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PLEXION (SULFACETAMIDE SODIUM/SULFUR)
- Plexion Topical Cream
- Plexion Topical Cleanser
- Plexion Lotion
- Plexion Cleansing Cloths
- By Indication
9.8 %-4.8 % topical cream
- Apply a thin layer to the affected area(s) after washing by topical route once daily
9.8 %-4.8 % topical cleanser
- Apply to wet skin by topical route once daily then massage gently 10-20 seconds, rinse, and pat dry
9.8 %-4.8 % lotion
- Apply a thin layer to the affected area(s) after washing by topical route once daily
9.8 %-4.8 %
- Wash the affected area(s) by topical route once daily with cleansing cloth then massage gently 10-20 seconds, rinse, and pat dry
Cleansing Cloths 9.8 %-4.8 %
- Wash the affected area(s) by topical route once daily with cleansing cloth then massage gently 10-20 seconds, rinse, and pat dry
Acne rosacea
- Apply to wet skin by topical route once daily then massage gently 10-20 seconds, rinse, and pat dry
- Apply to wet skin by topical route 2 times per day then massage gently 10-20 seconds, rinse, and pat dry
- Apply to wet skin by topical route 1-2 times daily then massage gently 10-20 seconds, rinse, and pat dry
- Apply a thin layer to the affected area(s) after washing by topical route once daily
- Apply a thin layer to the affected area(s) after washing by topical route 3 times per day
- Apply a thin layer to the affected area(s) after washing by topical route 1-3 times daily
- Wash the affected area(s) by topical route 1-2 times daily with cleansing cloth then massage gently 10-20 seconds, rinse, and pat dry
- Wash the affected area(s) by topical route once daily with cleansing cloth then massage gently 10-20 seconds, rinse, and pat dry
- Wash the affected area(s) by topical route 2 times per day with cleansing cloth then massage gently 10-20 seconds, rinse, and pat dry
Acne vulgaris
- Apply to wet skin by topical route once daily then massage gently 10-20 seconds, rinse, and pat dry
- Apply to wet skin by topical route 2 times per day then massage gently 10-20 seconds, rinse, and pat dry
- Apply to wet skin by topical route 1-2 times daily then massage gently 10-20 seconds, rinse, and pat dry
- Apply a thin layer to the affected area(s) after washing by topical route once daily
- Apply a thin layer to the affected area(s) after washing by topical route 3 times per day
- Apply a thin layer to the affected area(s) after washing by topical route 1-3 times daily
- Wash the affected area(s) by topical route 1-2 times daily with cleansing cloth then massage gently 10-20 seconds, rinse, and pat dry
- Wash the affected area(s) by topical route once daily with cleansing cloth then massage gently 10-20 seconds, rinse, and pat dry
- Wash the affected area(s) by topical route 2 times per day with cleansing cloth then massage gently 10-20 seconds, rinse, and pat dry
Seborrheic dermatitis
- Apply to wet skin by topical route once daily then massage gently 10-20 seconds, rinse, and pat dry
- Apply to wet skin by topical route 2 times per day then massage gently 10-20 seconds, rinse, and pat dry
- Apply to wet skin by topical route 1-2 times daily then massage gently 10-20 seconds, rinse, and pat dry
- Apply a thin layer to the affected area(s) after washing by topical route once daily
- Apply a thin layer to the affected area(s) after washing by topical route 3 times per day
- Apply a thin layer to the affected area(s) after washing by topical route 1-3 times daily
- Wash the affected area(s) by topical route 1-2 times daily with cleansing cloth then massage gently 10-20 seconds, rinse, and pat dry
- Wash the affected area(s) by topical route once daily with cleansing cloth then massage gently 10-20 seconds, rinse, and pat dry
- Wash the affected area(s) by topical route 2 times per day with cleansing cloth then massage gently 10-20 seconds, rinse, and pat dry
- None
Contraindicated
- Silvadene
- silver sulfadiazine
- Ssd
- Thermazene
Severe
Moderate
- None
- Glucose-6-phosphate dehydrogenase (g6Pd) deficiency
- Hemolytic anemia from PK and g6PD deficiencies
- Kidney disease with reduction in GFR
Contraindicated
- None
Severe
Moderate
- None
PLEXION (SULFACETAMIDE SODIUM/SULFUR)
- None
- None
More Frequent
Severe
Less Severe
- Skin irritation
- Abnormal desquamation
- Erythema
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Agranulocytosis
- Blood dyscrasias
- Erythema
- Glucose-6-phosphate dehydrogenase deficiency anemia
- Hepatic necrosis
- Hypersensitivity drug reaction
- Neutropenic disorder
- Pruritus of skin
- Skin irritation
- Skin rash
- Stevens-johnson syndrome
- Systemic lupus erythematosus
- Toxic epidermal necrolysis
Less Severe
- Skin inflammation
Contraindicated
Sulfacetamide Sodium (Top)
Not recommended in infants under 2 months. May cause kernicterus.
- 1 Day – 59 Days
- 1 Not recommended in infants under 2 months. May cause kernicterus.
Severe Precaution
None
Management or Monitoring Precaution
Sulfur (Topical)
Topical preparations containing sulfur should not be used age < 2 years except under the direction and supervision of a physician.
- 1 Day – 2 Years
- Topical preparations containing sulfur should not be used age < 2 years except under the direction and supervision of a physician.
Sulfacetamide Sodium (ophth & Top)
- Severity Level:
C
- Additional Notes: Insufficient human data
Sulfur (topical)
- Severity Level:
C
- Additional Notes: Fda risk category c in combination products
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Sulfacetamide (ophth, Top, Vag)
Absorp unknown;Kernicterus risk in newborn;Sulfas not rec if g6Pd def infant
Insuff data; systemic absorp w/ 25% conc applied to abraded skin in animals
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | Absorp unknown;Kernicterus risk in newborn;Sulfas not rec if g6Pd def infant |
Sulfur(topical)
Absorp unknown;Kernicterus risk in newborn;Sulfas not rec if g6Pd def infant
Insuff data; systemic absorp w/ 25% conc applied to abraded skin in animals
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | Insuff data; systemic absorp w/ 25% conc applied to abraded skin in animals |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- None
Formulary Reference Tool