NORETHINDRON-ETHINYL ESTRADIOL (NORETHINDRONE ACETATE-ETHINYL ESTRADIOL)
- Post-menopausal osteoporosis prevention
- Pregnancy contraception
- Vasomotor symptoms associated with menopause
- Norethindrone Acetate-ethinyl Estradiol Tablet
- Microgestin 1/20 (21) Tablet
- Microgestin 1.5/30 (21) Tablet
- Loestrin 1/20 (21) Tablet
- Loestrin 1.5/30 (21) Tablet
- Larin 1/20 (21) Tablet
- Larin 1.5/30 (21) Tablet
- Junel 1/20 (21) Tablet
- Junel 1.5/30 (21) Tablet
- Jinteli Tablet
- Hailey Tablet
- Fyavolv Tablet
- Femhrt Low Dose Tablet
- Aurovela 1/20 (21) Tablet
- Aurovela 1.5/30 (21) Tablet
- By Indication
norethindrone acetate 1 mg-ethinyl estradiol 20 mcg tablet
- 1 tablet by oral route once daily
norethindrone acetate-ethinyl estradiol 0.5 mg-2.5 mcg tablet
- 1 tablet by oral route once daily
norethindrone acetate-ethinyl estradiol 1 mg-5 mcg tablet
- 1 tablet by oral route once daily
norethindrone acetate-ethinyl estradiol 1.5 mg-30 mcg tablet
- 1 tablet by oral route once daily
1 mg-20 mcg tablet
- 1 tablet by oral route once daily
1/20 (21) 1 mg-20 mcg tablet
- 1 tablet by oral route once daily
1.5 mg-30 mcg tablet
- 1 tablet by oral route once daily
1.5/30 (21) 1.5 mg-30 mcg tablet
- 1 tablet by oral route once daily
1/20 (21) 1 mg-20 mcg tablet
- 1 tablet by oral route once daily
1.5/30 (21) 1.5 mg-30 mcg tablet
- 1 tablet by oral route once daily
1/20 (21) 1 mg-20 mcg tablet
- 1 tablet by oral route once daily
1.5/30 (21) 1.5 mg-30 mcg tablet
- 1 tablet by oral route once daily
1/20 (21) 1 mg-20 mcg tablet
- 1 tablet by oral route once daily
1.5/30 (21) 1.5 mg-30 mcg tablet
- 1 tablet by oral route once daily
1 mg-5 mcg tablet
- 1 tablet by oral route once daily
1.5 mg-30 mcg tablet
- 1 tablet by oral route once daily
0.5 mg-2.5 mcg tablet
- 1 tablet by oral route once daily
1 mg-5 mcg tablet
- 1 tablet by oral route once daily
0.5 mg-2.5 mcg tablet
- 1 tablet by oral route once daily
Low Dose 0.5 mg-2.5 mcg tablet
- 1 tablet by oral route once daily
1 mg-20 mcg tablet
- 1 tablet by oral route once daily
1.5 mg-30 mcg tablet
- 1 tablet by oral route once daily
Post-menopausal osteoporosis prevention
- 1 tablet by oral route once daily
Pregnancy contraception
- 1 tablet by oral route once daily
Vasomotor symptoms associated with menopause
- 1 tablet by oral route once daily
- anastrozole
- Arimidex
- Aromasin
- Cyklokapron
- exemestane
- Femara
- letrozole
- Lysteda
- sodium tetradecyl sulfate
- Sotradecol
- tranexamic acid
Contraindicated
- Alagesic Lq
- amobarbital
- Amytal
- Aptiom
- Aptivus
- artemether-lumefantrine
- Ascomp With Codeine
- atazanavir
- Atripla
- B cplx-C-St.Johnwrt-K.&S.ginsg
- Banzel
- Belladonna-phenobarbital
- boceprevir
- bosentan
- Brevital
- Bupap
- butabarbital
- Butalbital Compound W/codeine
- Butalbital Compound-codeine
- butalbital-acetaminop-caf-cod
- butalbital-acetaminophen
- butalbital-acetaminophen-caff
- butalbital-aspirin-caffeine
- Butisol
- calcium-mag-B complex-D3-hrb61
- Capacet
- carbamazepine
- Carbatrol
- Cellcept
- Cellcept Intravenous
- Cerebyx
- chloramphenicol sod succinate
- clobazam
- Coartem
- codeine-butalbital-ASA-caff
- Cold & Flu Fighter
- dabrafenib
- darunavir
- Dilantin
- Dilantin Extended
- Dilantin Infatabs
- Dilantin Kapseal
- Dilantin-125
- Donnatal
- efavirenz
- efavirenz-emtricitabin-tenofov
- elvitegr-cobicist-emtric-tenof
- Epitol
- Equetro
- Esgic
- eslicarbazepine
- ethotoin
- Fatigue Relief Complex
- felbamate
- Felbatol
- Fioricet
- Fioricet With Codeine
- Fiorinal
- Fiorinal-codeine #3
- fosamprenavir
- fosphenytoin
- Fycompa
- Grifulvin V
- Gris-peg (ultramicrosize)
- griseofulvin microsize
- griseofulvin ultramicrosize
- Incivek
- Invirase
- isoniazid-rifamp-pyrazinamide
- Kaletra
- Korlym
- Lexiva
- lopinavir-ritonavir
- Luminal
- Margesic
- Marten-tab
- methohexital
- mifepristone
- modafinil
- Mycobutin
- mycophenolate mofetil
- mycophenolate mofetil HCl
- mycophenolate sodium
- Myfortic
- Mysoline
- nelfinavir
- Nembutal Sodium
- nevirapine
- Norvir
- Norvir Soft Gelatin
- Onfi
- oxcarbazepine
- Oxtellar Xr
- Peganone
- pentobarbital sodium
- perampanel
- phenobarb-hyoscy-atropine-scop
- phenobarbital
- phenobarbital sodium
- phentermine-topiramate
- Phenytek
- phenytoin
- phenytoin sodium
- phenytoin sodium extended
- Prezista
- Priftin
- primidone
- Provigil
- Qsymia
- Reyataz
- rifabutin
- Rifadin
- Rifamate
- rifampin
- rifampin-isoniazid
- rifapentine
- Rifater
- ritonavir
- rufinamide
- saquinavir mesylate
- secobarbital sodium
- Seconal Sodium
- St. John's wort
- Stribild
- Sustiva
- Tafinlar
- Tegretol
- Tegretol Xr
- telaprevir
- Tencon
- tipranavir
- tizanidine
- Topamax
- Topiragen
- topiramate
- Tracleer
- Trileptal
- Trokendi Xr
- Victrelis
- Viracept
- Viramune
- Viramune Xr
- vit C-St. John wort-elder-hb30
- Women's Complex
- Zanaflex
- Zebutal
Severe
Moderate
- A-hydrocort
- A-methapred
- Adoxa
- aminophylline
- amoxicil-clarithromy-lansopraz
- amoxicillin
- amoxicillin-pot clavulanate
- ampicillin
- ampicillin sodium
- ampicillin-sulbactam
- Anucort-hc
- Anusol-hc
- aprepitant
- Aristospan Intra-articular
- Aristospan Intralesional
- Augmentin
- Augmentin Es-600
- Augmentin Xr
- Avidoxy
- betamethasone acet & sod phos
- Bicillin C-r
- Bicillin L-a
- Bivigam
- budesonide
- Carimune Nf Nanofiltered
- ceftazidime
- ceftazidime in D5W
- ceftazidime-dextrose (iso-osm)
- Ceftin
- cefuroxime axetil
- cefuroxime in sterile water
- cefuroxime sodium
- cefuroxime-dextrose (iso-osm)
- Celestone Soluspan
- colesevelam
- Colocort
- Cortef
- Cortenema
- Cortifoam
- cortisone
- demeclocycline
- Depo-medrol
- dexamethasone
- Dexamethasone Intensol
- dexamethasone sodium phos (PF)
- dexamethasone sodium phosphate
- Dexpak 10 Day
- Dexpak 13 Day
- Dexpak 6 Day
- dicloxacillin
- Doryx
- Doxy-100
- doxycycline calcium
- doxycycline hyclate
- doxycycline monohydrate
- Elixophyllin
- Emend
- Entocort Ec
- Evista
- Ez Use Joint-tunnel-trigger
- First-duke's
- First-mary's Mouthwash
- Flebogamma Dif
- Flo-pred
- fludrocortisone
- Fortaz
- Fortaz In Dextrose 5 %
- fosaprepitant
- Gamastan S/d
- Gammagard Liquid
- Gammagard S-d (iga < 1 Mcg/ml)
- Gammagard S/d
- Gammaked
- Gammaplex
- Gamunex-c
- Grx Hicort 25
- Hemril-30
- Hizentra
- hydrocortisone
- hydrocortisone acetate
- hydrocortisone sod succ (PF)
- hydrocortisone sod succinate
- immune glob(IgG)(hum)-maltose
- immune globulin (human) (IgG)
- immune globulin(hum),capr(IgG)
- Juxtapid
- Kenalog
- Lamictal
- Lamictal Odt
- Lamictal Odt Starter (blue)
- Lamictal Odt Starter (green)
- Lamictal Odt Starter (orange)
- Lamictal Starter (blue) Kit
- Lamictal Starter (green) Kit
- Lamictal Starter (orange) Kit
- Lamictal Xr
- Lamictal Xr Starter (blue)
- Lamictal Xr Starter (green)
- Lamictal Xr Starter (orange)
- lamotrigine
- lomitapide
- Medrol
- Medrol (pak)
- methylprednisolone
- methylprednisolone acetate
- methylprednisolone sod suc(PF)
- methylprednisolone sodium succ
- methylprednisolone-bupivacaine
- Millipred
- Millipred Dp
- Minocin
- minocycline
- Monodox
- Morgidox
- nafcillin
- nafcillin in dextrose iso-osm
- nystatin-hydrocortisone-diphen
- nystatin-TCN-HC-diphenhydramin
- Octagam
- Omeclamox-pak
- omeprazole-clarith-amoxicillin
- Oracea
- Orapred
- Orapred Odt
- oxacillin
- oxacillin in dextrose(iso-osm)
- Pediapred
- penicillin G benzathine
- penicillin G benzathine & proc
- penicillin G pot in dextrose
- penicillin G potassium
- penicillin G procaine
- penicillin G sodium
- penicillin V potassium
- Pfizerpen-g
- Physicians Ez Use M-pred
- piperacillin-tazobactam
- piperacillin-tazobactam-dextrs
- prednisolone
- prednisolone acetate
- prednisolone sodium phosphate
- prednisone
- Prednisone Intensol
- Prevpac
- Privigen
- Proctocort
- raloxifene
- Rayos
- Rectacort-hc
- Solodyn
- Solu-cortef
- Solu-cortef (pf)
- Solu-medrol
- Solu-medrol (pf)
- Tazicef
- tetracycline
- Theo-24
- Theochron
- theophylline
- theophylline in dextrose 5 %
- ticarcillin-clavulanate
- tigecycline
- Timentin
- triamcinolone acetonide
- triamcinolone hexacetonide
- triamcinolone-lidocaine
- Tygacil
- Uceris
- Unasyn
- Veripred 20
- Vibramycin
- Welchol
- Zinacef
- Zinacef In Sterile Water
- Zosyn
- Zosyn In Dextrose (iso-osm)
- Acute myocardial infarction
- Antithrombin III deficiency
- Carcinoma of breast
- Cerebrovascular accident
- Deep venous thrombosis
- Disease of liver
- Estrogen-dependent neoplasm
- Porphyria
- Predisposition to thrombosis
- Pregnancy
- Protein C deficiency disease
- Pulmonary thromboembolism
- Thromboembolic disorder
- Thrombophilia
- Thrombophlebitis
- Tobacco smoker
Contraindicated
- Acute myocardial infarction
- Bed-ridden
- Cerebrovascular accident
- Coronary artery disease
- Deep venous thrombosis
- Dementia
- Diabetes mellitus
- Edema
- Endometrial carcinoma
- Family history of malignant tumor of breast
- Hereditary angioedema
- Hypercalcemia
- Hypercholesterolemia
- Hypertension
- Increased cardiovascular event risk
- Invasive surgical procedure
- Malignant neoplasm of the ovary
- Migraine with aura
- Obesity
- Papilledema
- Predisposition to thrombosis
- Pulmonary thromboembolism
- Retinal thrombosis
- Systemic lupus erythematosus
- Thromboembolic disorder
- Thrombophlebitis
- Tobacco smoker
- Valvular heart disease
Severe
Moderate
- Asthma
- Chronic heart failure
- Depression
- Diabetes mellitus
- Edema
- Gallbladder disease
- Hepatic porphyria
- Hyperlipidemia
- Hypertension
- Hypertriglyceridemia
- Hypoparathyroidism
- Hypothyroidism
- Kidney disease with reduction in GFR
- Migraine
- Seizure disorder
- Systemic lupus erythematosus
- Unspecified lump in breast
- Uterine leiomyoma
NORETHINDRON-ETHINYL ESTRADIOL (NORETHINDRONE ACETATE-ETHINYL ESTRADIOL)
- Post-menopausal osteoporosis prevention
- Pregnancy contraception
- Vasomotor symptoms associated with menopause
- Abdominal distension
- Abnormal vaginal bleeding
- Irregular menstrual periods
- Abdominal distension
- Abdominal pain with cramps
- Acne vulgaris
- Anorexia
- Appetite changes
- Body fluid retention
- Breast milk flow decreased
- Dizziness
- Dysmenorrhea
- Edema
- Fatigue
- Gynecomastia
- Headache disorder
- Mastalgia
- Myalgias
- Nausea
- Peripheral edema
- Sinusitis
- Vaginitis
- Vomiting
- Vulvovaginal candidiasis
- Weight gain
- Weight loss
More Frequent
Severe
Less Severe
- Deep venous thrombosis
- Endometrial hyperplasia
- Gastroenteritis
- Hyperlipidemia
- Hypertension
- Abdominal pain with cramps
- Abnormal glucose tolerance
- Acute abdominal pain
- Bronchitis
- Chloasma
- Diarrhea
- Dizziness
- Dyspepsia
- Gynecomastia
- Headache disorder
- Hypertonia
- Irritability
- Libido changes
- Menorrhagia
- Migraine
- Mood changes
- Skin photosensitivity
- Vaginal discharge
- Vomiting
- Vulvovaginal candidiasis
- Weight gain
- Weight loss
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal hepatic function tests
- Acute myocardial infarction
- Acute occlusion of mesenteric vein
- Anaphylaxis
- Angioedema
- Arterial thrombosis
- Back pain
- Benign hepatic cell adenoma
- Biliary calculus
- Cataracts
- Cerebrovascular accident
- Change in corneal curvature
- Chest pain
- Colitis
- Cystitis
- Depression
- Dysplasia of cervix
- Dyspnea
- Ectopic pregnancy
- Endometrial carcinoma
- Erythema multiforme
- Erythema nodosum
- Focal nodular hyperplasia of liver
- Galactorrhea not associated with childbirth
- Gallbladder disease
- Gallbladder obstruction
- General weakness
- Hemolytic uremic syndrome
- Hemorrhagic stroke
- Hepatic vein thrombosis
- Hepatitis
- Hypersensitivity drug reaction
- Hypertension
- Hypertriglyceridemia
- Influenza
- Involuntary muscle movement
- Kidney disease with reduction in GFR
- Liver cell carcinoma
- Malignant neoplasm of the ovary
- Menorrhagia
- Neoplasm of breast
- Neoplasm of liver
- Obstructive hyperbilirubinemia
- Optic neuritis
- Ovarian cyst
- Pancreatitis
- Pruritus of skin
- Pulmonary thromboembolism
- Retinal thrombosis
- Skin rash
- Thromboembolic disorder
- Thrombophlebitis
- Thrombotic disorder
- Unconsciousness
- Unspecified lump in breast
- Urticaria
Less Severe
- Abnormal vaginal bleeding
- Acne vulgaris
- Alopecia
- Amenorrhea
- Appetite changes
- Back pain
- Body fluid retention
- Cervical discharge
- Change in corneal curvature
- Chest pain
- Chloasma
- Constipation
- Depression
- Diarrhea
- Drowsy
- Dysmenorrhea
- Edema
- Erosion of cervix
- Erythema multiforme
- Erythema nodosum
- Fatigue
- Fever
- Folate deficiency
- Galactorrhea not associated with childbirth
- Hirsutism
- Hyperglycemia
- Insomnia
- Irregular menstrual periods
- Limb pain
- Mastalgia
- Menorrhagia
- Migraine
- Mood changes
- Muscle spasm
- Nausea
- Nervousness
- Nipple discharge
- Oligomenorrhea
- Pelvic pain
- Peripheral edema
- Premenstrual syndrome
- Pruritus of skin
- Skin rash
- Symptoms of anxiety
- Upper respiratory infection
- Urticaria
- Vaginal dryness
- Vaginitis
- Weight gain
Contraindicated
None
Severe Precaution
Oral Contraceptives
Not indicated before menarche.
- 1 Day – 13 Years
- Not indicated before menarche.
Management or Monitoring Precaution
Ethinyl Estradiol (HRT, acne)
Safety and efficacy in children has not been established.
Safety and efficacy pre-menarche has not been established.
- 1 Day – 13 Years
- Safety and efficacy in children has not been established.
Norethindrone
Safety and efficacy in children has not been established.
Safety and efficacy pre-menarche has not been established.
- 1 Day – 13 Years
- Safety and efficacy pre-menarche has not been established.
Combination Oral Contraceptives
- Severity Level:
2
- Additional Notes: Avail data no known risk for developmental toxicity after inadvertent exposure
Ethinyl Estradiol
- Severity Level:
2
- Additional Notes: Not indicated during pregnancy, no known dev tox
Norethindrone
- Severity Level:
X
- Additional Notes:
Contraindicated
None
General | Excretion Potential | Effect on Infant | Notes |
None |
Precaution Exists
Ethinyl Estradiol
May decrease milk production, use lowest dose
General | Excretion Potential | Effect on Infant | Notes |
Evaluate use carefully | Excreted | Drug shown to have adverse effect | May decrease milk production, use lowest dose |
No Known Risk
Norethindrone
May inhibit lactation at high doses.
General | Excretion Potential | Effect on Infant | Notes |
No known risks; does not adversely affect lactation | Excreted | Not known; no or inclusive data | May inhibit lactation at high doses. |
Contraindicated
None
Precaution Exists
Estrogenic Agents (systemic)
General-Use lowest possible dose for shortest duration and in combination with a progestin as indicated to reduce the risk of endometrial hyperplasia and breast cancer. Cardiovascular-May increase risk for thromboembolic events. Avoid use in patients with known, suspected, or history of arterial or venous thromboembolic disease. Neuro/Psych-May increase the risk for dementia. Genitourinary-May aggravate urinary incontinence.
Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
Increased Risk / Adverse Effects | N | N | Y | Y | N | N |
BEERS: Y HEDIS: Y STOPP: Y
No Known Risk
None
- Do not use this medication if you smoke cigarettes/use tobacco and are over 35 years old. Smoking raises your risk of stroke, heart attack, blood clots, and high blood pressure from hormonal birth control (such as the pill, patch, ring). The risk of these serious problems increases with age and with the number of cigarettes you smoke. Do not smoke or use tobacco.
Post-menopausal osteoporosis prevention | |
Z78.0 | Asymptomatic menopausal state |
Pregnancy contraception | |
Z30 | Encounter for contraceptive management |
Z30.01 | Encounter for initial prescription of contraceptives |
Z30.011 | Encounter for initial prescription of contraceptive pills |
Z30.013 | Encounter for initial prescription of injectable contraceptive |
Z30.014 | Encounter for initial prescription of intrauterine contraceptive device |
Z30.015 | Encounter for initial prescription of vaginal ring hormonal contraceptive |
Z30.016 | Encounter for initial prescription of transdermal patch hormonal contraceptive device |
Z30.017 | Encounter for initial prescription of implantable subdermal contraceptive |
Z30.018 | Encounter for initial prescription of other contraceptives |
Z30.019 | Encounter for initial prescription of contraceptives, unspecified |
Z30.4 | Encounter for surveillance of contraceptives |
Z30.40 | Encounter for surveillance of contraceptives, unspecified |
Z30.41 | Encounter for surveillance of contraceptive pills |
Z30.42 | Encounter for surveillance of injectable contraceptive |
Z30.43 | Encounter for surveillance of intrauterine contraceptive device |
Z30.430 | Encounter for insertion of intrauterine contraceptive device |
Z30.431 | Encounter for routine checking of intrauterine contraceptive device |
Z30.433 | Encounter for removal and reinsertion of intrauterine contraceptive device |
Z30.44 | Encounter for surveillance of vaginal ring hormonal contraceptive device |
Z30.45 | Encounter for surveillance of transdermal patch hormonal contraceptive device |
Z30.46 | Encounter for surveillance of implantable subdermal contraceptive |
Z30.49 | Encounter for surveillance of other contraceptives |
Z30.8 | Encounter for other contraceptive management |
Z30.9 | Encounter for contraceptive management, unspecified |
Z79.3 | Long term (current) use of hormonal contraceptives |
Z97.5 | Presence of (intrauterine) contraceptive device |
Vasomotor symptoms associated with menopause | |
N95.1 | Menopausal and female climacteric states |
N95.9 | Unspecified menopausal and perimenopausal disorder |
0-9 | A-Z |
---|---|
N95.1 | Menopausal and female climacteric states |
N95.9 | Unspecified menopausal and perimenopausal disorder |
Z30 | Encounter for contraceptive management |
Z30.01 | Encounter for initial prescription of contraceptives |
Z30.011 | Encounter for initial prescription of contraceptive pills |
Z30.013 | Encounter for initial prescription of injectable contraceptive |
Z30.014 | Encounter for initial prescription of intrauterine contraceptive device |
Z30.015 | Encounter for initial prescription of vaginal ring hormonal contraceptive |
Z30.016 | Encounter for initial prescription of transdermal patch hormonal contraceptive device |
Z30.017 | Encounter for initial prescription of implantable subdermal contraceptive |
Z30.018 | Encounter for initial prescription of other contraceptives |
Z30.019 | Encounter for initial prescription of contraceptives, unspecified |
Z30.4 | Encounter for surveillance of contraceptives |
Z30.40 | Encounter for surveillance of contraceptives, unspecified |
Z30.41 | Encounter for surveillance of contraceptive pills |
Z30.42 | Encounter for surveillance of injectable contraceptive |
Z30.43 | Encounter for surveillance of intrauterine contraceptive device |
Z30.430 | Encounter for insertion of intrauterine contraceptive device |
Z30.431 | Encounter for routine checking of intrauterine contraceptive device |
Z30.433 | Encounter for removal and reinsertion of intrauterine contraceptive device |
Z30.44 | Encounter for surveillance of vaginal ring hormonal contraceptive device |
Z30.45 | Encounter for surveillance of transdermal patch hormonal contraceptive device |
Z30.46 | Encounter for surveillance of implantable subdermal contraceptive |
Z30.49 | Encounter for surveillance of other contraceptives |
Z30.8 | Encounter for other contraceptive management |
Z30.9 | Encounter for contraceptive management, unspecified |
Z78.0 | Asymptomatic menopausal state |
Z79.3 | Long term (current) use of hormonal contraceptives |
Z97.5 | Presence of (intrauterine) contraceptive device |