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TNKASE (tenecteplase)
- Acute myocardial infarction
50 mg intravenous solution
- Dosage information is not available
50 mg intravenous kit
- Dosage information is not available
- Coumadin
- Elmiron
- Jantoven
- pentosan polysulfate sodium
- warfarin
Contraindicated
- None
Severe
Moderate
- abciximab
- Aggrastat In Sodium Chloride
- Aggrenox
- Brilinta
- Brintellix
- Brisdelle
- Celexa
- cilostazol
- citalopram
- clopidogrel
- Cymbalta
- desvenlafaxine
- desvenlafaxine fumarate
- desvenlafaxine succinate
- dipyridamole
- dipyridamole-aspirin
- duloxetine
- Effexor Xr
- eptifibatide
- escitalopram oxalate
- Fetzima
- fluoxetine
- fluvoxamine
- Integrilin
- Khedezla
- levomilnacipran
- Lexapro
- Luvox Cr
- milnacipran
- olanzapine-fluoxetine
- paroxetine HCl
- paroxetine mesylate
- Paxil
- Paxil Cr
- Persantine
- Pexeva
- Plavix
- Pletal
- Pristiq
- Prozac
- Prozac Weekly
- Reopro
- Sarafem
- Savella
- sertraline
- Symbyax
- ticagrelor
- ticlopidine
- tirofiban-0.9% sodium chloride
- venlafaxine
- Viibryd
- vilazodone
- vortioxetine
- Zoloft
- Arterial aneurysm
- Arteriovenous malformation
- Hemorrhage
- Increased risk of bleeding
- Increased risk of bleeding due to coagulation disorder
- Invasive surgical procedure
- Major traumatic injury
- Severe uncontrolled hypertension
Contraindicated
- Acute pericarditis
- Blood dyscrasias
- Cholesterol embolism
- Genitourinary tract hemorrhage
- Retinal hemorrhage
- Septic thrombophlebitis
- Severe hepatic disease
- Subacute infective endocarditis
Severe
Moderate
- None
TNKASE (tenecteplase)
- Acute myocardial infarction
- None
- None
More Frequent
Severe
Less Severe
- Gastrointestinal hemorrhage
- Hemorrhage
- Epistaxis
- Hematoma
- Hemoptysis
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Anaphylaxis
- Angioedema
- Atrioventricular block
- Bradycardia
- Cerebrovascular accident
- Cholesterol embolism
- Genitourinary tract hemorrhage
- Hypersensitivity drug reaction
- Hypotension
- Injection site sequelae
- Intracranial bleeding
- Laryngeal edema
- Mitral valve regurgitation
- Pericardial effusion
- Pericardial tamponade
- Pericarditis
- Respiratory tract hemorrhage
- Ventricular premature beats
- Ventricular tachycardia
Less Severe
- Fever
- Nausea
- Skin rash
- Urticaria
- Vomiting
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Tenecteplase
No data available. No safety and efficacy established.
- 1 Day – 18 Years
- No data available. No safety and efficacy established.
Tenecteplase
- Severity Level:
2
- Additional Notes: Insufficient human data available
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Tenecteplase
Insufficient data available
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | Insufficient data available |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Tenecteplase
Hematologic-Increased rates of hemorrhagic events including stroke in the elderly.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | N | N | N | N | N | N |
BEERS: N HEDIS: N STOPP: N
No Known Risk
None
- None
| Acute myocardial infarction | |
| I21 | Acute myocardial infarction |
| I21.0 | ST elevation (STEMi) myocardial infarction of anterior wall |
| I21.01 | ST elevation (STEMi) myocardial infarction involving left main coronary artery |
| I21.02 | ST elevation (STEMi) myocardial infarction involving left anterior descending coronary artery |
| I21.09 | ST elevation (STEMi) myocardial infarction involving other coronary artery of anterior wall |
| I21.1 | ST elevation (STEMi) myocardial infarction of inferior wall |
| I21.11 | ST elevation (STEMi) myocardial infarction involving right coronary artery |
| I21.19 | ST elevation (STEMi) myocardial infarction involving other coronary artery of inferior wall |
| I21.2 | ST elevation (STEMi) myocardial infarction of other sites |
| I21.21 | ST elevation (STEMi) myocardial infarction involving left circumflex coronary artery |
| I21.29 | ST elevation (STEMi) myocardial infarction involving other sites |
| I21.3 | ST elevation (STEMi) myocardial infarction of unspecified site |
| I21.4 | Non-ST elevation (NSTEMi) myocardial infarction |
| I21.9 | Acute myocardial infarction, unspecified |
| I21.A | Other type of myocardial infarction |
| I21.A1 | Myocardial infarction type 2 |
| I21.A9 | Other myocardial infarction type |
| I22 | Subsequent ST elevation (STEMi) and non-ST elevation (NSTEMi) myocardial infarction |
| I22.0 | Subsequent ST elevation (STEMi) myocardial infarction of anterior wall |
| I22.1 | Subsequent ST elevation (STEMi) myocardial infarction of inferior wall |
| I22.2 | Subsequent non-ST elevation (NSTEMi) myocardial infarction |
| I22.8 | Subsequent ST elevation (STEMi) myocardial infarction of other sites |
| I22.9 | Subsequent ST elevation (STEMi) myocardial infarction of unspecified site |
| 0-9 | A-Z |
|---|---|
| I21 | Acute myocardial infarction |
| I21.0 | ST elevation (STEMi) myocardial infarction of anterior wall |
| I21.01 | ST elevation (STEMi) myocardial infarction involving left main coronary artery |
| I21.02 | ST elevation (STEMi) myocardial infarction involving left anterior descending coronary artery |
| I21.09 | ST elevation (STEMi) myocardial infarction involving other coronary artery of anterior wall |
| I21.1 | ST elevation (STEMi) myocardial infarction of inferior wall |
| I21.11 | ST elevation (STEMi) myocardial infarction involving right coronary artery |
| I21.19 | ST elevation (STEMi) myocardial infarction involving other coronary artery of inferior wall |
| I21.2 | ST elevation (STEMi) myocardial infarction of other sites |
| I21.21 | ST elevation (STEMi) myocardial infarction involving left circumflex coronary artery |
| I21.29 | ST elevation (STEMi) myocardial infarction involving other sites |
| I21.3 | ST elevation (STEMi) myocardial infarction of unspecified site |
| I21.4 | Non-ST elevation (NSTEMi) myocardial infarction |
| I21.9 | Acute myocardial infarction, unspecified |
| I21.A | Other type of myocardial infarction |
| I21.A1 | Myocardial infarction type 2 |
| I21.A9 | Other myocardial infarction type |
| I22 | Subsequent ST elevation (STEMi) and non-ST elevation (NSTEMi) myocardial infarction |
| I22.0 | Subsequent ST elevation (STEMi) myocardial infarction of anterior wall |
| I22.1 | Subsequent ST elevation (STEMi) myocardial infarction of inferior wall |
| I22.2 | Subsequent non-ST elevation (NSTEMi) myocardial infarction |
| I22.8 | Subsequent ST elevation (STEMi) myocardial infarction of other sites |
| I22.9 | Subsequent ST elevation (STEMi) myocardial infarction of unspecified site |
Formulary Reference Tool