SYMFI (efavirenz/lamivudine/tenofovir disoproxil fumarate)
- HIV infection
600 mg-300 mg-300 mg tablet
- 1 tablet by oral route once daily at bedtime
HIV infection
- 1 tablet by oral route once daily at bedtime
- adefovir
- B cplx-C-St.Johnwrt-K.&S.ginsg
- calcium-mag-B complex-D3-hrb61
- carbamazepine
- Carbatrol
- cidofovir
- Cold & Flu Fighter
- elvitegr-cobicist-emtric-tenof
- Epitol
- Equetro
- etravirine
- Fatigue Relief Complex
- Hepsera
- Intelence
- St. John's wort
- Stribild
- Tegretol
- Tegretol Xr
- Vistide
- vit C-St. John wort-elder-hb30
- Women's Complex
Contraindicated
- Altavera (28)
- Alyacen 1/35 (28)
- Alyacen 7/7/7 (28)
- Amethia
- Amethia Lo
- Amethyst
- apixaban
- Apri
- Aranelle (28)
- atazanavir
- Aubra
- Aviane
- axitinib
- Azurette (28)
- Balziva (28)
- bedaquiline
- Beyaz
- boceprevir
- Bosulif
- bosutinib
- Brevicon (28)
- Briellyn
- Camila
- Camrese
- Camrese Lo
- Caziant (28)
- Chateal
- Cryselle (28)
- Cyclafem 1/35 (28)
- Cyclafem 7/7/7 (28)
- Cyclessa (28)
- Dasetta 1/35 (28)
- Dasetta 7/7/7 (28)
- Daysee
- Depo-provera
- Depo-subq Provera 104
- desog-e.estradiol/e.estradiol
- Desogen
- desogestrel-ethinyl estradiol
- dolutegravir
- drospirenone-e.estradiol-lm.FA
- drospirenone-ethinyl estradiol
- Elinest
- Eliquis
- Emoquette
- Enpresse
- Enskyce
- enzalutamide
- Errin
- Estarylla
- estradiol valerate-dienogest
- Estrostep Fe-28
- ethynodiol diac-eth estradiol
- etonogestrel
- etonogestrel-ethinyl estradiol
- Falmina (28)
- Femcon Fe
- Generess Fe
- Gianvi (28)
- Gildagia
- Gildess
- Gildess Fe
- guanfacine
- Heather
- Incivek
- Inlyta
- Introvale
- Intuniv Er
- itraconazole
- Jencycla
- Jolessa
- Jolivette
- Junel 1.5/30 (21)
- Junel 1/20 (21)
- Junel Fe 1.5/30 (28)
- Junel Fe 1/20 (28)
- Kariva (28)
- Kelnor 1/35 (28)
- ketoconazole
- Kurvelo
- L norgest&E estradiol-E estrad
- Larin 1/20 (21)
- Larin Fe
- Leena 28
- Lessina
- Levonest (28)
- levonorg-eth estrad triphasic
- levonorgestrel
- levonorgestrel-ethinyl estrad
- Levora 0.15/30 (28)
- Levora-28
- Lo Loestrin Fe
- Loestrin 1.5/30 (21)
- Loestrin 1/20 (21)
- Loestrin Fe 1.5/30 (28)
- Loestrin Fe 1/20 (28)
- Lomedia 24 Fe
- Loryna (28)
- Loseasonique
- Low-ogestrel (28)
- Lutera (28)
- Lyza
- Marlissa
- medroxyprogesterone
- Microgestin 1.5/30 (21)
- Microgestin 1/20 (21)
- Microgestin Fe 1.5/30 (28)
- Microgestin Fe 1/20 (28)
- Minastrin 24 Fe
- Mircette (28)
- Mirena
- Modicon (28)
- Mono-linyah
- Mononessa (28)
- My Way
- Myzilra
- Natazia
- Necon 0.5/35 (28)
- Necon 1/35 (28)
- Necon 1/50 (28)
- Necon 10/11 (28)
- Necon 7/7/7 (28)
- Nexplanon
- Next Choice One Dose
- Nor-qd
- Nora-be
- norelgestrom-ethinyl estradiol
- noreth-ethinyl estradiol-iron
- norethin-e.estradiol triphasic
- norethin-eth estrad biphasic
- norethindrone (contraceptive)
- norethindrone ac-eth estradiol
- norethindrone-e.estradiol-iron
- norethindrone-ethin estradiol
- norethindrone-mestranol
- norgestimate-ethinyl estradiol
- norgestrel-ethinyl estradiol
- Norinyl 1+35 (28)
- Norinyl 1+50 (28)
- Nortrel 0.5/35 (28)
- Nortrel 1/35 (21)
- Nortrel 1/35 (28)
- Nortrel 7/7/7 (28)
- Noxafil
- Nuvaring
- Ocella
- Ogestrel (28)
- Olysio
- Onmel
- Orsythia
- Ortho Evra
- Ortho Micronor
- Ortho Tri-cyclen (28)
- Ortho Tri-cyclen Lo (28)
- Ortho-cept (28)
- Ortho-cyclen (28)
- Ortho-novum 1/35 (28)
- Ortho-novum 7/7/7 (28)
- Ovcon-35 (28)
- Philith
- Pimtrea (28)
- Pirmella
- Plan B One-step
- Portia
- posaconazole
- Previfem
- Quartette
- Quasense
- Reclipsen (28)
- Reyataz
- rivaroxaban
- Safyral
- Seasonique
- simeprevir
- Sirturo
- Skyla
- Sporanox
- Sporanox Pulsepak
- Sprintec (28)
- Sronyx
- Syeda
- telaprevir
- Tenex
- Tilia Fe
- Tivicay
- Tri-estarylla
- Tri-legest Fe
- Tri-linyah
- Tri-norinyl (28)
- Tri-previfem (28)
- Tri-sprintec (28)
- Trinessa (28)
- Trivora (28)
- Velivet Triphasic Regimen (28)
- Vestura (28)
- Vfend
- Vfend Iv
- Victrelis
- Viorele (28)
- voriconazole
- Vyfemla (28)
- Wera (28)
- Wymzya Fe
- Xarelto
- Xtandi
- Yasmin (28)
- Yaz 28
- Zarah
- Zenchent (28)
- Zenchent Fe
- Zeosa
- Zovia 1/35E (28)
- Zovia 1/50E (28)
Severe
Moderate
- Advil
- Advil Allergy Sinus
- Advil Allergy-congestion Rlf
- Advil Cold & Sinus
- Advil Congestion Relief
- Advil Liqui-gel
- Advil Migraine
- Advil Pm
- Advil Pm Liqui-gels
- afatinib
- Aleve
- Aleve Cold & Sinus
- Aleve Sinus & Headache
- Aleve-d Sinus & Cold
- Aleve-d Sinus & Headache
- All Day Pain Relief
- All Day Pain Relief Sinus & Co
- All Day Relief
- amlodipine-atorvastatin
- amoxicil-clarithromy-lansopraz
- Anaprox
- Anaprox Ds
- Ansaid
- Arthrotec 50
- atorvastatin
- Biaxin
- Biaxin Xl
- Biaxin Xl Pak
- Caduet
- Caldolor
- Cambia
- Cancidas
- caspofungin
- Cataflam
- Celebrex
- celecoxib
- Child Ibuprofen
- Children's Advil
- Children's Ibu-drops
- Children's Ibuprofen
- Children's Medi-profen
- Children's Motrin
- Children's Profen Ib
- chlorphen-phenyleph-ibuprofen
- chlorphen-pseudoeph-ibuprofen
- cilostazol
- clarithromycin
- Cold & Sinus Pain Relief
- Cold-sinus Relief
- Crixivan
- Daypro
- diclofenac epolamine
- diclofenac potassium
- diclofenac sodium
- diclofenac submicronized
- diclofenac-misoprostol
- didanosine
- Diskets
- Dolophine
- Duexis
- Ec-naprosyn
- etodolac
- ezetimibe-atorvastatin
- ezetimibe-simvastatin
- Feldene
- fenoprofen
- Flanax
- Flector
- flurbiprofen
- fosamprenavir
- Gilotrif
- hydrocodone-ibuprofen
- I-prin
- Ibu-drops
- Ibudone
- ibuprofen
- Ibuprofen Cold
- Ibuprofen Cold-sinus(with Pse)
- Ibuprofen Ib
- Ibuprofen Jr Strength
- ibuprofen lysine (PF)
- Ibuprofen Pm
- ibuprofen-diphenhydramine
- ibuprofen-diphenhydramine HCl
- ibuprofen-famotidine
- ibuprofen-oxycodone
- ibuprofen-phenylephrine HCl
- indinavir
- Indocin
- indomethacin
- indomethacin sodium
- Infant's Ibuprofen
- Infant's Medi-profen
- Infant's Motrin
- Infants Ibu-drops
- Infants Profenib
- Invirase
- Kaletra
- ketoprofen
- ketorolac
- Lexiva
- Lipitor
- Liptruzet
- lopinavir-ritonavir
- Medi-profen
- Mediproxen
- mefenamic acid
- meloxicam
- methadone
- Methadone Intensol
- Methadose
- Midol (naproxen)
- Mobic
- Motrin Ib
- Motrin Pm
- Mycobutin
- nabumetone
- Nalfon
- Naprelan Cr
- Naprosyn
- naproxen
- naproxen sodium
- naproxen-esomeprazole
- naproxen-pseudoephedrine
- Neoprofen (ibuprofen Lysn)(pf)
- niacin-simvastatin
- Omeclamox-pak
- omeprazole-clarith-amoxicillin
- oxaprozin
- Pennsaid
- piroxicam
- Pletal
- Ponstel
- Pravachol
- pravastatin
- Prevpac
- Provil
- pseudoephedrine-ibuprofen
- Reprexain
- rifabutin
- saquinavir mesylate
- Simcor
- simvastatin
- Sinus & Cold-d
- Solaraze
- Sprix
- sulindac
- tolmetin
- Vicoprofen
- Videx 2 Gram Pediatric
- Videx 4 Gram Pediatric
- Videx Ec
- Vimovo
- Voltaren-xr
- Vytorin 10-10
- Vytorin 10-20
- Vytorin 10-40
- Vytorin 10-80
- Wal-profen
- Wal-profen Cold-sinus
- Wal-proxen
- Zipsor
- Zocor
- Zorvolex
- Acute pancreatitis
- Chronic pancreatitis
- Lactating mother
- Lactic acidosis
Contraindicated
- Acute renal failure
- Chronic kidney disease stage 3A (moderate) GFR 45-59
- Chronic kidney disease stage 3B (moderate) GFR 30-44
- Chronic kidney disease stage 4 (severe) GFR 15-29 ml/min
- Chronic kidney disease stage 5 (failure) GFr<15 ml/min
- Depression
- Disease of liver
- Fanconi syndrome
- Hypophosphatemia
- Manic disorder
- Osteomalacia
- Paranoid disorder
- Pathological fracture
- Suicidal ideation
Severe
Moderate
- Aggressive behavior
- CYp2b6*6/*6 genotype
- Hypercholesterolemia
- Hypertriglyceridemia
- Insomnia
- Kidney disease with likely reduction in GFR
- Osteopenia
- Seizure disorder
SYMFI (efavirenz/lamivudine/tenofovir disoproxil fumarate)
- HIV infection
- Depression
- Elevated serum lipase
- Paresthesia
- Pruritus of skin
- Skin rash
- Acute abdominal pain
- Back pain
- Concentration difficulty
- Cough
- Diarrhea
- Dizziness
- Dream disorder
- Drowsy
- Fatigue
- Fever
- Flatulence
- General weakness
- Headache disorder
- Infection of ear
- Insomnia
- Lipodystrophy associated with HIV
- Malaise
- Nausea
- Pain
- Peripheral neuropathy
- Pruritus of skin
- Sore throat
- Vomiting
More Frequent
Severe
Less Severe
- Hallucinations
- Hypercholesterolemia
- Increased alanine transaminase
- Increased aspartate transaminase
- Neutropenic disorder
- Pneumonia
- Prolonged QT interval
- Thrombocytopenic disorder
- Abdominal pain with cramps
- Acute abdominal pain
- Anorexia
- Arthralgias
- Chest pain
- Chills
- Dizziness
- Dyspepsia
- Fatigue
- Hypercholesterolemia
- Hypertriglyceridemia
- Insomnia
- Myalgias
- Nervousness
- Pharyngitis
- Polyuria
- Proteinuria
- Rhinitis
- Sinusitis
- Symptoms of anxiety
- Vomiting
- Weight loss
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal desquamation
- Abnormal hepatic function tests
- Acute confusion
- Acute hepatic failure
- Acute pancreatitis
- Acute renal failure
- Anaphylaxis
- Anemia
- Angioedema
- Ataxia
- Behavioral disorders
- Blistering skin
- Catatonia
- Delusional disorder
- Dermal necrosis
- Drug-induced psychosis
- Dysphasia
- Dyspnea
- Encephalopathy
- Erythema multiforme
- Exfoliative dermatitis
- Fanconi syndrome
- Fever
- Graves' disease
- Guillain-barre syndrome
- Hepatitis
- Hypokalemia
- Hypophosphatemia
- Interstitial nephritis
- Kidney disease with reduction in GFR
- Lactic acidosis
- Lymphadenopathy
- Manic disorder
- Nephrogenic diabetes insipidus
- Osteomalacia
- Pancreatitis
- Paranoid disorder
- Paresthesia
- Peripheral neuropathy
- Phototoxicity
- Polymyositis
- Pure red cell aplasia
- Renal tubular necrosis
- Rhabdomyolysis
- Seizure disorder
- Skin ulcer
- Splenomegaly
- Steatosis of liver
- Stevens-johnson syndrome
- Suicidal
- Suicidal ideation
- Syncope
- Toxic epidermal necrolysis
- Tremor
- Urticaria
- Visual changes
- Wheezing
Less Severe
- Aggressive behavior
- Agitation
- Alopecia
- Anorexia
- Arthralgias
- Constipation
- Cough
- Cramps
- Depersonalization
- Euphoria
- Flushing
- Folliculitis
- General weakness
- Gynecomastia
- Hyperglycemia
- Hyperhidrosis
- Hypertriglyceridemia
- Hypesthesia
- Malabsorption states
- Memory impairment
- Mood changes
- Muscle weakness
- Myalgias
- Myopathy
- Palpitations
- Pruritus of skin
- Skin rash
- Stomatitis
- Tinnitus
- Urticaria
- Vertigo
- Wheezing
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Efavirenz, lamivudine,tenofovir DF
No established safety and efficacy established with weight < 35 kg.
Increased risk of pancreatitis due to lamivudine with prior antiretroviral nucleoside exposure and other risk factors for pancreatitis. Monitor for signs and symptoms.
- 1 Day – 8 Years
- No established safety and efficacy established with weight < 35 kg.
- Increased risk of pancreatitis due to lamivudine with prior antiretroviral nucleoside exposure and other risk factors for pancreatitis. Monitor for signs and symptoms.
- 8 Years – 18 Years
- No established safety and efficacy established with weight < 35 kg.
- Increased risk of pancreatitis due to lamivudine with prior antiretroviral nucleoside exposure and other risk factors for pancreatitis. Monitor for signs and symptoms.
Efavirenz
- Severity Level:
2
- Additional Notes: No fda cat;art preg registry data show no increased risk for major birth defects
Lamivudine
- Severity Level:
2
- Additional Notes: No fda cat;art preg registry data show no increased risk for major birth defects
Tenofovir
- Severity Level:
2
- Additional Notes: Available human data show no increased risk for major birth defects
Contraindicated
Efavirenz
Cdc does not recommend breastfeeding in hiv-positive women
Avoid breastfeeding in hiv positive women per cdc
General | Excretion Potential | Effect on Infant | Notes |
Drug should not be given to breast feeding mothers | Excreted | Not known; no or inclusive data | Cdc does not recommend breastfeeding in hiv-positive women |
Lamivudine
Cdc does not recommend breastfeeding in hiv-positive women
Avoid breastfeeding in hiv positive women per cdc
General | Excretion Potential | Effect on Infant | Notes |
Drug should not be given to breast feeding mothers | Excreted | Not known; no or inclusive data | Avoid breastfeeding in hiv positive women per cdc |
Precaution Exists
Tenofovir
Limited data suggest no known adverse effects in nursing infant
General | Excretion Potential | Effect on Infant | Notes |
Evaluate use carefully | Excreted | Not known; no or inclusive data | Limited data suggest no known adverse effects in nursing infant |
No Known Risk
None
General | Excretion Potential | Effect on Infant | Notes |
None |
Contraindicated
None
Precaution Exists
Tenofovir Disoproxil
Renal-Adjust dosing interval for CrCL<50mL/min. Fixed dose combinations containing tenofovir are not appropriate if dose adjustment is required. Musculoskeletal-Decreases in bone mineral density have been observed. Consider calcium and vitamin D3 supplementation.
Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
Increased Risk / Adverse Effects | Y | Y | Y | N | N | N |
BEERS: N HEDIS: N STOPP: N
No Known Risk
None
- If you have hepatitis B infection as well as HIV, your hepatitis symptoms may get worse or become very serious if you stop taking this medication. Talk with your doctor before stopping this medication. Your doctor will check your liver function tests for several months after you stop. Tell your doctor right away if you develop symptoms of worsening liver problems.
HIV infection | |
B20 | Human immunodeficiency virus [HIv] disease |
B97.35 | Human immunodeficiency virus, type 2 [HIV 2] as the cause of diseases classified elsewhere |
O98.7 | Human immunodeficiency virus [HIv] disease complicating pregnancy, childbirth and the puerperium |
O98.71 | Human immunodeficiency virus [HIv] disease complicating pregnancy |
O98.711 | Human immunodeficiency virus [HIv] disease complicating pregnancy, first trimester |
O98.712 | Human immunodeficiency virus [HIv] disease complicating pregnancy, second trimester |
O98.713 | Human immunodeficiency virus [HIv] disease complicating pregnancy, third trimester |
O98.719 | Human immunodeficiency virus [HIv] disease complicating pregnancy, unspecified trimester |
O98.72 | Human immunodeficiency virus [HIv] disease complicating childbirth |
O98.73 | Human immunodeficiency virus [HIv] disease complicating the puerperium |
Z21 | Asymptomatic human immunodeficiency virus [HIv] infection status |
0-9 | A-Z |
---|---|
B20 | Human immunodeficiency virus [HIv] disease |
B97.35 | Human immunodeficiency virus, type 2 [HIV 2] as the cause of diseases classified elsewhere |
O98.7 | Human immunodeficiency virus [HIv] disease complicating pregnancy, childbirth and the puerperium |
O98.71 | Human immunodeficiency virus [HIv] disease complicating pregnancy |
O98.711 | Human immunodeficiency virus [HIv] disease complicating pregnancy, first trimester |
O98.712 | Human immunodeficiency virus [HIv] disease complicating pregnancy, second trimester |
O98.713 | Human immunodeficiency virus [HIv] disease complicating pregnancy, third trimester |
O98.719 | Human immunodeficiency virus [HIv] disease complicating pregnancy, unspecified trimester |
O98.72 | Human immunodeficiency virus [HIv] disease complicating childbirth |
O98.73 | Human immunodeficiency virus [HIv] disease complicating the puerperium |
Z21 | Asymptomatic human immunodeficiency virus [HIv] infection status |