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RETAVASE (RETEPLASE)
- Acute myocardial infarction
10 unit intravenous solution
- Inject 10 unit over 2 minute(s) by intravenous route once; repeat dose 30 minutes after first dose for a total of 2 doses
10 unit x 2 (20 unit total) intravenous solution
- Inject 10 unit over 2 minute(s) by intravenous route once; repeat dose 30 minutes after first dose for a total of 2 doses
Acute myocardial infarction
- Inject 10 unit over 2 minute(s) by intravenous route once; repeat dose 30 minutes after first dose for a total of 2 doses
- None
Contraindicated
- None
Severe
Moderate
- abciximab
- Aggrastat In Sodium Chloride
- Aggrenox
- Arixtra
- Brilinta
- Brintellix
- Brisdelle
- Celexa
- cilostazol
- citalopram
- clopidogrel
- Coumadin
- Cymbalta
- dalteparin (porcine)
- desvenlafaxine
- desvenlafaxine fumarate
- desvenlafaxine succinate
- dipyridamole
- dipyridamole-aspirin
- duloxetine
- Effexor Xr
- Elmiron
- enoxaparin
- eptifibatide
- escitalopram oxalate
- Fetzima
- fluoxetine
- fluvoxamine
- fondaparinux
- Fragmin
- heparin (porcine)
- heparin (porcine) in D5W
- heparin (porcine) in NaCl (PF)
- heparin(porcine) in 0.45% NaCl
- heparin, porcine (PF)
- Integrilin
- Jantoven
- Khedezla
- levomilnacipran
- Lexapro
- Lovenox
- Luvox Cr
- milnacipran
- olanzapine-fluoxetine
- paroxetine HCl
- paroxetine mesylate
- Paxil
- Paxil Cr
- pentosan polysulfate sodium
- Persantine
- Pexeva
- Plavix
- Pletal
- Pristiq
- Prozac
- Prozac Weekly
- Reopro
- Sarafem
- Savella
- sertraline
- Symbyax
- ticagrelor
- ticlopidine
- tirofiban-0.9% sodium chloride
- venlafaxine
- Viibryd
- vilazodone
- vortioxetine
- warfarin
- Zoloft
- Arteriovenous malformation
- Brain aneurysm
- CNS trauma
- Deep peripheral nerve block
- Deep plexus block
- Increased risk of bleeding due to coagulation disorder
- Internal hemorrhage
- Invasive procedure on brain
- Invasive procedure on spine
- Neoplasm of brain
- Neuraxial anesthesia
- Placement of indwelling epidural catheter
- Severe uncontrolled hypertension
Contraindicated
- Acute pericarditis
- Atrial fibrillation with mitral stenosis
- Cholesterol embolism
- Genitourinary tract hemorrhage
- Hemorrhage
- Hemorrhagic diabetic retinopathy
- Invasive surgical procedure
- Major traumatic injury
- Moderate hypertension
- Mural thrombus of heart
- Puncture of artery in noncompressible site
- Puncture of vein in noncompressible site
- Retinal hemorrhage
- Septic thrombophlebitis
- Severe GI bleeding within last 10 days
- Severe hepatic disease
- Severe renal impairment
- Subacute infective endocarditis
Severe
Moderate
- None
RETAVASE (RETEPLASE)
- Acute myocardial infarction
- Bleeding from wound
- Gingival bleeding
- Hyperfibrinolysis-induced hemorrhage
- Superficial bleeding
- None
More Frequent
Severe
Less Severe
- None
- Nausea
- Vomiting
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Cholesterol embolism
- Dyspnea
- Fever
- Flushing
- Gastrointestinal hemorrhage
- Genitourinary tract hemorrhage
- Headache disorder
- Hemorrhage
- Hemorrhagic stroke
- Hypotension
- Intracranial bleeding
- Myalgias
- Pruritus of skin
- Respiratory tract hemorrhage
- Skin rash
- Urticaria
- Wheezing
Less Severe
- None
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Reteplase
Safety and efficacy not established.
- 1 Day – 18 Years
- Safety and efficacy not established.
Reteplase
- Severity Level:
C
- Additional Notes:
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Reteplase
Insufficient data available.
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | Insufficient data available. |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- None
| Acute myocardial infarction | |
| I21 | Acute myocardial infarction |
| I21.0 | ST elevation (STEMi) myocardial infarction of anterior wall |
| I21.01 | ST elevation (STEMi) myocardial infarction involving left main coronary artery |
| I21.02 | ST elevation (STEMi) myocardial infarction involving left anterior descending coronary artery |
| I21.09 | ST elevation (STEMi) myocardial infarction involving other coronary artery of anterior wall |
| I21.1 | ST elevation (STEMi) myocardial infarction of inferior wall |
| I21.11 | ST elevation (STEMi) myocardial infarction involving right coronary artery |
| I21.19 | ST elevation (STEMi) myocardial infarction involving other coronary artery of inferior wall |
| I21.2 | ST elevation (STEMi) myocardial infarction of other sites |
| I21.21 | ST elevation (STEMi) myocardial infarction involving left circumflex coronary artery |
| I21.29 | ST elevation (STEMi) myocardial infarction involving other sites |
| I21.3 | ST elevation (STEMi) myocardial infarction of unspecified site |
| I21.4 | Non-ST elevation (NSTEMi) myocardial infarction |
| I21.9 | Acute myocardial infarction, unspecified |
| I21.A | Other type of myocardial infarction |
| I21.A1 | Myocardial infarction type 2 |
| I21.A9 | Other myocardial infarction type |
| I22 | Subsequent ST elevation (STEMi) and non-ST elevation (NSTEMi) myocardial infarction |
| I22.0 | Subsequent ST elevation (STEMi) myocardial infarction of anterior wall |
| I22.1 | Subsequent ST elevation (STEMi) myocardial infarction of inferior wall |
| I22.2 | Subsequent non-ST elevation (NSTEMi) myocardial infarction |
| I22.8 | Subsequent ST elevation (STEMi) myocardial infarction of other sites |
| I22.9 | Subsequent ST elevation (STEMi) myocardial infarction of unspecified site |
| 0-9 | A-Z |
|---|---|
| I21 | Acute myocardial infarction |
| I21.0 | ST elevation (STEMi) myocardial infarction of anterior wall |
| I21.01 | ST elevation (STEMi) myocardial infarction involving left main coronary artery |
| I21.02 | ST elevation (STEMi) myocardial infarction involving left anterior descending coronary artery |
| I21.09 | ST elevation (STEMi) myocardial infarction involving other coronary artery of anterior wall |
| I21.1 | ST elevation (STEMi) myocardial infarction of inferior wall |
| I21.11 | ST elevation (STEMi) myocardial infarction involving right coronary artery |
| I21.19 | ST elevation (STEMi) myocardial infarction involving other coronary artery of inferior wall |
| I21.2 | ST elevation (STEMi) myocardial infarction of other sites |
| I21.21 | ST elevation (STEMi) myocardial infarction involving left circumflex coronary artery |
| I21.29 | ST elevation (STEMi) myocardial infarction involving other sites |
| I21.3 | ST elevation (STEMi) myocardial infarction of unspecified site |
| I21.4 | Non-ST elevation (NSTEMi) myocardial infarction |
| I21.9 | Acute myocardial infarction, unspecified |
| I21.A | Other type of myocardial infarction |
| I21.A1 | Myocardial infarction type 2 |
| I21.A9 | Other myocardial infarction type |
| I22 | Subsequent ST elevation (STEMi) and non-ST elevation (NSTEMi) myocardial infarction |
| I22.0 | Subsequent ST elevation (STEMi) myocardial infarction of anterior wall |
| I22.1 | Subsequent ST elevation (STEMi) myocardial infarction of inferior wall |
| I22.2 | Subsequent non-ST elevation (NSTEMi) myocardial infarction |
| I22.8 | Subsequent ST elevation (STEMi) myocardial infarction of other sites |
| I22.9 | Subsequent ST elevation (STEMi) myocardial infarction of unspecified site |
Formulary Reference Tool