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PANHEMATIN (HEMIN)
- Acute intermittent porphyria
- Hereditary coproporphyria
- Variegate porphyria
350 mg intravenous solution
- Infuse 3 mg/kg over at least 30 minute(s) by intravenous route once daily
Acute intermittent porphyria
- Infuse 1 mg/kg over at least 30 minute(s) by intravenous route once daily for 3 days
- Infuse 1 mg/kg over at least 30 minute(s) by intravenous route once daily
- Infuse 1 mg/kg over at least 30 minute(s) by intravenous route once daily for 14 days
- Infuse 3 mg/kg over at least 30 minute(s) by intravenous route once daily
- Infuse 3 mg/kg over at least 30 minute(s) by intravenous route once daily for 3 days
- Infuse 3 mg/kg over at least 30 minute(s) by intravenous route once daily for 14 days
- Infuse 4 mg/kg over at least 30 minute(s) by intravenous route once daily
- Infuse 4 mg/kg over at least 30 minute(s) by intravenous route once daily for 3 days
- Infuse 4 mg/kg over at least 30 minute(s) by intravenous route once daily for 14 days
- Infuse 2 mg/kg over at least 30 minute(s) by intravenous route once daily
- Infuse 2 mg/kg over at least 30 minute(s) by intravenous route once daily for 3 days
- Infuse 2 mg/kg over at least 30 minute(s) by intravenous route once daily for 14 days
- Infuse 1 mg/kg over at least 30 minute(s) by intravenous route once daily may repeat dose no earlier than every 12 hours not to exceed 6 mg/kg in 24Hrs
- Infuse 2 mg/kg over at least 30 minute(s) by intravenous route once daily may repeat dose no earlier than every 12 hours not to exceed 6 mg/kg in 24Hrs
- Infuse 3 mg/kg over at least 30 minute(s) by intravenous route once daily may repeat dose no earlier than every 12 hours not to exceed 6 mg/kg in 24Hrs
Hereditary coproporphyria
- Infuse 1 mg/kg over at least 30 minute(s) by intravenous route once daily for 3 days
- Infuse 1 mg/kg over at least 30 minute(s) by intravenous route once daily
- Infuse 1 mg/kg over at least 30 minute(s) by intravenous route once daily for 14 days
- Infuse 3 mg/kg over at least 30 minute(s) by intravenous route once daily
- Infuse 3 mg/kg over at least 30 minute(s) by intravenous route once daily for 3 days
- Infuse 3 mg/kg over at least 30 minute(s) by intravenous route once daily for 14 days
- Infuse 4 mg/kg over at least 30 minute(s) by intravenous route once daily
- Infuse 4 mg/kg over at least 30 minute(s) by intravenous route once daily for 3 days
- Infuse 4 mg/kg over at least 30 minute(s) by intravenous route once daily for 14 days
- Infuse 2 mg/kg over at least 30 minute(s) by intravenous route once daily
- Infuse 2 mg/kg over at least 30 minute(s) by intravenous route once daily for 3 days
- Infuse 2 mg/kg over at least 30 minute(s) by intravenous route once daily for 14 days
- Infuse 1 mg/kg over at least 30 minute(s) by intravenous route once daily may repeat dose no earlier than every 12 hours not to exceed 6 mg/kg in 24Hrs
- Infuse 2 mg/kg over at least 30 minute(s) by intravenous route once daily may repeat dose no earlier than every 12 hours not to exceed 6 mg/kg in 24Hrs
- Infuse 3 mg/kg over at least 30 minute(s) by intravenous route once daily may repeat dose no earlier than every 12 hours not to exceed 6 mg/kg in 24Hrs
Variegate porphyria
- Infuse 1 mg/kg over at least 30 minute(s) by intravenous route once daily for 3 days
- Infuse 1 mg/kg over at least 30 minute(s) by intravenous route once daily
- Infuse 1 mg/kg over at least 30 minute(s) by intravenous route once daily for 14 days
- Infuse 3 mg/kg over at least 30 minute(s) by intravenous route once daily
- Infuse 3 mg/kg over at least 30 minute(s) by intravenous route once daily for 3 days
- Infuse 3 mg/kg over at least 30 minute(s) by intravenous route once daily for 14 days
- Infuse 4 mg/kg over at least 30 minute(s) by intravenous route once daily
- Infuse 4 mg/kg over at least 30 minute(s) by intravenous route once daily for 3 days
- Infuse 4 mg/kg over at least 30 minute(s) by intravenous route once daily for 14 days
- Infuse 2 mg/kg over at least 30 minute(s) by intravenous route once daily
- Infuse 2 mg/kg over at least 30 minute(s) by intravenous route once daily for 3 days
- Infuse 2 mg/kg over at least 30 minute(s) by intravenous route once daily for 14 days
- Infuse 1 mg/kg over at least 30 minute(s) by intravenous route once daily may repeat dose no earlier than every 12 hours not to exceed 6 mg/kg in 24Hrs
- Infuse 2 mg/kg over at least 30 minute(s) by intravenous route once daily may repeat dose no earlier than every 12 hours not to exceed 6 mg/kg in 24Hrs
- Infuse 3 mg/kg over at least 30 minute(s) by intravenous route once daily may repeat dose no earlier than every 12 hours not to exceed 6 mg/kg in 24Hrs
- None
Contraindicated
- None
Severe
Moderate
- None
- None
Contraindicated
- Increased risk of bleeding due to coagulation disorder
Severe
Moderate
- Phlebitis
PANHEMATIN (HEMIN)
- Acute intermittent porphyria
- Hereditary coproporphyria
- Variegate porphyria
- None
- Fever
- Headache disorder
- Injection site sequelae
- Phlebitis after infusion
More Frequent
Severe
Less Severe
- None
- None
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Anaphylaxis
- Chronic iron overload
- Hemolysis
- Hypersensitivity drug reaction
- Increased risk of bleeding due to coagulation disorder
- Thrombocytopenic disorder
- Thrombotic disorder
Less Severe
- Cellulitis
- Erythema
- Skin rash
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Hemin
No established safety and efficacy age < 16 years.
- 1 Day – 16 Years
- No established safety and efficacy age < 16 years.
Hemin
- Severity Level:
C
- Additional Notes:
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Hemin
No data; unlikely drug is excreted
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | No data; unlikely drug is excreted |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- None
| Acute intermittent porphyria | |
| E80.21 | Acute intermittent (hepatic) porphyria |
| Hereditary coproporphyria | |
| E80.29 | Other porphyria |
| Variegate porphyria | |
| E80.20 | Unspecified porphyria |
| 0-9 | A-Z |
|---|---|
| E80.20 | Unspecified porphyria |
| E80.21 | Acute intermittent (hepatic) porphyria |
| E80.29 | Other porphyria |
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