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KLOXXADO (naloxone HCl)
- opioid overdose
- decrease in rate & depth of breathing due to opioid drug
8 mg/actuation nasal spray
- Spray 0.1 milliliter (8 mg) in 1 nostril by intranasal route may repeat dose every 2-3 minutes as needed alternating nostrils with each dose
Default screening record
- Spray 0.1 milliliter (8 mg) in 1 nostril by intranasal route may repeat dose every 2-3 minutes as needed alternating nostrils with each dose
- Spray 0.1 milliliter (8 mg) in 1 nostril by intranasal route may repeat dose in other nostril may give additional doses every 2-3 mins (alternating nostrils) until response or medical assistance
- None
Contraindicated
- None
Severe
Moderate
- None
- None
Contraindicated
- Opioid dependence
- Opioid withdrawal symptoms
Severe
Moderate
- Cardiac arrhythmia
- Disease of liver
KLOXXADO (naloxone HCl)
- opioid overdose
- decrease in rate & depth of breathing due to opioid drug
- Hypertension
- Dry nose
- Headache disorder
- Musculoskeletal pain
- Nasal congestion
- Nasal mucosa edematous
More Frequent
Severe
Less Severe
- Dyspnea
- Hypotension
- Ventricular fibrillation
- Ventricular tachycardia
- Constipation
- Hyperhidrosis
- Irritability
- Muscle spasm
- Nausea
- Toothache
- Vomiting
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Cardiac arrest
- Opioid withdrawal symptoms
- Pulmonary edema
Less Severe
- None
Contraindicated
None
Severe Precaution
Naloxone
Risk of seizures; not recommended for newborn resuscitation in delivery room.
- 1 Day – 2 Days
- Risk of seizures; not recommended for newborn resuscitation in delivery room.
Management or Monitoring Precaution
None
Naloxone (nasal Spray)
- Severity Level:
2
- Additional Notes: May precipitate withdrawal; monitor mother and fetus until stable
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Naloxone
Insufficient data available; poor oral absorption
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | Insufficient data available; poor oral absorption |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- None
| Opioid overdose | |
| T40.0x1A | Poisoning by opium, accidental (unintentional), initial encounter |
| T40.0x2A | Poisoning by opium, intentional self-harm, initial encounter |
| T40.0x3A | Poisoning by opium, assault, initial encounter |
| T40.0x4A | Poisoning by opium, undetermined, initial encounter |
| T40.1x1A | Poisoning by heroin, accidental (unintentional), initial encounter |
| T40.1x2A | Poisoning by heroin, intentional self-harm, initial encounter |
| T40.1x3A | Poisoning by heroin, assault, initial encounter |
| T40.1x4A | Poisoning by heroin, undetermined, initial encounter |
| T40.2x1A | Poisoning by other opioids, accidental (unintentional), initial encounter |
| T40.2x2A | Poisoning by other opioids, intentional self-harm, initial encounter |
| T40.2x3A | Poisoning by other opioids, assault, initial encounter |
| T40.2x4A | Poisoning by other opioids, undetermined, initial encounter |
| T40.3x1A | Poisoning by methadone, accidental (unintentional), initial encounter |
| T40.3x2A | Poisoning by methadone, intentional self-harm, initial encounter |
| T40.3x3A | Poisoning by methadone, assault, initial encounter |
| T40.3x4A | Poisoning by methadone, undetermined, initial encounter |
| T40.411A | Poisoning by fentanyl or fentanyl analogs, accidental (unintentional), initial encounter |
| T40.412A | Poisoning by fentanyl or fentanyl analogs, intentional self-harm, initial encounter |
| T40.413A | Poisoning by fentanyl or fentanyl analogs, assault, initial encounter |
| T40.414A | Poisoning by fentanyl or fentanyl analogs, undetermined, initial encounter |
| T40.421A | Poisoning by tramadol, accidental (unintentional), initial encounter |
| T40.422A | Poisoning by tramadol, intentional self-harm, initial encounter |
| T40.423A | Poisoning by tramadol, assault, initial encounter |
| T40.424A | Poisoning by tramadol, undetermined, initial encounter |
| T40.491A | Poisoning by other synthetic narcotics, accidental (unintentional), initial encounter |
| T40.492A | Poisoning by other synthetic narcotics, intentional self-harm, initial encounter |
| T40.493A | Poisoning by other synthetic narcotics, assault, initial encounter |
| T40.494A | Poisoning by other synthetic narcotics, undetermined, initial encounter |
| T40.601A | Poisoning by unspecified narcotics, accidental (unintentional), initial encounter |
| T40.602A | Poisoning by unspecified narcotics, intentional self-harm, initial encounter |
| T40.603A | Poisoning by unspecified narcotics, assault, initial encounter |
| T40.604A | Poisoning by unspecified narcotics, undetermined, initial encounter |
| T40.691A | Poisoning by other narcotics, accidental (unintentional), initial encounter |
| T40.692A | Poisoning by other narcotics, intentional self-harm, initial encounter |
| T40.693A | Poisoning by other narcotics, assault, initial encounter |
| T40.694A | Poisoning by other narcotics, undetermined, initial encounter |
| T50.7x1A | Poisoning by analeptics and opioid receptor antagonists, accidental (unintentional), initial encounter |
| T50.7x2A | Poisoning by analeptics and opioid receptor antagonists, intentional self-harm, initial encounter |
| T50.7x3A | Poisoning by analeptics and opioid receptor antagonists, assault, initial encounter |
| T50.7x4A | Poisoning by analeptics and opioid receptor antagonists, undetermined, initial encounter |
| Opioid-induced respiratory depression | |
| T40.0x1A | Poisoning by opium, accidental (unintentional), initial encounter |
| T40.0x2A | Poisoning by opium, intentional self-harm, initial encounter |
| T40.0x3A | Poisoning by opium, assault, initial encounter |
| T40.0x4A | Poisoning by opium, undetermined, initial encounter |
| T40.1x1A | Poisoning by heroin, accidental (unintentional), initial encounter |
| T40.1x2A | Poisoning by heroin, intentional self-harm, initial encounter |
| T40.1x3A | Poisoning by heroin, assault, initial encounter |
| T40.1x4A | Poisoning by heroin, undetermined, initial encounter |
| T40.2x1A | Poisoning by other opioids, accidental (unintentional), initial encounter |
| T40.2x2A | Poisoning by other opioids, intentional self-harm, initial encounter |
| T40.2x3A | Poisoning by other opioids, assault, initial encounter |
| T40.2x4A | Poisoning by other opioids, undetermined, initial encounter |
| T40.3x1A | Poisoning by methadone, accidental (unintentional), initial encounter |
| T40.3x2A | Poisoning by methadone, intentional self-harm, initial encounter |
| T40.3x3A | Poisoning by methadone, assault, initial encounter |
| T40.3x4A | Poisoning by methadone, undetermined, initial encounter |
| T40.411A | Poisoning by fentanyl or fentanyl analogs, accidental (unintentional), initial encounter |
| T40.412A | Poisoning by fentanyl or fentanyl analogs, intentional self-harm, initial encounter |
| T40.413A | Poisoning by fentanyl or fentanyl analogs, assault, initial encounter |
| T40.414A | Poisoning by fentanyl or fentanyl analogs, undetermined, initial encounter |
| T40.421A | Poisoning by tramadol, accidental (unintentional), initial encounter |
| T40.422A | Poisoning by tramadol, intentional self-harm, initial encounter |
| T40.423A | Poisoning by tramadol, assault, initial encounter |
| T40.424A | Poisoning by tramadol, undetermined, initial encounter |
| T40.491A | Poisoning by other synthetic narcotics, accidental (unintentional), initial encounter |
| T40.492A | Poisoning by other synthetic narcotics, intentional self-harm, initial encounter |
| T40.493A | Poisoning by other synthetic narcotics, assault, initial encounter |
| T40.494A | Poisoning by other synthetic narcotics, undetermined, initial encounter |
| T40.5x1A | Poisoning by cocaine, accidental (unintentional), initial encounter |
| T40.5x2A | Poisoning by cocaine, intentional self-harm, initial encounter |
| T40.5x3A | Poisoning by cocaine, assault, initial encounter |
| T40.5x4A | Poisoning by cocaine, undetermined, initial encounter |
| T40.601A | Poisoning by unspecified narcotics, accidental (unintentional), initial encounter |
| T40.602A | Poisoning by unspecified narcotics, intentional self-harm, initial encounter |
| T40.603A | Poisoning by unspecified narcotics, assault, initial encounter |
| T40.604A | Poisoning by unspecified narcotics, undetermined, initial encounter |
| T40.691A | Poisoning by other narcotics, accidental (unintentional), initial encounter |
| T40.692A | Poisoning by other narcotics, intentional self-harm, initial encounter |
| T40.693A | Poisoning by other narcotics, assault, initial encounter |
| T40.694A | Poisoning by other narcotics, undetermined, initial encounter |
| Risk mitigation for opioid overdose | |
| T40.0x1A | Poisoning by opium, accidental (unintentional), initial encounter |
| T40.0x2A | Poisoning by opium, intentional self-harm, initial encounter |
| T40.0x3A | Poisoning by opium, assault, initial encounter |
| T40.0x4A | Poisoning by opium, undetermined, initial encounter |
| T40.1x1A | Poisoning by heroin, accidental (unintentional), initial encounter |
| T40.1x2A | Poisoning by heroin, intentional self-harm, initial encounter |
| T40.1x3A | Poisoning by heroin, assault, initial encounter |
| T40.1x4A | Poisoning by heroin, undetermined, initial encounter |
| T40.2x1A | Poisoning by other opioids, accidental (unintentional), initial encounter |
| T40.2x2A | Poisoning by other opioids, intentional self-harm, initial encounter |
| T40.2x3A | Poisoning by other opioids, assault, initial encounter |
| T40.2x4A | Poisoning by other opioids, undetermined, initial encounter |
| T40.3x1A | Poisoning by methadone, accidental (unintentional), initial encounter |
| T40.3x2A | Poisoning by methadone, intentional self-harm, initial encounter |
| T40.3x3A | Poisoning by methadone, assault, initial encounter |
| T40.3x4A | Poisoning by methadone, undetermined, initial encounter |
| T40.411A | Poisoning by fentanyl or fentanyl analogs, accidental (unintentional), initial encounter |
| T40.412A | Poisoning by fentanyl or fentanyl analogs, intentional self-harm, initial encounter |
| T40.413A | Poisoning by fentanyl or fentanyl analogs, assault, initial encounter |
| T40.414A | Poisoning by fentanyl or fentanyl analogs, undetermined, initial encounter |
| T40.421A | Poisoning by tramadol, accidental (unintentional), initial encounter |
| T40.422A | Poisoning by tramadol, intentional self-harm, initial encounter |
| T40.423A | Poisoning by tramadol, assault, initial encounter |
| T40.424A | Poisoning by tramadol, undetermined, initial encounter |
| T40.491A | Poisoning by other synthetic narcotics, accidental (unintentional), initial encounter |
| T40.492A | Poisoning by other synthetic narcotics, intentional self-harm, initial encounter |
| T40.493A | Poisoning by other synthetic narcotics, assault, initial encounter |
| T40.494A | Poisoning by other synthetic narcotics, undetermined, initial encounter |
| T40.601A | Poisoning by unspecified narcotics, accidental (unintentional), initial encounter |
| T40.602A | Poisoning by unspecified narcotics, intentional self-harm, initial encounter |
| T40.603A | Poisoning by unspecified narcotics, assault, initial encounter |
| T40.604A | Poisoning by unspecified narcotics, undetermined, initial encounter |
| T40.691A | Poisoning by other narcotics, accidental (unintentional), initial encounter |
| T40.692A | Poisoning by other narcotics, intentional self-harm, initial encounter |
| T40.693A | Poisoning by other narcotics, assault, initial encounter |
| T40.694A | Poisoning by other narcotics, undetermined, initial encounter |
| T50.7x1A | Poisoning by analeptics and opioid receptor antagonists, accidental (unintentional), initial encounter |
| T50.7x2A | Poisoning by analeptics and opioid receptor antagonists, intentional self-harm, initial encounter |
| T50.7x3A | Poisoning by analeptics and opioid receptor antagonists, assault, initial encounter |
| T50.7x4A | Poisoning by analeptics and opioid receptor antagonists, undetermined, initial encounter |
| 0-9 | A-Z |
|---|---|
| T40.0x1A | Poisoning by opium, accidental (unintentional), initial encounter |
| T40.0x1A | Poisoning by opium, accidental (unintentional), initial encounter |
| T40.0x1A | Poisoning by opium, accidental (unintentional), initial encounter |
| T40.0x2A | Poisoning by opium, intentional self-harm, initial encounter |
| T40.0x2A | Poisoning by opium, intentional self-harm, initial encounter |
| T40.0x2A | Poisoning by opium, intentional self-harm, initial encounter |
| T40.0x3A | Poisoning by opium, assault, initial encounter |
| T40.0x3A | Poisoning by opium, assault, initial encounter |
| T40.0x3A | Poisoning by opium, assault, initial encounter |
| T40.0x4A | Poisoning by opium, undetermined, initial encounter |
| T40.0x4A | Poisoning by opium, undetermined, initial encounter |
| T40.0x4A | Poisoning by opium, undetermined, initial encounter |
| T40.1x1A | Poisoning by heroin, accidental (unintentional), initial encounter |
| T40.1x1A | Poisoning by heroin, accidental (unintentional), initial encounter |
| T40.1x1A | Poisoning by heroin, accidental (unintentional), initial encounter |
| T40.1x2A | Poisoning by heroin, intentional self-harm, initial encounter |
| T40.1x2A | Poisoning by heroin, intentional self-harm, initial encounter |
| T40.1x2A | Poisoning by heroin, intentional self-harm, initial encounter |
| T40.1x3A | Poisoning by heroin, assault, initial encounter |
| T40.1x3A | Poisoning by heroin, assault, initial encounter |
| T40.1x3A | Poisoning by heroin, assault, initial encounter |
| T40.1x4A | Poisoning by heroin, undetermined, initial encounter |
| T40.1x4A | Poisoning by heroin, undetermined, initial encounter |
| T40.1x4A | Poisoning by heroin, undetermined, initial encounter |
| T40.2x1A | Poisoning by other opioids, accidental (unintentional), initial encounter |
| T40.2x1A | Poisoning by other opioids, accidental (unintentional), initial encounter |
| T40.2x1A | Poisoning by other opioids, accidental (unintentional), initial encounter |
| T40.2x2A | Poisoning by other opioids, intentional self-harm, initial encounter |
| T40.2x2A | Poisoning by other opioids, intentional self-harm, initial encounter |
| T40.2x2A | Poisoning by other opioids, intentional self-harm, initial encounter |
| T40.2x3A | Poisoning by other opioids, assault, initial encounter |
| T40.2x3A | Poisoning by other opioids, assault, initial encounter |
| T40.2x3A | Poisoning by other opioids, assault, initial encounter |
| T40.2x4A | Poisoning by other opioids, undetermined, initial encounter |
| T40.2x4A | Poisoning by other opioids, undetermined, initial encounter |
| T40.2x4A | Poisoning by other opioids, undetermined, initial encounter |
| T40.3x1A | Poisoning by methadone, accidental (unintentional), initial encounter |
| T40.3x1A | Poisoning by methadone, accidental (unintentional), initial encounter |
| T40.3x1A | Poisoning by methadone, accidental (unintentional), initial encounter |
| T40.3x2A | Poisoning by methadone, intentional self-harm, initial encounter |
| T40.3x2A | Poisoning by methadone, intentional self-harm, initial encounter |
| T40.3x2A | Poisoning by methadone, intentional self-harm, initial encounter |
| T40.3x3A | Poisoning by methadone, assault, initial encounter |
| T40.3x3A | Poisoning by methadone, assault, initial encounter |
| T40.3x3A | Poisoning by methadone, assault, initial encounter |
| T40.3x4A | Poisoning by methadone, undetermined, initial encounter |
| T40.3x4A | Poisoning by methadone, undetermined, initial encounter |
| T40.3x4A | Poisoning by methadone, undetermined, initial encounter |
| T40.411A | Poisoning by fentanyl or fentanyl analogs, accidental (unintentional), initial encounter |
| T40.411A | Poisoning by fentanyl or fentanyl analogs, accidental (unintentional), initial encounter |
| T40.411A | Poisoning by fentanyl or fentanyl analogs, accidental (unintentional), initial encounter |
| T40.412A | Poisoning by fentanyl or fentanyl analogs, intentional self-harm, initial encounter |
| T40.412A | Poisoning by fentanyl or fentanyl analogs, intentional self-harm, initial encounter |
| T40.412A | Poisoning by fentanyl or fentanyl analogs, intentional self-harm, initial encounter |
| T40.413A | Poisoning by fentanyl or fentanyl analogs, assault, initial encounter |
| T40.413A | Poisoning by fentanyl or fentanyl analogs, assault, initial encounter |
| T40.413A | Poisoning by fentanyl or fentanyl analogs, assault, initial encounter |
| T40.414A | Poisoning by fentanyl or fentanyl analogs, undetermined, initial encounter |
| T40.414A | Poisoning by fentanyl or fentanyl analogs, undetermined, initial encounter |
| T40.414A | Poisoning by fentanyl or fentanyl analogs, undetermined, initial encounter |
| T40.421A | Poisoning by tramadol, accidental (unintentional), initial encounter |
| T40.421A | Poisoning by tramadol, accidental (unintentional), initial encounter |
| T40.421A | Poisoning by tramadol, accidental (unintentional), initial encounter |
| T40.422A | Poisoning by tramadol, intentional self-harm, initial encounter |
| T40.422A | Poisoning by tramadol, intentional self-harm, initial encounter |
| T40.422A | Poisoning by tramadol, intentional self-harm, initial encounter |
| T40.423A | Poisoning by tramadol, assault, initial encounter |
| T40.423A | Poisoning by tramadol, assault, initial encounter |
| T40.423A | Poisoning by tramadol, assault, initial encounter |
| T40.424A | Poisoning by tramadol, undetermined, initial encounter |
| T40.424A | Poisoning by tramadol, undetermined, initial encounter |
| T40.424A | Poisoning by tramadol, undetermined, initial encounter |
| T40.491A | Poisoning by other synthetic narcotics, accidental (unintentional), initial encounter |
| T40.491A | Poisoning by other synthetic narcotics, accidental (unintentional), initial encounter |
| T40.491A | Poisoning by other synthetic narcotics, accidental (unintentional), initial encounter |
| T40.492A | Poisoning by other synthetic narcotics, intentional self-harm, initial encounter |
| T40.492A | Poisoning by other synthetic narcotics, intentional self-harm, initial encounter |
| T40.492A | Poisoning by other synthetic narcotics, intentional self-harm, initial encounter |
| T40.493A | Poisoning by other synthetic narcotics, assault, initial encounter |
| T40.493A | Poisoning by other synthetic narcotics, assault, initial encounter |
| T40.493A | Poisoning by other synthetic narcotics, assault, initial encounter |
| T40.494A | Poisoning by other synthetic narcotics, undetermined, initial encounter |
| T40.494A | Poisoning by other synthetic narcotics, undetermined, initial encounter |
| T40.494A | Poisoning by other synthetic narcotics, undetermined, initial encounter |
| T40.5x1A | Poisoning by cocaine, accidental (unintentional), initial encounter |
| T40.5x2A | Poisoning by cocaine, intentional self-harm, initial encounter |
| T40.5x3A | Poisoning by cocaine, assault, initial encounter |
| T40.5x4A | Poisoning by cocaine, undetermined, initial encounter |
| T40.601A | Poisoning by unspecified narcotics, accidental (unintentional), initial encounter |
| T40.601A | Poisoning by unspecified narcotics, accidental (unintentional), initial encounter |
| T40.601A | Poisoning by unspecified narcotics, accidental (unintentional), initial encounter |
| T40.602A | Poisoning by unspecified narcotics, intentional self-harm, initial encounter |
| T40.602A | Poisoning by unspecified narcotics, intentional self-harm, initial encounter |
| T40.602A | Poisoning by unspecified narcotics, intentional self-harm, initial encounter |
| T40.603A | Poisoning by unspecified narcotics, assault, initial encounter |
| T40.603A | Poisoning by unspecified narcotics, assault, initial encounter |
| T40.603A | Poisoning by unspecified narcotics, assault, initial encounter |
| T40.604A | Poisoning by unspecified narcotics, undetermined, initial encounter |
| T40.604A | Poisoning by unspecified narcotics, undetermined, initial encounter |
| T40.604A | Poisoning by unspecified narcotics, undetermined, initial encounter |
| T40.691A | Poisoning by other narcotics, accidental (unintentional), initial encounter |
| T40.691A | Poisoning by other narcotics, accidental (unintentional), initial encounter |
| T40.691A | Poisoning by other narcotics, accidental (unintentional), initial encounter |
| T40.692A | Poisoning by other narcotics, intentional self-harm, initial encounter |
| T40.692A | Poisoning by other narcotics, intentional self-harm, initial encounter |
| T40.692A | Poisoning by other narcotics, intentional self-harm, initial encounter |
| T40.693A | Poisoning by other narcotics, assault, initial encounter |
| T40.693A | Poisoning by other narcotics, assault, initial encounter |
| T40.693A | Poisoning by other narcotics, assault, initial encounter |
| T40.694A | Poisoning by other narcotics, undetermined, initial encounter |
| T40.694A | Poisoning by other narcotics, undetermined, initial encounter |
| T40.694A | Poisoning by other narcotics, undetermined, initial encounter |
| T50.7x1A | Poisoning by analeptics and opioid receptor antagonists, accidental (unintentional), initial encounter |
| T50.7x1A | Poisoning by analeptics and opioid receptor antagonists, accidental (unintentional), initial encounter |
| T50.7x2A | Poisoning by analeptics and opioid receptor antagonists, intentional self-harm, initial encounter |
| T50.7x2A | Poisoning by analeptics and opioid receptor antagonists, intentional self-harm, initial encounter |
| T50.7x3A | Poisoning by analeptics and opioid receptor antagonists, assault, initial encounter |
| T50.7x3A | Poisoning by analeptics and opioid receptor antagonists, assault, initial encounter |
| T50.7x4A | Poisoning by analeptics and opioid receptor antagonists, undetermined, initial encounter |
| T50.7x4A | Poisoning by analeptics and opioid receptor antagonists, undetermined, initial encounter |
Formulary Reference Tool