic hypotension
- Anorexia
- Constipation
- Dizziness
- Dream disorder
- Drowsy
- Fatigue
- Gait abnormality
- Hallucinations
- Headache disorder
- Muscle spasm
- Peripheral edema
- Xerostomia
More Frequent
Severe
Less Severe
- Accommodation disorder
- Acute confusion
- Akathisia
- Chest pain
- Fever
- Increased urinary frequency
- Insomnia
- Memory impairment
- Muscle weakness
- Myalgias
- Myoclonus
- Paranoid disorder
- Pneumonia
- Acquired dystonia
- Arthralgias
- Bursitis
- Diplopia
- Dysphagia
- Edema
- Erectile dysfunction
- Hypertension
- Hypertonia
- Hypesthesia
- Libido changes
- Malaise
- Rhinitis
- Skin rash
- Vertigo
- Visual changes
- Weight loss
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Altered mental status
- Delusional disorder
- Dyspnea
- Fibrotic drug-induced cardiac valvulopathy
- Heart failure
- Neuroleptic malignant syndrome
- Pericarditis
- Pleural effusions
- Postural deformity
- Pulmonary fibrosis
- Pulmonary infiltrates
- Retroperitoneal fibrosis
- Rhabdomyolysis
- SIADH syndrome
- Sudden onset of sleep
- Urinary incontinence
Less Severe
- Aggressive behavior
- Agitation
- Behavioral disorders
- Delirium
- Erythema
- Hyperhidrosis
- Impulse control disorder
- Pruritus of skin
- Syncope
- Urinary tract infection
- Urticaria
- Vomiting
- Weight gain
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Pramipexole
Safety and efficacy not established. Risk of compulsive behavior, somnolence.
- 1 Day – 18 Years
- Safety and efficacy not established. Risk of compulsive behavior, somnolence.
Pramipexole
- Severity Level:
2
- Additional Notes: Insuff human data; animal data do not sug dev tox
Contraindicated
Pramipexole
Not recommended; may inhibit prolactin secretion; excreted in rats
| General | Excretion Potential | Effect on Infant | Notes |
| Drug should not be given to breast feeding mothers | Unknown | Not known; no or inclusive data | Not recommended; may inhibit prolactin secretion; excreted in rats |
Precaution Exists
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Pramipexole
Neuro/Psych-Increased risk for hallucinations in the elderly with parkinsonism. Renal-Total drug clearance is 30% lower in elderly. Use caution in dosing. Cardiovascular-Postural hypotension risk.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | Y | N | Y | Y | N | N |
BEERS: N HEDIS: N STOPP: Y
No Known Risk
None
- None
| Idiopathic parkinsonism | |
| G20 | Parkinson's disease |
| Restless legs syndrome | |
| G25.81 | Restless legs syndrome |
| 0-9 | A-Z |
|---|---|
| G20 | Parkinson's disease |
| G25.81 | Restless legs syndrome |
Formulary Reference Tool