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PENTOXIFYLLINE (PENTOXIFYLLINE)
- Intermittent claudication
ER 400 mg tablet,extended release
- 1 tablet (400 mg) by oral route 2 times per day with meals
Intermittent claudication
- 1 tablet (400 mg) by oral route 3 times per day with meals
- 1 tablet (400 mg) by oral route 2 times per day with meals
- ketorolac
- Sprix
Contraindicated
- Acid Reducer (cimetidine)
- Acid Relief (cimetidine)
- Adenocard
- Adenoscan
- adenosine
- adenosine (diagnostic)
- cimetidine
- Heartburn Relief
- Lexiscan
- regadenoson
- Tagamet Hb
Severe
Moderate
- None
- Hemorrhagic stroke
- Retinal hemorrhage
Contraindicated
- None
Severe
Moderate
- Increased risk of bleeding
- Kidney disease with reduction in GFR
PENTOXIFYLLINE (PENTOXIFYLLINE)
- Intermittent claudication
- None
- Dizziness
- Dyspepsia
- Eructation
- Nausea
More Frequent
Severe
Less Severe
- None
- Abdominal distension
- Acute abdominal pain
- Agitation
- Blurred vision
- Diarrhea
- Flushing
- Headache disorder
- Insomnia
- Palpitations
- Vomiting
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal hepatic function tests
- Anaphylaxis
- Angioedema
- Aplastic anemia
- Cardiac arrhythmia
- Chest pain
- Cholecystitis
- Cholestasis
- Hepatitis
- Hypofibrinogenemia
- Jaundice
- Leukopenia
- Non-infective meningitis
- Pancytopenia
- Purpura
- Seizure disorder
- Thrombocytopenic disorder
Less Severe
- Acute confusion
- Anorexia
- Conjunctivitis
- Depression
- Dysgeusia
- Dyspnea
- Earache
- Edema
- Epistaxis
- Flu-like symptoms
- Hypotension
- Laryngitis
- Malaise
- Nasal congestion
- Nervousness
- Onychia sicca
- Pruritus of skin
- Scotomata
- Sialorrhea
- Skin rash
- Sore throat
- Symptoms of anxiety
- Tachycardia
- Urticaria
- Xerostomia
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Pentoxifylline
Safety and efficacy not established.
- 1 Day – 18 Years
- Safety and efficacy not established.
Pentoxifylline
- Severity Level:
C
- Additional Notes:
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Pentoxifylline
Use is not recommended by manufacturer. tumorigenic in animal studies.
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Excreted | Not known; no or inclusive data | Use is not recommended by manufacturer. tumorigenic in animal studies. |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Pentoxifylline
Renal-Elderly have a higher incidence of systemic toxicities due to increased bioavailability and decreased clearance of an active metabolite in renal dysfunction.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | Y | N | N | N | N | N |
BEERS: N HEDIS: N STOPP: N
No Known Risk
None
- None
| Intermittent claudication | |
| I70.21 | Atherosclerosis of native arteries of extremities with intermittent claudication |
| I70.211 | Atherosclerosis of native arteries of extremities with intermittent claudication, right leg |
| I70.212 | Atherosclerosis of native arteries of extremities with intermittent claudication, left leg |
| I70.213 | Atherosclerosis of native arteries of extremities with intermittent claudication, bilateral legs |
| I70.218 | Atherosclerosis of native arteries of extremities with intermittent claudication, other extremity |
| I70.219 | Atherosclerosis of native arteries of extremities with intermittent claudication, unspecified extremity |
| I70.31 | Atherosclerosis of unspecified type of bypass graft(s) of the extremities with intermittent claudication |
| I70.311 | Atherosclerosis of unspecified type of bypass graft(s) of the extremities with intermittent claudication, right leg |
| I70.312 | Atherosclerosis of unspecified type of bypass graft(s) of the extremities with intermittent claudication, left leg |
| I70.313 | Atherosclerosis of unspecified type of bypass graft(s) of the extremities with intermittent claudication, bilateral legs |
| I70.318 | Atherosclerosis of unspecified type of bypass graft(s) of the extremities with intermittent claudication, other extremity |
| I70.319 | Atherosclerosis of unspecified type of bypass graft(s) of the extremities with intermittent claudication, unspecified extremity |
| I70.41 | Atherosclerosis of autologous vein bypass graft(s) of the extremities with intermittent claudication |
| I70.411 | Atherosclerosis of autologous vein bypass graft(s) of the extremities with intermittent claudication, right leg |
| I70.412 | Atherosclerosis of autologous vein bypass graft(s) of the extremities with intermittent claudication, left leg |
| I70.413 | Atherosclerosis of autologous vein bypass graft(s) of the extremities with intermittent claudication, bilateral legs |
| I70.418 | Atherosclerosis of autologous vein bypass graft(s) of the extremities with intermittent claudication, other extremity |
| I70.419 | Atherosclerosis of autologous vein bypass graft(s) of the extremities with intermittent claudication, unspecified extremity |
| I70.51 | Atherosclerosis of nonautologous biological bypass graft(s) of the extremities intermittent claudication |
| I70.511 | Atherosclerosis of nonautologous biological bypass graft(s) of the extremities with intermittent claudication, right leg |
| I70.512 | Atherosclerosis of nonautologous biological bypass graft(s) of the extremities with intermittent claudication, left leg |
| I70.513 | Atherosclerosis of nonautologous biological bypass graft(s) of the extremities with intermittent claudication, bilateral legs |
| I70.518 | Atherosclerosis of nonautologous biological bypass graft(s) of the extremities with intermittent claudication, other extremity |
| I70.519 | Atherosclerosis of nonautologous biological bypass graft(s) of the extremities with intermittent claudication, unspecified extremity |
| I70.61 | Atherosclerosis of nonbiological bypass graft(s) of the extremities with intermittent claudication |
| I70.611 | Atherosclerosis of nonbiological bypass graft(s) of the extremities with intermittent claudication, right leg |
| I70.612 | Atherosclerosis of nonbiological bypass graft(s) of the extremities with intermittent claudication, left leg |
| I70.613 | Atherosclerosis of nonbiological bypass graft(s) of the extremities with intermittent claudication, bilateral legs |
| I70.618 | Atherosclerosis of nonbiological bypass graft(s) of the extremities with intermittent claudication, other extremity |
| I70.619 | Atherosclerosis of nonbiological bypass graft(s) of the extremities with intermittent claudication, unspecified extremity |
| I70.71 | Atherosclerosis of other type of bypass graft(s) of the extremities with intermittent claudication |
| I70.711 | Atherosclerosis of other type of bypass graft(s) of the extremities with intermittent claudication, right leg |
| I70.712 | Atherosclerosis of other type of bypass graft(s) of the extremities with intermittent claudication, left leg |
| I70.713 | Atherosclerosis of other type of bypass graft(s) of the extremities with intermittent claudication, bilateral legs |
| I70.718 | Atherosclerosis of other type of bypass graft(s) of the extremities with intermittent claudication, other extremity |
| I70.719 | Atherosclerosis of other type of bypass graft(s) of the extremities with intermittent claudication, unspecified extremity |
| 0-9 | A-Z |
|---|---|
| I70.21 | Atherosclerosis of native arteries of extremities with intermittent claudication |
| I70.211 | Atherosclerosis of native arteries of extremities with intermittent claudication, right leg |
| I70.212 | Atherosclerosis of native arteries of extremities with intermittent claudication, left leg |
| I70.213 | Atherosclerosis of native arteries of extremities with intermittent claudication, bilateral legs |
| I70.218 | Atherosclerosis of native arteries of extremities with intermittent claudication, other extremity |
| I70.219 | Atherosclerosis of native arteries of extremities with intermittent claudication, unspecified extremity |
| I70.31 | Atherosclerosis of unspecified type of bypass graft(s) of the extremities with intermittent claudication |
| I70.311 | Atherosclerosis of unspecified type of bypass graft(s) of the extremities with intermittent claudication, right leg |
| I70.312 | Atherosclerosis of unspecified type of bypass graft(s) of the extremities with intermittent claudication, left leg |
| I70.313 | Atherosclerosis of unspecified type of bypass graft(s) of the extremities with intermittent claudication, bilateral legs |
| I70.318 | Atherosclerosis of unspecified type of bypass graft(s) of the extremities with intermittent claudication, other extremity |
| I70.319 | Atherosclerosis of unspecified type of bypass graft(s) of the extremities with intermittent claudication, unspecified extremity |
| I70.41 | Atherosclerosis of autologous vein bypass graft(s) of the extremities with intermittent claudication |
| I70.411 | Atherosclerosis of autologous vein bypass graft(s) of the extremities with intermittent claudication, right leg |
| I70.412 | Atherosclerosis of autologous vein bypass graft(s) of the extremities with intermittent claudication, left leg |
| I70.413 | Atherosclerosis of autologous vein bypass graft(s) of the extremities with intermittent claudication, bilateral legs |
| I70.418 | Atherosclerosis of autologous vein bypass graft(s) of the extremities with intermittent claudication, other extremity |
| I70.419 | Atherosclerosis of autologous vein bypass graft(s) of the extremities with intermittent claudication, unspecified extremity |
| I70.51 | Atherosclerosis of nonautologous biological bypass graft(s) of the extremities intermittent claudication |
| I70.511 | Atherosclerosis of nonautologous biological bypass graft(s) of the extremities with intermittent claudication, right leg |
| I70.512 | Atherosclerosis of nonautologous biological bypass graft(s) of the extremities with intermittent claudication, left leg |
| I70.513 | Atherosclerosis of nonautologous biological bypass graft(s) of the extremities with intermittent claudication, bilateral legs |
| I70.518 | Atherosclerosis of nonautologous biological bypass graft(s) of the extremities with intermittent claudication, other extremity |
| I70.519 | Atherosclerosis of nonautologous biological bypass graft(s) of the extremities with intermittent claudication, unspecified extremity |
| I70.61 | Atherosclerosis of nonbiological bypass graft(s) of the extremities with intermittent claudication |
| I70.611 | Atherosclerosis of nonbiological bypass graft(s) of the extremities with intermittent claudication, right leg |
| I70.612 | Atherosclerosis of nonbiological bypass graft(s) of the extremities with intermittent claudication, left leg |
| I70.613 | Atherosclerosis of nonbiological bypass graft(s) of the extremities with intermittent claudication, bilateral legs |
| I70.618 | Atherosclerosis of nonbiological bypass graft(s) of the extremities with intermittent claudication, other extremity |
| I70.619 | Atherosclerosis of nonbiological bypass graft(s) of the extremities with intermittent claudication, unspecified extremity |
| I70.71 | Atherosclerosis of other type of bypass graft(s) of the extremities with intermittent claudication |
| I70.711 | Atherosclerosis of other type of bypass graft(s) of the extremities with intermittent claudication, right leg |
| I70.712 | Atherosclerosis of other type of bypass graft(s) of the extremities with intermittent claudication, left leg |
| I70.713 | Atherosclerosis of other type of bypass graft(s) of the extremities with intermittent claudication, bilateral legs |
| I70.718 | Atherosclerosis of other type of bypass graft(s) of the extremities with intermittent claudication, other extremity |
| I70.719 | Atherosclerosis of other type of bypass graft(s) of the extremities with intermittent claudication, unspecified extremity |
Formulary Reference Tool