ATRIPLA (EFAVIRENZ/EMTRICITABINE/TENOFOVIR DISOPROXIL FUMARATE)
- HIV infection
600 mg-200 mg-300 mg tablet
- 1 tablet by oral route once daily on an empty stomach
HIV infection
- 1 tablet by oral route once daily on an empty stomach
- adefovir
- B cplx-C-St.Johnwrt-K.&S.ginsg
- calcium-mag-B complex-D3-hrb61
- carbamazepine
- Carbatrol
- cidofovir
- Cold & Flu Fighter
- elvitegr-cobicist-emtric-tenof
- Epitol
- Equetro
- etravirine
- Fatigue Relief Complex
- Hepsera
- Intelence
- St. John's wort
- Stribild
- Tegretol
- Tegretol Xr
- Vfend
- Vfend Iv
- Women's Complex
- voriconazole
- vit C-St. John wort-elder-hb30
- Vistide
Contraindicated
- Altavera (28)
- Alyacen 1/35 (28)
- Alyacen 7/7/7 (28)
- Amethia
- Amethia Lo
- Amethyst
- apixaban
- Apri
- Aranelle (28)
- atazanavir
- Aubra
- Aviane
- axitinib
- Azurette (28)
- Balziva (28)
- bedaquiline
- Beyaz
- boceprevir
- Bosulif
- bosutinib
- Brevicon (28)
- Briellyn
- Camila
- Camrese
- Camrese Lo
- Caziant (28)
- Chateal
- Cryselle (28)
- Cyclafem 1/35 (28)
- Cyclafem 7/7/7 (28)
- Cyclessa (28)
- Dasetta 1/35 (28)
- Dasetta 7/7/7 (28)
- Daysee
- Depo-provera
- Depo-subq Provera 104
- desog-e.estradiol/e.estradiol
- Desogen
- desogestrel-ethinyl estradiol
- dolutegravir
- drospirenone-e.estradiol-lm.FA
- drospirenone-ethinyl estradiol
- Elinest
- Eliquis
- Emoquette
- Enpresse
- Enskyce
- enzalutamide
- Errin
- Estarylla
- estradiol valerate-dienogest
- Estrostep Fe-28
- ethynodiol diac-eth estradiol
- etonogestrel
- etonogestrel-ethinyl estradiol
- Falmina (28)
- Femcon Fe
- Generess Fe
- Gianvi (28)
- Gildagia
- Gildess
- Gildess Fe
- guanfacine
- Heather
- Incivek
- Inlyta
- Introvale
- Intuniv Er
- itraconazole
- Jencycla
- Jolessa
- Jolivette
- Junel 1.5/30 (21)
- Junel 1/20 (21)
- Junel Fe 1.5/30 (28)
- Junel Fe 1/20 (28)
- Kariva (28)
- Kelnor 1/35 (28)
- ketoconazole
- Kurvelo
- L norgest&E estradiol-E estrad
- Larin 1/20 (21)
- Larin Fe
- Leena 28
- Lessina
- Levonest (28)
- levonorg-eth estrad triphasic
- levonorgestrel
- levonorgestrel-ethinyl estrad
- Levora 0.15/30 (28)
- Levora-28
- Lo Loestrin Fe
- Loestrin 1.5/30 (21)
- Loestrin 1/20 (21)
- Loestrin Fe 1.5/30 (28)
- Loestrin Fe 1/20 (28)
- Lomedia 24 Fe
- Loryna (28)
- Loseasonique
- Low-ogestrel (28)
- Lutera (28)
- Lyza
- Marlissa
- medroxyprogesterone
- Microgestin 1.5/30 (21)
- Microgestin 1/20 (21)
- Microgestin Fe 1.5/30 (28)
- Microgestin Fe 1/20 (28)
- Minastrin 24 Fe
- Mircette (28)
- Mirena
- Modicon (28)
- Mono-linyah
- Mononessa (28)
- My Way
- Myzilra
- Natazia
- Necon 0.5/35 (28)
- Necon 1/35 (28)
- Necon 1/50 (28)
- Necon 10/11 (28)
- Necon 7/7/7 (28)
- Nexplanon
- Next Choice One Dose
- Nor-qd
- Nora-be
- norelgestrom-ethinyl estradiol
- noreth-ethinyl estradiol-iron
- norethin-e.estradiol triphasic
- norethin-eth estrad biphasic
- norethindrone (contraceptive)
- norethindrone ac-eth estradiol
- norethindrone-e.estradiol-iron
- norethindrone-ethin estradiol
- norethindrone-mestranol
- norgestimate-ethinyl estradiol
- norgestrel-ethinyl estradiol
- Norinyl 1+35 (28)
- Norinyl 1+50 (28)
- Nortrel 0.5/35 (28)
- Nortrel 1/35 (21)
- Nortrel 1/35 (28)
- Nortrel 7/7/7 (28)
- Noxafil
- Nuvaring
- Ocella
- Ogestrel (28)
- Olysio
- Onmel
- Orsythia
- Ortho Evra
- Ortho Micronor
- Ortho Tri-cyclen (28)
- Ortho Tri-cyclen Lo (28)
- Ortho-cept (28)
- Ortho-cyclen (28)
- Ortho-novum 1/35 (28)
- Ortho-novum 7/7/7 (28)
- Ovcon-35 (28)
- Philith
- Pimtrea (28)
- Pirmella
- Plan B One-step
- Portia
- posaconazole
- Previfem
- Quartette
- Quasense
- Reclipsen (28)
- Reyataz
- rivaroxaban
- Safyral
- Seasonique
- simeprevir
- Sirturo
- Skyla
- Sporanox
- Sporanox Pulsepak
- Sprintec (28)
- Sronyx
- Syeda
- telaprevir
- Tenex
- Tilia Fe
- Tivicay
- Tri-estarylla
- Tri-legest Fe
- Tri-linyah
- Tri-norinyl (28)
- Tri-previfem (28)
- Tri-sprintec (28)
- Trinessa (28)
- Trivora (28)
- Velivet Triphasic Regimen (28)
- Vestura (28)
- Zovia 1/50E (28)
- Zovia 1/35E (28)
- Zeosa
- Zenchent Fe
- Zenchent (28)
- Zarah
- Yaz 28
- Yasmin (28)
- Xtandi
- Xarelto
- Wymzya Fe
- Wera (28)
- Vyfemla (28)
- Viorele (28)
- Victrelis
Severe
Moderate
- Advil
- Advil Allergy Sinus
- Advil Allergy-congestion Rlf
- Advil Cold & Sinus
- Advil Congestion Relief
- Advil Liqui-gel
- Advil Migraine
- Advil Pm
- Advil Pm Liqui-gels
- afatinib
- Aleve
- Aleve Cold & Sinus
- Aleve Sinus & Headache
- Aleve-d Sinus & Cold
- Aleve-d Sinus & Headache
- All Day Pain Relief
- All Day Pain Relief Sinus & Co
- All Day Relief
- amlodipine-atorvastatin
- amoxicil-clarithromy-lansopraz
- Anaprox
- Anaprox Ds
- Ansaid
- Arthrotec 50
- atorvastatin
- Biaxin
- Biaxin Xl
- Biaxin Xl Pak
- Caduet
- Caldolor
- Cambia
- Cancidas
- caspofungin
- Cataflam
- Celebrex
- celecoxib
- Child Ibuprofen
- Children's Advil
- Children's Ibu-drops
- Children's Ibuprofen
- Children's Medi-profen
- Children's Motrin
- Children's Profen Ib
- chlorphen-phenyleph-ibuprofen
- chlorphen-pseudoeph-ibuprofen
- cilostazol
- clarithromycin
- Cold & Sinus Pain Relief
- Cold-sinus Relief
- Crixivan
- Daypro
- diclofenac epolamine
- diclofenac potassium
- diclofenac sodium
- diclofenac submicronized
- diclofenac-misoprostol
- didanosine
- Diskets
- Dolophine
- Duexis
- Ec-naprosyn
- etodolac
- ezetimibe-atorvastatin
- ezetimibe-simvastatin
- Feldene
- fenoprofen
- Flanax
- Flector
- flurbiprofen
- fosamprenavir
- Gilotrif
- hydrocodone-ibuprofen
- I-prin
- Ibu-drops
- Ibudone
- ibuprofen
- Ibuprofen Cold
- Ibuprofen Cold-sinus(with Pse)
- Ibuprofen Ib
- Ibuprofen Jr Strength
- ibuprofen lysine (PF)
- Ibuprofen Pm
- ibuprofen-diphenhydramine
- ibuprofen-diphenhydramine HCl
- ibuprofen-famotidine
- ibuprofen-oxycodone
- ibuprofen-phenylephrine HCl
- indinavir
- Indocin
- indomethacin
- indomethacin sodium
- Infant's Ibuprofen
- Infant's Medi-profen
- Infant's Motrin
- Infants Ibu-drops
- Infants Profenib
- Invirase
- Kaletra
- ketoprofen
- ketorolac
- Lexiva
- Lipitor
- Liptruzet
- lopinavir-ritonavir
- Medi-profen
- Mediproxen
- mefenamic acid
- meloxicam
- methadone
- Methadone Intensol
- Methadose
- Midol (naproxen)
- Mobic
- Motrin Ib
- Motrin Pm
- Mycobutin
- nabumetone
- Nalfon
- Naprelan Cr
- Naprosyn
- naproxen
- naproxen sodium
- naproxen-esomeprazole
- naproxen-pseudoephedrine
- Neoprofen (ibuprofen Lysn)(pf)
- niacin-simvastatin
- Omeclamox-pak
- omeprazole-clarith-amoxicillin
- oxaprozin
- Pennsaid
- piroxicam
- Pletal
- Ponstel
- Pravachol
- pravastatin
- Prevpac
- Provil
- pseudoephedrine-ibuprofen
- Reprexain
- rifabutin
- saquinavir mesylate
- Simcor
- simvastatin
- Sinus & Cold-d
- Solaraze
- Sprix
- sulindac
- tolmetin
- Vicoprofen
- Zorvolex
- Zocor
- Zipsor
- Wal-proxen
- Wal-profen Cold-sinus
- Wal-profen
- Vytorin 10-80
- Vytorin 10-40
- Vytorin 10-20
- Vytorin 10-10
- Voltaren-xr
- Vimovo
- Videx Ec
- Videx 4 Gram Pediatric
- Videx 2 Gram Pediatric
- Lactating mother
- Lactic acidosis
Contraindicated
- Acute renal failure
- Chronic kidney disease stage 3A (moderate) GFR 45-59
- Chronic kidney disease stage 3B (moderate) GFR 30-44
- Chronic kidney disease stage 4 (severe) GFR 15-29 ml/min
- Chronic kidney disease stage 5 (failure) GFr<15 ml/min
- Depression
- Disease of liver
- Fanconi syndrome
- Hypophosphatemia
- Kidney disease with reduction in GFR
- Manic disorder
- Osteomalacia
- Paranoid disorder
- Pathological fracture
- Suicidal ideation
Severe
Moderate
- Aggressive behavior
- Chronic hepatitis B
- CYp2b6*6/*6 genotype
- Hypercholesterolemia
- Hypertriglyceridemia
- Insomnia
- Kidney disease with likely reduction in GFR
- Osteopenia
- Seizure disorder
ATRIPLA (EFAVIRENZ/EMTRICITABINE/TENOFOVIR DISOPROXIL FUMARATE)
- HIV infection
- Depression
- Gastroenteritis
- Pruritus of skin
- Skin rash
- Vomiting
- Acute abdominal pain
- Back pain
- Concentration difficulty
- Cough
- Diarrhea
- Dizziness
- Dream disorder
- Drowsy
- Fatigue
- Fever
- Flatulence
- General weakness
- Headache disorder
- Insomnia
- Lipodystrophy associated with HIV
- Nausea
- Pain
- Pruritus of skin
- Rhinitis
- Skin rash
- Vomiting
More Frequent
Severe
Less Severe
- Anemia
- Bullous dermatitis
- Hallucinations
- Hypercholesterolemia
- Increased alanine transaminase
- Increased aspartate transaminase
- Maculopapular rash
- Peripheral neuropathy
- Pneumonia
- Prolonged QT interval
- Urticaria
- Acute abdominal pain
- Acute bacterial otitis media
- Anorexia
- Arthralgias
- Chest pain
- Dyspepsia
- Fatigue
- Hypercholesterolemia
- Hypertriglyceridemia
- Insomnia
- Myalgias
- Nervousness
- Paresthesia
- Pharyngitis
- Polyuria
- Proteinuria
- Sinusitis
- Symptoms of anxiety
- Weight loss
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal desquamation
- Abnormal hepatic function tests
- Acute confusion
- Acute hepatic failure
- Acute pancreatitis
- Acute renal failure
- Angioedema
- Ataxia
- Behavioral disorders
- Blistering skin
- Catatonia
- Delusional disorder
- Dermal necrosis
- Drug-induced psychosis
- Dysphasia
- Dyspnea
- Encephalopathy
- Erythema multiforme
- Exfoliative dermatitis
- Fanconi syndrome
- Fever
- Graves' disease
- Guillain-barre syndrome
- Hepatitis
- Hypokalemia
- Hypophosphatemia
- Interstitial nephritis
- Kidney disease with reduction in GFR
- Lactic acidosis
- Manic disorder
- Nephrogenic diabetes insipidus
- Osteomalacia
- Pancreatitis
- Paranoid disorder
- Paresthesia
- Peripheral neuropathy
- Phototoxicity
- Pneumonia
- Polymyositis
- Renal tubular necrosis
- Rhabdomyolysis
- Seizure disorder
- Skin ulcer
- Steatosis of liver
- Stevens-johnson syndrome
- Suicidal
- Suicidal ideation
- Syncope
- Toxic epidermal necrolysis
- Tremor
- Urticaria
- Visual changes
- Wheezing
Less Severe
- Aggressive behavior
- Agitation
- Anorexia
- Arthralgias
- Constipation
- Cough
- Depersonalization
- Dyschromia
- Euphoria
- Flushing
- Folliculitis
- General weakness
- Gynecomastia
- Hyperhidrosis
- Hypertriglyceridemia
- Hypesthesia
- Malabsorption states
- Memory impairment
- Mood changes
- Muscle weakness
- Myalgias
- Myopathy
- Palpitations
- Tinnitus
- Urticaria
- Vertigo
Contraindicated
None
Severe Precaution
Emtricitabine_Tenofovir_Efavirenz
Fixed dose combination not appropriate age< 12 years, body weight < 40 kg.
- 1 Day – 12 Years
- Fixed dose combination not appropriate age< 12 years, body weight < 40 kg.
Management or Monitoring Precaution
Emtricitabine_Tenofovir_Efavirenz
Higher incidence of rash and Grade 3 or 4 rash. Consider antihistamine prophylaxis. Risk of lower bone density with tenofovir use in pediatrics. Assess BMD if history of fracture or bone loss.
- 12 Years – 18 Years
- Higher incidence of rash and Grade 3 or 4 rash. Consider antihistamine prophylaxis. Risk of lower bone density with tenofovir use in pediatrics. Assess BMD if history of fracture or bone loss.
Efavirenz
- Severity Level:
2
- Additional Notes: No fda cat;art preg registry data show no increased risk for major birth defects
Emtricitabine
- Severity Level:
2
- Additional Notes: Available human data show no increased risk for major malformations.
Tenofovir
- Severity Level:
2
- Additional Notes: Available human data show no increased risk for major birth defects
Contraindicated
Efavirenz
Cdc does not recommend breastfeeding in hiv-positive women
Cdc does not recommend breastfeeding in hiv-positive women.
General | Excretion Potential | Effect on Infant | Notes |
Drug should not be given to breast feeding mothers | Excreted | Not known; no or inclusive data | Cdc does not recommend breastfeeding in hiv-positive women |
Emtricitabine
Cdc does not recommend breastfeeding in hiv-positive women
Cdc does not recommend breastfeeding in hiv-positive women.
General | Excretion Potential | Effect on Infant | Notes |
Drug should not be given to breast feeding mothers | Excreted | Not known; no or inclusive data | Cdc does not recommend breastfeeding in hiv-positive women. |
Precaution Exists
Tenofovir
Limited data suggest no known adverse effects in nursing infant
General | Excretion Potential | Effect on Infant | Notes |
Evaluate use carefully | Excreted | Not known; no or inclusive data | Limited data suggest no known adverse effects in nursing infant |
No Known Risk
None
General | Excretion Potential | Effect on Infant | Notes |
None |
Contraindicated
None
Precaution Exists
Emtricitabine
Renal- Adhere to manufacturer guidelines for renal impairment and lower CrCL.
Renal-Adjust dosing interval for CrCL<50mL/min. Fixed dose combinations containing tenofovir are not appropriate if dose adjustment is required. Musculoskeletal-Decreases in bone mineral density have been observed. Consider calcium and vitamin D3 supplementation.
Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
Increased Risk / Adverse Effects | Y | Y | N | N | N | N |
BEERS: N HEDIS: N STOPP: N
Tenofovir Disoproxil
Renal- Adhere to manufacturer guidelines for renal impairment and lower CrCL.
Renal-Adjust dosing interval for CrCL<50mL/min. Fixed dose combinations containing tenofovir are not appropriate if dose adjustment is required. Musculoskeletal-Decreases in bone mineral density have been observed. Consider calcium and vitamin D3 supplementation.
Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
Increased Risk / Adverse Effects | Y | Y | Y | N | N | N |
BEERS: N HEDIS: N STOPP: N
No Known Risk
None
- If you have hepatitis B infection, your hepatitis symptoms may get worse or become very serious if you stop taking this medication. Talk with your doctor before stopping this medication. Your doctor will monitor liver tests for several months after you stop efavirenz/emtricitabine/tenofovir. Tell your doctor right away if you develop symptoms of worsening liver problems.
HIV infection | |
B20 | Human immunodeficiency virus [HIv] disease |
B97.35 | Human immunodeficiency virus, type 2 [HIV 2] as the cause of diseases classified elsewhere |
O98.7 | Human immunodeficiency virus [HIv] disease complicating pregnancy, childbirth and the puerperium |
O98.71 | Human immunodeficiency virus [HIv] disease complicating pregnancy |
O98.711 | Human immunodeficiency virus [HIv] disease complicating pregnancy, first trimester |
O98.712 | Human immunodeficiency virus [HIv] disease complicating pregnancy, second trimester |
O98.713 | Human immunodeficiency virus [HIv] disease complicating pregnancy, third trimester |
O98.719 | Human immunodeficiency virus [HIv] disease complicating pregnancy, unspecified trimester |
O98.72 | Human immunodeficiency virus [HIv] disease complicating childbirth |
O98.73 | Human immunodeficiency virus [HIv] disease complicating the puerperium |
Z21 | Asymptomatic human immunodeficiency virus [HIv] infection status |
0-9 | A-Z |
---|---|
B20 | Human immunodeficiency virus [HIv] disease |
B97.35 | Human immunodeficiency virus, type 2 [HIV 2] as the cause of diseases classified elsewhere |
O98.7 | Human immunodeficiency virus [HIv] disease complicating pregnancy, childbirth and the puerperium |
O98.71 | Human immunodeficiency virus [HIv] disease complicating pregnancy |
O98.711 | Human immunodeficiency virus [HIv] disease complicating pregnancy, first trimester |
O98.712 | Human immunodeficiency virus [HIv] disease complicating pregnancy, second trimester |
O98.713 | Human immunodeficiency virus [HIv] disease complicating pregnancy, third trimester |
O98.719 | Human immunodeficiency virus [HIv] disease complicating pregnancy, unspecified trimester |
O98.72 | Human immunodeficiency virus [HIv] disease complicating childbirth |
O98.73 | Human immunodeficiency virus [HIv] disease complicating the puerperium |
Z21 | Asymptomatic human immunodeficiency virus [HIv] infection status |