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CLONAZEPAM (CLONAZEPAM)
- Lennox-gastaut epilepsy
- Myoclonic epilepsy
- Panic disorder
- Absence epilepsy
- Atonic seizure
0.5 mg tablet
- 1 tablet (0.5 mg) by oral route 3 times per day
1 mg tablet
- 1 tablet (1 mg) by oral route 3 times per day
2 mg tablet
- 1 tablet (2 mg) by oral route 3 times per day
0.5 mg tablet
- 1 tablet (0.5 mg) by oral route 3 times per day
1 mg tablet
- 1 tablet (1 mg) by oral route 3 times per day
2 mg tablet
- 1 tablet (2 mg) by oral route 3 times per day
0.125 mg disintegrating tablet
- Place 2 tablets (0.25 mg) on top of the tongue where they will dissolve, then swallow by translingual route 2 times per day
0.25 mg disintegrating tablet
- Place 1 tablet (0.25 mg) on top of the tongue where it will dissolve,then swallow by translingual route 2 times per day
0.5 mg disintegrating tablet
- Place 1 tablet (0.5 mg) on top of the tongue where it will dissolve, then swallow by translingual route 2 times per day
1 mg disintegrating tablet
- Place 1 tablet (1 mg) on top of the tongue where it will dissolve, then swallow by translingual route 2 times per day
2 mg disintegrating tablet
- Place 1 tablet (2 mg) on top of the tongue where it will dissolve, then swallow by translingual route 2 times per day
Absence epilepsy
- Place 2 tablets (0.5 mg) on top of the tongue where they will dissolve, then swallow by translingual route 3 times per day
- 2 tablets (0.5 mg) and place on top of the tongue where they will dissolve, then swallow by oral route 3 times per day
- Place 1 tablet (0.5 mg) on top of the tongue where it will dissolve, then swallow by translingual route 3 times per day
- 1 tablet (0.5 mg) and place on top of the tongue where it will dissolve, then swallow by oral route 3 times per day
- 1 tablet (0.5 mg) by oral route 3 times per day
- 2 tablets (1 mg) by oral route 3 times per day
- 1 tablet (1 mg) by oral route 3 times per day
- 1 tablet (1 mg) and place on top of the tongue where it will dissolve, then swallow by oral route 3 times per day
- Place 2 tablets (1 mg) on top of the tongue where they will dissolve,then swallow by translingual route 3 times per day
- Place 1 tablet (1 mg) on top of the tongue where it will dissolve, then swallow by translingual route 3 times per day
- 2 tablets (1 mg) and place on top of the tongue where they will dissolve, then swallow by oral route 3 times per day
- 2 tablets (2 mg) and place on top of the tongue where they will dissolve, then swallow by oral route 3 times per day
- Place 2 tablets (2 mg) on top of the tongue where they will dissolve,then swallow by translingual route 3 times per day
- Place 1 tablet (2 mg) on top of the tongue where it will dissolve, then swallow by translingual route 3 times per day
- 1 tablet (2 mg) and place on top of the tongue where it will dissolve, then swallow by oral route 3 times per day
- 2 tablets (2 mg) by oral route 3 times per day
- 1 tablet (2 mg) by oral route 3 times per day
- 2 tablets (4 mg) by oral route 3 times per day
- Place 2 tablets (4 mg) on top of the tongue where they will dissolve,then swallow by translingual route 3 times per day
- 2 tablets (4 mg) and place on top of the tongue where they will dissolve, then swallow by oral route 3 times per day
Atonic seizure
- Place 2 tablets (0.5 mg) on top of the tongue where they will dissolve, then swallow by translingual route 3 times per day
- 2 tablets (0.5 mg) and place on top of the tongue where they will dissolve, then swallow by oral route 3 times per day
- Place 1 tablet (0.5 mg) on top of the tongue where it will dissolve, then swallow by translingual route 3 times per day
- 1 tablet (0.5 mg) and place on top of the tongue where it will dissolve, then swallow by oral route 3 times per day
- 1 tablet (0.5 mg) by oral route 3 times per day
- 2 tablets (1 mg) by oral route 3 times per day
- 1 tablet (1 mg) by oral route 3 times per day
- 1 tablet (1 mg) and place on top of the tongue where it will dissolve, then swallow by oral route 3 times per day
- Place 2 tablets (1 mg) on top of the tongue where they will dissolve,then swallow by translingual route 3 times per day
- Place 1 tablet (1 mg) on top of the tongue where it will dissolve, then swallow by translingual route 3 times per day
- 2 tablets (1 mg) and place on top of the tongue where they will dissolve, then swallow by oral route 3 times per day
- 2 tablets (2 mg) and place on top of the tongue where they will dissolve, then swallow by oral route 3 times per day
- Place 2 tablets (2 mg) on top of the tongue where they will dissolve,then swallow by translingual route 3 times per day
- Place 1 tablet (2 mg) on top of the tongue where it will dissolve, then swallow by translingual route 3 times per day
- 1 tablet (2 mg) and place on top of the tongue where it will dissolve, then swallow by oral route 3 times per day
- 2 tablets (2 mg) by oral route 3 times per day
- 1 tablet (2 mg) by oral route 3 times per day
- 2 tablets (4 mg) by oral route 3 times per day
- Place 2 tablets (4 mg) on top of the tongue where they will dissolve,then swallow by translingual route 3 times per day
- 2 tablets (4 mg) and place on top of the tongue where they will dissolve, then swallow by oral route 3 times per day
Lennox-gastaut epilepsy
- Place 2 tablets (0.5 mg) on top of the tongue where they will dissolve, then swallow by translingual route 3 times per day
- 2 tablets (0.5 mg) and place on top of the tongue where they will dissolve, then swallow by oral route 3 times per day
- Place 1 tablet (0.5 mg) on top of the tongue where it will dissolve, then swallow by translingual route 3 times per day
- 1 tablet (0.5 mg) and place on top of the tongue where it will dissolve, then swallow by oral route 3 times per day
- 1 tablet (0.5 mg) by oral route 3 times per day
- 2 tablets (1 mg) by oral route 3 times per day
- 1 tablet (1 mg) by oral route 3 times per day
- 1 tablet (1 mg) and place on top of the tongue where it will dissolve, then swallow by oral route 3 times per day
- Place 2 tablets (1 mg) on top of the tongue where they will dissolve,then swallow by translingual route 3 times per day
- Place 1 tablet (1 mg) on top of the tongue where it will dissolve, then swallow by translingual route 3 times per day
- 2 tablets (1 mg) and place on top of the tongue where they will dissolve, then swallow by oral route 3 times per day
- 2 tablets (2 mg) and place on top of the tongue where they will dissolve, then swallow by oral route 3 times per day
- Place 2 tablets (2 mg) on top of the tongue where they will dissolve,then swallow by translingual route 3 times per day
- Place 1 tablet (2 mg) on top of the tongue where it will dissolve, then swallow by translingual route 3 times per day
- 1 tablet (2 mg) and place on top of the tongue where it will dissolve, then swallow by oral route 3 times per day
- 2 tablets (2 mg) by oral route 3 times per day
- 1 tablet (2 mg) by oral route 3 times per day
- 2 tablets (4 mg) by oral route 3 times per day
- Place 2 tablets (4 mg) on top of the tongue where they will dissolve,then swallow by translingual route 3 times per day
- 2 tablets (4 mg) and place on top of the tongue where they will dissolve, then swallow by oral route 3 times per day
Myoclonic epilepsy
- Place 2 tablets (0.5 mg) on top of the tongue where they will dissolve, then swallow by translingual route 3 times per day
- 2 tablets (0.5 mg) and place on top of the tongue where they will dissolve, then swallow by oral route 3 times per day
- Place 1 tablet (0.5 mg) on top of the tongue where it will dissolve, then swallow by translingual route 3 times per day
- 1 tablet (0.5 mg) and place on top of the tongue where it will dissolve, then swallow by oral route 3 times per day
- 1 tablet (0.5 mg) by oral route 3 times per day
- 2 tablets (1 mg) by oral route 3 times per day
- 1 tablet (1 mg) by oral route 3 times per day
- 1 tablet (1 mg) and place on top of the tongue where it will dissolve, then swallow by oral route 3 times per day
- Place 2 tablets (1 mg) on top of the tongue where they will dissolve,then swallow by translingual route 3 times per day
- Place 1 tablet (1 mg) on top of the tongue where it will dissolve, then swallow by translingual route 3 times per day
- 2 tablets (1 mg) and place on top of the tongue where they will dissolve, then swallow by oral route 3 times per day
- 2 tablets (2 mg) and place on top of the tongue where they will dissolve, then swallow by oral route 3 times per day
- Place 2 tablets (2 mg) on top of the tongue where they will dissolve,then swallow by translingual route 3 times per day
- Place 1 tablet (2 mg) on top of the tongue where it will dissolve, then swallow by translingual route 3 times per day
- 1 tablet (2 mg) and place on top of the tongue where it will dissolve, then swallow by oral route 3 times per day
- 2 tablets (2 mg) by oral route 3 times per day
- 1 tablet (2 mg) by oral route 3 times per day
- 2 tablets (4 mg) by oral route 3 times per day
- Place 2 tablets (4 mg) on top of the tongue where they will dissolve,then swallow by translingual route 3 times per day
- 2 tablets (4 mg) and place on top of the tongue where they will dissolve, then swallow by oral route 3 times per day
Panic disorder
- Place 2 tablets (0.25 mg) on top of the tongue where they will dissolve, then swallow by translingual route 2 times per day
- 2 tablets (0.25 mg) and place on top of the tongue where they will dissolve, then swallow by oral route 2 times per day
- 1 tablet (0.25 mg) and place on top of the tongue where it will dissolve, then swallow by oral route 2 times per day
- Place 1 tablet (0.25 mg) on top of the tongue where it will dissolve,then swallow by translingual route 2 times per day
- Place 2 tablets (0.5 mg) on top of the tongue where they will dissolve, then swallow by translingual route 2 times per day
- 2 tablets (0.5 mg) and place on top of the tongue where they will dissolve, then swallow by oral route 2 times per day
- Place 1 tablet (0.5 mg) on top of the tongue where it will dissolve, then swallow by translingual route 2 times per day
- 1 tablet (0.5 mg) by oral route 2 times per day
- 1 tablet (0.5 mg) and place on top of the tongue where it will dissolve, then swallow by oral route 2 times per day
- 2 tablets (1 mg) by oral route 2 times per day
- 1 tablet (1 mg) and place on top of the tongue where it will dissolve, then swallow by oral route 2 times per day
- Place 1 tablet (1 mg) on top of the tongue where it will dissolve, then swallow by translingual route 2 times per day
- 1 tablet (1 mg) by oral route 2 times per day
- Place 2 tablets (1 mg) on top of the tongue where they will dissolve,then swallow by translingual route 2 times per day
- 2 tablets (1 mg) and place on top of the tongue where they will dissolve, then swallow by oral route 2 times per day
- 2 tablets (2 mg) by oral route 2 times per day
- Place 2 tablets (2 mg) on top of the tongue where they will dissolve,then swallow by translingual route 2 times per day
- Place 1 tablet (2 mg) on top of the tongue where it will dissolve, then swallow by translingual route 2 times per day
- 2 tablets (2 mg) and place on top of the tongue where they will dissolve, then swallow by oral route 2 times per day
- 1 tablet (2 mg) and place on top of the tongue where it will dissolve, then swallow by oral route 2 times per day
- 1 tablet (2 mg) by oral route 2 times per day
- sodium oxybate
- Xyrem
Contraindicated
- clozapine
- Clozaril
- Dehydrated Alcohol
- ethanol (ethyl alcohol)
- ethyl alcohol-herbal drugs
- Fazaclo
- Lydia Pinkham Herbal
- Versacloz
Severe
Moderate
- Acid Reducer (cimetidine)
- Acid Relief (cimetidine)
- buprenorphine-naloxone
- cimetidine
- Heartburn Relief
- isoniazid-rifamp-pyrazinamide
- Rifadin
- Rifamate
- rifampin
- rifampin-isoniazid
- Rifater
- Suboxone
- Tagamet Hb
- Zubsolv
- Abnormal hepatic function tests
- Angle-closure glaucoma
- Severe hepatic disease
Contraindicated
- Alcohol intoxication
- Depression
- Drug abuse
- Porphyria
- Pregnancy
- Sleep apnea
- Suicidal ideation
Severe
Moderate
- Chronic pulmonary disease
- Disease of liver
- Kidney disease with likely reduction in GFR
- Open angle glaucoma
- Predisposition to aspiration
- Respiratory depression
CLONAZEPAM (CLONAZEPAM)
- Lennox-gastaut epilepsy
- Myoclonic epilepsy
- Panic disorder
- Absence epilepsy
- Atonic seizure
- Muscle weakness
- Ataxia
- Dizziness
- Drowsy
- Dyspepsia
- Slurred speech
More Frequent
Severe
Less Severe
- Acute confusion
- Behavioral disorders
- CNS depression
- Diarrhea
- Fatigue
- General weakness
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal hepatic function tests
- Accidental fall
- Agranulocytosis
- Anaphylaxis
- Anemia
- Angioedema
- Aplastic anemia
- Apnea
- Coma
- Dehydration
- Depression
- Disease of liver
- Drug-induced psychosis
- Eosinophilia
- Hallucinations
- Hemolytic anemia
- Hepatomegaly
- Hostility
- Hypotension
- Jaundice
- Leukocytosis
- Leukopenia
- Manic disorder
- Memory impairment
- Neutropenic disorder
- Respiratory depression
- Seizure disorder
- Skin rash
- Sleep walking disorder
- Suicidal ideation
- Thrombocytopenic disorder
- Urinary retention
Less Severe
- Aggressive behavior
- Agitation
- Alopecia
- Anorexia
- Aphonia
- Blurred vision
- Bronchial congestion
- Complex sleep behavior
- Concentration difficulty
- Conjunctivitis
- Constipation
- Contact dermatitis
- Cramps
- Delirium
- Depersonalization
- Diplopia
- Disturbance in thinking
- Dream disorder
- Drug dependence
- Dry eye
- Dry skin
- Dysarthria
- Dyspnea
- Dysuria
- Excitement
- Eyes vertical deviation
- Facial edema
- Gastritis
- Gingival pain
- Glossitis
- Headache disorder
- Hiccups
- Hirsutism
- Increased appetite
- Irritability
- Libido changes
- Loss of taste
- Lymphadenopathy
- Menstrual disorder
- Myalgias
- Nausea
- Nervousness
- Nightmares
- Nocturia
- Nystagmus
- Orthostatic hypotension
- Palpitations
- Paranoid disorder
- Polydipsia
- Pruritus of skin
- Rhinorrhea
- Sialorrhea
- Sleep disorder
- Sneezing
- Sore tongue
- Stomatitis
- Swelling of ankles or feet
- Syncope
- Tachycardia
- Tremor
- Urinary incontinence
- Urine discoloration
- Vertigo
- Visual changes
- Visual field defect
- Vomiting
- Weight gain
- Weight loss
- Xerostomia
- Yawning
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Clonazepam
Adverse effects unknown on physical and mental development with long term use.
- 1 Day – 18 Years
- Adverse effects unknown on physical and mental development with long term use.
Clonazepam
- Severity Level:
D
- Additional Notes: Limited data suggest fetal dev tox; consider maternal benefit vs. fetal risk
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Clonazepam
Not recommended by mfr; monitor infant for apnea, cns sedation
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Excreted | Not known; no or inclusive data | Not recommended by mfr; monitor infant for apnea, cns sedation |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Clonazepam
Neuro/Psych-Increased risk of cognitive impairment, delirium, falls, fractures, and motor vehicle crashes. Long half-life benzodiazepines are generally not preferred in the elderly. Limit dose to 1.5mg/day. Pulmonary- Use caution in patient with compromised respiratory function. General-May be appropriate for select indications including severe generalized anxiety disorder and seizure disorder.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | Y | Y | N | Y | Y | N |
BEERS: Y HEDIS: Y STOPP: Y
No Known Risk
None
- Taking clonazepam with opioid medications (such as codeine, hydrocodone) may increase your risk of very serious side effects, including death. To lower your risk, your doctor should have you take the smallest dose of clonazepam that works, and take it for the shortest possible time. Get medical help right away if any of these very serious side effects occur: slow/shallow breathing, unusual lightheadedness, severe drowsiness/dizziness, difficulty waking up.
| Absence epilepsy | |
| G40.A | Absence epileptic syndrome |
| G40.A0 | Absence epileptic syndrome, not intractable |
| G40.A09 | Absence epileptic syndrome, not intractable, without status epilepticus |
| G40.A1 | Absence epileptic syndrome, intractable |
| G40.A19 | Absence epileptic syndrome, intractable, without status epilepticus |
| Atonic seizure | |
| G40.3 | Generalized idiopathic epilepsy and epileptic syndromes |
| G40.30 | Generalized idiopathic epilepsy and epileptic syndromes, not intractable |
| G40.309 | Generalized idiopathic epilepsy and epileptic syndromes, not intractable, without status epilepticus |
| G40.31 | Generalized idiopathic epilepsy and epileptic syndromes, intractable |
| G40.319 | Generalized idiopathic epilepsy and epileptic syndromes, intractable, without status epilepticus |
| G40.4 | Other generalized epilepsy and epileptic syndromes |
| G40.40 | Other generalized epilepsy and epileptic syndromes, not intractable |
| G40.409 | Other generalized epilepsy and epileptic syndromes, not intractable, without status epilepticus |
| G40.41 | Other generalized epilepsy and epileptic syndromes, intractable |
| G40.419 | Other generalized epilepsy and epileptic syndromes, intractable, without status epilepticus |
| Lennox-gastaut epilepsy | |
| G40.81 | Lennox-gastaut syndrome |
| G40.812 | Lennox-gastaut syndrome, not intractable, without status epilepticus |
| G40.814 | Lennox-gastaut syndrome, intractable, without status epilepticus |
| Myoclonic epilepsy | |
| G40.3 | Generalized idiopathic epilepsy and epileptic syndromes |
| G40.30 | Generalized idiopathic epilepsy and epileptic syndromes, not intractable |
| G40.309 | Generalized idiopathic epilepsy and epileptic syndromes, not intractable, without status epilepticus |
| G40.31 | Generalized idiopathic epilepsy and epileptic syndromes, intractable |
| G40.319 | Generalized idiopathic epilepsy and epileptic syndromes, intractable, without status epilepticus |
| G40.4 | Other generalized epilepsy and epileptic syndromes |
| G40.40 | Other generalized epilepsy and epileptic syndromes, not intractable |
| G40.409 | Other generalized epilepsy and epileptic syndromes, not intractable, without status epilepticus |
| G40.41 | Other generalized epilepsy and epileptic syndromes, intractable |
| G40.419 | Other generalized epilepsy and epileptic syndromes, intractable, without status epilepticus |
| G40.B | Juvenile myoclonic epilepsy [impulsive petit mal] |
| G40.B0 | Juvenile myoclonic epilepsy, not intractable |
| G40.B01 | Juvenile myoclonic epilepsy, not intractable, with status epilepticus |
| G40.B09 | Juvenile myoclonic epilepsy, not intractable, without status epilepticus |
| G40.B1 | Juvenile myoclonic epilepsy, intractable |
| G40.B11 | Juvenile myoclonic epilepsy, intractable, with status epilepticus |
| G40.B19 | Juvenile myoclonic epilepsy, intractable, without status epilepticus |
| Panic disorder | |
| F40.01 | Agoraphobia with panic disorder |
| F41.0 | Panic disorder [episodic paroxysmal anxiety] |
| 0-9 | A-Z |
|---|---|
| F40.01 | Agoraphobia with panic disorder |
| F41.0 | Panic disorder [episodic paroxysmal anxiety] |
| G40.3 | Generalized idiopathic epilepsy and epileptic syndromes |
| G40.3 | Generalized idiopathic epilepsy and epileptic syndromes |
| G40.30 | Generalized idiopathic epilepsy and epileptic syndromes, not intractable |
| G40.30 | Generalized idiopathic epilepsy and epileptic syndromes, not intractable |
| G40.309 | Generalized idiopathic epilepsy and epileptic syndromes, not intractable, without status epilepticus |
| G40.309 | Generalized idiopathic epilepsy and epileptic syndromes, not intractable, without status epilepticus |
| G40.31 | Generalized idiopathic epilepsy and epileptic syndromes, intractable |
| G40.31 | Generalized idiopathic epilepsy and epileptic syndromes, intractable |
| G40.319 | Generalized idiopathic epilepsy and epileptic syndromes, intractable, without status epilepticus |
| G40.319 | Generalized idiopathic epilepsy and epileptic syndromes, intractable, without status epilepticus |
| G40.4 | Other generalized epilepsy and epileptic syndromes |
| G40.4 | Other generalized epilepsy and epileptic syndromes |
| G40.40 | Other generalized epilepsy and epileptic syndromes, not intractable |
| G40.40 | Other generalized epilepsy and epileptic syndromes, not intractable |
| G40.409 | Other generalized epilepsy and epileptic syndromes, not intractable, without status epilepticus |
| G40.409 | Other generalized epilepsy and epileptic syndromes, not intractable, without status epilepticus |
| G40.41 | Other generalized epilepsy and epileptic syndromes, intractable |
| G40.41 | Other generalized epilepsy and epileptic syndromes, intractable |
| G40.419 | Other generalized epilepsy and epileptic syndromes, intractable, without status epilepticus |
| G40.419 | Other generalized epilepsy and epileptic syndromes, intractable, without status epilepticus |
| G40.81 | Lennox-gastaut syndrome |
| G40.812 | Lennox-gastaut syndrome, not intractable, without status epilepticus |
| G40.814 | Lennox-gastaut syndrome, intractable, without status epilepticus |
| G40.A | Absence epileptic syndrome |
| G40.A0 | Absence epileptic syndrome, not intractable |
| G40.A09 | Absence epileptic syndrome, not intractable, without status epilepticus |
| G40.A1 | Absence epileptic syndrome, intractable |
| G40.A19 | Absence epileptic syndrome, intractable, without status epilepticus |
| G40.B | Juvenile myoclonic epilepsy [impulsive petit mal] |
| G40.B0 | Juvenile myoclonic epilepsy, not intractable |
| G40.B01 | Juvenile myoclonic epilepsy, not intractable, with status epilepticus |
| G40.B09 | Juvenile myoclonic epilepsy, not intractable, without status epilepticus |
| G40.B1 | Juvenile myoclonic epilepsy, intractable |
| G40.B11 | Juvenile myoclonic epilepsy, intractable, with status epilepticus |
| G40.B19 | Juvenile myoclonic epilepsy, intractable, without status epilepticus |
Formulary Reference Tool