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CLOFARABINE (clofarabine)
- Acute lymphoid leukemia
20 mg/20 mL intravenous solution
- Dosage information is not available
20 mg/20 mL intravenous solution
- Dosage information is not available
- adenovirus vac live type-4 & 7
- adenovirus vaccine live type-4
- adenovirus vaccine live type-7
- BCG vaccine, live (PF)
- flu vac,qval 2013-14 (2-49yrs)
- Flumist 2013-2014
- M-m-r Ii (pf)
- measles,mumps&rubella vacc(PF)
- measles,mumps,rub,varicel(PF)
- natalizumab
- Proquad (pf)
- Rotateq Vaccine
- rotavirus vaccine live, penta
- typhoid vaccine
- Tysabri
- varicella virus vacc live (PF)
- Varivax (pf)
- Vivotif Berna Vaccine
- yellow fever vaccine live (PF)
- Yf-vax (pf)
- Zostavax (pf)
- zoster vaccine live (PF)
Contraindicated
- clozapine
- Clozaril
- deferiprone
- Fazaclo
- Ferriprox
- Versacloz
Severe
Moderate
- None
- Lactating mother
Contraindicated
- Abnormal hepatic function tests
- Anemia
- Bacterial infection
- Bone marrow depression
- Capillary leak syndrome
- Chronic kidney disease stage 3A (moderate) GFR 45-59
- Chronic kidney disease stage 3B (moderate) GFR 30-44
- Dehydration
- Disease of liver
- Enterocolitis
- Hemorrhage
- Hyperbilirubinemia
- Hypotension
- Neutropenic disorder
- Opportunistic fungal infection
- Opportunistic viral infection
- Pregnancy
- Sepsis
- Thrombocytopenic disorder
Severe
Moderate
- None
CLOFARABINE (clofarabine)
- Acute lymphoid leukemia
- Anemia
- Bacteremia
- Bacterial sepsis
- Capillary leak syndrome
- Dyspnea
- Hematuria
- Herpes simplex infection
- Hypotension
- Infection
- Jaundice
- Leukopenia
- Neutropenic disorder
- Pleural effusions
- Pneumonia
- Severe dyspnea
- Tachycardia
- Thrombocytopenic disorder
- Acute abdominal pain
- Anorexia
- Arthralgias
- Back pain
- Chills
- Diarrhea
- Drowsy
- Edema
- Epistaxis
- Erythema
- Fatigue
- Fever
- Flushing
- General weakness
- Gingival bleeding
- Headache disorder
- Injection site sequelae
- Irritability
- Lethargy
- Limb pain
- Myalgias
- Nausea
- Pain
- Palmar-plantar erythrodysesthesia
- Petechiae
- Pruritus of skin
- Skin rash
- Stomatitis
- Symptoms of anxiety
- Vomiting
More Frequent
Severe
Less Severe
- Candidiasis
- Clostridium difficile infection
- Cytokine release syndrome
- Hyperbilirubinemia
- Hypertension
- Kidney disease with reduction in GFR
- Opportunistic fungal infection
- Pericardial effusion
- Tachypnea
- Altered mental status
- Bone pain
- Rectal pain
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal hepatic function tests
- Chemotherapy-induced hyperuricemia
- Enterocolitis
- Gastroenteritis
- Gastrointestinal hemorrhage
- Hemorrhage
- Hepatic failure
- Hepatic veno-occlusive disease
- Hepatitis
- Hyponatremia
- Intracerebral hemorrhage
- Multiple organ failure
- Pancreatitis
- Pulmonary edema
- Pulmonary hemorrhage
- Renal failure
- Sepsis
- Stevens-johnson syndrome
- Toxic epidermal necrolysis
Less Severe
- None
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Clofarabine
No safety and efficacy established age < 1 year.
- 1 Day – 364 Days
- No safety and efficacy established age < 1 year.
Clofarabine
- Severity Level:
D
- Additional Notes:
Contraindicated
Clofarabine
Not recommended, potential severe toxicity. tumorigenic in animal studies.
| General | Excretion Potential | Effect on Infant | Notes |
| Drug should not be given to breast feeding mothers | Unknown | Not known; no or inclusive data | Not recommended, potential severe toxicity. tumorigenic in animal studies. |
Precaution Exists
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- None
| Acute lymphoid leukemia | |
| C91.0 | Acute lymphoblastic leukemia [ALl] |
| C91.00 | Acute lymphoblastic leukemia not having achieved remission |
| C91.02 | Acute lymphoblastic leukemia, in relapse |
| 0-9 | A-Z |
|---|---|
| C91.0 | Acute lymphoblastic leukemia [ALl] |
| C91.00 | Acute lymphoblastic leukemia not having achieved remission |
| C91.02 | Acute lymphoblastic leukemia, in relapse |
Formulary Reference Tool