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URELLE (METHENAMINE/METHYLENE BLUE/SOD PHOS/P.SALICYLATE/HYOSCYAMINE)
81 mg-10.8 mg-40.8 mg tablet
- Dosage information is not available
81 mg-10.8 mg-40.8 mg tablet
- Dosage information is not available
81 mg-10.8 mg-40.8 mg tablet
- Dosage information is not available
- acetazolamide
- acetazolamide sodium
- Azulfidine
- Azulfidine En-tabs
- Bactrim
- Bactrim Ds
- Diamox Sequels
- erythromycin-sulfisoxazole
- ketorolac
- methazolamide
- Neptazane
- pramlintide
- Sprix
- sulfadiazine
- sulfamethoxazole-trimethoprim
- sulfasalazine
- Sulfatrim
- Sulfazine
- Sulfazine Ec
- Symlinpen 120
- Symlinpen 60
Contraindicated
- Coumadin
- flu vac,qval 2013-14 (2-49yrs)
- Flumist 2013-2014
- Jantoven
- K-tab
- Klor-con
- Klor-con 10
- Klor-con M10
- Klor-con M15
- Klor-con M20
- Medi-lyte
- potassium chloride
- potassium citrate
- potassium Cl-calcium phos-mag
- sodium Cl-potassium chloride
- Thermotabs
- Urocit-k 10
- Urocit-k 15
- Urocit-k 5
- varicella virus vacc live (PF)
- Varivax (pf)
- warfarin
Severe
Moderate
- Adasuve
- Amaryl
- Arixtra
- chlorpromazine
- colchicine-probenecid
- Compazine
- Compro
- dalteparin (porcine)
- Diabeta
- Duetact
- Elmiron
- enoxaparin
- fluphenazine decanoate
- fluphenazine HCl
- fondaparinux
- Fragmin
- glimepiride
- glipizide
- glipizide-metformin
- Glucotrol
- Glucotrol Xl
- Glucovance
- glyburide
- glyburide micronized
- glyburide-metformin
- Glynase
- Haldol
- Haldol Decanoate
- haloperidol
- haloperidol decanoate
- haloperidol lactate
- heparin (porcine)
- heparin (porcine) in D5W
- heparin(porcine) in 0.45% NaCl
- heparin, porcine (PF)
- itraconazole
- ketoconazole
- Lovenox
- loxapine
- loxapine succinate
- Loxitane
- nateglinide
- Onmel
- pentosan polysulfate sodium
- perphenazine
- perphenazine-amitriptyline
- Phenadoz
- Phenergan
- pioglitazone-glimepiride
- probenecid
- prochlorperazine
- prochlorperazine Edisylate
- prochlorperazine maleate
- promethazine
- Promethazine Vc
- Promethazine Vc-codeine
- promethazine-codeine
- promethazine-DM
- promethazine-phenyleph-codeine
- promethazine-phenylephrine
- Promethegan
- Sporanox
- Sporanox Pulsepak
- Starlix
- thioridazine
- tolazamide
- tolbutamide
- trifluoperazine
- Achalasia of esophagus
- Aspirin exacerbated respiratory disease
- Atony of colon
- Benign prostatic hyperplasia
- Bladder outflow obstruction
- Gastrointestinal hemorrhage
- Glaucoma
- Glucose-6-phosphate dehydrogenase (g6Pd) deficiency
- Hemolytic anemia from PK and g6PD deficiencies
- Hemophilia
- Hypernatremia
- Hyperphosphatemia
- Hypocalcemia
- Hypovolemic shock
- Increased risk of bleeding due to coagulation disorder
- Lactating mother
- Myasthenia gravis
- Paralytic ileus
- Pregnancy
- Pyloroduodenal obstruction
- Severe dehydration
- Severe hepatic disease
- Severe renal impairment
- Severe ulcerative colitis
- Toxic megacolon
Contraindicated
- Chronic heart failure
- Edema
- Gastritis
- Gastroesophageal reflux disease
- Gastrointestinal ulcer
- Hypoprothrombinemia
- Increased cardiovascular event risk
- Increased risk of bleeding
- Kidney disease with reduction in GFR
- Nasal polyp
- Pregnancy
- Severe hepatic disease
- Severe renal impairment
- Thrombotic thrombocytopenic purpura
- Vitamin K deficiency
Severe
Moderate
- Abnormal hepatic function tests
- Anemia
- Autonomic neuropathy
- Cardiac arrhythmia
- Chronic heart failure
- Coronary artery disease
- Diabetes mellitus
- Disease of liver
- Edema
- Gastroesophageal reflux disease
- Hepatic cirrhosis
- Hiatal hernia
- High fever >101 degrees fahrenheit
- Hypertension
- Hyperthyroidism
- Kidney disease with reduction in GFR
- Severe hepatic disease
- Thyrotoxicosis
URELLE (METHENAMINE/METHYLENE BLUE/SOD PHOS/P.SALICYLATE/HYOSCYAMINE)
- None
- Blurred vision
- Decreased sweating
- Urine discoloration
More Frequent
Severe
Less Severe
- Skin rash
- Abdominal pain with cramps
- Breast milk flow decreased
- Constipation
- Diarrhea
- Dyspepsia
- Increased urinary frequency
- Mydriasis
- Nausea
- Nausea and vomiting
- Vomiting
- Xerostomia
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Acute confusion
- Allergic dermatitis
- Cardiac arrhythmia
- Dyspnea
- Hematuria
- Hypernatremia
- Hyperphosphatemia
- Hypocalcemia
- Nephrocalcinosis
- Ocular hypertension
- Oliguria
- Orthostatic hypotension
- Renal failure
- Seizure disorder
- Skin rash
- Urticaria
Less Severe
- Acute abdominal pain
- Acute confusion
- Arthralgias
- Bone pain
- Cramps
- Dizziness
- Drowsy
- Dysuria
- Fatigue
- Fever
- Flatulence
- General weakness
- Headache disorder
- Memory impairment
- Nausea
- Oral paresthesia
- Paresthesia
- Peripheral edema
- Polydipsia
- Pruritus of skin
- Vomiting
- Weight gain
Contraindicated
Phenyl Salicylate (Salol)
Do not use in viral illness due to possible increase risk of Reye syndrome.
- 1 Day – 18 Years
- 1 Do not use in viral illness due to possible increase risk of Reye syndrome.
Severe Precaution
Hyoscyamine
Infants and children are more sensitive to anticholinergic and adverse effects.
- 1 Day – 13 Years
- Infants and children are more sensitive to anticholinergic and adverse effects.
Management or Monitoring Precaution
None
Hyoscyamine
- Severity Level:
C
- Additional Notes:
Methenamine
- Severity Level:
C
- Additional Notes:
Methylene Blue
- Severity Level:
D
- Additional Notes: Serious fetal/neonatal adverse effects with intra-amniotic admin
Salicylates
- Severity Level:
1
- Additional Notes: Salicylates not recommended especially in 3rd trimester/near term
Contraindicated
Salicylates
One report of metabol acidosis w/asa;Risk of reye's syn w/viral illness/fever
| General | Excretion Potential | Effect on Infant | Notes |
| Drug should not be given to breast feeding mothers | Excreted | Not known; no or inclusive data | One report of metabol acidosis w/asa;Risk of reye's syn w/viral illness/fever |
Precaution Exists
Hyoscyamine
Trace amt excreted,not recom per mfr;Neonates sensitive to antichlolinergics
Insufficient data available
Insufficient data available; should not be used if infant has g6Pd deficiency
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Excreted | Not known; no or inclusive data | Trace amt excreted,not recom per mfr;Neonates sensitive to antichlolinergics |
Methenamine
Trace amt excreted,not recom per mfr;Neonates sensitive to antichlolinergics
Insufficient data available
Insufficient data available; should not be used if infant has g6Pd deficiency
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Excreted | Not known; no or inclusive data | Insufficient data available |
Methylene Blue
Trace amt excreted,not recom per mfr;Neonates sensitive to antichlolinergics
Insufficient data available
Insufficient data available; should not be used if infant has g6Pd deficiency
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | Insufficient data available; should not be used if infant has g6Pd deficiency |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Hyoscyamine
Neuro/Psych-Anticholinergic effects may cause sedation, worsen cognitive impairment and increase fall risk. Non-sedating agents preferred. Gastrointestinal-Avoid with gastrointestinal ileus. May cause or worsen pre-existing constipation. Genitourinary-Best avoided in patients with urinary retention from any cause.
General-Elderly have a higher incidence of systemic toxicities. Dose reduction may be needed.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | Y | N | N | Y | N | N |
BEERS: Y HEDIS: Y STOPP: Y
Phenyl Salicylate (salol)
Neuro/Psych-Anticholinergic effects may cause sedation, worsen cognitive impairment and increase fall risk. Non-sedating agents preferred. Gastrointestinal-Avoid with gastrointestinal ileus. May cause or worsen pre-existing constipation. Genitourinary-Best avoided in patients with urinary retention from any cause.
General-Elderly have a higher incidence of systemic toxicities. Dose reduction may be needed.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | Y | N | N | Y | N | N |
BEERS: N HEDIS: N STOPP: N
No Known Risk
None
- None
Formulary Reference Tool