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ARIPIPRAZOLE ODT (aripiprazole)
- Mania associated with bipolar disorder
- Mixed bipolar I disorder
- Schizophrenia
- Bipolar disorder in remission
- Depression treatment adjunct
- Gilles de la tourette syndrome
- Infantile autism
aripiprazole 10 mg disintegrating tablet
- 1 tablet (10 mg) and place on top of the tongue where it will dissolve, then swallow by oral route once daily
aripiprazole 15 mg disintegrating tablet
- 1 tablet (15 mg) and place on top of the tongue where it will dissolve, then swallow by oral route once daily
Bipolar disorder in remission
- 1 tablet (10 mg) and place on top of the tongue where it will dissolve, then swallow by oral route once daily
- Place 1 tablet (10 mg) on top of the tongue where it will dissolve, then swallow by translingual route once daily
- Place 1 tablet (15 mg) on top of the tongue where it will dissolve, then swallow by translingual route once daily
- 1 tablet (15 mg) and place on top of the tongue where it will dissolve, then swallow by oral route once daily
- 2 tablets (20 mg) and place on top of the tongue where they willdissolve, then swallow by oral route once daily
- Place 2 tablets (20 mg) on top of the tongue where they will dissolve, then swallow by translingual route once daily
- Place 2 tablets (30 mg) on top of the tongue where they will dissolve, then swallow by translingual route once daily
- 2 tablets (30 mg) and place on top of the tongue where they willdissolve, then swallow by oral route once daily
Depression treatment adjunct
- 1 tablet (10 mg) and place on top of the tongue where it will dissolve, then swallow by oral route once daily
- Place 1 tablet (10 mg) on top of the tongue where it will dissolve, then swallow by translingual route once daily
- Place 1 tablet (15 mg) on top of the tongue where it will dissolve, then swallow by translingual route once daily
- 1 tablet (15 mg) and place on top of the tongue where it will dissolve, then swallow by oral route once daily
Mania associated with bipolar disorder
- 1 tablet (10 mg) and place on top of the tongue where it will dissolve, then swallow by oral route once daily
- Place 1 tablet (10 mg) on top of the tongue where it will dissolve, then swallow by translingual route once daily
- Place 1 tablet (15 mg) on top of the tongue where it will dissolve, then swallow by translingual route once daily
- 1 tablet (15 mg) and place on top of the tongue where it will dissolve, then swallow by oral route once daily
- 2 tablets (20 mg) and place on top of the tongue where they willdissolve, then swallow by oral route once daily
- Place 2 tablets (20 mg) on top of the tongue where they will dissolve, then swallow by translingual route once daily
- Place 2 tablets (30 mg) on top of the tongue where they will dissolve, then swallow by translingual route once daily
- 2 tablets (30 mg) and place on top of the tongue where they willdissolve, then swallow by oral route once daily
Mixed bipolar I disorder
- Place 1 tablet (15 mg) on top of the tongue where it will dissolve, then swallow by translingual route once daily
- 1 tablet (15 mg) and place on top of the tongue where it will dissolve, then swallow by oral route once daily
- Place 2 tablets (30 mg) on top of the tongue where they will dissolve, then swallow by translingual route once daily
- 2 tablets (30 mg) and place on top of the tongue where they willdissolve, then swallow by oral route once daily
Schizophrenia
- 1 tablet (10 mg) and place on top of the tongue where it will dissolve, then swallow by oral route once daily
- Place 1 tablet (10 mg) on top of the tongue where it will dissolve, then swallow by translingual route once daily
- Place 1 tablet (15 mg) on top of the tongue where it will dissolve, then swallow by translingual route once daily
- 1 tablet (15 mg) and place on top of the tongue where it will dissolve, then swallow by oral route once daily
- 2 tablets (20 mg) and place on top of the tongue where they willdissolve, then swallow by oral route once daily
- Place 2 tablets (20 mg) on top of the tongue where they will dissolve, then swallow by translingual route once daily
- Place 2 tablets (30 mg) on top of the tongue where they will dissolve, then swallow by translingual route once daily
- 2 tablets (30 mg) and place on top of the tongue where they willdissolve, then swallow by oral route once daily
- metoclopramide HCl
- Metozolv Odt
- Reglan
Contraindicated
- cabergoline
Severe
Moderate
- Alagesic Lq
- amobarbital
- amoxicil-clarithromy-lansopraz
- Amytal
- Aplenzin
- Apokyn
- apomorphine
- Ascomp With Codeine
- atazanavir
- B cplx-C-St.Johnwrt-K.&S.ginsg
- Belladonna-phenobarbital
- Biaxin
- Biaxin Xl
- Biaxin Xl Pak
- boceprevir
- Brisdelle
- Bupap
- Buproban
- bupropion HBr
- bupropion HCl
- butabarbital
- Butalbital Compound W/codeine
- Butalbital Compound-codeine
- butalbital-acetaminop-caf-cod
- butalbital-acetaminophen
- butalbital-acetaminophen-caff
- butalbital-aspirin-caffeine
- Butisol
- calcium-mag-B complex-D3-hrb61
- Capacet
- carbamazepine
- Carbatrol
- carbidopa-levodopa
- carbidopa-levodopa-entacapone
- Cerebyx
- clarithromycin
- codeine-butalbital-ASA-caff
- Cold & Flu Fighter
- Comtan
- conivaptan in 5 % dextrose
- Crixivan
- Cymbalta
- Dilantin
- Dilantin Extended
- Dilantin Infatabs
- Dilantin Kapseal
- Dilantin-125
- Donnatal
- duloxetine
- elvitegr-cobicist-emtric-tenof
- entacapone
- enzalutamide
- Epitol
- Equetro
- Esgic
- Fatigue Relief Complex
- Fioricet
- Fioricet With Codeine
- Fiorinal
- Fiorinal-codeine #3
- fluoxetine
- Forfivo Xl
- fosphenytoin
- Incivek
- indinavir
- Invirase
- isoniazid-rifamp-pyrazinamide
- itraconazole
- Kaletra
- Ketek
- ketoconazole
- lopinavir-ritonavir
- Luminal
- Lysodren
- Margesic
- Marten-tab
- Mirapex
- Mirapex Er
- mitotane
- Mycobutin
- Mysoline
- nefazodone
- nelfinavir
- Nembutal Sodium
- Norvir
- Norvir Soft Gelatin
- Noxafil
- olanzapine-fluoxetine
- Omeclamox-pak
- omeprazole-clarith-amoxicillin
- Onmel
- paroxetine HCl
- paroxetine mesylate
- Paxil
- Paxil Cr
- pentobarbital sodium
- Pexeva
- phenobarb-hyoscy-atropine-scop
- phenobarbital
- phenobarbital sodium
- Phenytek
- phenytoin
- phenytoin sodium
- phenytoin sodium extended
- posaconazole
- pramipexole
- Prevpac
- primidone
- Prozac
- Prozac Weekly
- Requip
- Requip Xl
- Reyataz
- rifabutin
- Rifadin
- Rifamate
- rifampin
- rifampin-isoniazid
- Rifater
- ritonavir
- ropinirole
- saquinavir mesylate
- Sarafem
- secobarbital sodium
- Seconal Sodium
- Sinemet
- Sinemet Cr
- Sporanox
- Sporanox Pulsepak
- St. John's wort
- Stalevo 100
- Stalevo 125
- Stalevo 150
- Stalevo 200
- Stalevo 50
- Stalevo 75
- Stribild
- Symbyax
- Tegretol
- Tegretol Xr
- telaprevir
- telithromycin
- Tencon
- Vaprisol
- Vfend
- Vfend Iv
- Victrelis
- Viracept
- vit C-St. John wort-elder-hb30
- voriconazole
- Wellbutrin
- Wellbutrin Sr
- Wellbutrin Xl
- Women's Complex
- Xtandi
- Zebutal
- Zyban
- None
Contraindicated
- Chronic heart failure
- CYp2d6 poor metabolizer
- Metabolic syndrome X
- Neuroleptic malignant syndrome
- Parkinsonism
- Senile dementia
- Suicidal ideation
- Tardive dyskinesia
Severe
Moderate
- Acute confusion
- Agranulocytosis
- Alzheimer's disease
- Cerebrovascular disorder
- Diabetes mellitus
- Esophageal dysmotility
- Hypotension
- Leukopenia
- Lower seizure threshold
- Myocardial ischemia
- Neutropenic disorder
- Obesity
- Orthostatic hypotension
- Predisposition to aspiration
- Seizure disorder
- Weight gain
ARIPIPRAZOLE ODT (aripiprazole)
- Mania associated with bipolar disorder
- Mixed bipolar I disorder
- Schizophrenia
- Bipolar disorder in remission
- Depression treatment adjunct
- Gilles de la tourette syndrome
- Infantile autism
- Akathisia
- Agitation
- Constipation
- Dizziness
- Drowsy
- Dyspepsia
- Headache disorder
- Hypertriglyceridemia
- Increased appetite
- Insomnia
- Nausea
- Symptoms of anxiety
- Vomiting
More Frequent
Severe
Less Severe
- Acquired dystonia
- Extrapyramidal disease
- Fever
- Skin rash
- Tardive dyskinesia
- Anorexia
- Arthralgias
- Cough
- Diarrhea
- Dysmenorrhea
- Fatigue
- General weakness
- Hyperlipidemia
- Hyperprolactinemia
- Injection site sequelae
- Myalgias
- Nasal congestion
- Nervousness
- Orthostatic hypotension
- Pain
- Pharyngitis
- Toothache
- Tremor
- Weight gain
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal hepatic function tests
- Accidental fall
- Acute myocardial infarction
- Agranulocytosis
- Anaphylaxis
- Angioedema
- Aspiration pneumonia
- Atrial flutter
- Atrioventricular block
- Biliary calculus
- Bradycardia
- Chest pain
- Diabetes mellitus
- Diabetic ketoacidosis
- DRESS syndrome
- Dysphagia
- Esophageal dysmotility
- Heat stroke
- Hepatic failure
- Hepatitis
- Hepatomegaly
- Homicidal ideation
- Hyperglycemia
- Hypertension
- Hypoglycemic disorder
- Hypokalemia
- Hyponatremia
- Hypotension
- Increased creatine kinase level
- Jaundice
- Laryngismus
- Leukopenia
- Myocardial ischemia
- Neuroleptic malignant syndrome
- Neutropenic disorder
- Pancreatitis
- Parkinsonism
- Peripheral edema
- Pneumonia
- Priapism
- Prolonged QT interval
- Rhabdomyolysis
- Seizure disorder
- Serotonin syndrome
- Sleep apnea
- Splenomegaly
- Steatosis of liver
- Stevens-johnson syndrome
- Suicidal ideation
- Tachycardia
- Thrombocytopenic disorder
- Upper respiratory infection
- Urinary retention
- Ventricular tachycardia
Less Severe
- Abdominal pain with cramps
- Amenorrhea
- Ataxia
- Blurred vision
- Diplopia
- Dyspnea
- Erectile dysfunction
- Eyelid edema
- Facial edema
- Gastroesophageal reflux disease
- Gynecomastia
- Hiccups
- Hirsutism
- Hypokinesia
- Impulse control disorder
- Lethargy
- Mastalgia
- Memory impairment
- Menstrual disorder
- Muscle rigidity
- Muscle weakness
- Myoclonus
- Palpitations
- Photophobia
- Pruritus of skin
- Sialorrhea
- Skin photosensitivity
- Sleep walking disorder
- Urinary incontinence
- Weight loss
- Xerostomia
Contraindicated
None
Severe Precaution
Aripiprazole (Oral)
Risk of weight gain, glucose, lipid abnormalities. Possible increased suicidal ideation. Safety and efficacy not established age< 6 years.
Higher risk of somnolence, akathisia, extrapyramidal reaction, salivary hypersecretion, possible suicidal ideation. Monitor for weight gain, blood glucose abnormalities, lipid abnormalities.
- 1 Day – 6 Years
- Risk of weight gain, glucose, lipid abnormalities. Possible increased suicidal ideation. Safety and efficacy not established age< 6 years.
- Higher risk of somnolence, akathisia, extrapyramidal reaction, salivary hypersecretion, possible suicidal ideation. Monitor for weight gain, blood glucose abnormalities, lipid abnormalities.
- 6 Years – 18 Years
- Risk of weight gain, glucose, lipid abnormalities. Possible increased suicidal ideation. Safety and efficacy not established age< 6 years.
- Higher risk of somnolence, akathisia, extrapyramidal reaction, salivary hypersecretion, possible suicidal ideation. Monitor for weight gain, blood glucose abnormalities, lipid abnormalities.
Management or Monitoring Precaution
None
Aripiprazole
- Severity Level:
2
- Additional Notes: Non-teratogenic complications (resp, gi,cns) with exposure during 3rd trimester
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Aripiprazole
Limited data sugg small amounts excreted; consider maternal tx vs infant risk
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Excreted | Not known; no or inclusive data | Limited data sugg small amounts excreted; consider maternal tx vs infant risk |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Aripiprazole
Neuro/Psych-Higher risk of tardive dyskinesia. CNS effects; sedation, cognitive impairment, and increased fall risk. Avoid use for behavioral problems of dementia or delirium unless failed nonpharmacological options. Increased risk of stroke, cognitive decline, and death when used with senile dementia. Endocrine-May exacerbate or cause SIADH or hyponatremia. Cardiovascular-May cause orthostatic hypotension. Gastrointestinal-May cause or worsen pre-existing constipation.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | N | N | Y | Y | N | Y |
BEERS: Y HEDIS: Y STOPP: Y
No Known Risk
None
- If you are using aripiprazole in combination with other medication to treat depression, also carefully read the drug information for the other medication. There may be a slightly increased risk of serious, possibly fatal side effects (such as stroke, heart failure, fast/irregular heartbeat, pneumonia) when this medication is used by older adults with dementia. This medication is not approved for the treatment of dementia-related behavior problems. Discuss the risks and benefits of this medication, as well as other effective and possibly safer treatments for dementia-related behavior problems, with the doctor.
| Bipolar disorder in remission | |
| F31.7 | Bipolar disorder, currently in remission |
| F31.70 | Bipolar disorder, currently in remission, most recent episode unspecified |
| F31.71 | Bipolar disorder, in partial remission, most recent episode hypomanic |
| F31.72 | Bipolar disorder, in full remission, most recent episode hypomanic |
| F31.73 | Bipolar disorder, in partial remission, most recent episode manic |
| F31.74 | Bipolar disorder, in full remission, most recent episode manic |
| F31.75 | Bipolar disorder, in partial remission, most recent episode depressed |
| F31.76 | Bipolar disorder, in full remission, most recent episode depressed |
| F31.77 | Bipolar disorder, in partial remission, most recent episode mixed |
| F31.78 | Bipolar disorder, in full remission, most recent episode mixed |
| Depression treatment adjunct | |
| F32 | Major depressive disorder, single episode |
| F32.0 | Major depressive disorder, single episode, mild |
| F32.1 | Major depressive disorder, single episode, moderate |
| F32.2 | Major depressive disorder, single episode, severe without psychotic features |
| F32.3 | Major depressive disorder, single episode, severe with psychotic features |
| F32.4 | Major depressive disorder, single episode, in partial remission |
| F32.5 | Major depressive disorder, single episode, in full remission |
| F32.9 | Major depressive disorder, single episode, unspecified |
| F33 | Major depressive disorder, recurrent |
| F33.0 | Major depressive disorder, recurrent, mild |
| F33.1 | Major depressive disorder, recurrent, moderate |
| F33.2 | Major depressive disorder, recurrent severe without psychotic features |
| F33.3 | Major depressive disorder, recurrent, severe with psychotic symptoms |
| F33.4 | Major depressive disorder, recurrent, in remission |
| F33.40 | Major depressive disorder, recurrent, in remission, unspecified |
| F33.41 | Major depressive disorder, recurrent, in partial remission |
| F33.42 | Major depressive disorder, recurrent, in full remission |
| F33.8 | Other recurrent depressive disorders |
| F33.9 | Major depressive disorder, recurrent, unspecified |
| Gilles de la tourette syndrome | |
| F95.2 | Tourette's disorder |
| Infantile autism | |
| F84.0 | Autistic disorder |
| Mania associated with bipolar disorder | |
| F31.1 | Bipolar disorder, current episode manic without psychotic features |
| F31.10 | Bipolar disorder, current episode manic without psychotic features, unspecified |
| F31.11 | Bipolar disorder, current episode manic without psychotic features, mild |
| F31.12 | Bipolar disorder, current episode manic without psychotic features, moderate |
| F31.13 | Bipolar disorder, current episode manic without psychotic features, severe |
| F31.2 | Bipolar disorder, current episode manic severe with psychotic features |
| F31.73 | Bipolar disorder, in partial remission, most recent episode manic |
| Mixed bipolar I disorder | |
| F31.6 | Bipolar disorder, current episode mixed |
| F31.60 | Bipolar disorder, current episode mixed, unspecified |
| F31.61 | Bipolar disorder, current episode mixed, mild |
| F31.62 | Bipolar disorder, current episode mixed, moderate |
| F31.63 | Bipolar disorder, current episode mixed, severe, without psychotic features |
| F31.64 | Bipolar disorder, current episode mixed, severe, with psychotic features |
| F31.77 | Bipolar disorder, in partial remission, most recent episode mixed |
| F31.78 | Bipolar disorder, in full remission, most recent episode mixed |
| Schizophrenia | |
| F20 | Schizophrenia |
| F20.0 | Paranoid schizophrenia |
| F20.1 | Disorganized schizophrenia |
| F20.2 | Catatonic schizophrenia |
| F20.3 | Undifferentiated schizophrenia |
| F20.5 | Residual schizophrenia |
| F20.8 | Other schizophrenia |
| F20.81 | Schizophreniform disorder |
| F20.89 | Other schizophrenia |
| F20.9 | Schizophrenia, unspecified |
| 0-9 | A-Z |
|---|---|
| F20 | Schizophrenia |
| F20.0 | Paranoid schizophrenia |
| F20.1 | Disorganized schizophrenia |
| F20.2 | Catatonic schizophrenia |
| F20.3 | Undifferentiated schizophrenia |
| F20.5 | Residual schizophrenia |
| F20.8 | Other schizophrenia |
| F20.81 | Schizophreniform disorder |
| F20.89 | Other schizophrenia |
| F20.9 | Schizophrenia, unspecified |
| F31.1 | Bipolar disorder, current episode manic without psychotic features |
| F31.10 | Bipolar disorder, current episode manic without psychotic features, unspecified |
| F31.11 | Bipolar disorder, current episode manic without psychotic features, mild |
| F31.12 | Bipolar disorder, current episode manic without psychotic features, moderate |
| F31.13 | Bipolar disorder, current episode manic without psychotic features, severe |
| F31.2 | Bipolar disorder, current episode manic severe with psychotic features |
| F31.6 | Bipolar disorder, current episode mixed |
| F31.60 | Bipolar disorder, current episode mixed, unspecified |
| F31.61 | Bipolar disorder, current episode mixed, mild |
| F31.62 | Bipolar disorder, current episode mixed, moderate |
| F31.63 | Bipolar disorder, current episode mixed, severe, without psychotic features |
| F31.64 | Bipolar disorder, current episode mixed, severe, with psychotic features |
| F31.7 | Bipolar disorder, currently in remission |
| F31.70 | Bipolar disorder, currently in remission, most recent episode unspecified |
| F31.71 | Bipolar disorder, in partial remission, most recent episode hypomanic |
| F31.72 | Bipolar disorder, in full remission, most recent episode hypomanic |
| F31.73 | Bipolar disorder, in partial remission, most recent episode manic |
| F31.73 | Bipolar disorder, in partial remission, most recent episode manic |
| F31.74 | Bipolar disorder, in full remission, most recent episode manic |
| F31.75 | Bipolar disorder, in partial remission, most recent episode depressed |
| F31.76 | Bipolar disorder, in full remission, most recent episode depressed |
| F31.77 | Bipolar disorder, in partial remission, most recent episode mixed |
| F31.77 | Bipolar disorder, in partial remission, most recent episode mixed |
| F31.78 | Bipolar disorder, in full remission, most recent episode mixed |
| F31.78 | Bipolar disorder, in full remission, most recent episode mixed |
| F32 | Major depressive disorder, single episode |
| F32.0 | Major depressive disorder, single episode, mild |
| F32.1 | Major depressive disorder, single episode, moderate |
| F32.2 | Major depressive disorder, single episode, severe without psychotic features |
| F32.3 | Major depressive disorder, single episode, severe with psychotic features |
| F32.4 | Major depressive disorder, single episode, in partial remission |
| F32.5 | Major depressive disorder, single episode, in full remission |
| F32.9 | Major depressive disorder, single episode, unspecified |
| F33 | Major depressive disorder, recurrent |
| F33.0 | Major depressive disorder, recurrent, mild |
| F33.1 | Major depressive disorder, recurrent, moderate |
| F33.2 | Major depressive disorder, recurrent severe without psychotic features |
| F33.3 | Major depressive disorder, recurrent, severe with psychotic symptoms |
| F33.4 | Major depressive disorder, recurrent, in remission |
| F33.40 | Major depressive disorder, recurrent, in remission, unspecified |
| F33.41 | Major depressive disorder, recurrent, in partial remission |
| F33.42 | Major depressive disorder, recurrent, in full remission |
| F33.8 | Other recurrent depressive disorders |
| F33.9 | Major depressive disorder, recurrent, unspecified |
| F84.0 | Autistic disorder |
| F95.2 | Tourette's disorder |
Formulary Reference Tool