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PYRAZINAMIDE (pyrazinamide)
- Active tuberculosis
- Pulmonary tuberculosis
- Tuberculosis meningitis
500 mg tablet
- 30 mg/kg by oral route once daily not to exceed 2 grams in 24Hrs
Active tuberculosis
- 15 mg/kg by oral route once daily not to exceed 2 grams in 24Hrs
- 30 mg/kg by oral route once daily not to exceed 2 grams in 24Hrs
- 50 mg/kg by oral route twice weekly not to exceed 4 grams in 24Hrs
- 70 mg/kg by oral route twice weekly not to exceed 4 grams in 24Hrs
- 35 mg/kg by oral route 3 times per week not to exceed 3 grams in24Hrs
- 70 mg/kg by oral route 3 times per week not to exceed 3 grams in24Hrs
Pulmonary tuberculosis
- 15 mg/kg by oral route once daily not to exceed 2 grams in 24Hrs
- 30 mg/kg by oral route once daily not to exceed 2 grams in 24Hrs
- 50 mg/kg by oral route twice weekly not to exceed 4 grams in 24Hrs
- 70 mg/kg by oral route twice weekly not to exceed 4 grams in 24Hrs
- 35 mg/kg by oral route 3 times per week not to exceed 3 grams in24Hrs
- 70 mg/kg by oral route 3 times per week not to exceed 3 grams in24Hrs
- typhoid vaccine
- Vivotif Berna Vaccine
Contraindicated
- isoniazid-rifamp-pyrazinamide
- Rifadin
- Rifamate
- rifampin
- rifampin-isoniazid
- Rifater
Severe
Moderate
- None
- None
Contraindicated
- Alcoholism
- Porphyria
- Severe hepatic disease
Severe
Moderate
- Diabetes mellitus
- Gout
PYRAZINAMIDE (pyrazinamide)
- Active tuberculosis
- Pulmonary tuberculosis
- Tuberculosis meningitis
- None
- Arthralgias
- Myalgias
More Frequent
Severe
Less Severe
- None
- Anorexia
- Nausea
- Vomiting
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal hepatic function tests
- Acute gouty arthritis
- Angioedema
- Bronchospastic pulmonary disease
- DRESS syndrome
- Gout
- Hepatitis
- Hypersensitivity drug reaction
- Hyperuricemia
- Hypotension
- Interstitial nephritis
- Jaundice
- Porphyria
- Sideroblastic anemia
- Thrombocytopenic disorder
Less Severe
- Acne vulgaris
- Conjunctivitis
- Dysuria
- Eosinophilia
- Erythema
- Fever
- Flu-like symptoms
- Neutropenic disorder
- Pruritus of skin
- Skin photosensitivity
- Skin rash
- Urticaria
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
None
Pyrazinamide
- Severity Level:
C
- Additional Notes:
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Pyrazinamide
Use with caution, consider risk-benefit.
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Excreted | Not known; no or inclusive data | Use with caution, consider risk-benefit. |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- None
| Active tuberculosis | |
| A15 | Respiratory tuberculosis |
| A15.0 | Tuberculosis of lung |
| A15.4 | Tuberculosis of intrathoracic lymph nodes |
| A15.5 | Tuberculosis of larynx, trachea and bronchus |
| A15.6 | Tuberculous pleurisy |
| A15.7 | Primary respiratory tuberculosis |
| A15.8 | Other respiratory tuberculosis |
| A15.9 | Respiratory tuberculosis unspecified |
| A17 | Tuberculosis of nervous system |
| A17.0 | Tuberculous meningitis |
| A17.1 | Meningeal tuberculoma |
| A17.8 | Other tuberculosis of nervous system |
| A17.81 | Tuberculoma of brain and spinal cord |
| A17.82 | Tuberculous meningoencephalitis |
| A17.83 | Tuberculous neuritis |
| A17.89 | Other tuberculosis of nervous system |
| A17.9 | Tuberculosis of nervous system, unspecified |
| A18 | Tuberculosis of other organs |
| A18.0 | Tuberculosis of bones and joints |
| A18.01 | Tuberculosis of spine |
| A18.02 | Tuberculous arthritis of other joints |
| A18.03 | Tuberculosis of other bones |
| A18.09 | Other musculoskeletal tuberculosis |
| A18.1 | Tuberculosis of genitourinary system |
| A18.10 | Tuberculosis of genitourinary system, unspecified |
| A18.11 | Tuberculosis of kidney and ureter |
| A18.12 | Tuberculosis of bladder |
| A18.13 | Tuberculosis of other urinary organs |
| A18.14 | Tuberculosis of prostate |
| A18.15 | Tuberculosis of other male genital organs |
| A18.16 | Tuberculosis of cervix |
| A18.17 | Tuberculous female pelvic inflammatory disease |
| A18.18 | Tuberculosis of other female genital organs |
| A18.2 | Tuberculous peripheral lymphadenopathy |
| A18.3 | Tuberculosis of intestines, peritoneum and mesenteric glands |
| A18.31 | Tuberculous peritonitis |
| A18.32 | Tuberculous enteritis |
| A18.39 | Retroperitoneal tuberculosis |
| A18.4 | Tuberculosis of skin and subcutaneous tissue |
| A18.5 | Tuberculosis of eye |
| A18.50 | Tuberculosis of eye, unspecified |
| A18.51 | Tuberculous episcleritis |
| A18.52 | Tuberculous keratitis |
| A18.53 | Tuberculous chorioretinitis |
| A18.54 | Tuberculous iridocyclitis |
| A18.59 | Other tuberculosis of eye |
| A18.6 | Tuberculosis of (inner) (middle) ear |
| A18.7 | Tuberculosis of adrenal glands |
| A18.8 | Tuberculosis of other specified organs |
| A18.81 | Tuberculosis of thyroid gland |
| A18.82 | Tuberculosis of other endocrine glands |
| A18.83 | Tuberculosis of digestive tract organs, not elsewhere classified |
| A18.84 | Tuberculosis of heart |
| A18.85 | Tuberculosis of spleen |
| A18.89 | Tuberculosis of other sites |
| A19 | Miliary tuberculosis |
| A19.0 | Acute miliary tuberculosis of a single specified site |
| A19.1 | Acute miliary tuberculosis of multiple sites |
| A19.2 | Acute miliary tuberculosis, unspecified |
| A19.8 | Other miliary tuberculosis |
| A19.9 | Miliary tuberculosis, unspecified |
| O98.0 | Tuberculosis complicating pregnancy, childbirth and the puerperium |
| O98.01 | Tuberculosis complicating pregnancy |
| O98.011 | Tuberculosis complicating pregnancy, first trimester |
| O98.012 | Tuberculosis complicating pregnancy, second trimester |
| O98.013 | Tuberculosis complicating pregnancy, third trimester |
| O98.019 | Tuberculosis complicating pregnancy, unspecified trimester |
| O98.02 | Tuberculosis complicating childbirth |
| O98.03 | Tuberculosis complicating the puerperium |
| P37.0 | Congenital tuberculosis |
| Pulmonary tuberculosis | |
| A15 | Respiratory tuberculosis |
| A15.0 | Tuberculosis of lung |
| A15.7 | Primary respiratory tuberculosis |
| A15.8 | Other respiratory tuberculosis |
| Tuberculosis meningitis | |
| A17.0 | Tuberculous meningitis |
| A17.82 | Tuberculous meningoencephalitis |
| 0-9 | A-Z |
|---|---|
| A15 | Respiratory tuberculosis |
| A15 | Respiratory tuberculosis |
| A15.0 | Tuberculosis of lung |
| A15.0 | Tuberculosis of lung |
| A15.4 | Tuberculosis of intrathoracic lymph nodes |
| A15.5 | Tuberculosis of larynx, trachea and bronchus |
| A15.6 | Tuberculous pleurisy |
| A15.7 | Primary respiratory tuberculosis |
| A15.7 | Primary respiratory tuberculosis |
| A15.8 | Other respiratory tuberculosis |
| A15.8 | Other respiratory tuberculosis |
| A15.9 | Respiratory tuberculosis unspecified |
| A17 | Tuberculosis of nervous system |
| A17.0 | Tuberculous meningitis |
| A17.0 | Tuberculous meningitis |
| A17.1 | Meningeal tuberculoma |
| A17.8 | Other tuberculosis of nervous system |
| A17.81 | Tuberculoma of brain and spinal cord |
| A17.82 | Tuberculous meningoencephalitis |
| A17.82 | Tuberculous meningoencephalitis |
| A17.83 | Tuberculous neuritis |
| A17.89 | Other tuberculosis of nervous system |
| A17.9 | Tuberculosis of nervous system, unspecified |
| A18 | Tuberculosis of other organs |
| A18.0 | Tuberculosis of bones and joints |
| A18.01 | Tuberculosis of spine |
| A18.02 | Tuberculous arthritis of other joints |
| A18.03 | Tuberculosis of other bones |
| A18.09 | Other musculoskeletal tuberculosis |
| A18.1 | Tuberculosis of genitourinary system |
| A18.10 | Tuberculosis of genitourinary system, unspecified |
| A18.11 | Tuberculosis of kidney and ureter |
| A18.12 | Tuberculosis of bladder |
| A18.13 | Tuberculosis of other urinary organs |
| A18.14 | Tuberculosis of prostate |
| A18.15 | Tuberculosis of other male genital organs |
| A18.16 | Tuberculosis of cervix |
| A18.17 | Tuberculous female pelvic inflammatory disease |
| A18.18 | Tuberculosis of other female genital organs |
| A18.2 | Tuberculous peripheral lymphadenopathy |
| A18.3 | Tuberculosis of intestines, peritoneum and mesenteric glands |
| A18.31 | Tuberculous peritonitis |
| A18.32 | Tuberculous enteritis |
| A18.39 | Retroperitoneal tuberculosis |
| A18.4 | Tuberculosis of skin and subcutaneous tissue |
| A18.5 | Tuberculosis of eye |
| A18.50 | Tuberculosis of eye, unspecified |
| A18.51 | Tuberculous episcleritis |
| A18.52 | Tuberculous keratitis |
| A18.53 | Tuberculous chorioretinitis |
| A18.54 | Tuberculous iridocyclitis |
| A18.59 | Other tuberculosis of eye |
| A18.6 | Tuberculosis of (inner) (middle) ear |
| A18.7 | Tuberculosis of adrenal glands |
| A18.8 | Tuberculosis of other specified organs |
| A18.81 | Tuberculosis of thyroid gland |
| A18.82 | Tuberculosis of other endocrine glands |
| A18.83 | Tuberculosis of digestive tract organs, not elsewhere classified |
| A18.84 | Tuberculosis of heart |
| A18.85 | Tuberculosis of spleen |
| A18.89 | Tuberculosis of other sites |
| A19 | Miliary tuberculosis |
| A19.0 | Acute miliary tuberculosis of a single specified site |
| A19.1 | Acute miliary tuberculosis of multiple sites |
| A19.2 | Acute miliary tuberculosis, unspecified |
| A19.8 | Other miliary tuberculosis |
| A19.9 | Miliary tuberculosis, unspecified |
| O98.0 | Tuberculosis complicating pregnancy, childbirth and the puerperium |
| O98.01 | Tuberculosis complicating pregnancy |
| O98.011 | Tuberculosis complicating pregnancy, first trimester |
| O98.012 | Tuberculosis complicating pregnancy, second trimester |
| O98.013 | Tuberculosis complicating pregnancy, third trimester |
| O98.019 | Tuberculosis complicating pregnancy, unspecified trimester |
| O98.02 | Tuberculosis complicating childbirth |
| O98.03 | Tuberculosis complicating the puerperium |
| P37.0 | Congenital tuberculosis |
Formulary Reference Tool