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LEVOLEUCOVORIN CALCIUM (levoleucovorin calcium)
- Adjunct to fluorouracil treatment of colorectal cancer
- Bone marrow suppression due to folic acid antagonism
- Methotrexate toxicity
- Pyrimethamine toxicity
- Sulfadiazine toxicity
- Trimethoprim toxicity
- Trimetrexate toxicity
- Levoleucovorin Intravenous Powder For Solution
- Levoleucovorin Calcium Intravenous Solution
- Levoleucovorin Calcium Intravenous Powder For Solution
- Fusilev Intravenous Solution
- By Indication
50 mg intravenous powder for solution
- Infuse 7.5 mg by intravenous route every 6 hours for 10 doses
10 mg/mL intravenous solution
- Infuse 7.5 mg by intravenous route every 6 hours for 10 doses
50 mg intravenous powder for solution
- Infuse 7.5 mg by intravenous route every 6 hours for 10 doses
50 mg intravenous solution
- Infuse 7.5 mg by intravenous route every 6 hours for 10 doses
Adjunct to fluorouracil treatment of colorectal cancer
- Infuse 10 mg/m2 by intravenous route once daily for 5 days
- Infuse 100 mg/m2 over at least 3 minute(s) by intravenous route once daily for 5 days
Methotrexate toxicity
- Infuse 5 mg/m2 by intravenous route every 6 hours for 10 doses
- Infuse 7.5 mg by intravenous route every 6 hours for 10 doses
- None
Contraindicated
- None
Severe
Moderate
- Adrucil
- Bactrim
- Bactrim Ds
- capecitabine
- Cerebyx
- Dilantin
- Dilantin Extended
- Dilantin Infatabs
- Dilantin Kapseal
- Dilantin-125
- ethotoin
- fluorouracil
- fosphenytoin
- glucarpidase
- Peganone
- Phenytek
- phenytoin
- phenytoin sodium
- phenytoin sodium extended
- sulfamethoxazole-trimethoprim
- Sulfatrim
- Voraxaze
- Xeloda
- None
Contraindicated
- None
Severe
Moderate
- Colitis
LEVOLEUCOVORIN CALCIUM (levoleucovorin calcium)
- Adjunct to fluorouracil treatment of colorectal cancer
- Bone marrow suppression due to folic acid antagonism
- Methotrexate toxicity
- Pyrimethamine toxicity
- Sulfadiazine toxicity
- Trimethoprim toxicity
- Trimetrexate toxicity
- None
- None
More Frequent
Severe
Less Severe
- None
- None
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Anaphylaxis
- Seizure disorder
- Urticaria
Less Severe
- None
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Leucovorin
May increase possibility of seizures in children on hydantoins.
- 1 Day – 18 Years
- May increase possibility of seizures in children on hydantoins.
Levoleucovorin
- Severity Level:
2
- Additional Notes: Insufficient human data available.
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Levoleucovorin
Caution advised; insufficient data available.
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | Caution advised; insufficient data available. |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- None
| Adjunct to fluorouracil treatment of colorectal cancer | |
| C18 | Malignant neoplasm of colon |
| C18.0 | Malignant neoplasm of cecum |
| C18.1 | Malignant neoplasm of appendix |
| C18.2 | Malignant neoplasm of ascending colon |
| C18.3 | Malignant neoplasm of hepatic flexure |
| C18.4 | Malignant neoplasm of transverse colon |
| C18.5 | Malignant neoplasm of splenic flexure |
| C18.6 | Malignant neoplasm of descending colon |
| C18.7 | Malignant neoplasm of sigmoid colon |
| C18.8 | Malignant neoplasm of overlapping sites of colon |
| C18.9 | Malignant neoplasm of colon, unspecified |
| C19 | Malignant neoplasm of rectosigmoid junction |
| C20 | Malignant neoplasm of rectum |
| 0-9 | A-Z |
|---|---|
| C18 | Malignant neoplasm of colon |
| C18.0 | Malignant neoplasm of cecum |
| C18.1 | Malignant neoplasm of appendix |
| C18.2 | Malignant neoplasm of ascending colon |
| C18.3 | Malignant neoplasm of hepatic flexure |
| C18.4 | Malignant neoplasm of transverse colon |
| C18.5 | Malignant neoplasm of splenic flexure |
| C18.6 | Malignant neoplasm of descending colon |
| C18.7 | Malignant neoplasm of sigmoid colon |
| C18.8 | Malignant neoplasm of overlapping sites of colon |
| C18.9 | Malignant neoplasm of colon, unspecified |
| C19 | Malignant neoplasm of rectosigmoid junction |
| C20 | Malignant neoplasm of rectum |
Formulary Reference Tool