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NIZATIDINE (NIZATIDINE)
- Duodenal ulcer
- Gastroesophageal reflux disease
- Peptic ulcer
- Erosive esophagitis
- Gastric ulcer
- Heartburn
- Maintenance of healing duodenal ulcer
- Reflux esophagitis
150 mg capsule
- 1 capsule (150 mg) by oral route 2 times per day
300 mg capsule
- 1 capsule (300 mg) by oral route once daily at bedtime
Duodenal ulcer
- 1 capsule (150 mg) by oral route 2 times per day
- 2 capsules (300 mg) by oral route once daily at bedtime
- 1 capsule (300 mg) by oral route once daily at bedtime
Erosive esophagitis
- 1 capsule (150 mg) by oral route 2 times per day
- 1 capsule (300 mg) by oral route once daily at bedtime
Gastric ulcer
- 1 capsule (150 mg) by oral route 2 times per day
- 2 capsules (300 mg) by oral route once daily at bedtime
- 1 capsule (300 mg) by oral route once daily at bedtime
Gastroesophageal reflux disease
- 1 capsule (150 mg) by oral route 2 times per day
- 2 capsules (300 mg) by oral route once daily at bedtime
- 1 capsule (300 mg) by oral route once daily at bedtime
Heartburn
- 1 capsule (150 mg) by oral route 2 times per day
Maintenance of healing duodenal ulcer
- 1 capsule (150 mg) by oral route once daily at bedtime
Peptic ulcer
- 1 capsule (150 mg) by oral route 2 times per day
- 2 capsules (300 mg) by oral route once daily at bedtime
- 1 capsule (300 mg) by oral route once daily at bedtime
Reflux esophagitis
- 1 capsule (150 mg) by oral route 2 times per day
- 1 capsule (300 mg) by oral route once daily at bedtime
- None
Contraindicated
- itraconazole
- ketoconazole
- Onmel
- Sporanox
- Sporanox Pulsepak
Severe
Moderate
- Adderall
- Adderall Xr
- Amphetamine Salt Combo
- atazanavir
- Ceftin
- cefuroxime axetil
- Complera
- Dexedrine Spansule
- dextroamphetamine
- dextroamphetamine-amphetamine
- Edurant
- emtricitab-rilpivirine-tenofov
- Isentress
- Procentra
- raltegravir
- Reyataz
- rilpivirine
- Zenzedi
- None
Contraindicated
- Chronic kidney disease stage 3A (moderate) GFR 45-59
- Chronic kidney disease stage 3B (moderate) GFR 30-44
- Chronic kidney disease stage 4 (severe) GFR 15-29 ml/min
- Chronic kidney disease stage 5 (failure) GFr<15 ml/min
- Gastric cancer
Severe
Moderate
- Kidney disease with likely reduction in GFR
NIZATIDINE (NIZATIDINE)
- Duodenal ulcer
- Gastroesophageal reflux disease
- Peptic ulcer
- Erosive esophagitis
- Gastric ulcer
- Heartburn
- Maintenance of healing duodenal ulcer
- Reflux esophagitis
- None
- Drowsy
More Frequent
Severe
Less Severe
- None
- Hyperhidrosis
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Acute confusion
- Allergic dermatitis
- Angioedema
- Bradycardia
- Bronchospastic pulmonary disease
- Fever
- Neutropenic disorder
- Skin rash
- Tachycardia
- Thrombocytopenic disorder
Less Severe
- None
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Nizatidine
Safety and efficacy not established in pediatrics age < 12 years.
- 1 Day – 12 Years
- Safety and efficacy not established in pediatrics age < 12 years.
Nizatidine
- Severity Level:
B
- Additional Notes:
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Nizatidine
Limited data suggest low amounts excreted resulting in no infant adv effects
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Excreted | Not known; no or inclusive data | Limited data suggest low amounts excreted resulting in no infant adv effects |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Nizatidine
Neuro/Psych-Avoid in older adults with or at high risk of delirium because of inducing or worsening delirium. Avoid in elderly with dementia or cognitive impairment. Renal-Drug is highly renally excreted which may worsen risk for confusion. Reduce dose for CrCl <50 mL/min.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | Y | N | N | Y | N | N |
BEERS: Y HEDIS: N STOPP: N
No Known Risk
None
- None
| Duodenal ulcer | |
| K26 | Duodenal ulcer |
| K26.0 | Acute duodenal ulcer with hemorrhage |
| K26.1 | Acute duodenal ulcer with perforation |
| K26.2 | Acute duodenal ulcer with both hemorrhage and perforation |
| K26.3 | Acute duodenal ulcer without hemorrhage or perforation |
| K26.4 | Chronic or unspecified duodenal ulcer with hemorrhage |
| K26.5 | Chronic or unspecified duodenal ulcer with perforation |
| K26.6 | Chronic or unspecified duodenal ulcer with both hemorrhage and perforation |
| K26.7 | Chronic duodenal ulcer without hemorrhage or perforation |
| K26.9 | Duodenal ulcer, unspecified as acute or chronic, without hemorrhage or perforation |
| Erosive esophagitis | |
| K22.1 | Ulcer of esophagus |
| K22.10 | Ulcer of esophagus without bleeding |
| K22.11 | Ulcer of esophagus with bleeding |
| Gastric ulcer | |
| K25 | Gastric ulcer |
| K25.0 | Acute gastric ulcer with hemorrhage |
| K25.1 | Acute gastric ulcer with perforation |
| K25.2 | Acute gastric ulcer with both hemorrhage and perforation |
| K25.3 | Acute gastric ulcer without hemorrhage or perforation |
| K25.4 | Chronic or unspecified gastric ulcer with hemorrhage |
| K25.5 | Chronic or unspecified gastric ulcer with perforation |
| K25.6 | Chronic or unspecified gastric ulcer with both hemorrhage and perforation |
| K25.7 | Chronic gastric ulcer without hemorrhage or perforation |
| K25.9 | Gastric ulcer, unspecified as acute or chronic, without hemorrhage or perforation |
| Gastroesophageal reflux disease | |
| K21 | Gastro-esophageal reflux disease |
| K21.0 | Gastro-esophageal reflux disease with esophagitis |
| K21.9 | Gastro-esophageal reflux disease without esophagitis |
| Heartburn | |
| R12 | Heartburn |
| Maintenance of healing duodenal ulcer | |
| K26 | Duodenal ulcer |
| K26.0 | Acute duodenal ulcer with hemorrhage |
| K26.1 | Acute duodenal ulcer with perforation |
| K26.2 | Acute duodenal ulcer with both hemorrhage and perforation |
| K26.3 | Acute duodenal ulcer without hemorrhage or perforation |
| K26.4 | Chronic or unspecified duodenal ulcer with hemorrhage |
| K26.5 | Chronic or unspecified duodenal ulcer with perforation |
| K26.6 | Chronic or unspecified duodenal ulcer with both hemorrhage and perforation |
| K26.7 | Chronic duodenal ulcer without hemorrhage or perforation |
| K26.9 | Duodenal ulcer, unspecified as acute or chronic, without hemorrhage or perforation |
| Peptic ulcer | |
| K27 | Peptic ulcer, site unspecified |
| K27.0 | Acute peptic ulcer, site unspecified, with hemorrhage |
| K27.1 | Acute peptic ulcer, site unspecified, with perforation |
| K27.2 | Acute peptic ulcer, site unspecified, with both hemorrhage and perforation |
| K27.3 | Acute peptic ulcer, site unspecified, without hemorrhage or perforation |
| K27.4 | Chronic or unspecified peptic ulcer, site unspecified, with hemorrhage |
| K27.5 | Chronic or unspecified peptic ulcer, site unspecified, with perforation |
| K27.6 | Chronic or unspecified peptic ulcer, site unspecified, with both hemorrhage and perforation |
| K27.7 | Chronic peptic ulcer, site unspecified, without hemorrhage or perforation |
| K27.9 | Peptic ulcer, site unspecified, unspecified as acute or chronic, without hemorrhage or perforation |
| P78.82 | Peptic ulcer of newborn |
| Reflux esophagitis | |
| K21.0 | Gastro-esophageal reflux disease with esophagitis |
| 0-9 | A-Z |
|---|---|
| K21 | Gastro-esophageal reflux disease |
| K21.0 | Gastro-esophageal reflux disease with esophagitis |
| K21.0 | Gastro-esophageal reflux disease with esophagitis |
| K21.9 | Gastro-esophageal reflux disease without esophagitis |
| K22.1 | Ulcer of esophagus |
| K22.10 | Ulcer of esophagus without bleeding |
| K22.11 | Ulcer of esophagus with bleeding |
| K25 | Gastric ulcer |
| K25.0 | Acute gastric ulcer with hemorrhage |
| K25.1 | Acute gastric ulcer with perforation |
| K25.2 | Acute gastric ulcer with both hemorrhage and perforation |
| K25.3 | Acute gastric ulcer without hemorrhage or perforation |
| K25.4 | Chronic or unspecified gastric ulcer with hemorrhage |
| K25.5 | Chronic or unspecified gastric ulcer with perforation |
| K25.6 | Chronic or unspecified gastric ulcer with both hemorrhage and perforation |
| K25.7 | Chronic gastric ulcer without hemorrhage or perforation |
| K25.9 | Gastric ulcer, unspecified as acute or chronic, without hemorrhage or perforation |
| K26 | Duodenal ulcer |
| K26 | Duodenal ulcer |
| K26.0 | Acute duodenal ulcer with hemorrhage |
| K26.0 | Acute duodenal ulcer with hemorrhage |
| K26.1 | Acute duodenal ulcer with perforation |
| K26.1 | Acute duodenal ulcer with perforation |
| K26.2 | Acute duodenal ulcer with both hemorrhage and perforation |
| K26.2 | Acute duodenal ulcer with both hemorrhage and perforation |
| K26.3 | Acute duodenal ulcer without hemorrhage or perforation |
| K26.3 | Acute duodenal ulcer without hemorrhage or perforation |
| K26.4 | Chronic or unspecified duodenal ulcer with hemorrhage |
| K26.4 | Chronic or unspecified duodenal ulcer with hemorrhage |
| K26.5 | Chronic or unspecified duodenal ulcer with perforation |
| K26.5 | Chronic or unspecified duodenal ulcer with perforation |
| K26.6 | Chronic or unspecified duodenal ulcer with both hemorrhage and perforation |
| K26.6 | Chronic or unspecified duodenal ulcer with both hemorrhage and perforation |
| K26.7 | Chronic duodenal ulcer without hemorrhage or perforation |
| K26.7 | Chronic duodenal ulcer without hemorrhage or perforation |
| K26.9 | Duodenal ulcer, unspecified as acute or chronic, without hemorrhage or perforation |
| K26.9 | Duodenal ulcer, unspecified as acute or chronic, without hemorrhage or perforation |
| K27 | Peptic ulcer, site unspecified |
| K27.0 | Acute peptic ulcer, site unspecified, with hemorrhage |
| K27.1 | Acute peptic ulcer, site unspecified, with perforation |
| K27.2 | Acute peptic ulcer, site unspecified, with both hemorrhage and perforation |
| K27.3 | Acute peptic ulcer, site unspecified, without hemorrhage or perforation |
| K27.4 | Chronic or unspecified peptic ulcer, site unspecified, with hemorrhage |
| K27.5 | Chronic or unspecified peptic ulcer, site unspecified, with perforation |
| K27.6 | Chronic or unspecified peptic ulcer, site unspecified, with both hemorrhage and perforation |
| K27.7 | Chronic peptic ulcer, site unspecified, without hemorrhage or perforation |
| K27.9 | Peptic ulcer, site unspecified, unspecified as acute or chronic, without hemorrhage or perforation |
| P78.82 | Peptic ulcer of newborn |
| R12 | Heartburn |
Formulary Reference Tool