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OFLOXACIN (OFLOXACIN)
- Otitis externa
- Acute pseudomonas aeruginosa otitis externa
- Acute staphylococcus aureus otitis externa
- Acute suppurative otitis media with tympanostomy tubes
- Bacterial conjunctivitis
- Bacterial corneal ulcer infection
- Chronic tubotympanic suppurative otitis media
0.3 % eye drops
- Instill 1 drop into affected eye(s) by ophthalmic route 4 times per day
0.3 % ear drops
- Instill 10 drops into affected ear(s) by otic route once daily
0.3 % eye drops
- Instill 1 drop into affected eye(s) by ophthalmic route 4 times per day
Acute pseudomonas aeruginosa otitis externa
- Instill 10 drops into right ear by otic route once daily
- Instill 10 drops into left ear by otic route once daily
- Instill 10 drops into both ears by otic route once daily
- Instill 10 drops into both ears by otic route once daily for 10 days
- Instill 10 drops into left ear by otic route once daily for 10 days
- Instill 10 drops into right ear by otic route once daily for 10 days
- Instill 10 drops into affected ear(s) by otic route once daily
- Instill 10 drops into affected ear(s) by otic route once daily for 10Days
Acute staphylococcus aureus otitis externa
- Instill 10 drops into right ear by otic route once daily
- Instill 10 drops into left ear by otic route once daily
- Instill 10 drops into both ears by otic route once daily
- Instill 10 drops into both ears by otic route once daily for 10 days
- Instill 10 drops into left ear by otic route once daily for 10 days
- Instill 10 drops into right ear by otic route once daily for 10 days
- Instill 10 drops into affected ear(s) by otic route once daily
- Instill 10 drops into affected ear(s) by otic route once daily for 10Days
Bacterial conjunctivitis
- Instill 1 drop into left eye by ophthalmic route every 2 hours for 2 days then 1 drop four times daily for 5 days
- Instill 1 drop into left eye by ophthalmic route every 4 hours for 2 days then 1 drop four times daily for 5 days
- Instill 2 drops into left eye by ophthalmic route every 2 hours for 2Days then 2 drops four times daily for 5 days
- Instill 2 drops into left eye by ophthalmic route every 4 hours for 2Days then 2 drops four times daily for 5 days
- Instill 1 drop into right eye by ophthalmic route every 2 hours for 2Days then 1 drop four times daily for 5 days
- Instill 1 drop into right eye by ophthalmic route every 4 hours for 2Days then 1 drop four times daily for 5 days
- Instill 2 drops into right eye by ophthalmic route every 2 hours for 2 days then 2 drops four times daily for 5 days
- Instill 2 drops into right eye by ophthalmic route every 4 hours for 2 days then 2 drops four times daily for 5 days
- Instill 1 drop into both eyes by ophthalmic route every 2 hours for 2Days then 1 drop four times daily for 5 days
- Instill 1 drop into both eyes by ophthalmic route every 4 hours for 2Days then 1 drop four times daily for 5 days
- Instill 2 drops into both eyes by ophthalmic route every 2 hours for 2 days then 2 drops four times daily for 5 days
- Instill 2 drops into both eyes by ophthalmic route every 4 hours for 2 days then 2 drops four times daily for 5 days
- Instill 1 drop into affected eye(s) by ophthalmic route every 2 hoursfor 2 days then 1 drop four times daily for 5 days
- Apply 1 drop into affected eye(s) by ophthalmic route every 4 hours for 2 days then 1 drop four times daily for 5 days
- Instill 2 drops into affected eye(s) by ophthalmic route every 2 hours for 2 days then 2 drops four times daily for 5 days
- Instill 2 drops into affected eye(s) by ophthalmic route every 4 hours for 2 days then 2 drops four times daily for 5 days
Bacterial corneal ulcer infection
- Instill 2 drops into right eye by ophthalmic route 4 times per day
- Instill 2 drops into left eye by ophthalmic route 4 times per day
- Instill 2 drops into both eyes by ophthalmic route 4 times per day
- Instill 1 drop into left eye by ophthalmic route 4 times per day
- Instill 1 drop into right eye by ophthalmic route 4 times per day
- Instill 1 drop into both eyes by ophthalmic route 4 times per day
- Instill 2 drops into affected eye(s) by ophthalmic route 4 times per day
- Instill 1 drop into affected eye(s) by ophthalmic route 4 times per day
Chronic tubotympanic suppurative otitis media
- Instill 10 drops into right ear by otic route 2 times per day
- Instill 10 drops into right ear by otic route 2 times per day for 14 days
- Instill 10 drops into left ear by otic route 2 times per day for 14 days
- Instill 10 drops into left ear by otic route 2 times per day
- Instill 10 drops into both ears by otic route 2 times per day
- Instill 10 drops into both ears by otic route 2 times per day for 14 days
- Instill 10 drops into affected ear(s) by otic route 2 times per day
- Instill 10 drops into affected ear(s) by otic route 2 times per day for 14 days
Otitis externa
- Instill 10 drops into right ear by otic route once daily
- Instill 10 drops into left ear by otic route once daily
- Instill 10 drops into both ears by otic route once daily
- Instill 10 drops into both ears by otic route once daily for 10 days
- Instill 10 drops into left ear by otic route once daily for 10 days
- Instill 10 drops into right ear by otic route once daily for 10 days
- Instill 10 drops into affected ear(s) by otic route once daily
- Instill 10 drops into affected ear(s) by otic route once daily for 10Days
- None
Contraindicated
- None
Severe
Moderate
- None
- None
Contraindicated
- None
Severe
Moderate
- No disease contraindications
OFLOXACIN (OFLOXACIN)
- Otitis externa
- Acute pseudomonas aeruginosa otitis externa
- Acute staphylococcus aureus otitis externa
- Acute suppurative otitis media with tympanostomy tubes
- Bacterial conjunctivitis
- Bacterial corneal ulcer infection
- Chronic tubotympanic suppurative otitis media
- None
- Ocular irritation
More Frequent
Severe
Less Severe
- Dizziness
- Treatment site sequelae
- Vertigo
- Blurred vision
- Dry eye
- Dysgeusia
- Earache
- Eye tearing
- Foreign body sensation of eye
- Hypesthesia
- Ocular itching
- Ocular pain
- Ocular redness
- Paresthesia
- Periorbital edema
- Photophobia
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Fever
- Headache disorder
- Pharyngitis
- Rhinitis
- Sinusitis
- Stevens-johnson syndrome
- Tachycardia
- Tinnitus
- Toxic epidermal necrolysis
Less Severe
- Dizziness
- Facial edema
- Nausea
- Pruritus of skin
- Skin rash
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Select Quinolones (Ophth)
Safety and efficacy not established for pediatric patients less than 1 year.
- 1 Day – 364 Days
- Safety and efficacy not established for pediatric patients less than 1 year.
Ofloxacin
- Severity Level:
C
- Additional Notes: Reports of arthropathy with quinolones in animal studies;consider risk/benefit
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Ofloxacin (ophth, Otic)
Insufficient data available
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | Insufficient data available |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- None
| Acute pseudomonas aeruginosa otitis externa | |
| B96.5 | Pseudomonas (aeruginosa) (mallei) (pseudomallei) as the cause of diseases classified elsewhere |
| H60.2 | Malignant otitis externa |
| H60.20 | Malignant otitis externa, unspecified ear |
| H60.21 | Malignant otitis externa, right ear |
| H60.22 | Malignant otitis externa, left ear |
| H60.23 | Malignant otitis externa, bilateral |
| H60.31 | Diffuse otitis externa |
| H60.311 | Diffuse otitis externa, right ear |
| H60.312 | Diffuse otitis externa, left ear |
| H60.313 | Diffuse otitis externa, bilateral |
| H60.319 | Diffuse otitis externa, unspecified ear |
| H60.32 | Hemorrhagic otitis externa |
| H60.321 | Hemorrhagic otitis externa, right ear |
| H60.322 | Hemorrhagic otitis externa, left ear |
| H60.323 | Hemorrhagic otitis externa, bilateral |
| H60.329 | Hemorrhagic otitis externa, unspecified ear |
| H60.33 | Swimmer's ear |
| H60.331 | Swimmer's ear, right ear |
| H60.332 | Swimmer's ear, left ear |
| H60.333 | Swimmer's ear, bilateral |
| H60.339 | Swimmer's ear, unspecified ear |
| Acute staphylococcus aureus otitis externa | |
| B95.6 | Staphylococcus aureus as the cause of diseases classified elsewhere |
| H60.31 | Diffuse otitis externa |
| H60.311 | Diffuse otitis externa, right ear |
| H60.312 | Diffuse otitis externa, left ear |
| H60.313 | Diffuse otitis externa, bilateral |
| H60.319 | Diffuse otitis externa, unspecified ear |
| H60.33 | Swimmer's ear |
| H60.331 | Swimmer's ear, right ear |
| H60.332 | Swimmer's ear, left ear |
| H60.333 | Swimmer's ear, bilateral |
| H60.339 | Swimmer's ear, unspecified ear |
| H60.39 | Other infective otitis externa |
| H60.391 | Other infective otitis externa, right ear |
| H60.392 | Other infective otitis externa, left ear |
| H60.393 | Other infective otitis externa, bilateral |
| H60.399 | Other infective otitis externa, unspecified ear |
| Acute suppurative otitis media with tympanostomy tubes | |
| H66 | Suppurative and unspecified otitis media |
| H66.0 | Acute suppurative otitis media |
| H66.00 | Acute suppurative otitis media without spontaneous rupture of ear drum |
| H66.001 | Acute suppurative otitis media without spontaneous rupture of ear drum, right ear |
| H66.002 | Acute suppurative otitis media without spontaneous rupture of ear drum, left ear |
| H66.003 | Acute suppurative otitis media without spontaneous rupture of ear drum, bilateral |
| H66.004 | Acute suppurative otitis media without spontaneous rupture of ear drum, recurrent, right ear |
| H66.005 | Acute suppurative otitis media without spontaneous rupture of ear drum, recurrent, left ear |
| H66.006 | Acute suppurative otitis media without spontaneous rupture of ear drum, recurrent, bilateral |
| H66.007 | Acute suppurative otitis media without spontaneous rupture of ear drum, recurrent, unspecified ear |
| H66.009 | Acute suppurative otitis media without spontaneous rupture of ear drum, unspecified ear |
| H66.011 | Acute suppurative otitis media with spontaneous rupture of ear drum, right ear |
| H66.012 | Acute suppurative otitis media with spontaneous rupture of ear drum, left ear |
| H66.013 | Acute suppurative otitis media with spontaneous rupture of ear drum, bilateral |
| H66.014 | Acute suppurative otitis media with spontaneous rupture of ear drum, recurrent, right ear |
| H66.015 | Acute suppurative otitis media with spontaneous rupture of ear drum, recurrent, left ear |
| H66.016 | Acute suppurative otitis media with spontaneous rupture of ear drum, recurrent, bilateral |
| H66.017 | Acute suppurative otitis media with spontaneous rupture of ear drum, recurrent, unspecified ear |
| H66.019 | Acute suppurative otitis media with spontaneous rupture of ear drum, unspecified ear |
| H66.40 | Suppurative otitis media, unspecified, unspecified ear |
| H66.41 | Suppurative otitis media, unspecified, right ear |
| H66.42 | Suppurative otitis media, unspecified, left ear |
| H66.43 | Suppurative otitis media, unspecified, bilateral |
| Bacterial conjunctivitis | |
| H10.02 | Other mucopurulent conjunctivitis |
| H10.021 | Other mucopurulent conjunctivitis, right eye |
| H10.022 | Other mucopurulent conjunctivitis, left eye |
| H10.023 | Other mucopurulent conjunctivitis, bilateral |
| H10.029 | Other mucopurulent conjunctivitis, unspecified eye |
| H10.3 | Unspecified acute conjunctivitis |
| H10.30 | Unspecified acute conjunctivitis, unspecified eye |
| H10.31 | Unspecified acute conjunctivitis, right eye |
| H10.32 | Unspecified acute conjunctivitis, left eye |
| H10.33 | Unspecified acute conjunctivitis, bilateral |
| Bacterial corneal ulcer infection | |
| H16.0 | Corneal ulcer |
| H16.00 | Unspecified corneal ulcer |
| H16.001 | Unspecified corneal ulcer, right eye |
| H16.002 | Unspecified corneal ulcer, left eye |
| H16.003 | Unspecified corneal ulcer, bilateral |
| H16.009 | Unspecified corneal ulcer, unspecified eye |
| H16.01 | Central corneal ulcer |
| H16.011 | Central corneal ulcer, right eye |
| H16.012 | Central corneal ulcer, left eye |
| H16.013 | Central corneal ulcer, bilateral |
| H16.019 | Central corneal ulcer, unspecified eye |
| H16.02 | Ring corneal ulcer |
| H16.021 | Ring corneal ulcer, right eye |
| H16.022 | Ring corneal ulcer, left eye |
| H16.023 | Ring corneal ulcer, bilateral |
| H16.029 | Ring corneal ulcer, unspecified eye |
| H16.03 | Corneal ulcer with hypopyon |
| H16.031 | Corneal ulcer with hypopyon, right eye |
| H16.032 | Corneal ulcer with hypopyon, left eye |
| H16.033 | Corneal ulcer with hypopyon, bilateral |
| H16.039 | Corneal ulcer with hypopyon, unspecified eye |
| H16.04 | Marginal corneal ulcer |
| H16.041 | Marginal corneal ulcer, right eye |
| H16.042 | Marginal corneal ulcer, left eye |
| H16.043 | Marginal corneal ulcer, bilateral |
| H16.049 | Marginal corneal ulcer, unspecified eye |
| H16.07 | Perforated corneal ulcer |
| H16.071 | Perforated corneal ulcer, right eye |
| H16.072 | Perforated corneal ulcer, left eye |
| H16.073 | Perforated corneal ulcer, bilateral |
| H16.079 | Perforated corneal ulcer, unspecified eye |
| Chronic tubotympanic suppurative otitis media | |
| H66.1 | Chronic tubotympanic suppurative otitis media |
| H66.10 | Chronic tubotympanic suppurative otitis media, unspecified |
| H66.11 | Chronic tubotympanic suppurative otitis media, right ear |
| H66.12 | Chronic tubotympanic suppurative otitis media, left ear |
| H66.13 | Chronic tubotympanic suppurative otitis media, bilateral |
| Otitis externa | |
| H60.31 | Diffuse otitis externa |
| H60.311 | Diffuse otitis externa, right ear |
| H60.312 | Diffuse otitis externa, left ear |
| H60.313 | Diffuse otitis externa, bilateral |
| H60.319 | Diffuse otitis externa, unspecified ear |
| H60.33 | Swimmer's ear |
| H60.331 | Swimmer's ear, right ear |
| H60.332 | Swimmer's ear, left ear |
| H60.333 | Swimmer's ear, bilateral |
| H60.339 | Swimmer's ear, unspecified ear |
| H60.60 | Unspecified chronic otitis externa, unspecified ear |
| H60.61 | Unspecified chronic otitis externa, right ear |
| H60.62 | Unspecified chronic otitis externa, left ear |
| H60.63 | Unspecified chronic otitis externa, bilateral |
| H60.9 | Unspecified otitis externa |
| H60.90 | Unspecified otitis externa, unspecified ear |
| H60.91 | Unspecified otitis externa, right ear |
| H60.92 | Unspecified otitis externa, left ear |
| H60.93 | Unspecified otitis externa, bilateral |
| 0-9 | A-Z |
|---|---|
| B95.6 | Staphylococcus aureus as the cause of diseases classified elsewhere |
| B96.5 | Pseudomonas (aeruginosa) (mallei) (pseudomallei) as the cause of diseases classified elsewhere |
| H10.02 | Other mucopurulent conjunctivitis |
| H10.021 | Other mucopurulent conjunctivitis, right eye |
| H10.022 | Other mucopurulent conjunctivitis, left eye |
| H10.023 | Other mucopurulent conjunctivitis, bilateral |
| H10.029 | Other mucopurulent conjunctivitis, unspecified eye |
| H10.3 | Unspecified acute conjunctivitis |
| H10.30 | Unspecified acute conjunctivitis, unspecified eye |
| H10.31 | Unspecified acute conjunctivitis, right eye |
| H10.32 | Unspecified acute conjunctivitis, left eye |
| H10.33 | Unspecified acute conjunctivitis, bilateral |
| H16.0 | Corneal ulcer |
| H16.00 | Unspecified corneal ulcer |
| H16.001 | Unspecified corneal ulcer, right eye |
| H16.002 | Unspecified corneal ulcer, left eye |
| H16.003 | Unspecified corneal ulcer, bilateral |
| H16.009 | Unspecified corneal ulcer, unspecified eye |
| H16.01 | Central corneal ulcer |
| H16.011 | Central corneal ulcer, right eye |
| H16.012 | Central corneal ulcer, left eye |
| H16.013 | Central corneal ulcer, bilateral |
| H16.019 | Central corneal ulcer, unspecified eye |
| H16.02 | Ring corneal ulcer |
| H16.021 | Ring corneal ulcer, right eye |
| H16.022 | Ring corneal ulcer, left eye |
| H16.023 | Ring corneal ulcer, bilateral |
| H16.029 | Ring corneal ulcer, unspecified eye |
| H16.03 | Corneal ulcer with hypopyon |
| H16.031 | Corneal ulcer with hypopyon, right eye |
| H16.032 | Corneal ulcer with hypopyon, left eye |
| H16.033 | Corneal ulcer with hypopyon, bilateral |
| H16.039 | Corneal ulcer with hypopyon, unspecified eye |
| H16.04 | Marginal corneal ulcer |
| H16.041 | Marginal corneal ulcer, right eye |
| H16.042 | Marginal corneal ulcer, left eye |
| H16.043 | Marginal corneal ulcer, bilateral |
| H16.049 | Marginal corneal ulcer, unspecified eye |
| H16.07 | Perforated corneal ulcer |
| H16.071 | Perforated corneal ulcer, right eye |
| H16.072 | Perforated corneal ulcer, left eye |
| H16.073 | Perforated corneal ulcer, bilateral |
| H16.079 | Perforated corneal ulcer, unspecified eye |
| H60.2 | Malignant otitis externa |
| H60.20 | Malignant otitis externa, unspecified ear |
| H60.21 | Malignant otitis externa, right ear |
| H60.22 | Malignant otitis externa, left ear |
| H60.23 | Malignant otitis externa, bilateral |
| H60.31 | Diffuse otitis externa |
| H60.31 | Diffuse otitis externa |
| H60.31 | Diffuse otitis externa |
| H60.311 | Diffuse otitis externa, right ear |
| H60.311 | Diffuse otitis externa, right ear |
| H60.311 | Diffuse otitis externa, right ear |
| H60.312 | Diffuse otitis externa, left ear |
| H60.312 | Diffuse otitis externa, left ear |
| H60.312 | Diffuse otitis externa, left ear |
| H60.313 | Diffuse otitis externa, bilateral |
| H60.313 | Diffuse otitis externa, bilateral |
| H60.313 | Diffuse otitis externa, bilateral |
| H60.319 | Diffuse otitis externa, unspecified ear |
| H60.319 | Diffuse otitis externa, unspecified ear |
| H60.319 | Diffuse otitis externa, unspecified ear |
| H60.32 | Hemorrhagic otitis externa |
| H60.321 | Hemorrhagic otitis externa, right ear |
| H60.322 | Hemorrhagic otitis externa, left ear |
| H60.323 | Hemorrhagic otitis externa, bilateral |
| H60.329 | Hemorrhagic otitis externa, unspecified ear |
| H60.33 | Swimmer's ear |
| H60.33 | Swimmer's ear |
| H60.33 | Swimmer's ear |
| H60.331 | Swimmer's ear, right ear |
| H60.331 | Swimmer's ear, right ear |
| H60.331 | Swimmer's ear, right ear |
| H60.332 | Swimmer's ear, left ear |
| H60.332 | Swimmer's ear, left ear |
| H60.332 | Swimmer's ear, left ear |
| H60.333 | Swimmer's ear, bilateral |
| H60.333 | Swimmer's ear, bilateral |
| H60.333 | Swimmer's ear, bilateral |
| H60.339 | Swimmer's ear, unspecified ear |
| H60.339 | Swimmer's ear, unspecified ear |
| H60.339 | Swimmer's ear, unspecified ear |
| H60.39 | Other infective otitis externa |
| H60.391 | Other infective otitis externa, right ear |
| H60.392 | Other infective otitis externa, left ear |
| H60.393 | Other infective otitis externa, bilateral |
| H60.399 | Other infective otitis externa, unspecified ear |
| H60.60 | Unspecified chronic otitis externa, unspecified ear |
| H60.61 | Unspecified chronic otitis externa, right ear |
| H60.62 | Unspecified chronic otitis externa, left ear |
| H60.63 | Unspecified chronic otitis externa, bilateral |
| H60.9 | Unspecified otitis externa |
| H60.90 | Unspecified otitis externa, unspecified ear |
| H60.91 | Unspecified otitis externa, right ear |
| H60.92 | Unspecified otitis externa, left ear |
| H60.93 | Unspecified otitis externa, bilateral |
| H66 | Suppurative and unspecified otitis media |
| H66.0 | Acute suppurative otitis media |
| H66.00 | Acute suppurative otitis media without spontaneous rupture of ear drum |
| H66.001 | Acute suppurative otitis media without spontaneous rupture of ear drum, right ear |
| H66.002 | Acute suppurative otitis media without spontaneous rupture of ear drum, left ear |
| H66.003 | Acute suppurative otitis media without spontaneous rupture of ear drum, bilateral |
| H66.004 | Acute suppurative otitis media without spontaneous rupture of ear drum, recurrent, right ear |
| H66.005 | Acute suppurative otitis media without spontaneous rupture of ear drum, recurrent, left ear |
| H66.006 | Acute suppurative otitis media without spontaneous rupture of ear drum, recurrent, bilateral |
| H66.007 | Acute suppurative otitis media without spontaneous rupture of ear drum, recurrent, unspecified ear |
| H66.009 | Acute suppurative otitis media without spontaneous rupture of ear drum, unspecified ear |
| H66.011 | Acute suppurative otitis media with spontaneous rupture of ear drum, right ear |
| H66.012 | Acute suppurative otitis media with spontaneous rupture of ear drum, left ear |
| H66.013 | Acute suppurative otitis media with spontaneous rupture of ear drum, bilateral |
| H66.014 | Acute suppurative otitis media with spontaneous rupture of ear drum, recurrent, right ear |
| H66.015 | Acute suppurative otitis media with spontaneous rupture of ear drum, recurrent, left ear |
| H66.016 | Acute suppurative otitis media with spontaneous rupture of ear drum, recurrent, bilateral |
| H66.017 | Acute suppurative otitis media with spontaneous rupture of ear drum, recurrent, unspecified ear |
| H66.019 | Acute suppurative otitis media with spontaneous rupture of ear drum, unspecified ear |
| H66.1 | Chronic tubotympanic suppurative otitis media |
| H66.10 | Chronic tubotympanic suppurative otitis media, unspecified |
| H66.11 | Chronic tubotympanic suppurative otitis media, right ear |
| H66.12 | Chronic tubotympanic suppurative otitis media, left ear |
| H66.13 | Chronic tubotympanic suppurative otitis media, bilateral |
| H66.40 | Suppurative otitis media, unspecified, unspecified ear |
| H66.41 | Suppurative otitis media, unspecified, right ear |
| H66.42 | Suppurative otitis media, unspecified, left ear |
| H66.43 | Suppurative otitis media, unspecified, bilateral |
Formulary Reference Tool