OXYCODONE-ACETAMINOPHEN (OXYCODONE HCL/ACETAMINOPHEN)

Moderate

• Acid Reducer (cimetidine)

• Acid Relief (cimetidine)

• aprepitant

• atazanavir

• Buprenex

• buprenorphine

• buprenorphine-naloxone

• butorphanol tartrate

• Butrans

• Calan

• Calan Sr

• Cardizem

• Cardizem Cd

• Cardizem La

• Cartia Xt

• cimetidine

• Cipro

• Cipro In D5W

• Cipro Xr

• ciprofloxacin

• ciprofloxacin (mixture)

• ciprofloxacin in D5W

• Coumadin

• darunavir

• Dilacor Xr

• Dilt-xr

• diltiazem HCl

• dronedarone

• Emend

• Fanatrex

• fosamprenavir

• fosaprepitant

• gabapentin

• gabapentin enacarbil

• Gleevec

• Gralise

• Gralise 30-day Starter Pack

• Heartburn Relief

• Horizant

• imatinib

• isoniazid

• isoniazid-rifamp-pyrazinamide

• Jantoven

• Lexiva

• Matzim La

• Multaq

• nalbuphine

• Neurontin

• Prezista

• Reyataz

• Rifadin

• Rifamate

• rifampin

• rifampin-isoniazid

• Rifater

• Suboxone

• Tagamet Hb

• Tarka

• Taztia Xt

• Tiazac

• trandolapril-verapamil

• verapamil

• Verelan

• Verelan Pm

• warfarin

• Zubsolv

Moderate

• Acute abdominal pain

• Biliary spasm

• Constipation

• Disease of liver

• Drug dependence

• Gallbladder disease

• Kidney disease with reduction in GFR

• Mood changes

• Untreated hypothyroidism

Acetaminophen

• Severity Level:

  2

• Additional Notes: Available data suggest no known risk; otc product, no fda pregnancy warnings

Oxycodone

• Severity Level:

  2

• Additional Notes: Risk of neonatal withdrawal syndrome with chronic use

Contraindicated

None

Precaution Exists

Oxycodone

Monitor for changes in respiration, gi effects, sedation, feeding pattern

No Known Risk

Acetaminophen

Low levels excreted with low risk for adverse effects in infant

Contraindicated

None

Precaution Exists

Acetaminophen (oral,rectal)

Hepatic-Elderly may be more susceptible to hepatotoxicity. Strict adherence to a maximum daily dose is recommended, and the maximum dose recommendation varies between 3000-3800 mg depending on strength used and source of the recommendation.

General-Consider adding naloxone Rx. Pulmonary-Life threatening respiratory depression risk with high doses, cachexia, or debilitation due to altered pharmacokinetics (poor fat stores, muscle wasting, or altered clearance). Monitor closely at initiation and dose titration. Neuro/Psych-Risk for increased confusion and delirium. May increase fall risk. Avoid treatment with 3 or more CNS active drugs. Gastrointestinal-Constipation risk. Urogenital-Urinary retention risk.

BEERS: N     HEDIS: N     STOPP: N

Oxycodone

Hepatic-Elderly may be more susceptible to hepatotoxicity. Strict adherence to a maximum daily dose is recommended, and the maximum dose recommendation varies between 3000-3800 mg depending on strength used and source of the recommendation.

General-Consider adding naloxone Rx. Pulmonary-Life threatening respiratory depression risk with high doses, cachexia, or debilitation due to altered pharmacokinetics (poor fat stores, muscle wasting, or altered clearance). Monitor closely at initiation and dose titration. Neuro/Psych-Risk for increased confusion and delirium. May increase fall risk. Avoid treatment with 3 or more CNS active drugs. Gastrointestinal-Constipation risk. Urogenital-Urinary retention risk.

BEERS: Y     HEDIS: N     STOPP: Y

No Known Risk

None