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LEUCOVORIN CALCIUM (leucovorin calcium)
- Adjunct to fluorouracil treatment of colorectal cancer
- Bone marrow suppression due to folic acid antagonism
- Methotrexate toxicity
- Folic acid deficient megaloblastic anemia
- Pyrimethamine toxicity
- Sulfadiazine toxicity
- Trimethoprim toxicity
- Trimetrexate toxicity
10 mg/mL injection solution
- Inject 0.1 milliliter (1 mg) by intramuscular route once daily
Adjunct to fluorouracil treatment of colorectal cancer
- Infuse 200 mg/m2 over at least 3 minute(s) by intravenous route once daily on days 1 through 5 of treatment
- Infuse 20 mg/m2 over at least 3 minute(s) by intravenous route once daily on days 1 through 5 of treatment
Folic acid deficient megaloblastic anemia
- Inject 0.1 milliliter (1 mg) by intramuscular route once daily
- None
Contraindicated
- None
Severe
Moderate
- Adrucil
- Bactrim
- Bactrim Ds
- capecitabine
- Cerebyx
- Dilantin
- Dilantin Extended
- Dilantin Infatabs
- Dilantin Kapseal
- Dilantin-125
- ethotoin
- fluorouracil
- fosphenytoin
- glucarpidase
- Peganone
- Phenytek
- phenytoin
- phenytoin sodium
- phenytoin sodium extended
- sulfamethoxazole-trimethoprim
- Sulfatrim
- Voraxaze
- Xeloda
- Pernicious anemia
- Vitamin b12 deficiency
Contraindicated
- None
Severe
Moderate
- None
LEUCOVORIN CALCIUM (leucovorin calcium)
- Adjunct to fluorouracil treatment of colorectal cancer
- Bone marrow suppression due to folic acid antagonism
- Methotrexate toxicity
- Folic acid deficient megaloblastic anemia
- Pyrimethamine toxicity
- Sulfadiazine toxicity
- Trimethoprim toxicity
- Trimetrexate toxicity
- None
- None
More Frequent
Severe
Less Severe
- None
- None
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Anaphylaxis
- Seizure disorder
- Urticaria
Less Severe
- None
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Leucovorin
May increase possibility of seizures in children on hydantoins.
- 1 Day – 18 Years
- May increase possibility of seizures in children on hydantoins.
Leucovorin Calcium
- Severity Level:
C
- Additional Notes:
Contraindicated
None
General | Excretion Potential | Effect on Infant | Notes |
None |
Precaution Exists
None
General | Excretion Potential | Effect on Infant | Notes |
None |
No Known Risk
Leucovorin Calcium
Active metabolite of folic acid
General | Excretion Potential | Effect on Infant | Notes |
No known risks; does not adversely affect lactation | Unknown | Not known; no or inclusive data | Active metabolite of folic acid |
Contraindicated
None
Precaution Exists
Leucovorin
Elderly at increased risk of severe gastrointestinal toxicity in combination with 5-FU.
Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
Increased Risk / Adverse Effects | Y | N | N | N | N | N |
BEERS: N HEDIS: N STOPP: N
No Known Risk
None
- None
Adjunct to fluorouracil treatment of colorectal cancer | |
C18 | Malignant neoplasm of colon |
C18.0 | Malignant neoplasm of cecum |
C18.1 | Malignant neoplasm of appendix |
C18.2 | Malignant neoplasm of ascending colon |
C18.3 | Malignant neoplasm of hepatic flexure |
C18.4 | Malignant neoplasm of transverse colon |
C18.5 | Malignant neoplasm of splenic flexure |
C18.6 | Malignant neoplasm of descending colon |
C18.7 | Malignant neoplasm of sigmoid colon |
C18.8 | Malignant neoplasm of overlapping sites of colon |
C18.9 | Malignant neoplasm of colon, unspecified |
C19 | Malignant neoplasm of rectosigmoid junction |
C20 | Malignant neoplasm of rectum |
Folic acid deficient megaloblastic anemia | |
D52 | Folate deficiency anemia |
D52.0 | Dietary folate deficiency anemia |
D52.1 | Drug-induced folate deficiency anemia |
D52.8 | Other folate deficiency anemias |
D52.9 | Folate deficiency anemia, unspecified |
0-9 | A-Z |
---|---|
C18 | Malignant neoplasm of colon |
C18.0 | Malignant neoplasm of cecum |
C18.1 | Malignant neoplasm of appendix |
C18.2 | Malignant neoplasm of ascending colon |
C18.3 | Malignant neoplasm of hepatic flexure |
C18.4 | Malignant neoplasm of transverse colon |
C18.5 | Malignant neoplasm of splenic flexure |
C18.6 | Malignant neoplasm of descending colon |
C18.7 | Malignant neoplasm of sigmoid colon |
C18.8 | Malignant neoplasm of overlapping sites of colon |
C18.9 | Malignant neoplasm of colon, unspecified |
C19 | Malignant neoplasm of rectosigmoid junction |
C20 | Malignant neoplasm of rectum |
D52 | Folate deficiency anemia |
D52.0 | Dietary folate deficiency anemia |
D52.1 | Drug-induced folate deficiency anemia |
D52.8 | Other folate deficiency anemias |
D52.9 | Folate deficiency anemia, unspecified |
Formulary Reference Tool