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TACROLIMUS (TACROLIMUS)
- Intractable eczema
- Prevention of cardiac transplant rejection
- Prevention of kidney transplant rejection
- Prevention of liver transplant rejection
- Atopic dermatitis
- Tacrolimus Topical Ointment
- Tacrolimus Capsule
- Protopic Topical Ointment
- Prograf Capsule
- By Indication
0.03 % topical ointment
- Apply a thin layer to the affected area(s) by topical route 2 times per day ; rub in gently and completely
0.1 % topical ointment
- Apply a thin layer to the affected area(s) by topical route 2 times per day ; rub in gently and completely
0.5 mg capsule
- Dosage information is not available
1 mg capsule
- Dosage information is not available
5 mg capsule
- Dosage information is not available
0.03 % topical ointment
- Apply a thin layer to the affected area(s) by topical route 2 times per day ; rub in gently and completely
0.1 % topical ointment
- Apply a thin layer to the affected area(s) by topical route 2 times per day ; rub in gently and completely
0.5 mg capsule
- Dosage information is not available
1 mg capsule
- Dosage information is not available
5 mg capsule
- Dosage information is not available
Atopic dermatitis
- Apply a thin layer to the affected area(s) by topical route 2 times per day ; rub in gently and completely
Intractable eczema
- Apply a thin layer to the affected area(s) by topical route 2 times per day ; rub in gently and completely
Prevention of cardiac transplant rejection
- 0.0375 mg/kg by oral route every 12 hours
Prevention of kidney transplant rejection
- 0.1 mg/kg by oral route every 12 hours
- 0.05 mg/kg by oral route every 12 hours
Prevention of liver transplant rejection
- 0.075 mg/kg by oral route every 12 hours
- 0.05 mg/kg by oral route every 12 hours
- adenovirus vac live type-4 & 7
- adenovirus vaccine live type-4
- adenovirus vaccine live type-7
- Aldactazide
- Aldactone
- amiloride
- amiloride-hydrochlorothiazide
- BCG vaccine, live (PF)
- cyclosporine
- cyclosporine modified
- Dyazide
- Dyrenium
- flu vac,qval 2013-14 (2-49yrs)
- Flumist 2013-2014
- Gengraf
- Geodon
- Korlym
- M-m-r Ii (pf)
- Maxzide
- Maxzide-25Mg
- measles,mumps&rubella vacc(PF)
- measles,mumps,rub,varicel(PF)
- Mifeprex
- mifepristone
- natalizumab
- Neoral
- Proquad (pf)
- Rotateq Vaccine
- rotavirus vaccine live, penta
- Sandimmune
- spironolacton-hydrochlorothiaz
- spironolactone
- triamterene
- triamterene-hydrochlorothiazid
- typhoid vaccine
- Tysabri
- varicella virus vacc live (PF)
- Varivax (pf)
- Vivotif Berna Vaccine
- yellow fever vaccine live (PF)
- Yf-vax (pf)
- ziprasidone HCl
- ziprasidone mesylate
- Zostavax (pf)
- zoster vaccine live (PF)
Contraindicated
- 1-day
- 3 Day Vaginal
- 3-day Vaginal
- Alagesic Lq
- amiodarone
- amiodarone in dextrose,iso-osm
- amobarbital
- amoxicil-clarithromy-lansopraz
- Amytal
- Aptivus
- artemether-lumefantrine
- Ascomp With Codeine
- atazanavir
- B cplx-C-St.Johnwrt-K.&S.ginsg
- Belladonna-phenobarbital
- Biaxin
- Biaxin Xl
- Biaxin Xl Pak
- boceprevir
- Bupap
- butabarbital
- Butalbital Compound W/codeine
- Butalbital Compound-codeine
- butalbital-acetaminop-caf-cod
- butalbital-acetaminophen
- butalbital-acetaminophen-caff
- butalbital-aspirin-caffeine
- Butisol
- butoconazole nitrate
- calcium-mag-B complex-D3-hrb61
- Capacet
- carbamazepine
- Carbatrol
- Cerebyx
- clarithromycin
- clotrimazole
- Clotrimazole 3 Day
- Clotrimazole-3
- Clotrimazole-7
- clozapine
- Clozaril
- Coartem
- codeine-butalbital-ASA-caff
- Cold & Flu Fighter
- Cordarone
- Crixivan
- crizotinib
- darunavir
- deferiprone
- Diflucan
- Dilantin
- Dilantin Extended
- Dilantin Infatabs
- Dilantin Kapseal
- Dilantin-125
- disopyramide
- Donnatal
- droperidol
- enzalutamide
- Epitol
- Equetro
- Erythrocin
- erythromycin
- erythromycin-sulfisoxazole
- Esgic
- ethotoin
- Fatigue Relief Complex
- Fazaclo
- Ferriprox
- Fioricet
- Fioricet With Codeine
- Fiorinal
- Fiorinal-codeine #3
- fluconazole
- fluconazole in dextrose(iso-o)
- fluconazole in NaCl (iso-osm)
- fosamprenavir
- fosphenytoin
- Gynazole-1
- Gyne-lotrimin
- Gyne-lotrimin 7
- Incivek
- indinavir
- Invirase
- isoniazid-rifamp-pyrazinamide
- itraconazole
- Kaletra
- Ketek
- ketoconazole
- Lexiva
- lopinavir-ritonavir
- Luminal
- Margesic
- Marten-tab
- miconazole
- Miconazole 7
- miconazole nitrate
- Miconazole-3
- Miconazole-3 Prefil,cream,wipe
- miconazole-skin clnsr17
- Monistat 1 Combo Pack
- Monistat 3
- Monistat 7
- Monistat 7 Cream, Appl, Wipes
- Mycobutin
- Mysoline
- nafcillin
- nafcillin in dextrose iso-osm
- nefazodone
- nelfinavir
- Nembutal Sodium
- Nexterone
- Norpace
- Norpace Cr
- Norvir
- Norvir Soft Gelatin
- Noxafil
- Omeclamox-pak
- omeprazole-clarith-amoxicillin
- Onmel
- Orap
- Oravig
- Pacerone
- Peganone
- pentobarbital sodium
- phenobarb-hyoscy-atropine-scop
- phenobarbital
- phenobarbital sodium
- Phenytek
- phenytoin
- phenytoin sodium
- phenytoin sodium extended
- pimozide
- posaconazole
- Prevpac
- Prezista
- Priftin
- primidone
- Rapamune
- Reyataz
- rifabutin
- Rifadin
- Rifamate
- rifampin
- rifampin-isoniazid
- rifapentine
- Rifater
- ritonavir
- saquinavir mesylate
- secobarbital sodium
- Seconal Sodium
- sirolimus
- Sporanox
- Sporanox Pulsepak
- St. John's wort
- Tegretol
- Tegretol Xr
- telaprevir
- telithromycin
- temsirolimus
- Tencon
- thioridazine
- tioconazole
- Tioconazole-1
- tipranavir
- Torisel
- Vagistat-1
- Vagistat-3
- Versacloz
- Vfend
- Vfend Iv
- Victrelis
- Viracept
- vit C-St. John wort-elder-hb30
- voriconazole
- Women's Complex
- Xalkori
- Xtandi
- Zebutal
Severe
Moderate
- Ablavar
- Aciphex
- Aciphex Sprinkle
- Adalat Cc
- Advil
- Advil Allergy Sinus
- Advil Allergy-congestion Rlf
- Advil Cold & Sinus
- Advil Congestion Relief
- Advil Liqui-gel
- Advil Migraine
- Advil Pm
- Advil Pm Liqui-gels
- afatinib
- Afeditab Cr
- Aleve
- Aleve Cold & Sinus
- Aleve Sinus & Headache
- Aleve-d Sinus & Cold
- Aleve-d Sinus & Headache
- alfuzosin
- All Day Pain Relief
- All Day Pain Relief Sinus & Co
- All Day Relief
- Anaprox
- Anaprox Ds
- Ansaid
- Anzemet
- Apokyn
- apomorphine
- arsenic trioxide
- Arthrotec 50
- Atripla
- Avelox
- Avelox Abc Pack
- Avelox In Nacl (iso-osmotic)
- bedaquiline
- Betapace
- Betapace Af
- Calan
- Calan Sr
- Caldolor
- Cambia
- Cancidas
- Caprelsa
- Cardene Iv
- Cardene Iv In Dextrose
- Cardene Iv In Sodium Chloride
- Cardene Sr
- Cardizem
- Cardizem Cd
- Cardizem La
- Cartia Xt
- caspofungin
- Cataflam
- Celexa
- Child Ibuprofen
- Children's Advil
- Children's Ibu-drops
- Children's Ibuprofen
- Children's Medi-profen
- Children's Motrin
- Children's Profen Ib
- chlorphen-phenyleph-ibuprofen
- chlorphen-pseudoeph-ibuprofen
- Cipro
- Cipro In D5W
- Cipro Xr
- ciprofloxacin
- ciprofloxacin (mixture)
- ciprofloxacin in D5W
- citalopram
- Cold & Sinus Pain Relief
- Cold-sinus Relief
- Complera
- danazol
- dasatinib
- Daypro
- Dexilant
- dexlansoprazole
- diclofenac epolamine
- diclofenac potassium
- diclofenac sodium
- diclofenac submicronized
- diclofenac-misoprostol
- Dilacor Xr
- Dilt-xr
- diltiazem HCl
- Diskets
- dofetilide
- dolasetron
- Dolophine
- Duexis
- Ec-naprosyn
- Edurant
- efavirenz-emtricitabin-tenofov
- elvitegr-cobicist-emtric-tenof
- emtricitab-rilpivirine-tenofov
- emtricitabine-tenofovir
- eribulin
- ertapenem
- escitalopram oxalate
- esomeprazole magnesium
- esomeprazole sodium
- esomeprazole strontium
- etodolac
- ezogabine
- Fareston
- Feldene
- felodipine
- fenoprofen
- First-lansoprazole
- First-omeprazole
- Flanax
- Flector
- flurbiprofen
- gadofosveset trisodium
- Gilotrif
- Halaven
- Haldol
- Haldol Decanoate
- haloperidol
- haloperidol decanoate
- haloperidol lactate
- Heartburn Relief 24 Hour
- Heartburn Treatment 24 Hour
- hydrocodone-ibuprofen
- I-prin
- Ibu-drops
- Ibudone
- ibuprofen
- Ibuprofen Cold
- Ibuprofen Cold-sinus(with Pse)
- Ibuprofen Ib
- Ibuprofen Jr Strength
- ibuprofen lysine (PF)
- Ibuprofen Pm
- ibuprofen-diphenhydramine
- ibuprofen-diphenhydramine HCl
- ibuprofen-famotidine
- ibuprofen-oxycodone
- ibuprofen-phenylephrine HCl
- Indocin
- indomethacin
- indomethacin sodium
- Infant's Ibuprofen
- Infant's Medi-profen
- Infant's Motrin
- Infants Ibu-drops
- Infants Profenib
- Invanz
- Invega
- Invega Sustenna
- Istodax
- Juxtapid
- ketoprofen
- ketorolac
- lansoprazole
- lapatinib
- Levaquin
- Levaquin In 5 % Dextrose
- levofloxacin
- levofloxacin in D5W
- Lexapro
- lomitapide
- Matzim La
- Medi-profen
- Mediproxen
- mefenamic acid
- methadone
- Methadone Intensol
- Methadose
- Midol (naproxen)
- Motrin Ib
- Motrin Pm
- moxifloxacin
- moxifloxacin in NaCl (iso-osm)
- nabumetone
- Nalfon
- Naprelan Cr
- Naprosyn
- naproxen
- naproxen sodium
- naproxen-esomeprazole
- naproxen-pseudoephedrine
- Neoprofen (ibuprofen Lysn)(pf)
- Nexavar
- Nexium
- Nexium Iv
- Nexium Packet
- nicardipine
- nicardipine in dextrose,iso-os
- nicardipine in NaCl (iso-os)
- Nifedical Xl
- nifedipine
- nilotinib
- norfloxacin
- Noroxin
- omeprazole
- omeprazole magnesium
- Omeprazole+syrspend Sf Alka
- omeprazole-sodium bicarbonate
- ondansetron
- ondansetron HCl
- ondansetron HCl (PF)
- oxaprozin
- paliperidone
- paliperidone palmitate
- pasireotide
- Pennsaid
- piroxicam
- Ponstel
- Potiga
- Prevacid
- Prevacid 24Hr
- Prevacid Solutab
- Prilosec
- Prilosec Otc
- Procardia
- Procardia Xl
- propafenone
- Provil
- pseudoephedrine-ibuprofen
- Qualaquin
- quetiapine
- quinine sulfate
- rabeprazole
- Reprexain
- rilpivirine
- romidepsin
- Rythmol
- Seroquel
- Seroquel Xr
- Signifor
- Sinus & Cold-d
- Sirturo
- Solaraze
- sorafenib
- Sorine
- sotalol
- Sotalol Af
- Sprix
- Sprycel
- Stribild
- sulindac
- Tarka
- Tasigna
- Taztia Xt
- telavancin
- tenofovir disoproxil fumarate
- tetrabenazine
- Tiazac
- Tikosyn
- tolmetin
- toremifene
- trandolapril-verapamil
- Trisenox
- Truvada
- Tykerb
- Uroxatral
- vandetanib
- vemurafenib
- verapamil
- Verelan
- Verelan Pm
- Vibativ
- Vicoprofen
- Vimovo
- Viread
- Voltaren-xr
- Wal-profen
- Wal-profen Cold-sinus
- Wal-proxen
- Xenazine
- Zegerid
- Zegerid Otc
- Zelboraf
- Zipsor
- Zofran
- Zofran Odt
- Zorvolex
- Zuplenz
- BK polyomavirus reactivation nephropathy
- Congenital long QT syndrome
- Malignant lymphoma
- Posterior reversible encephalopathy syndrome
- Progressive multifocal leukoencephalopathy
- Torsades de pointes
Contraindicated
- Bradycardia
- Chronic heart failure
- Coma
- Delirium
- Eczema herpeticum
- Gastrointestinal perforation
- Graft versus host disease
- Herpes simplex infection
- Herpes zoster
- Hyperkalemia
- Hypocalcemia
- Hypokalemia
- Hypomagnesemia
- Immunosuppression
- Infectious mononucleosis
- Lamellar ichthyosis
- Malignancy
- Nephrotoxicity
- Netherton's syndrome
- Post-transplant lymphoproliferative disease
- Pregnancy
- Prolonged QT interval
- Pure red cell aplasia
- Severe hepatic disease
- Severe infection
Severe
Moderate
- Diabetes mellitus
- Hypertension
- Lymphadenopathy
- Malignancy
- Malignant lymphoma
TACROLIMUS (TACROLIMUS)
- Intractable eczema
- Prevention of cardiac transplant rejection
- Prevention of kidney transplant rejection
- Prevention of liver transplant rejection
- Atopic dermatitis
- Anemia
- Blood dyscrasias
- CNS toxicity
- Flushing
- Hyperglycemia
- Hyperkalemia
- Hypomagnesemia
- Infection
- Insomnia
- Kidney disease with reduction in GFR
- Leukopenia
- Nephrotoxicity
- Pleural effusions
- Seizure disorder
- Skin rash
- Wheezing
- Acute confusion
- Agitation
- Anorexia
- Constipation
- Depression
- Diabetes mellitus
- Diarrhea
- Dizziness
- Fever
- Flu-like symptoms
- Gastrointestinal irritation
- General weakness
- Hallucinations
- Headache disorder
- Nausea
- Nervousness
- Nightmares
- Paresthesia
- Peripheral edema
- Pruritus of skin
- Skin rash
- Symptoms of anxiety
- Treatment site sequelae
- Tremor
- Vomiting
More Frequent
Severe
Less Severe
- Cardiomyopathy
- Dyspnea
- Fungal infection
- Hypercortisolism
- Hypertension
- Hypokalemia
- Osteoporosis
- Abdominal distension
- Acne vulgaris
- Acute abdominal pain
- Alcohol intolerance
- Aphthous stomatitis
- Back pain
- Bullous dermatitis
- Chest pain
- Cramps
- Dyspepsia
- Dyspnea
- Eye tearing
- Eyelid erythema
- Folliculitis
- Hyperhidrosis
- Hyperlipidemia
- Hypertriglyceridemia
- Hypesthesia
- Myalgias
- Ocular itching
- Ocular redness
- Pain
- Paresthesia
- Peripheral neuropathy
- Sinusitis
- Tinnitus
- Urinary tract infection
- Visual changes
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal ECG
- Abnormal hepatic function tests
- Acute pancreatitis
- Agranulocytosis
- Anaphylaxis
- Angina
- Aphasia
- Atrial fibrillation
- Atrial flutter
- Basal cell carcinoma of skin
- Biliary obstruction
- BK polyomavirus reactivation nephropathy
- Bradycardia
- Cholangitis
- Chronic heart failure
- Coma
- Cytomegalovirus disease
- Deep venous thrombosis
- Disseminated intravascular coagulation
- Gastric ulcer
- Gastroenteritis
- Gastrointestinal perforation
- Hemiparesis
- Hemolytic anemia
- Hemolytic uremic syndrome
- Hemorrhage
- Hemorrhagic cystitis
- Hepatic necrosis
- Hepatitis
- Hypertrophic cardiomyopathy
- Idiopathic thrombocytopenic purpura
- Interstitial lung disease
- Left ventricular hypertrophy
- Leukocytosis
- Malignancy
- Malignant lymphoma
- Neutropenic disorder
- Optic neuropathy
- Pancytopenia
- Paralysis
- Pericardial effusion
- Post-transplant lymphoproliferative disease
- Posterior reversible encephalopathy syndrome
- Progressive multifocal leukoencephalopathy
- Prolonged QT interval
- Pulmonary hypertension
- Pulmonary thromboembolism
- Pure red cell aplasia
- Renal failure
- Rhabdomyolysis
- Squamous cell carcinoma
- Stevens-johnson syndrome
- Supraventricular premature beats
- Thrombocytopenic disorder
- Thrombotic thrombocytopenic purpura
- Torsades de pointes
- Toxic epidermal necrolysis
- Transient blindness
- Urinary retention
- Ventricular fibrillation
- Viral infection
- Vision loss
Less Severe
- Altered mental status
- Arthritis
- Delirium
- Drowsy
- Dysarthria
- Gastritis
- Glycosuria
- Hearing loss
- Hematuria
- Hiccups
- Impaired wound healing
- Limb pain
- Localized edema
- Mood changes
- Myalgias
- Photophobia
- Rhinitis
- Skin photosensitivity
- Skin pigmentation enhancement
- Syncope
- Tachycardia
- Urinary incontinence
Contraindicated
None
Severe Precaution
Tacrolimus 0.03% (Top)
Off-label use for mild to severe atopic dermatitis as steroid sparing agent. Possible risk of infection, unknown risk of malignancy.
Possible risk of infection, unknown risk of malignancy. 0.1% strength not approved age< 18 years.
- 1 Day – 2 Years
- Off-label use for mild to severe atopic dermatitis as steroid sparing agent. Possible risk of infection, unknown risk of malignancy.
- 1 Day – 18 Years
- Off-label use for mild to severe atopic dermatitis as steroid sparing agent. Possible risk of infection, unknown risk of malignancy.
Tacrolimus 0.1% (Top)
Off-label use for mild to severe atopic dermatitis as steroid sparing agent. Possible risk of infection, unknown risk of malignancy.
Possible risk of infection, unknown risk of malignancy. 0.1% strength not approved age< 18 years.
- 1 Day – 2 Years
- Possible risk of infection, unknown risk of malignancy. 0.1% strength not approved age< 18 years.
- 1 Day – 18 Years
- Possible risk of infection, unknown risk of malignancy. 0.1% strength not approved age< 18 years.
Management or Monitoring Precaution
None
Tacrolimus (systemic)
- Severity Level:
D
- Additional Notes: Avail human data suggest increased risk of dev tox; consider risk vs benefit
Tacrolimus (topical)
- Severity Level:
C
- Additional Notes: Insufficient human and animal data with topical form; minimally absorbed
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Tacrolimus (systemic)
Limited data suggest minimal excretion; no known adverse infant effects
Minimal systemic absorption expected
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Excreted | Not known; no or inclusive data | Limited data suggest minimal excretion; no known adverse infant effects |
Tacrolimus(topical)
Limited data suggest minimal excretion; no known adverse infant effects
Minimal systemic absorption expected
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | Minimal systemic absorption expected |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Tacrolimus (systemic)
Cardiovascular-Risk of myocardial hypertrophy can occur. May require reduced dose. General-Altered pharmacokinetics may occur and require more frequent monitoring.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | Y | Y | Y | N | N | N |
BEERS: N HEDIS: N STOPP: N
No Known Risk
None
- Patients have benefited from tacrolimus when it is used correctly. Long-term safety for this drug is not known at this time. There have been rare reports of cancers (e.g., skin cancer, lymphoma) in patients using tacrolimus.<br /><br />It is not known whether tacrolimus caused these cancers when used on the skin. Further studies to determine the long-term safety of this product are ongoing. In the unlikely event that unusual lumps, swollen glands, or growths (especially on the skin) occur, contact your doctor right away.<br /><br /> The US Food and Drug Administration recommends the following: This drug should be used only if other drugs have failed or if other medications are not considered appropriate by your doctor. Tacrolimus should be used on the skin for short treatment periods only. If needed, treatment may be repeated with breaks in between.<br /><br />Use the smallest amount that will treat your condition properly, and apply only on the affected skin. Also, this medication should not be used in children younger than 2 years. As with all medications, discuss the risks, benefits, and proper use of this medication with your doctor.
| Atopic dermatitis | |
| L20 | Atopic dermatitis |
| L20.0 | Besnier's prurigo |
| L20.8 | Other atopic dermatitis |
| L20.81 | Atopic neurodermatitis |
| L20.82 | Flexural eczema |
| L20.84 | Intrinsic (allergic) eczema |
| L20.89 | Other atopic dermatitis |
| L20.9 | Atopic dermatitis, unspecified |
| Intractable eczema | |
| L20.82 | Flexural eczema |
| L20.84 | Intrinsic (allergic) eczema |
| Prevention of cardiac transplant rejection | |
| Z94.1 | Heart transplant status |
| Z94.3 | Heart and lungs transplant status |
| Prevention of kidney transplant rejection | |
| Z94.0 | Kidney transplant status |
| Prevention of liver transplant rejection | |
| Z94.4 | Liver transplant status |
| 0-9 | A-Z |
|---|---|
| L20 | Atopic dermatitis |
| L20.0 | Besnier's prurigo |
| L20.8 | Other atopic dermatitis |
| L20.81 | Atopic neurodermatitis |
| L20.82 | Flexural eczema |
| L20.82 | Flexural eczema |
| L20.84 | Intrinsic (allergic) eczema |
| L20.84 | Intrinsic (allergic) eczema |
| L20.89 | Other atopic dermatitis |
| L20.9 | Atopic dermatitis, unspecified |
| Z94.0 | Kidney transplant status |
| Z94.1 | Heart transplant status |
| Z94.3 | Heart and lungs transplant status |
| Z94.4 | Liver transplant status |
Formulary Reference Tool