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THIORIDAZINE HCL (THIORIDAZINE HCL)
- Treatment-resistant schizophrenia
thioridazine 10 mg tablet
- 2 tablets (20 mg) by oral route 3 times per day
thioridazine 100 mg tablet
- 1 tablet (100 mg) by oral route 2 times per day
thioridazine 25 mg tablet
- 1 tablet (25 mg) by oral route 3 times per day
thioridazine 50 mg tablet
- 1 tablet (50 mg) by oral route 2 times per day
Treatment-resistant schizophrenia
- 2 tablets (20 mg) by oral route 3 times per day
- 2 tablets (20 mg) by oral route 4 times per day
- 1 tablet (25 mg) by oral route 3 times per day
- 1 tablet (25 mg) by oral route 4 times per day
- 1 tablet (50 mg) by oral route 2 times per day
- 1 tablet (50 mg) by oral route 3 times per day
- 2 tablets (50 mg) by oral route 2 times per day
- 2 tablets (50 mg) by oral route 3 times per day
- 2 tablets (50 mg) by oral route 4 times per day
- 1 tablet (50 mg) by oral route 4 times per day
- 2 tablets (100 mg) by oral route 4 times per day
- 2 tablets (100 mg) by oral route 3 times per day
- 2 tablets (100 mg) by oral route 2 times per day
- 1 tablet (100 mg) by oral route 3 times per day
- 1 tablet (100 mg) by oral route 2 times per day
- 1 tablet (100 mg) by oral route 4 times per day
- 2 tablets (200 mg) by oral route 2 times per day
- 2 tablets (200 mg) by oral route 3 times per day
- 2 tablets (200 mg) by oral route 4 times per day
- artemether-lumefantrine
- Brisdelle
- Coartem
- Cymbalta
- disopyramide
- dronedarone
- droperidol
- duloxetine
- fluoxetine
- fluvoxamine
- Geodon
- Inderal La
- Inderal Xl
- Innopran Xl
- Luvox Cr
- metoclopramide HCl
- Metozolv Odt
- Multaq
- Norpace
- Norpace Cr
- olanzapine-fluoxetine
- Orap
- paroxetine HCl
- paroxetine mesylate
- Paxil
- Paxil Cr
- Pexeva
- pimozide
- pindolol
- propranolol
- propranolol-hydrochlorothiazid
- Prozac
- Prozac Weekly
- Reglan
- Sarafem
- Symbyax
- ziprasidone HCl
- ziprasidone mesylate
Contraindicated
- abiraterone
- Advair Diskus
- Advair Hfa
- alfuzosin
- Aloxi
- amantadine HCl
- amiodarone
- amiodarone in dextrose,iso-osm
- amitriptyline
- amitriptyline-chlordiazepoxide
- Anafranil
- Anzemet
- Apokyn
- apomorphine
- arformoterol
- arsenic trioxide
- Astagraf Xl
- atazanavir
- Avelox
- Avelox Abc Pack
- Avelox In Nacl (iso-osmotic)
- bedaquiline
- Betapace
- Betapace Af
- Brovana
- budesonide-formoterol
- cabergoline
- Caprelsa
- carbidopa-levodopa
- carbidopa-levodopa-entacapone
- Cardene Iv
- Cardene Iv In Dextrose
- Cardene Iv In Sodium Chloride
- Cardene Sr
- Celexa
- chloroquine phosphate
- chlorpromazine
- citalopram
- clomipramine
- clozapine
- Clozaril
- Comtan
- Cordarone
- Corvert
- crizotinib
- dasatinib
- desipramine
- dextromethorphan-quinidine
- Diflucan
- Diskets
- dofetilide
- dolasetron
- Dolophine
- doxepin
- Dulera
- Effexor Xr
- entacapone
- Eovist
- escitalopram oxalate
- Fareston
- Fazaclo
- felbamate
- Felbatol
- flecainide
- fluconazole
- fluconazole in dextrose(iso-o)
- fluconazole in NaCl (iso-osm)
- fluticasone-salmeterol
- Foradil Aerolizer
- formoterol fumarate
- foscarnet
- Foscavir
- gadoxetate
- granisetron
- granisetron (PF)
- Granisol
- guanfacine
- Haldol
- Haldol Decanoate
- haloperidol
- haloperidol decanoate
- haloperidol lactate
- Hecoria
- ibutilide fumarate
- imipramine HCl
- imipramine pamoate
- indapamide
- Intuniv Er
- Invega
- Invega Sustenna
- isradipine
- Kaletra
- Ketek
- lapatinib
- Levaquin
- Levaquin In 5 % Dextrose
- Levitra
- levofloxacin
- levofloxacin in D5W
- Lexapro
- lithium carbonate
- lithium citrate
- Lithobid
- lopinavir-ritonavir
- methadone
- Methadone Intensol
- Methadose
- mirabegron
- Mirapex
- Mirapex Er
- moexipril
- moexipril-hydrochlorothiazide
- mometasone-formoterol
- moxifloxacin
- moxifloxacin in NaCl (iso-osm)
- Myrbetriq
- Nebupent
- Nexterone
- nicardipine
- nicardipine in dextrose,iso-os
- nicardipine in NaCl (iso-os)
- nilotinib
- norfloxacin
- Noroxin
- Norpramin
- nortriptyline
- Noxafil
- Nuedexta
- octreotide acetate
- ofloxacin
- ondansetron
- ondansetron HCl
- ondansetron HCl (PF)
- Pacerone
- paliperidone
- paliperidone palmitate
- palonosetron
- Pamelor
- pasireotide
- Pentam
- pentamidine
- Perforomist
- perphenazine-amitriptyline
- posaconazole
- pramipexole
- procainamide
- Prograf
- Qualaquin
- quetiapine
- quinidine gluconate
- quinidine sulfate
- quinine sulfate
- Requip
- Requip Xl
- Reyataz
- Risperdal
- Risperdal Consta
- Risperdal M-tab
- risperidone
- risperidone microspheres
- ropinirole
- salmeterol
- Sancuso
- Sandostatin
- Sandostatin Lar Depot
- Serevent Diskus
- Seroquel
- Seroquel Xr
- sertraline
- Signifor
- Silenor
- Sinemet
- Sinemet Cr
- Sirturo
- sodium oxybate
- Soltamox
- Sorine
- sotalol
- Sotalol Af
- Sprycel
- Stalevo 100
- Stalevo 125
- Stalevo 150
- Stalevo 200
- Stalevo 50
- Stalevo 75
- sunitinib
- Sutent
- Symbicort
- tacrolimus
- tamoxifen
- Tasigna
- telavancin
- telithromycin
- Tenex
- tetrabenazine
- Tikosyn
- tizanidine
- Tofranil
- Tofranil-pm
- toremifene
- Trisenox
- Tykerb
- Uniretic
- Univasc
- Uroxatral
- vandetanib
- vardenafil
- vemurafenib
- venlafaxine
- Versacloz
- Vfend
- Vfend Iv
- Vibativ
- voriconazole
- Xalkori
- Xenazine
- Xyrem
- Zanaflex
- Zelboraf
- Zofran
- Zofran Odt
- Zoloft
- Zuplenz
- Zytiga
Severe
Moderate
- Alagesic Lq
- amobarbital
- Amytal
- Anaspaz
- Aplenzin
- Ascomp With Codeine
- Atropen
- atropine
- belladonna alkaloids-opium
- Belladonna-opium
- Belladonna-phenobarbital
- Bentyl
- benztropine
- Bupap
- Buproban
- bupropion HBr
- bupropion HCl
- butabarbital
- Butalbital Compound W/codeine
- Butalbital Compound-codeine
- butalbital-acetaminop-caf-cod
- butalbital-acetaminophen
- butalbital-acetaminophen-caff
- butalbital-aspirin-caffeine
- Butisol
- Cantil
- Capacet
- chlordiazepoxide-clidinium
- chlorphen-pseudoeph-bellad alk
- codeine-butalbital-ASA-caff
- Cogentin
- Complera
- Cuvposa
- dicyclomine
- diphenoxylate-atropine
- Ditropan Xl
- Donnatal
- Duodote
- Ed-spaz
- edrophonium Cl-atropine
- Edurant
- emtricitab-rilpivirine-tenofov
- Enlon-plus
- Esgic
- fingolimod
- Fioricet
- Fioricet With Codeine
- Fiorinal
- Fiorinal-codeine #3
- flavoxate
- Forfivo Xl
- Gelnique
- Gilenya
- Glycate
- glycopyrrolate
- Hydrocodone Compound
- hydrocodone-homatropine
- Hydromet
- Hyophen
- hyoscyamine sulfate
- Hyosyne
- Levbid
- Levsin
- Levsin/sl
- Librax (with Clidinium)
- Lomotil
- Luminal
- Margesic
- Marten-tab
- mepenzolate bromide
- methen-hyos-me blue-ba-salicyl
- methen-hyosc-m.blue-sal-naphos
- methen-sod phos-meth blue-hyos
- methscopolamine
- mth-me blue-sod phos-phsal-hyo
- Mysoline
- Nembutal Sodium
- Nulev
- Oscimin
- Oscimin Sl
- Oscimin Sr
- oxybutynin
- oxybutynin chloride
- Oxytrol
- Oxytrol For Women
- Pamine
- Pamine Forte
- pazopanib
- pentobarbital sodium
- phenobarb-hyoscy-atropine-scop
- phenobarbital
- phenobarbital sodium
- Phosphasal
- pralidoxime-atropine
- primidone
- propantheline
- Prosed/ds (atropine Free)
- Respa-ar
- rilpivirine
- Robinul
- Robinul Forte
- scopolamine base
- scopolamine HBr
- secobarbital sodium
- Seconal Sodium
- Symax Duotab
- Symax Fastabs
- Symax-sl
- Symax-sr
- Tencon
- Transderm-scop
- trihexyphenidyl
- Tussigon
- Ur N-c
- Urelle
- Uretron D-s
- Uribel
- Urimar-t
- Urin Ds
- Urogesic-blue
- Uryl
- Ustell
- Uta
- Votrient
- Wellbutrin
- Wellbutrin Sr
- Wellbutrin Xl
- Zebutal
- Zyban
- Coma
- Congenital long QT syndrome
- CYp2d6 poor metabolizer
- Neuroleptic malignant syndrome
- Prolonged QT interval
- Torsades de pointes
Contraindicated
- Bradycardia
- Hypokalemia
- Hypomagnesemia
- Pregnancy
- Senile dementia
- Tardive dyskinesia
Severe
Moderate
- Neutropenic disorder
- Orthostatic hypotension
- Seizure disorder
THIORIDAZINE HCL (THIORIDAZINE HCL)
- Treatment-resistant schizophrenia
- Akathisia
- Blurred vision
- Extrapyramidal disease
- Hypotension
- Pigmentary retinopathy
- Syncope
- Tardive dyskinesia
- Constipation
- Decreased sweating
- Dizziness
- Drowsy
- Nasal congestion
- Orthostatic hypotension
- Sialorrhea
- Xerostomia
More Frequent
Severe
Less Severe
- Contact dermatitis
- Dysuria
- Skin photosensitivity
- Abnormal sexual function
- Breast engorgement
- Fever
- Galactorrhea not associated with childbirth
- Irregular menstrual periods
- Mastalgia
- Weight gain
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Agranulocytosis
- Heat stroke
- Hypothermia
- Leukopenia
- Melanosis
- Neuroleptic malignant syndrome
- Neutropenic disorder
- Obstructive hyperbilirubinemia
- Priapism
- Prolonged QT interval
- Seizure disorder
- Torsades de pointes
- Visual changes
Less Severe
- Photophobia
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Thioridazine Hydrochloride
Safety and efficacy not established age <2 years.
- 1 Day – 2 Years
- Safety and efficacy not established age <2 years.
Thioridazine Hydrochloride
- Severity Level:
D
- Additional Notes: No fda category; insufficient human data available
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Thioridazine
Low amnt excr w/similar drug chlorpromazine, resulting in infant drowsiness
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | Low amnt excr w/similar drug chlorpromazine, resulting in infant drowsiness |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
Thioridazine
Neuro/Psych-Generally avoid in the elderly. Higher risk of tardive dyskinesia. Anticholinergic effects cause sedation, worsen cognitive impairment and increase fall risk. Increased risk of death in senile dementia. Cardiovascular-May cause orthostatic hypotension, syncope, bradycardia. Risk for QT prolongation. Gastrointestinal-May cause or worsen pre-existing constipation. Genitourinary-Best avoided in patients with urinary retention from any cause.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | Y | Y | Y | Y | N | N |
BEERS: Y HEDIS: Y STOPP: Y
Precaution Exists
None
No Known Risk
None
- Thioridazine rarely has caused very serious (possibly fatal) irregular heartbeat (QT prolongation in the EKG). Therefore, it should be used only in patients who have not shown improvement with at least 2 other antipsychotic medications or who cannot tolerate other antipsychotic medications. This medication should not be used with other medications that can also cause a slow or irregular heartbeat.<br /><br />(See also Drug Interactions.) There may be a slightly increased risk of serious, possibly fatal side effects (such as heart failure, fast/irregular heartbeat, pneumonia) when this medication is used by older adults with dementia. This medication is not approved for the treatment of dementia-related behavior problems. Discuss the risks and benefits of this medication, as well as other effective and possibly safer treatments for dementia-related behavior problems, with the doctor.
| Treatment-resistant schizophrenia | |
| F20 | Schizophrenia |
| F20.0 | Paranoid schizophrenia |
| F20.1 | Disorganized schizophrenia |
| F20.2 | Catatonic schizophrenia |
| F20.3 | Undifferentiated schizophrenia |
| F20.5 | Residual schizophrenia |
| F20.8 | Other schizophrenia |
| F20.81 | Schizophreniform disorder |
| F20.89 | Other schizophrenia |
| F20.9 | Schizophrenia, unspecified |
| 0-9 | A-Z |
|---|---|
| F20 | Schizophrenia |
| F20.0 | Paranoid schizophrenia |
| F20.1 | Disorganized schizophrenia |
| F20.2 | Catatonic schizophrenia |
| F20.3 | Undifferentiated schizophrenia |
| F20.5 | Residual schizophrenia |
| F20.8 | Other schizophrenia |
| F20.81 | Schizophreniform disorder |
| F20.89 | Other schizophrenia |
| F20.9 | Schizophrenia, unspecified |
Formulary Reference Tool