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LEVSIN (HYOSCYAMINE SULFATE)
- Gastrointestinal radiography adjunct
- Sinus bradycardia
- Cholinesterase inhibitors toxicity
- Muscarine toxicity
- Sialorrhea
0.125 mg tablet
- 1 tablet (0.125 mg) by oral route every 4 hours as needed
0.125 mg tablet
- 1 tablet (0.125 mg) by oral route every 4 hours as needed
0.5 mg/mL injection solution
- Inject 0.005 mg/kg by subcutaneous route once 30-60 minutes before anesthesia induction
0.125 mg tablet
- 1 tablet (0.125 mg) by oral route every 4 hours as needed
Gastrointestinal radiography adjunct
- Inject 0.5 milliliter (0.25 mg) by intravenous route once 5-10 minutes before procedure
- Inject 1 milliliter (0.5 mg) by intravenous route once 5-10 minutes before procedure
Irritable bowel syndrome
- 1 tablet (0.125 mg) by oral route every 4 hours as needed
- 1 tablet (0.125 mg) by oral route every 4 hours
- 1 tablet (0.125 mg) by oral route 3 times per day
- 1 tablet (0.125 mg) by oral route 4 times per day
- 2 tablets (0.25 mg) by oral route 3 times per day
- 2 tablets (0.25 mg) by oral route 4 times per day
- 2 tablets (0.25 mg) by oral route every 4 hours
- 2 tablets (0.25 mg) by oral route every 4 hours as needed
Neurogenic bladder
- 1 tablet (0.125 mg) by oral route every 4 hours as needed
- 1 tablet (0.125 mg) by oral route every 4 hours
- 1 tablet (0.125 mg) by oral route 3 times per day
- 1 tablet (0.125 mg) by oral route 4 times per day
- 2 tablets (0.25 mg) by oral route 3 times per day
- 2 tablets (0.25 mg) by oral route 4 times per day
- 2 tablets (0.25 mg) by oral route every 4 hours
- 2 tablets (0.25 mg) by oral route every 4 hours as needed
Sialorrhea
- Inject 0.005 mg/kg by subcutaneous route once 30-60 minutes before anesthesia induction
- Inject 0.005 mg/kg by intravenous route once 30-60 minutes before anesthesia induction
- Inject 0.005 mg/kg by intramuscular route once 30-60 minutes before anesthesia induction
- pramlintide
- Symlinpen 120
- Symlinpen 60
Contraindicated
- K-tab
- Klor-con
- Klor-con 10
- Klor-con M10
- Klor-con M15
- Klor-con M20
- Medi-lyte
- potassium chloride
- potassium citrate
- potassium Cl-calcium phos-mag
- sodium Cl-potassium chloride
- Thermotabs
- Urocit-k 10
- Urocit-k 15
- Urocit-k 5
Severe
Moderate
- Adasuve
- chlorpromazine
- Compazine
- Compro
- fluphenazine decanoate
- fluphenazine HCl
- Haldol
- Haldol Decanoate
- haloperidol
- haloperidol decanoate
- haloperidol lactate
- itraconazole
- ketoconazole
- loxapine
- loxapine succinate
- Loxitane
- Onmel
- perphenazine
- perphenazine-amitriptyline
- Phenadoz
- Phenergan
- prochlorperazine
- prochlorperazine Edisylate
- prochlorperazine maleate
- promethazine
- Promethazine Vc
- Promethazine Vc-codeine
- promethazine-codeine
- promethazine-DM
- promethazine-phenyleph-codeine
- promethazine-phenylephrine
- Promethegan
- Sporanox
- Sporanox Pulsepak
- thioridazine
- trifluoperazine
- Achalasia of esophagus
- Atony of colon
- Benign prostatic hyperplasia
- Bladder outflow obstruction
- Glaucoma
- Hypovolemic shock
- Myasthenia gravis
- Paralytic ileus
- Pyloroduodenal obstruction
- Severe ulcerative colitis
- Toxic megacolon
Contraindicated
- None
Severe
Moderate
- Autonomic neuropathy
- Cardiac arrhythmia
- Chronic heart failure
- Coronary artery disease
- Gastroesophageal reflux disease
- Hiatal hernia
- High fever >101 degrees fahrenheit
- Hypertension
- Hyperthyroidism
- Kidney disease with reduction in GFR
LEVSIN (HYOSCYAMINE SULFATE)
- Gastrointestinal radiography adjunct
- Sinus bradycardia
- Cholinesterase inhibitors toxicity
- Muscarine toxicity
- Sialorrhea
- None
- Blurred vision
- Decreased sweating
More Frequent
Severe
Less Severe
- None
- Breast milk flow decreased
- Constipation
- Mydriasis
- Xerostomia
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Acute confusion
- Allergic dermatitis
- Ocular hypertension
- Orthostatic hypotension
- Skin rash
- Urticaria
Less Severe
- Dizziness
- Drowsy
- Dysuria
- Fatigue
- Flatulence
- General weakness
- Headache disorder
- Memory impairment
- Nausea
- Vomiting
Contraindicated
None
Severe Precaution
Hyoscyamine
Infants and children are more sensitive to anticholinergic and adverse effects.
- 1 Day – 13 Years
- Infants and children are more sensitive to anticholinergic and adverse effects.
Management or Monitoring Precaution
None
Hyoscyamine
- Severity Level:
C
- Additional Notes:
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Hyoscyamine
Trace amt excreted,not recom per mfr;Neonates sensitive to antichlolinergics
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Excreted | Not known; no or inclusive data | Trace amt excreted,not recom per mfr;Neonates sensitive to antichlolinergics |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Hyoscyamine
Neuro/Psych-Anticholinergic effects may cause sedation, worsen cognitive impairment and increase fall risk. Non-sedating agents preferred. Gastrointestinal-Avoid with gastrointestinal ileus. May cause or worsen pre-existing constipation. Genitourinary-Best avoided in patients with urinary retention from any cause.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | Y | N | N | Y | N | N |
BEERS: Y HEDIS: Y STOPP: Y
No Known Risk
None
- None
| Cholinesterase inhibitors toxicity | |
| T44.0x1A | Poisoning by anticholinesterase agents, accidental (unintentional), initial encounter |
| T44.0x2A | Poisoning by anticholinesterase agents, intentional self-harm, initial encounter |
| T44.0x3A | Poisoning by anticholinesterase agents, assault, initial encounter |
| T44.0x4A | Poisoning by anticholinesterase agents, undetermined, initial encounter |
| Muscarine toxicity | |
| T44.1x1A | Poisoning by other parasympathomimetics [cholinergics], accidental (unintentional), initial encounter |
| T44.1x2A | Poisoning by other parasympathomimetics [cholinergics], intentional self-harm, initial encounter |
| T44.1x3A | Poisoning by other parasympathomimetics [cholinergics], assault, initial encounter |
| T44.1x4A | Poisoning by other parasympathomimetics [cholinergics], undetermined, initial encounter |
| Sialorrhea | |
| K11.7 | Disturbances of salivary secretion |
| Sinus bradycardia | |
| P29.12 | Neonatal bradycardia |
| R00.1 | Bradycardia, unspecified |
| 0-9 | A-Z |
|---|---|
| K11.7 | Disturbances of salivary secretion |
| P29.12 | Neonatal bradycardia |
| R00.1 | Bradycardia, unspecified |
| T44.0x1A | Poisoning by anticholinesterase agents, accidental (unintentional), initial encounter |
| T44.0x2A | Poisoning by anticholinesterase agents, intentional self-harm, initial encounter |
| T44.0x3A | Poisoning by anticholinesterase agents, assault, initial encounter |
| T44.0x4A | Poisoning by anticholinesterase agents, undetermined, initial encounter |
| T44.1x1A | Poisoning by other parasympathomimetics [cholinergics], accidental (unintentional), initial encounter |
| T44.1x2A | Poisoning by other parasympathomimetics [cholinergics], intentional self-harm, initial encounter |
| T44.1x3A | Poisoning by other parasympathomimetics [cholinergics], assault, initial encounter |
| T44.1x4A | Poisoning by other parasympathomimetics [cholinergics], undetermined, initial encounter |
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