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ALPRAZOLAM (ALPRAZOLAM)
- Anxiety
- Generalized anxiety disorder
- Panic disorder
- Anxiety with depression
0.25 mg tablet
- 1 tablet (0.25 mg) by oral route 3 times per day
0.5 mg tablet
- 1 tablet (0.5 mg) by oral route 3 times per day
1 mg tablet
- 1 tablet (1 mg) by oral route 3 times per day
2 mg tablet
- 1 tablet (2 mg) by oral route 3 times per day
0.25 mg tablet
- 1 tablet (0.25 mg) by oral route 3 times per day
0.5 mg tablet
- 1 tablet (0.5 mg) by oral route 3 times per day
1 mg tablet
- 1 tablet (1 mg) by oral route 3 times per day
2 mg tablet
- 1 tablet (2 mg) by oral route 3 times per day
Anxiety
- 1 tablet (0.25 mg) by oral route 3 times per day
- 2 tablets (0.5 mg) by oral route 3 times per day
- 1 tablet (0.5 mg) by oral route 3 times per day
- 2 tablets (1 mg) by oral route 3 times per day
- 1 tablet (1 mg) by oral route 3 times per day
Panic disorder
- 2 tablets (0.5 mg) by oral route 3 times per day
- 1 tablet (0.5 mg) by oral route 3 times per day
- 2 tablets (1 mg) by oral route 3 times per day
- 1 tablet (1 mg) by oral route 3 times per day
- 2 tablets (2 mg) by oral route 3 times per day
- 1 tablet (2 mg) by oral route 3 times per day
- 1 tablet (2 mg) by oral route 4 times per day
- Crixivan
- delavirdine
- indinavir
- itraconazole
- ketoconazole
- Onmel
- Rescriptor
- sodium oxybate
- Sporanox
- Sporanox Pulsepak
- Xyrem
Contraindicated
- clozapine
- Clozaril
- Dehydrated Alcohol
- ethanol (ethyl alcohol)
- ethyl alcohol-herbal drugs
- Fazaclo
- Lydia Pinkham Herbal
- Versacloz
Severe
Moderate
- Acid Reducer (cimetidine)
- Acid Relief (cimetidine)
- aprepitant
- boceprevir
- buprenorphine-naloxone
- cimetidine
- Diflucan
- Emend
- fluconazole
- fluconazole in dextrose(iso-o)
- fluconazole in NaCl (iso-osm)
- fosaprepitant
- Heartburn Relief
- Incivek
- isoniazid-rifamp-pyrazinamide
- Juxtapid
- Kaletra
- lomitapide
- lopinavir-ritonavir
- Norvir
- Norvir Soft Gelatin
- Noxafil
- posaconazole
- Rifadin
- Rifamate
- rifampin
- rifampin-isoniazid
- Rifater
- ritonavir
- Suboxone
- Tagamet Hb
- telaprevir
- Vfend
- Vfend Iv
- Victrelis
- voriconazole
- Zubsolv
- Angle-closure glaucoma
- Lactating mother
Contraindicated
- Alcohol intoxication
- Depression
- Drug abuse
- Pregnancy
- Respiratory depression
- Sleep apnea
- Suicidal ideation
Severe
Moderate
- Chronic pulmonary disease
- Debilitation
- Disease of liver
- Kidney disease with reduction in GFR
- Obesity
- Open angle glaucoma
- Tobacco smoker
ALPRAZOLAM (ALPRAZOLAM)
- Anxiety
- Generalized anxiety disorder
- Panic disorder
- Anxiety with depression
- None
- Depression
- Drowsy
- Fatigue
- Libido changes
- Sedation
More Frequent
Severe
Less Severe
- Dyskinesia
- Dyspnea
- Abnormal sexual function
- Acute confusion
- Agitation
- Allergic dermatitis
- Anorexia
- Appetite changes
- Arthralgias
- Ataxia
- Constipation
- Diarrhea
- Disturbance of attention
- Dizziness
- Dream disorder
- Dysmenorrhea
- Headache disorder
- Hypersomnia
- Hyperventilation
- Hypesthesia
- Insomnia
- Lethargy
- Limb pain
- Menstrual disorder
- Myalgias
- Nausea and vomiting
- Nervousness
- Paresthesia
- Premenstrual syndrome
- Sensation of warmth
- Sialorrhea
- Skin rash
- Symptoms of anxiety
- Weight gain
- Weight loss
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal hepatic function tests
- Angioedema
- Drug-induced hepatitis
- Hepatic failure
- Hypotension
- Manic disorder
- Seizure disorder
- Stevens-johnson syndrome
Less Severe
- Acquired dystonia
- Acute abdominal pain
- Back pain
- Behavioral disorders
- Blurred vision
- Chest pain
- Concentration difficulty
- Cramps
- Depersonalization
- Dysarthria
- Dyspepsia
- Dysuria
- Galactorrhea not associated with childbirth
- General weakness
- Gynecomastia
- Hyperhidrosis
- Hyperprolactinemia
- Hypomania
- Increased libido
- Irritability
- Malaise
- Memory impairment
- Muscle spasm
- Muscle weakness
- Nasal congestion
- Nightmares
- Palpitations
- Peripheral edema
- Pruritus of skin
- Slurred speech
- Tremor
- Twitching
- Urinary retention
- Vertigo
- Visual changes
- Xerostomia
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Alprazolam
Safety and efficacy not established in pediatrics. Limited data available.
- 1 Day – 18 Years
- Safety and efficacy not established in pediatrics. Limited data available.
Alprazolam
- Severity Level:
D
- Additional Notes:
Contraindicated
Alprazolam
Reports of irritability & sleep disturbances, withdrawal rxn w/ repeated use
| General | Excretion Potential | Effect on Infant | Notes |
| Drug should not be given to breast feeding mothers | Excreted | Drug shown to have adverse effect | Reports of irritability & sleep disturbances, withdrawal rxn w/ repeated use |
Precaution Exists
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Alprazolam
Neuro/Psych-Increased risk of cognitive impairment, delirium, falls, fractures, and motor vehicle crashes. General-May be appropriate for select indications including severe generalized anxiety disorder and seizure disorder. Shorter-acting benzodiazepines are not safer than longer-acting ones.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | Y | Y | N | Y | N | N |
BEERS: Y HEDIS: Y STOPP: Y
No Known Risk
None
- Taking alprazolam with opioid medications (such as codeine, hydrocodone) may increase your risk of very serious side effects, including death. To lower your risk, your doctor should have you take the smallest dose of alprazolam that works, and take it for the shortest possible time. Get medical help right away if any of these very serious side effects occur: slow/shallow breathing, unusual lightheadedness, severe drowsiness/dizziness, difficulty waking up.
| Anxiety | |
| F06.4 | Anxiety disorder due to known physiological condition |
| F10.180 | Alcohol abuse with alcohol-induced anxiety disorder |
| F10.280 | Alcohol dependence with alcohol-induced anxiety disorder |
| F10.980 | Alcohol use, unspecified with alcohol-induced anxiety disorder |
| F12.180 | Cannabis abuse with cannabis-induced anxiety disorder |
| F12.280 | Cannabis dependence with cannabis-induced anxiety disorder |
| F12.980 | Cannabis use, unspecified with anxiety disorder |
| F14.180 | Cocaine abuse with cocaine-induced anxiety disorder |
| F14.280 | Cocaine dependence with cocaine-induced anxiety disorder |
| F14.980 | Cocaine use, unspecified with cocaine-induced anxiety disorder |
| F15.180 | Other stimulant abuse with stimulant-induced anxiety disorder |
| F15.280 | Other stimulant dependence with stimulant-induced anxiety disorder |
| F15.980 | Other stimulant use, unspecified with stimulant-induced anxiety disorder |
| F16.180 | Hallucinogen abuse with hallucinogen-induced anxiety disorder |
| F16.280 | Hallucinogen dependence with hallucinogen-induced anxiety disorder |
| F16.980 | Hallucinogen use, unspecified with hallucinogen-induced anxiety disorder |
| F18.180 | Inhalant abuse with inhalant-induced anxiety disorder |
| F18.280 | Inhalant dependence with inhalant-induced anxiety disorder |
| F18.980 | Inhalant use, unspecified with inhalant-induced anxiety disorder |
| F19.180 | Other psychoactive substance abuse with psychoactive substance-induced anxiety disorder |
| F19.280 | Other psychoactive substance dependence with psychoactive substance-induced anxiety disorder |
| F19.980 | Other psychoactive substance use, unspecified with psychoactive substance-induced anxiety disorder |
| F40 | Phobic anxiety disorders |
| F40.0 | Agoraphobia |
| F40.00 | Agoraphobia, unspecified |
| F40.01 | Agoraphobia with panic disorder |
| F40.02 | Agoraphobia without panic disorder |
| F40.1 | Social phobias |
| F40.10 | Social phobia, unspecified |
| F40.11 | Social phobia, generalized |
| F40.8 | Other phobic anxiety disorders |
| F40.9 | Phobic anxiety disorder, unspecified |
| F41 | Other anxiety disorders |
| F41.0 | Panic disorder [episodic paroxysmal anxiety] |
| F41.1 | Generalized anxiety disorder |
| F41.3 | Other mixed anxiety disorders |
| F41.8 | Other specified anxiety disorders |
| F41.9 | Anxiety disorder, unspecified |
| F93.0 | Separation anxiety disorder of childhood |
| Anxiety with depression | |
| F41.8 | Other specified anxiety disorders |
| Generalized anxiety disorder | |
| F41.1 | Generalized anxiety disorder |
| Panic disorder | |
| F40.01 | Agoraphobia with panic disorder |
| F41.0 | Panic disorder [episodic paroxysmal anxiety] |
| 0-9 | A-Z |
|---|---|
| F06.4 | Anxiety disorder due to known physiological condition |
| F10.180 | Alcohol abuse with alcohol-induced anxiety disorder |
| F10.280 | Alcohol dependence with alcohol-induced anxiety disorder |
| F10.980 | Alcohol use, unspecified with alcohol-induced anxiety disorder |
| F12.180 | Cannabis abuse with cannabis-induced anxiety disorder |
| F12.280 | Cannabis dependence with cannabis-induced anxiety disorder |
| F12.980 | Cannabis use, unspecified with anxiety disorder |
| F14.180 | Cocaine abuse with cocaine-induced anxiety disorder |
| F14.280 | Cocaine dependence with cocaine-induced anxiety disorder |
| F14.980 | Cocaine use, unspecified with cocaine-induced anxiety disorder |
| F15.180 | Other stimulant abuse with stimulant-induced anxiety disorder |
| F15.280 | Other stimulant dependence with stimulant-induced anxiety disorder |
| F15.980 | Other stimulant use, unspecified with stimulant-induced anxiety disorder |
| F16.180 | Hallucinogen abuse with hallucinogen-induced anxiety disorder |
| F16.280 | Hallucinogen dependence with hallucinogen-induced anxiety disorder |
| F16.980 | Hallucinogen use, unspecified with hallucinogen-induced anxiety disorder |
| F18.180 | Inhalant abuse with inhalant-induced anxiety disorder |
| F18.280 | Inhalant dependence with inhalant-induced anxiety disorder |
| F18.980 | Inhalant use, unspecified with inhalant-induced anxiety disorder |
| F19.180 | Other psychoactive substance abuse with psychoactive substance-induced anxiety disorder |
| F19.280 | Other psychoactive substance dependence with psychoactive substance-induced anxiety disorder |
| F19.980 | Other psychoactive substance use, unspecified with psychoactive substance-induced anxiety disorder |
| F40 | Phobic anxiety disorders |
| F40.0 | Agoraphobia |
| F40.00 | Agoraphobia, unspecified |
| F40.01 | Agoraphobia with panic disorder |
| F40.01 | Agoraphobia with panic disorder |
| F40.02 | Agoraphobia without panic disorder |
| F40.1 | Social phobias |
| F40.10 | Social phobia, unspecified |
| F40.11 | Social phobia, generalized |
| F40.8 | Other phobic anxiety disorders |
| F40.9 | Phobic anxiety disorder, unspecified |
| F41 | Other anxiety disorders |
| F41.0 | Panic disorder [episodic paroxysmal anxiety] |
| F41.0 | Panic disorder [episodic paroxysmal anxiety] |
| F41.1 | Generalized anxiety disorder |
| F41.1 | Generalized anxiety disorder |
| F41.3 | Other mixed anxiety disorders |
| F41.8 | Other specified anxiety disorders |
| F41.8 | Other specified anxiety disorders |
| F41.9 | Anxiety disorder, unspecified |
| F93.0 | Separation anxiety disorder of childhood |
Formulary Reference Tool